Terazosin Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
Description A piperazine that has formula C19H25N5O4. (Chemical Entities of Biological Interest Ontology, CHEBI_9445)
External Link https://pubchem.ncbi.nlm.nih.gov/compound/5401
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Genes

200 proteins with high or low expression in Terazosin relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3 2.6
NAT9 N-acetyltransferase 9 (GCN5-related, putative) 1.1
ZNF518B zinc finger protein 518B 0.82
PCLO piccolo presynaptic cytomatrix protein 0.6
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 0.52
TNIP2 TNFAIP3 interacting protein 2 0.5
PEX5 peroxisomal biogenesis factor 5 0.48
TFCP2L1 transcription factor CP2-like 1 0.45
AAMDC adipogenesis associated, Mth938 domain containing 0.42
BLOC1S3 biogenesis of lysosomal organelles complex-1, subunit 3 0.38
ZNF646 zinc finger protein 646 0.38
TOMM7 translocase of outer mitochondrial membrane 7 homolog (yeast) 0.37
NENF neudesin neurotrophic factor 0.37
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H 0.37
MLH3 mutL homolog 3 0.37
RWDD1 RWD domain containing 1 0.36
SATB2 SATB homeobox 2 0.36
ZNF485 zinc finger protein 485 0.36
ZXDB zinc finger, X-linked, duplicated B 0.36
TMEM222 transmembrane protein 222 0.36
ATG4C autophagy related 4C, cysteine peptidase 0.36
PTMA prothymosin, alpha 0.36
PLEKHG2 pleckstrin homology domain containing, family G (with RhoGef domain) member 2 0.35
PPTC7 PTC7 protein phosphatase homolog (S. cerevisiae) 0.35
PML promyelocytic leukemia 0.35
JAG2 jagged 2 0.34
CCNDBP1 cyclin D-type binding-protein 1 0.34
FAM171A1 family with sequence similarity 171, member A1 0.34
CD320 CD320 molecule 0.34
FUBP1 far upstream element (FUSE) binding protein 1 0.34
ZNF362 zinc finger protein 362 0.34
PTMS parathymosin 0.33
LYSMD3 LysM, putative peptidoglycan-binding, domain containing 3 0.33
F10 coagulation factor X 0.33
C11ORF95 chromosome 11 open reading frame 95 0.32
LMF1 lipase maturation factor 1 0.32
FOXD2 forkhead box D2 0.32
ZNF428 zinc finger protein 428 0.31
E2F2 E2F transcription factor 2 0.31
GFOD2 glucose-fructose oxidoreductase domain containing 2 0.31
MDM4 MDM4, p53 regulator 0.31
TCP11L1 t-complex 11, testis-specific-like 1 0.31
PNPO pyridoxamine 5'-phosphate oxidase 0.3
CNTNAP1 contactin associated protein 1 0.3
MDK midkine (neurite growth-promoting factor 2) 0.3
MKS1 Meckel syndrome, type 1 0.3
PIGW phosphatidylinositol glycan anchor biosynthesis, class W 0.3
ADGRG6 adhesion G protein-coupled receptor G6 0.3
E2F4 E2F transcription factor 4, p107/p130-binding 0.3
PIMREG PICALM interacting mitotic regulator 0.29
MALSU1 mitochondrial assembly of ribosomal large subunit 1 0.29
TTC1 tetratricopeptide repeat domain 1 0.29
NASP nuclear autoantigenic sperm protein (histone-binding) 0.29
REEP1 receptor accessory protein 1 0.29
KLHL21 kelch-like family member 21 0.29
FGB fibrinogen beta chain 0.29
RASSF2 Ras association (RalGDS/AF-6) domain family member 2 0.29
SPATA13 spermatogenesis associated 13 0.29
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase) 0.28
RNF115 ring finger protein 115 0.28
RABEP1 rabaptin, RAB GTPase binding effector protein 1 0.28
BAG3 BCL2-associated athanogene 3 0.28
ARL2BP ADP-ribosylation factor-like 2 binding protein 0.28
ATP6V1E2 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E2 0.28
