| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Terfenadine perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Terfenadine_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.170792 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.127073 |
| VIM | vimentin | 0.0794361 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0565738 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.047258 |
| RPS12 | ribosomal protein S12 | 0.0423416 |
| EHBP1 | EH domain binding protein 1 | 0.0415348 |
| HMGA2 | high mobility group AT-hook 2 | 0.0374931 |
| RPL35A | ribosomal protein L35a | 0.0354656 |
| INTS6 | integrator complex subunit 6 | 0.034966 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0348384 |
| OLR1 | oxidized low density lipoprotein (lectin-like) receptor 1 | 0.0342543 |
| PFN1 | profilin 1 | 0.0326851 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0317605 |
| RPS8 | ribosomal protein S8 | 0.0317587 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | 0.0317263 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0316804 |
| JMJD1C | jumonji domain containing 1C | 0.030299 |
| NRXN3 | neurexin 3 | 0.0298173 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0296824 |
| ADIPOR2 | adiponectin receptor 2 | 0.0294633 |
| RPL37A | ribosomal protein L37a | 0.0288421 |
| RACK1 | receptor for activated C kinase 1 | 0.0285384 |
| ANK2 | ankyrin 2, neuronal | 0.0278099 |
| DDIT3 | DNA-damage-inducible transcript 3 | 0.0271693 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | 0.0270251 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | 0.0268132 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0257331 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0248527 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0247084 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0246814 |
| DENND5A | DENN/MADD domain containing 5A | 0.0232734 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0219968 |
| PCDH9 | protocadherin 9 | 0.0217182 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0214531 |
| RPS3 | ribosomal protein S3 | 0.0209464 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0206883 |
| RNF213 | ring finger protein 213 | 0.0206868 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0206848 |
| MAP1B | microtubule-associated protein 1B | 0.0206089 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0202487 |
| NEBL | nebulette | 0.0200712 |
| CAMK2D | calcium/calmodulin-dependent protein kinase II delta | 0.0200612 |
| RPL23 | ribosomal protein L23 | 0.0199709 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | 0.0198075 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | 0.0195433 |
| PEG10 | paternally expressed 10 | 0.0195127 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0193081 |
| JUN | jun proto-oncogene | 0.0190593 |
| FTL | ferritin, light polypeptide | 0.0186187 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 0.0181153 |
| RPL36 | ribosomal protein L36 | 0.0178275 |
| CEP112 | centrosomal protein 112kDa | 0.0178212 |
| PDGFC | platelet derived growth factor C | 0.0178179 |
| IGF2 | insulin-like growth factor 2 | 0.0176746 |
| ASXL2 | additional sex combs like transcriptional regulator 2 | 0.0176466 |
| ZNF638 | zinc finger protein 638 | 0.0176363 |
| PARD3B | par-3 family cell polarity regulator beta | 0.0175839 |
| FSTL5 | follistatin-like 5 | 0.0175524 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0175203 |
| NFIB | nuclear factor I/B | 0.017447 |
| FLNA | filamin A, alpha | 0.0171685 |
| RPS27 | ribosomal protein S27 | 0.0170924 |
| PCBP1 | poly(rC) binding protein 1 | 0.0170097 |
| BCL6 | B-cell CLL/lymphoma 6 | 0.0167633 |
| HDAC9 | histone deacetylase 9 | 0.0167063 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0163113 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0161624 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0160107 |
| KLF6 | Kruppel-like factor 6 | 0.0158458 |
| EGR1 | early growth response 1 | 0.0157309 |
| PCBP2 | poly(rC) binding protein 2 | 0.0156807 |
| WWOX | WW domain containing oxidoreductase | 0.0156684 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 0.0156643 |
| PLP2 | proteolipid protein 2 (colonic epithelium-enriched) | 0.0155817 |
| SESN2 | sestrin 2 | 0.0154466 |
| PACS1 | phosphofurin acidic cluster sorting protein 1 | 0.0151498 |
| HLA-A | major histocompatibility complex, class I, A | 0.0151458 |
| AFF4 | AF4/FMR2 family, member 4 | 0.0151295 |
| L3MBTL4 | l(3)mbt-like 4 (Drosophila) | 0.0151004 |
| SERTAD2 | SERTA domain containing 2 | 0.0148929 |
| ASXL1 | additional sex combs like transcriptional regulator 1 | 0.0148758 |
| PRKCE | protein kinase C, epsilon | 0.0148143 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0147988 |
| HOMER1 | homer scaffolding protein 1 | 0.0147959 |
| ETV6 | ets variant 6 | 0.0146776 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0144821 |
| TBL1X | transducin (beta)-like 1X-linked | 0.0144667 |
| NEGR1 | neuronal growth regulator 1 | 0.014409 |
| LGALS12 | lectin, galactoside-binding, soluble, 12 | 0.0142883 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0140767 |
| RPS26 | ribosomal protein S26 | 0.0140552 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0140435 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0140428 |
| FASN | fatty acid synthase | 0.0140032 |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) | 0.0138476 |
| FAT1 | FAT atypical cadherin 1 | 0.0137469 |
| KSR2 | kinase suppressor of ras 2 | 0.0134021 |
| INTS4 | integrator complex subunit 4 | 0.0133848 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0133584 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.208141 |
