| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Terfenadine perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Terfenadine_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EGFR | epidermal growth factor receptor | 0.237808 |
| NDRG1 | N-myc downstream regulated 1 | 0.137518 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.108455 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.101473 |
| SLTM | SAFB-like, transcription modulator | 0.0989639 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.096692 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0877364 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.081175 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0761838 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0747177 |
| EGR1 | early growth response 1 | 0.0635363 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0596502 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0535033 |
| FAM13A | family with sequence similarity 13, member A | 0.0500257 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0490517 |
| RPS12 | ribosomal protein S12 | 0.0454548 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0449888 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0440325 |
| STC1 | stanniocalcin 1 | 0.0433331 |
| RNF213 | ring finger protein 213 | 0.0425953 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0421353 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0420837 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0410452 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | 0.0402502 |
| MYO1E | myosin IE | 0.0394827 |
| MT2A | metallothionein 2A | 0.0391444 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0389049 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0372623 |
| ATP11A | ATPase, class VI, type 11A | 0.0355512 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0348243 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0342503 |
| NSUN6 | NOP2/Sun domain family, member 6 | 0.0328227 |
| CPE | carboxypeptidase E | 0.0326224 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0314289 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0312898 |
| EFNA5 | ephrin-A5 | 0.0296799 |
| RPS2 | ribosomal protein S2 | 0.0295341 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0294886 |
| RPL35A | ribosomal protein L35a | 0.0287893 |
| TMEM45B | transmembrane protein 45B | 0.0286615 |
| CAV2 | caveolin 2 | 0.0284487 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0282856 |
| PYGL | phosphorylase, glycogen, liver | 0.0279877 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | 0.0279726 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0278842 |
| EYA2 | EYA transcriptional coactivator and phosphatase 2 | 0.0277609 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0273984 |
| RAD51B | RAD51 paralog B | 0.026278 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | 0.0253524 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0252511 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.0251348 |
| AREG | amphiregulin | 0.0250148 |
| HMGA1 | high mobility group AT-hook 1 | 0.0246974 |
| RPL37A | ribosomal protein L37a | 0.0242135 |
| MCL1 | myeloid cell leukemia 1 | 0.0241245 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0239408 |
| RPS27 | ribosomal protein S27 | 0.0237173 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0232465 |
| SLK | STE20-like kinase | 0.0232251 |
| MSN | moesin | 0.023199 |
| SIK3 | SIK family kinase 3 | 0.0227869 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0226689 |
| CES1 | carboxylesterase 1 | 0.0223964 |
| RNASEH2A | ribonuclease H2, subunit A | 0.0222298 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0221955 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0219487 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0213213 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.021257 |
| RPS3 | ribosomal protein S3 | 0.0209828 |
| CD163L1 | CD163 molecule-like 1 | 0.0207263 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0206529 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 0.0205454 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.020436 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0202975 |
| RPS8 | ribosomal protein S8 | 0.0202597 |
| HDAC9 | histone deacetylase 9 | 0.0201663 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.0199858 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0197291 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0197191 |
| BMP6 | bone morphogenetic protein 6 | 0.0195922 |
| ZNF292 | zinc finger protein 292 | 0.019435 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.019308 |
| GPATCH2L | G patch domain containing 2-like | 0.018402 |
| ANGPTL4 | angiopoietin-like 4 | 0.0182016 |
| BLZF1 | basic leucine zipper nuclear factor 1 | 0.0181541 |
| LAMA4 | laminin, alpha 4 | 0.0180837 |
| PDXDC1 | pyridoxal-dependent decarboxylase domain containing 1 | 0.0179534 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | 0.0178634 |
| RPL37 | ribosomal protein L37 | 0.0177144 |
| ATF4 | activating transcription factor 4 | 0.017467 |
| B2M | beta-2-microglobulin | 0.0174573 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0171913 |
| RALGAPA1 | Ral GTPase activating protein, alpha subunit 1 (catalytic) | 0.0171112 |
| AP1G1 | adaptor-related protein complex 1, gamma 1 subunit | 0.0167457 |
| MX1 | MX dynamin-like GTPase 1 | 0.016734 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0167202 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0166534 |
