Terfenadine_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Terfenadine perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Terfenadine_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.13286
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.125288
IGFBP3 insulin-like growth factor binding protein 3 0.116981
VIM vimentin 0.102278
NDRG1 N-myc downstream regulated 1 0.100243
MEF2A myocyte enhancer factor 2A 0.0944225
AKAP12 A kinase (PRKA) anchor protein 12 0.0913685
CXCL8 chemokine (C-X-C motif) ligand 8 0.0851672
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0799069
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0794126
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0777694
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0776677
LOX lysyl oxidase 0.0771173
FN1 fibronectin 1 0.0711856
STC1 stanniocalcin 1 0.0624867
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0606174
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0584339
CA12 carbonic anhydrase XII 0.0566391
GRB10 growth factor receptor-bound protein 10 0.0560916
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0545582
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0529674
PCBP2 poly(rC) binding protein 2 0.0524575
MTSS1 metastasis suppressor 1 0.0515944
FAM13A family with sequence similarity 13, member A 0.0514329
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0492723
MAML3 mastermind-like 3 (Drosophila) 0.0470052
HILPDA hypoxia inducible lipid droplet-associated 0.0467023
HMGA1 high mobility group AT-hook 1 0.0457308
B2M beta-2-microglobulin 0.044649
CDH13 cadherin 13 0.0442112
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.044039
FTL ferritin, light polypeptide 0.0435879
PIAS2 protein inhibitor of activated STAT, 2 0.0435481
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0410737
FTH1 ferritin, heavy polypeptide 1 0.0409724
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0409475
PDIA3 protein disulfide isomerase family A, member 3 0.0386809
KTN1 kinectin 1 (kinesin receptor) 0.0385735
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0377599
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0356837
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0354962
NAV2 neuron navigator 2 0.0354497
PDGFA platelet-derived growth factor alpha polypeptide 0.0354356
RCOR1 REST corepressor 1 0.0351247
ANGPTL4 angiopoietin-like 4 0.0348269
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0347005
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0333771
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0330497
MACF1 microtubule-actin crosslinking factor 1 0.0326307
PYGL phosphorylase, glycogen, liver 0.0321909
EEF2 eukaryotic translation elongation factor 2 0.0320952
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0316375
RAB7A RAB7A, member RAS oncogene family 0.0308252
PTMA prothymosin, alpha 0.0306467
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0302143
SEPTIN9 septin 9 0.0300332
ESYT2 extended synaptotagmin-like protein 2 0.0296679
FBXO11 F-box protein 11 0.0294081
HDAC9 histone deacetylase 9 0.0294032
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0290935
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0285662
RAI14 retinoic acid induced 14 0.0282405
SDK1 sidekick cell adhesion molecule 1 0.028149
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.026927
HMGA2 high mobility group AT-hook 2 0.0268212
INSIG1 insulin induced gene 1 0.0267126
PLIN2 perilipin 2 0.0264552
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0262856
HIP1 huntingtin interacting protein 1 0.0262539
SRP54 signal recognition particle 54kDa 0.0262268
BIRC3 baculoviral IAP repeat containing 3 0.0261498
SYT1 synaptotagmin I 0.0260584
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0259632
RPS12 ribosomal protein S12 0.0258407
MT2A metallothionein 2A 0.0257925
PARP8 poly (ADP-ribose) polymerase family, member 8 0.025772
PFN1 profilin 1 0.0256438
RIOK3 RIO kinase 3 0.0256297
ADM adrenomedullin 0.0255776
IFI44L interferon-induced protein 44-like 0.0255101
PKM pyruvate kinase, muscle 0.0254859
PRR16 proline rich 16 0.0254483
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0254084
BHLHE40 basic helix-loop-helix family, member e40 0.025292
RAB8B RAB8B, member RAS oncogene family 0.0250856
PTK2 protein tyrosine kinase 2 0.0249058
ANKRD28 ankyrin repeat domain 28 0.0247898
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0246888
TGFB1 transforming growth factor, beta 1 0.0245172
IRAK2 interleukin-1 receptor-associated kinase 2 0.0243941
RPS27 ribosomal protein S27 0.0243411
AMPD3 adenosine monophosphate deaminase 3 0.0239798
INTS6 integrator complex subunit 6 0.0237612
SNX9 sorting nexin 9 0.0237473
MARCKS myristoylated alanine-rich protein kinase C substrate 0.0237141
ANTXR2 anthrax toxin receptor 2 0.0236473
CNIH3 cornichon family AMPA receptor auxiliary protein 3 0.0235802
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0235796
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0235784
WWC2 WW and C2 domain containing 2 0.0233865

decreased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase -0.135564
