| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Terfenadine perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Terfenadine_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NDRG1 | N-myc downstream regulated 1 | 0.417795 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.176172 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.142326 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.126393 |
| COL6A3 | collagen, type VI, alpha 3 | 0.123616 |
| MT2A | metallothionein 2A | 0.0986929 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0957653 |
| LOX | lysyl oxidase | 0.0907122 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0774166 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0576534 |
| FMNL2 | formin-like 2 | 0.056698 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0516567 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0503942 |
| FLNA | filamin A, alpha | 0.0480749 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0475716 |
| CALR | calreticulin | 0.046811 |
| RPS3 | ribosomal protein S3 | 0.0445958 |
| RPS12 | ribosomal protein S12 | 0.0440784 |
| RACK1 | receptor for activated C kinase 1 | 0.040824 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0403827 |
| RPL35A | ribosomal protein L35a | 0.0388898 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0361716 |
| RPS8 | ribosomal protein S8 | 0.0350669 |
| ACTG1 | actin gamma 1 | 0.0348153 |
| PDE10A | phosphodiesterase 10A | 0.0343276 |
| SEC61A1 | Sec61 alpha 1 subunit (S. cerevisiae) | 0.0342423 |
| RAB2A | RAB2A, member RAS oncogene family | 0.0339516 |
| DPYSL2 | dihydropyrimidinase-like 2 | 0.0335827 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0333126 |
| EGFR | epidermal growth factor receptor | 0.0326343 |
| CADM1 | cell adhesion molecule 1 | 0.0323402 |
| PLEC | plectin | 0.0321815 |
| FGFR1 | fibroblast growth factor receptor 1 | 0.0320079 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0313387 |
| RPL37A | ribosomal protein L37a | 0.0311771 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0305671 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0303371 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0302254 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0284837 |
| EFNA5 | ephrin-A5 | 0.0277589 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.0275573 |
| RPL23 | ribosomal protein L23 | 0.027092 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0268419 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | 0.0260471 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0260405 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0259911 |
| LOXL2 | lysyl oxidase-like 2 | 0.0257936 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0255717 |
| RPN1 | ribophorin I | 0.0250932 |
| URI1 | URI1, prefoldin-like chaperone | 0.0246439 |
| ATP13A3 | ATPase type 13A3 | 0.0237516 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0235501 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | 0.0233213 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0231918 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0231564 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 0.022989 |
| COL6A2 | collagen, type VI, alpha 2 | 0.0229294 |
| NAV2 | neuron navigator 2 | 0.0228063 |
| RASA2 | RAS p21 protein activator 2 | 0.0227941 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.022543 |
| RPL26 | ribosomal protein L26 | 0.0223011 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0222433 |
| STC2 | stanniocalcin 2 | 0.0221284 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0219857 |
| PGM3 | phosphoglucomutase 3 | 0.0217965 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | 0.0217607 |
| MRPS6 | mitochondrial ribosomal protein S6 | 0.0214862 |
| GNAS | GNAS complex locus | 0.0214597 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0213424 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0213421 |
| RPL37 | ribosomal protein L37 | 0.0212929 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0211305 |
| COG5 | component of oligomeric golgi complex 5 | 0.0210077 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | 0.0209422 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0207522 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0204265 |
| MRTFA | myocardin related transcription factor A | 0.0202205 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | 0.0201448 |
| CTBP2 | C-terminal binding protein 2 | 0.0200138 |
| RPL30 | ribosomal protein L30 | 0.020002 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0199213 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0197091 |
| ITGB5 | integrin, beta 5 | 0.0196941 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0195027 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0194478 |
| ANO10 | anoctamin 10 | 0.0193868 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | 0.0190129 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.019006 |
| RPL36 | ribosomal protein L36 | 0.0189291 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0188233 |
| CDK13 | cyclin-dependent kinase 13 | 0.0187581 |
| PDIA5 | protein disulfide isomerase family A, member 5 | 0.0187429 |
| HMGA2 | high mobility group AT-hook 2 | 0.0186761 |
| SRP54 | signal recognition particle 54kDa | 0.018651 |
| WRN | Werner syndrome, RecQ helicase-like | 0.0186321 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.01844 |
| AGO3 | argonaute RISC catalytic component 3 | 0.018398 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0182547 |
| IGF2 | insulin-like growth factor 2 | 0.0182343 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0180062 |