ALG14 ALG14, UDP-N-acetylglucosaminyltransferase subunit 0.28
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.28
CDR2 cerebellar degeneration-related protein 2, 62kDa 0.28
RCN2 reticulocalbin 2, EF-hand calcium binding domain 0.28
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21 0.28
TNNC2 troponin C type 2 (fast) 0.28
CALU calumenin 0.27
SYAP1 synapse associated protein 1 0.27
CMIP c-Maf inducing protein 0.27
ARMC7 armadillo repeat containing 7 0.27
STX1A syntaxin 1A (brain) 0.27
GINS4 GINS complex subunit 4 (Sld5 homolog) 0.27
LCORL ligand dependent nuclear receptor corepressor-like 0.27
STARD4 StAR-related lipid transfer (START) domain containing 4 0.27
TSR2 TSR2, 20S rRNA accumulation, homolog (S. cerevisiae) 0.26
ASF1B anti-silencing function 1B histone chaperone 0.26
UBE2B ubiquitin-conjugating enzyme E2B 0.26
ADAM22 ADAM metallopeptidase domain 22 0.26
GTSF1 gametocyte specific factor 1 0.26
EEF1B2 eukaryotic translation elongation factor 1 beta 2 0.26
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.26
NET1 neuroepithelial cell transforming 1 0.26
SUMO2 small ubiquitin-like modifier 2 0.26
FNTA farnesyltransferase, CAAX box, alpha 0.26
MTERF1 mitochondrial transcription termination factor 1 0.26
FSIP2 fibrous sheath interacting protein 2 0.26
WTAP Wilms tumor 1 associated protein 0.26
CD2BP2 CD2 (cytoplasmic tail) binding protein 2 0.25
EMC10 ER membrane protein complex subunit 10 0.25
AKT1S1 AKT1 substrate 1 (proline-rich) 0.25
CFAP47 cilia and flagella associated protein 47 0.25
FBXO42 F-box protein 42 0.25
COBLL1 cordon-bleu WH2 repeat protein-like 1 0.25
CUEDC2 CUE domain containing 2 0.25
FEZ2 fasciculation and elongation protein zeta 2 (zygin II) 0.25
ENTR1 endosome associated trafficking regulator 1 0.25

low expression

Symbol Name Standardized Value
MLXIPL MLX interacting protein-like -1.14
ZNF600 zinc finger protein 600 -0.89
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 -0.81
CSRNP2 cysteine-serine-rich nuclear protein 2 -0.74
APOBEC3F apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F -0.68
ESPN espin -0.63
SH2D5 SH2 domain containing 5 -0.53
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) -0.47
PDGFA platelet-derived growth factor alpha polypeptide -0.46
GTF3A general transcription factor IIIA -0.43
DGCR2 DiGeorge syndrome critical region gene 2 -0.43
TMEM184A transmembrane protein 184A -0.42
KRT222 keratin 222, type II -0.41
PCGF5 polycomb group ring finger 5 -0.41
CBX7 chromobox homolog 7 -0.4
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28 -0.4
MCF2L MCF.2 cell line derived transforming sequence-like -0.4
OASL 2'-5'-oligoadenylate synthetase-like -0.39
RPP25 ribonuclease P/MRP 25kDa subunit -0.39
DHRS1 dehydrogenase/reductase (SDR family) member 1 -0.39
RPP21 ribonuclease P/MRP 21kDa subunit -0.38
ZNF189 zinc finger protein 189 -0.38
FRK fyn-related Src family tyrosine kinase -0.37
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 -0.35
PPARD peroxisome proliferator-activated receptor delta -0.35
NEB nebulin -0.35
FABP6 fatty acid binding protein 6, ileal -0.35
COL1A1 collagen, type I, alpha 1 -0.34
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -0.34
SARDH sarcosine dehydrogenase -0.33
MAPKBP1 mitogen-activated protein kinase binding protein 1 -0.33
DENND4A DENN/MADD domain containing 4A -0.33
UBXN8 UBX domain protein 8 -0.33
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A -0.32
