Terfenadine_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Terfenadine perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Terfenadine_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 0.223749
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.16223
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.10691
FNDC3B fibronectin type III domain containing 3B 0.0925963
IGFBP1 insulin-like growth factor binding protein 1 0.0777112
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0716008
AFDN afadin, adherens junction formation factor 0.0697744
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0693998
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0678182
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0674367
CCL20 chemokine (C-C motif) ligand 20 0.0672428
GOLGA4 golgin A4 0.0655501
RBM39 RNA binding motif protein 39 0.0634445
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0632483
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0590804
DDIT4 DNA-damage-inducible transcript 4 0.0581203
ERRFI1 ERBB receptor feedback inhibitor 1 0.0570655
DTNA dystrobrevin, alpha 0.056249
SPAG9 sperm associated antigen 9 0.0562277
ZFAND3 zinc finger, AN1-type domain 3 0.0562234
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.053804
BIRC6 baculoviral IAP repeat containing 6 0.0535011
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0533526
NUP58 nucleoporin 58 0.0502816
EEF2 eukaryotic translation elongation factor 2 0.0497659
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0483083
RPS6 ribosomal protein S6 0.0476126
KMT2C lysine (K)-specific methyltransferase 2C 0.0473041
ELL2 elongation factor, RNA polymerase II, 2 0.0467743
TOP1 topoisomerase (DNA) I 0.0464705
SVIL supervillin 0.0461304
VEGFA vascular endothelial growth factor A 0.045925
MYO1B myosin IB 0.0455374
UBA6 ubiquitin-like modifier activating enzyme 6 0.0451024
KDM3A lysine (K)-specific demethylase 3A 0.0446991
ZEB1 zinc finger E-box binding homeobox 1 0.0443072
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0439497
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0430961
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0424865
NCKAP1 NCK-associated protein 1 0.0420038
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0418069
QKI QKI, KH domain containing, RNA binding 0.0418032
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0413458
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.040576
WAC WW domain containing adaptor with coiled-coil 0.0404696
DENND4A DENN/MADD domain containing 4A 0.0403273
PUM2 pumilio RNA-binding family member 2 0.0400423
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0398106
JMJD1C jumonji domain containing 1C 0.0395579
FBXO42 F-box protein 42 0.0394553
INSIG2 insulin induced gene 2 0.0393604
FAM13A family with sequence similarity 13, member A 0.0389725
ITCH itchy E3 ubiquitin protein ligase 0.038935
RAB6A RAB6A, member RAS oncogene family 0.0387932
SETD5 SET domain containing 5 0.0387105
HP1BP3 heterochromatin protein 1, binding protein 3 0.0386084
WDR45B WD repeat domain 45B 0.0380765
PCBP2 poly(rC) binding protein 2 0.0380257
BHLHE40 basic helix-loop-helix family, member e40 0.0377468
DLC1 DLC1 Rho GTPase activating protein 0.0376386
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0376005
ZNF292 zinc finger protein 292 0.03757
CAMTA1 calmodulin binding transcription activator 1 0.0374476
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 0.0374306
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0372875
C3 complement component 3 0.0370795
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0369069
GRB10 growth factor receptor-bound protein 10 0.0368254
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0365386
JAK1 Janus kinase 1 0.0361498
RBM25 RNA binding motif protein 25 0.036102
SOS1 son of sevenless homolog 1 (Drosophila) 0.0354686
MED13 mediator complex subunit 13 0.035194
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.035077
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0349906
KMT2E lysine (K)-specific methyltransferase 2E 0.0348977
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.034355
ANXA5 annexin A5 0.0343141
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0342372
MACF1 microtubule-actin crosslinking factor 1 0.0342324
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0338052
MAP2K1 mitogen-activated protein kinase kinase 1 0.0337481
RICTOR RPTOR independent companion of MTOR, complex 2 0.0334167
SNX9 sorting nexin 9 0.0333898
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0333694
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0333228
HELZ helicase with zinc finger 0.033262
FTH1 ferritin, heavy polypeptide 1 0.0332471
AAK1 AP2 associated kinase 1 0.0331157
RB1CC1 RB1-inducible coiled-coil 1 0.0328747
STRN3 striatin, calmodulin binding protein 3 0.0326371
FOXP1 forkhead box P1 0.0325445
ACSL5 acyl-CoA synthetase long-chain family member 5 0.0325308
DIAPH1 diaphanous-related formin 1 0.0321949