| AREG | amphiregulin | -0.171998 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.117737 |
| PTMA | prothymosin, alpha | -0.101986 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | -0.0871406 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0831331 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0790925 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.078791 |
| MMP12 | matrix metallopeptidase 12 | -0.0767471 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0744924 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.0744826 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0728855 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0726728 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | -0.0657022 |
| CELF2 | CUGBP, Elav-like family member 2 | -0.0647568 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0607817 |
| LMO7 | LIM domain 7 | -0.0602151 |
| TMSB10 | thymosin beta 10 | -0.0568532 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0530871 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | -0.0517455 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0505987 |
| MGAT4C | MGAT4 family, member C | -0.0487277 |
| TUBA1B | tubulin, alpha 1b | -0.0483965 |
| CPOX | coproporphyrinogen oxidase | -0.0483007 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0463675 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0462119 |
| XPO1 | exportin 1 | -0.0457344 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0455156 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | -0.0447476 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.0427946 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0419194 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0417775 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | -0.0414269 |
| RPS24 | ribosomal protein S24 | -0.0405898 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0403154 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.040254 |
| BIRC2 | baculoviral IAP repeat containing 2 | -0.0395014 |
| AHNAK | AHNAK nucleoprotein | -0.0392296 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0388028 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0384122 |
| CLTC | clathrin, heavy chain (Hc) | -0.0383584 |
| IL6ST | interleukin 6 signal transducer | -0.0381743 |
| ZNF804A | zinc finger protein 804A | -0.036836 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0363169 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | -0.0360352 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0359349 |
| TMEM123 | transmembrane protein 123 | -0.0358487 |
| CXADR | coxsackie virus and adenovirus receptor | -0.0356807 |
| ASPH | aspartate beta-hydroxylase | -0.0356445 |
| RRM2 | ribonucleotide reductase M2 | -0.0354513 |
| CENPF | centromere protein F, 350/400kDa | -0.0341333 |
| RPS21 | ribosomal protein S21 | -0.034055 |
| SETD5 | SET domain containing 5 | -0.0328411 |
| TPI1 | triosephosphate isomerase 1 | -0.0326355 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0317152 |
| HSPA4 | heat shock 70kDa protein 4 | -0.0315928 |
| RPL38 | ribosomal protein L38 | -0.031307 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | -0.031209 |
| PRR11 | proline rich 11 | -0.0311664 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0311229 |
| ZNF217 | zinc finger protein 217 | -0.0304764 |
| RPS2 | ribosomal protein S2 | -0.030378 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0303495 |
| YBX3 | Y box binding protein 3 | -0.0302255 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | -0.0300738 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | -0.030025 |
| NKTR | natural killer cell triggering receptor | -0.0298273 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0296268 |
| RPS6 | ribosomal protein S6 | -0.0296007 |
| ECT2 | epithelial cell transforming 2 | -0.0290938 |
| H1-0 | H1.0 linker histone | -0.0290517 |
| HDLBP | high density lipoprotein binding protein | -0.0289238 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | -0.0287223 |
| RPL8 | ribosomal protein L8 | -0.0286951 |
| RPL19 | ribosomal protein L19 | -0.0286314 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | -0.0284729 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | -0.0283501 |
| KIF5B | kinesin family member 5B | -0.0278758 |
| TUBB | tubulin, beta class I | -0.0278477 |
| CCT8 | chaperonin containing TCP1, subunit 8 (theta) | -0.0278244 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0277771 |
| H3-3B | H3.3 histone B | -0.0277711 |
| AXIN2 | axin 2 | -0.0277139 |
| CEP192 | centrosomal protein 192kDa | -0.0277075 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0275516 |
| CDK17 | cyclin-dependent kinase 17 | -0.0273683 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | -0.0273133 |
| MKI67 | marker of proliferation Ki-67 | -0.0272406 |
| THOC2 | THO complex 2 | -0.0271806 |
| CANX | calnexin | -0.0270427 |
| CSE1L | CSE1 chromosome segregation 1-like (yeast) | -0.0270247 |
| GNB4 | guanine nucleotide binding protein (G protein), beta polypeptide 4 | -0.0267784 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | -0.0265398 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0264817 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.026038 |
| POTEF | POTE ankyrin domain family, member F | -0.0258862 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0258586 |
| R3HDM1 | R3H domain containing 1 | -0.0257667 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0255542 |
| AFG3L2 | AFG3-like AAA ATPase 2 | -0.0252929 |