HECW2 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 -0.32
ZNF250 zinc finger protein 250 -0.32
ISL2 ISL LIM homeobox 2 -0.32
GRK5 G protein-coupled receptor kinase 5 -0.31
BCL6 B-cell CLL/lymphoma 6 -0.31
HSP90AA4P heat shock protein 90kDa alpha (cytosolic), class A member 4, pseudogene -0.31
TECPR1 tectonin beta-propeller repeat containing 1 -0.3
ARNTL aryl hydrocarbon receptor nuclear translocator-like -0.3
ZNF543 zinc finger protein 543 -0.3
ACTN3 actinin, alpha 3 (gene/pseudogene) -0.3
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 -0.3
PROS1 protein S (alpha) -0.29
HBA1 hemoglobin, alpha 1 -0.29
ZFP90 ZFP90 zinc finger protein -0.29
ZMYM6 zinc finger, MYM-type 6 -0.29
ZNF146 zinc finger protein 146 -0.29
DNAH8 dynein, axonemal, heavy chain 8 -0.29
GDF15 growth differentiation factor 15 -0.28
LEPROTL1 leptin receptor overlapping transcript-like 1 -0.28
ABCD4 ATP-binding cassette, sub-family D (ALD), member 4 -0.28
MTF1 metal-regulatory transcription factor 1 -0.27
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 -0.27
EXTL2 exostosin-like glycosyltransferase 2 -0.27
BTBD3 BTB (POZ) domain containing 3 -0.27
SYNE3 spectrin repeat containing, nuclear envelope family member 3 -0.27
ZNF608 zinc finger protein 608 -0.26
TSC22D2 TSC22 domain family, member 2 -0.25
FBXL8 F-box and leucine-rich repeat protein 8 -0.25
CCND3 cyclin D3 -0.25
GKAP1 G kinase anchoring protein 1 -0.24
GVINP1 GTPase, very large interferon inducible pseudogene 1 -0.24
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.24
ADAMTS7 ADAM metallopeptidase with thrombospondin type 1 motif, 7 -0.24
LPIN1 lipin 1 -0.24
GMCL2 germ cell-less 2, spermatogenesis associated -0.24
IER3IP1 immediate early response 3 interacting protein 1 -0.24
DGKH diacylglycerol kinase, eta -0.24
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.23
IGSF8 immunoglobulin superfamily, member 8 -0.23
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 -0.23
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.23
BHLHE40 basic helix-loop-helix family, member e40 -0.23
NDUFA11 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa -0.23
LTBP3 latent transforming growth factor beta binding protein 3 -0.23
ITPKB inositol-trisphosphate 3-kinase B -0.22
ZKSCAN2 zinc finger with KRAB and SCAN domains 2 -0.22
ATAT1 alpha tubulin acetyltransferase 1 -0.22
COQ10B coenzyme Q10 homolog B (S. cerevisiae) -0.22
ABLIM3 actin binding LIM protein family, member 3 -0.22
PPP1R16A protein phosphatase 1, regulatory subunit 16A -0.22
ACTR1B ARP1 actin-related protein 1 homolog B, centractin beta (yeast) -0.22
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2 -0.22
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) -0.22
TK2 thymidine kinase 2, mitochondrial -0.22
ADGRE2 adhesion G protein-coupled receptor E2 -0.22
PLEKHG6 pleckstrin homology domain containing, family G (with RhoGef domain) member 6 -0.22
LMO4 LIM domain only 4 -0.22
GORAB golgin, RAB6-interacting -0.21
NEU1 sialidase 1 (lysosomal sialidase) -0.21
CAMTA1 calmodulin binding transcription activator 1 -0.21
F2R coagulation factor II (thrombin) receptor -0.21
HAPLN3 hyaluronan and proteoglycan link protein 3 -0.21
APOE apolipoprotein E -0.21
DGKQ diacylglycerol kinase, theta 110kDa -0.21
PCMTD1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 -0.21
CCDC102A coiled-coil domain containing 102A -0.21