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.0320582
MEMO1 mediator of cell motility 1 0.0319626
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0315597
NDRG1 N-myc downstream regulated 1 0.0315404
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0315301
GSPT1 G1 to S phase transition 1 0.0314984

decreased expression

Symbol Name Standardized Value
GPC6 glypican 6 -0.147808
FN1 fibronectin 1 -0.117567
ENO1 enolase 1, (alpha) -0.114383
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.113562
LRMDA leucine rich melanocyte differentiation associated -0.0813329
MAML2 mastermind-like 2 (Drosophila) -0.0805843
TM4SF1 transmembrane 4 L six family member 1 -0.0780778
GPC3 glypican 3 -0.0750514
ZBTB20 zinc finger and BTB domain containing 20 -0.0745978
TMSB10 thymosin beta 10 -0.0718068
EHBP1 EH domain binding protein 1 -0.0702887
TPT1 tumor protein, translationally-controlled 1 -0.068912
NPAS2 neuronal PAS domain protein 2 -0.0654894
DST dystonin -0.0650893
SAMD4A sterile alpha motif domain containing 4A -0.0643588
DSPP dentin sialophosphoprotein -0.0578356
CP ceruloplasmin (ferroxidase) -0.0573656
AHNAK AHNAK nucleoprotein -0.0550206
VCL vinculin -0.0522718
SLC38A2 solute carrier family 38, member 2 -0.0511882
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0498738
RPS27A ribosomal protein S27a -0.0495712
ASPH aspartate beta-hydroxylase -0.0450433
GMDS GDP-mannose 4,6-dehydratase -0.0441551
APOB apolipoprotein B -0.0425122
NKD1 naked cuticle homolog 1 (Drosophila) -0.0411441
PTCHD4 patched domain containing 4 -0.0406757
MT2A metallothionein 2A -0.0403699
PEG3 paternally expressed 3 -0.0393328
UBC ubiquitin C -0.0391417
FRMD5 FERM domain containing 5 -0.0389017
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0368228
AKAP12 A kinase (PRKA) anchor protein 12 -0.035316
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0338609
LPP LIM domain containing preferred translocation partner in lipoma -0.0334798
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) -0.0333895
PDLIM5 PDZ and LIM domain 5 -0.0329922
RPS24 ribosomal protein S24 -0.0328921
MBNL3 muscleblind-like splicing regulator 3 -0.0326745
HDAC4 histone deacetylase 4 -0.0320218
RAD51B RAD51 paralog B -0.0314498
LRRTM4 leucine rich repeat transmembrane neuronal 4 -0.0312079
APOE apolipoprotein E -0.0310266
ATP10A ATPase, class V, type 10A -0.03088
DNAH17 dynein, axonemal, heavy chain 17 -0.0305494
PLXDC2 plexin domain containing 2 -0.0283484
PTPRK protein tyrosine phosphatase, receptor type, K -0.0282165
TRIM26 tripartite motif containing 26 -0.0281045
A2M alpha-2-macroglobulin -0.0276373
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0273717
LDHA lactate dehydrogenase A -0.0272327
H1-0 H1.0 linker histone -0.0265865
RACK1 receptor for activated C kinase 1 -0.026431
RNF213 ring finger protein 213 -0.0253348
PTPRF protein tyrosine phosphatase, receptor type, F -0.0252954
RNASET2 ribonuclease T2 -0.025288
SMAD3 SMAD family member 3 -0.0248939
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.0247199
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) -0.0244806
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0243858
KRT18 keratin 18, type I -0.0239073
ACTN4 actinin, alpha 4 -0.0238995
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 -0.0237354
LMCD1 LIM and cysteine-rich domains 1 -0.0236641
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0233632
RPL23 ribosomal protein L23 -0.0233136
HMGA2 high mobility group AT-hook 2 -0.0232535
RPL11 ribosomal protein L11 -0.0232352
STK17A serine/threonine kinase 17a -0.023213
INTS6 integrator complex subunit 6 -0.0231931
RPL31 ribosomal protein L31 -0.02317
ARHGAP5 Rho GTPase activating protein 5 -0.0222356
PEG10 paternally expressed 10 -0.0218419
DOCK4 dedicator of cytokinesis 4 -0.0217968
RPS3 ribosomal protein S3 -0.0215857
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 -0.0215767
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0215527
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0214791
ATF7IP2 activating transcription factor 7 interacting protein 2 -0.0214505
ITGA1 integrin, alpha 1 -0.0212801
FILIP1L filamin A interacting protein 1-like -0.0208118
RPL9 ribosomal protein L9 -0.0206709
KRT19 keratin 19, type I -0.0201687
IGF1R insulin-like growth factor 1 receptor -0.0201256
SEPTIN9 septin 9 -0.0200805
ITGAV integrin, alpha V -0.0200611
ENKUR enkurin, TRPC channel interacting protein -0.0200226
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0199318
RPL12 ribosomal protein L12 -0.0199002
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide -0.0198771
ARHGAP18 Rho GTPase activating protein 18 -0.0196582
ACTG1 actin gamma 1 -0.0196205
KRT23 keratin 23, type I -0.0195096
ZHX2 zinc fingers and homeoboxes 2 -0.0194877
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0187253
RPL36A ribosomal protein L36a -0.0186895
RHOB ras homolog family member B -0.0186368
PTPRM protein tyrosine phosphatase, receptor type, M -0.0184997
KRT8 keratin 8, type II -0.0183938
JUN jun proto-oncogene -0.0183897