| Symbol | Name | Standardized Value |
|---|---|---|
| COL1A1 | collagen, type I, alpha 1 | -0.269983 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.145538 |
| COL1A2 | collagen, type I, alpha 2 | -0.113772 |
| FN1 | fibronectin 1 | -0.103487 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.100276 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0949483 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0881787 |
| PTMA | prothymosin, alpha | -0.085784 |
| CANX | calnexin | -0.0742705 |
| IL6ST | interleukin 6 signal transducer | -0.0740949 |
| TPM4 | tropomyosin 4 | -0.0639172 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | -0.0583778 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0563765 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0562881 |
| CALD1 | caldesmon 1 | -0.054927 |
| RPS6 | ribosomal protein S6 | -0.0541705 |
| AHNAK | AHNAK nucleoprotein | -0.0522485 |
| VIM | vimentin | -0.0517228 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0503982 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | -0.0497637 |
| IER3 | immediate early response 3 | -0.049608 |
| DPYSL3 | dihydropyrimidinase-like 3 | -0.0494327 |
| MAP1B | microtubule-associated protein 1B | -0.0469429 |
| CLIC4 | chloride intracellular channel 4 | -0.0460186 |
| TMSB4X | thymosin beta 4, X-linked | -0.0448348 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0425965 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0422556 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0417288 |
| VCAN | versican | -0.0404781 |
| TPM1 | tropomyosin 1 (alpha) | -0.0397999 |
| UBC | ubiquitin C | -0.0395013 |
| TNIP1 | TNFAIP3 interacting protein 1 | -0.0388817 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.0372315 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0371538 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0361602 |
| DST | dystonin | -0.0354182 |
| ASPH | aspartate beta-hydroxylase | -0.0347786 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0343261 |
| SMAD3 | SMAD family member 3 | -0.0339979 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0338222 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0337218 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0336426 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0335024 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0334847 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0320947 |
| RRBP1 | ribosome binding protein 1 | -0.0318862 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0309716 |
| CNTN5 | contactin 5 | -0.0306639 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0305724 |
| S100A9 | S100 calcium binding protein A9 | -0.0298095 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0294221 |
| PALLD | palladin, cytoskeletal associated protein | -0.0276217 |
| CENPF | centromere protein F, 350/400kDa | -0.02685 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.0267857 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | -0.026582 |
| HAS2 | hyaluronan synthase 2 | -0.0264426 |
| H1-0 | H1.0 linker histone | -0.0263477 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0262176 |
| DSTN | destrin (actin depolymerizing factor) | -0.0261257 |
| FSTL1 | follistatin-like 1 | -0.0261138 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0260816 |
| IL6 | interleukin 6 | -0.0259648 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0259155 |
| S100A10 | S100 calcium binding protein A10 | -0.0254914 |
| TMSB10 | thymosin beta 10 | -0.0253213 |
| CD44 | CD44 molecule (Indian blood group) | -0.0250659 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0250313 |
| IRF1 | interferon regulatory factor 1 | -0.024939 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0248307 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0247291 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0247159 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.024652 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0244512 |
| THY1 | Thy-1 cell surface antigen | -0.0241462 |
| ZFPM2 | zinc finger protein, FOG family member 2 | -0.0240995 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | -0.0238355 |
| CSF1 | colony stimulating factor 1 (macrophage) | -0.0238192 |
| MX2 | MX dynamin-like GTPase 2 | -0.0237076 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0233981 |
| EBF1 | early B-cell factor 1 | -0.0233526 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0231968 |
| TPM2 | tropomyosin 2 (beta) | -0.0231631 |
| PFKP | phosphofructokinase, platelet | -0.0229771 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.022801 |
| VCL | vinculin | -0.0227436 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0225986 |
| FCHSD2 | FCH and double SH3 domains 2 | -0.0222558 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.022069 |
| B2M | beta-2-microglobulin | -0.0220127 |
| NREP | neuronal regeneration related protein | -0.0219545 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0217259 |
| FBXO32 | F-box protein 32 | -0.0214628 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.0214427 |
| STK38L | serine/threonine kinase 38 like | -0.0213841 |
| POTEF | POTE ankyrin domain family, member F | -0.021322 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.0212257 |
| IGFBP7 | insulin-like growth factor binding protein 7 | -0.0211314 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0211162 |
| TENM3 | teneurin transmembrane protein 3 | -0.0208758 |
| CDH2 | cadherin 2, type 1, N-cadherin (neuronal) | -0.0207795 |