FNDC3B fibronectin type III domain containing 3B -0.120846
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.117319
OSMR oncostatin M receptor -0.117236
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.087233
RBM39 RNA binding motif protein 39 -0.0864575
NCOA7 nuclear receptor coactivator 7 -0.0839177
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0643888
CD44 CD44 molecule (Indian blood group) -0.0585177
ETV6 ets variant 6 -0.0559301
FAM20C family with sequence similarity 20, member C -0.0549503
PID1 phosphotyrosine interaction domain containing 1 -0.0540962
ZBTB20 zinc finger and BTB domain containing 20 -0.053085
DSCAM Down syndrome cell adhesion molecule -0.0523751
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0515887
TMSB10 thymosin beta 10 -0.0500423
PDE4D phosphodiesterase 4D, cAMP-specific -0.0461891
KYNU kynureninase -0.0452957
RAD51B RAD51 paralog B -0.0431135
SMAD3 SMAD family member 3 -0.042716
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0424908
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0416252
AHNAK AHNAK nucleoprotein -0.0406872
SBF2 SET binding factor 2 -0.04015
TBC1D5 TBC1 domain family, member 5 -0.0400216
COL12A1 collagen, type XII, alpha 1 -0.0398203
OGA O-GlcNAcase -0.038767
SOD2 superoxide dismutase 2, mitochondrial -0.0385141
SAMD4A sterile alpha motif domain containing 4A -0.0376872
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0375662
GLCCI1 glucocorticoid induced 1 -0.0370785
ZMYND8 zinc finger, MYND-type containing 8 -0.0366324
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0363932
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0357851
RAB27B RAB27B, member RAS oncogene family -0.0348449
CDK17 cyclin-dependent kinase 17 -0.0345933
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0340518
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0337406
NPC1 Niemann-Pick disease, type C1 -0.0332601
VCL vinculin -0.0324284
FRMD5 FERM domain containing 5 -0.0317936
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0314419
MON2 MON2 homolog (S. cerevisiae) -0.0313869
ZC3H12C zinc finger CCCH-type containing 12C -0.030634
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0306188
GCC2 GRIP and coiled-coil domain containing 2 -0.0302243
TM4SF1 transmembrane 4 L six family member 1 -0.02984
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 -0.0293925
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0289885
ADD3 adducin 3 (gamma) -0.0287732
TRIO trio Rho guanine nucleotide exchange factor -0.0285225
TNNC1 troponin C type 1 (slow) -0.0285015
USP34 ubiquitin specific peptidase 34 -0.0275021
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.027482
DOCK4 dedicator of cytokinesis 4 -0.027331
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0269299
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0264882
MBD5 methyl-CpG binding domain protein 5 -0.0263005
NF1 neurofibromin 1 -0.0261032
ACTN4 actinin, alpha 4 -0.0255729
PRELID2 PRELI domain containing 2 -0.0251895
HDLBP high density lipoprotein binding protein -0.024718
ANKRD17 ankyrin repeat domain 17 -0.0247092
BABAM2 BRISC and BRCA1 A complex member 2 -0.0246097
GLIPR1 GLI pathogenesis-related 1 -0.0242818
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0242673
BMAL2 basic helix-loop-helix ARNT like 2 -0.0240063
AOPEP aminopeptidase O (putative) -0.0238783
RB1CC1 RB1-inducible coiled-coil 1 -0.0238749
KCTD16 potassium channel tetramerization domain containing 16 -0.0237217
CFDP1 craniofacial development protein 1 -0.0237059
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0236389
VRK2 vaccinia related kinase 2 -0.0233191
SPIDR scaffolding protein involved in DNA repair -0.0232015
KDM3A lysine (K)-specific demethylase 3A -0.0228843
ERCC6L2 excision repair cross-complementation group 6-like 2 -0.0228175
PCNX1 pecanex 1 -0.022306
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0220744
IGF2R insulin-like growth factor 2 receptor -0.0219384
PRKCSH protein kinase C substrate 80K-H -0.0215316
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0214701
PSD3 pleckstrin and Sec7 domain containing 3 -0.0213168
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0212365
ANAPC5 anaphase promoting complex subunit 5 -0.0211269
CENPE centromere protein E, 312kDa -0.0210394
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0208609
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0208391
TM9SF3 transmembrane 9 superfamily member 3 -0.0206604
NIPBL Nipped-B homolog (Drosophila) -0.0205948
SPRED1 sprouty-related, EVH1 domain containing 1 -0.020568
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0204909
ARID5B AT rich interactive domain 5B (MRF1-like) -0.0204787
EFNA5 ephrin-A5 -0.0204226
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0204059
METTL15 methyltransferase like 15 -0.0204011
PTPRR protein tyrosine phosphatase, receptor type, R -0.0203941
CD109 CD109 molecule -0.0202573
MAML2 mastermind-like 2 (Drosophila) -0.0202165
GNAQ guanine nucleotide binding protein (G protein), q polypeptide -0.0201615
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0201564