| CCSER1 | coiled-coil serine-rich protein 1 | 0.0166477 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0161558 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0161476 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | -0.204094 |
| UBC | ubiquitin C | -0.15105 |
| ASPH | aspartate beta-hydroxylase | -0.133963 |
| AHNAK | AHNAK nucleoprotein | -0.104528 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0991569 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0967095 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0922476 |
| TMSB10 | thymosin beta 10 | -0.0657826 |
| H1-0 | H1.0 linker histone | -0.0653813 |
| LMO7 | LIM domain 7 | -0.062073 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0602663 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0585259 |
| HDLBP | high density lipoprotein binding protein | -0.0538722 |
| LOC112694756 | uncharaterized LOC112694756 | -0.053576 |
| RPS27A | ribosomal protein S27a | -0.0498361 |
| CANX | calnexin | -0.049816 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0491184 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0465875 |
| OGA | O-GlcNAcase | -0.0444795 |
| ENO1 | enolase 1, (alpha) | -0.0435512 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0423431 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.0411501 |
| SDC4 | syndecan 4 | -0.0411105 |
| OSMR | oncostatin M receptor | -0.0409478 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0389956 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0387502 |
| ZC3H11A | zinc finger CCCH-type containing 11A | -0.0364358 |
| PTMA | prothymosin, alpha | -0.0364356 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0336757 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0334388 |
| KRT18 | keratin 18, type I | -0.0331806 |
| RAB10 | RAB10, member RAS oncogene family | -0.0329703 |
| MYOF | myoferlin | -0.0325281 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0324896 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0315676 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.0312689 |
| GSK3B | glycogen synthase kinase 3 beta | -0.031235 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0307958 |
| KRT8 | keratin 8, type II | -0.0302306 |
| LDHA | lactate dehydrogenase A | -0.0300537 |
| KRT7 | keratin 7, type II | -0.0295019 |
| LRP1B | low density lipoprotein receptor-related protein 1B | -0.0291239 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0284227 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.028291 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | -0.0281254 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0280494 |
| ZFC3H1 | zinc finger, C3H1-type containing | -0.027716 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0277047 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.0276203 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0275828 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | -0.0275275 |
| CTTN | cortactin | -0.0267818 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0265843 |
| RPS24 | ribosomal protein S24 | -0.0265616 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.02652 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0264645 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0262819 |
| PLEC | plectin | -0.0261647 |
| SIPA1L2 | signal-induced proliferation-associated 1 like 2 | -0.0258704 |
| S100A10 | S100 calcium binding protein A10 | -0.025851 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.0258463 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0255025 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0252461 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.0251518 |
| SEPTIN10 | septin 10 | -0.0250421 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0250087 |
| LANCL2 | LanC lantibiotic synthetase component C-like 2 (bacterial) | -0.0249946 |
| DSCAM | Down syndrome cell adhesion molecule | -0.024905 |
| VCL | vinculin | -0.0247246 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0247029 |
| TAOK1 | TAO kinase 1 | -0.0246095 |
| ANKLE2 | ankyrin repeat and LEM domain containing 2 | -0.0243516 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0243351 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0242654 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0236409 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0235621 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0234265 |
| SHTN1 | shootin 1 | -0.0232784 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0231539 |
| ARHGAP32 | Rho GTPase activating protein 32 | -0.0223845 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.0223837 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0220866 |
| ABCC1 | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 | -0.0219888 |
| TNS3 | tensin 3 | -0.0219457 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0218942 |
| RPL4 | ribosomal protein L4 | -0.0215114 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0214561 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.021441 |
| PGK1 | phosphoglycerate kinase 1 | -0.0214335 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0212262 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.020934 |
| ACIN1 | apoptotic chromatin condensation inducer 1 | -0.0203646 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0200499 |
| SETD5 | SET domain containing 5 | -0.0199633 |
| NCOA3 | nuclear receptor coactivator 3 | -0.0197153 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0194427 |
| ABCC2 | ATP-binding cassette, sub-family C (CFTR/MRP), member 2 | -0.019388 |
| CCND1 | cyclin D1 | -0.0193566 |
| RAD21 | RAD21 homolog (S. pombe) | -0.019341 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0193135 |
