| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Terfenadine perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Terfenadine_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.133469 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.130313 |
| TXNRD1 | thioredoxin reductase 1 | 0.105233 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0949149 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.082735 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0709686 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0691573 |
| JMJD1C | jumonji domain containing 1C | 0.0647671 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0628616 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | 0.0539724 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.050944 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0505207 |
| CLTC | clathrin, heavy chain (Hc) | 0.050098 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0494731 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0483746 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0479331 |
| ADIPOR2 | adiponectin receptor 2 | 0.0465124 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0448849 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0437738 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | 0.0435577 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0406321 |
| UBAP2L | ubiquitin associated protein 2-like | 0.040629 |
| TPM3 | tropomyosin 3 | 0.0406248 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0406209 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0405633 |
| HOMER1 | homer scaffolding protein 1 | 0.039595 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0380032 |
| COPA | coatomer protein complex, subunit alpha | 0.0374863 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0373467 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0371812 |
| EXOC6B | exocyst complex component 6B | 0.0366868 |
| STC1 | stanniocalcin 1 | 0.0354326 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | 0.0353849 |
| INTS6 | integrator complex subunit 6 | 0.0350531 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0326857 |
| TLN1 | talin 1 | 0.0325439 |
| ATP11A | ATPase, class VI, type 11A | 0.0321399 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0309676 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0308481 |
| PCBP2 | poly(rC) binding protein 2 | 0.0307663 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0303594 |
| ARID1A | AT rich interactive domain 1A (SWI-like) | 0.0296177 |
| ERBIN | erbb2 interacting protein | 0.0295358 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0291804 |
| XPO1 | exportin 1 | 0.0291539 |
| PRKCE | protein kinase C, epsilon | 0.0288964 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0282655 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0280992 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0280084 |
| SENP6 | SUMO1/sentrin specific peptidase 6 | 0.0280005 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.0279917 |
| PREPL | prolyl endopeptidase-like | 0.027627 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0275502 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.0274026 |
| NCKAP1 | NCK-associated protein 1 | 0.0271393 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0267903 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 0.026643 |
| RPS12 | ribosomal protein S12 | 0.026398 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0261515 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0259981 |
| ANO6 | anoctamin 6 | 0.025529 |
| YES1 | YES proto-oncogene 1, Src family tyrosine kinase | 0.0254113 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0253578 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0252855 |
| SPAG9 | sperm associated antigen 9 | 0.025223 |
| KDM7A | lysine (K)-specific demethylase 7A | 0.0251514 |
| TMEM41B | transmembrane protein 41B | 0.0250821 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0246496 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0245375 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0245346 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0243779 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0242986 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0242282 |
| GATAD2B | GATA zinc finger domain containing 2B | 0.0240336 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0239952 |
| STK4 | serine/threonine kinase 4 | 0.0237527 |
| REL | v-rel avian reticuloendotheliosis viral oncogene homolog | 0.0236521 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0233585 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0233152 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.0231743 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.0231103 |
| GPHN | gephyrin | 0.0228225 |
| YME1L1 | YME1-like 1 ATPase | 0.0226716 |
| ARHGEF11 | Rho guanine nucleotide exchange factor (GEF) 11 | 0.0225583 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 0.022537 |
| CUL3 | cullin 3 | 0.0224286 |
| PFDN2 | prefoldin subunit 2 | 0.0222315 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0221789 |
| FBXO11 | F-box protein 11 | 0.0218977 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.021831 |
| ZNF638 | zinc finger protein 638 | 0.0217524 |
| GPATCH2L | G patch domain containing 2-like | 0.0217327 |
| MYO6 | myosin VI | 0.0216526 |
| RALGAPB | Ral GTPase activating protein, beta subunit (non-catalytic) | 0.0215888 |
| COG5 | component of oligomeric golgi complex 5 | 0.0215133 |
| WDR26 | WD repeat domain 26 | 0.0214964 |
| POLR2B | polymerase (RNA) II (DNA directed) polypeptide B, 140kDa | 0.0213324 |
| AFF4 | AF4/FMR2 family, member 4 | 0.0211025 |
| UBAP2 | ubiquitin associated protein 2 | 0.0210772 |
| SRP54 | signal recognition particle 54kDa | 0.0210193 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.207891 |
| PTMA | prothymosin, alpha | -0.1654 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0997568 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0996098 |
| RPS21 | ribosomal protein S21 | -0.0739081 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0734507 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0729129 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0705673 |
| TMSB10 | thymosin beta 10 | -0.0591249 |
| RYR3 | ryanodine receptor 3 | -0.0585921 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0577839 |
| MCL1 | myeloid cell leukemia 1 | -0.0577139 |
| RPS29 | ribosomal protein S29 | -0.0568759 |
| PDE10A | phosphodiesterase 10A | -0.0558571 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0534642 |
| RPS15 | ribosomal protein S15 | -0.053262 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0503432 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0488261 |
| ACTG1 | actin gamma 1 | -0.0481057 |
| HLA-B | major histocompatibility complex, class I, B | -0.047565 |
| CAVIN1 | caveolae associated protein 1 | -0.0473119 |
| YBX3 | Y box binding protein 3 | -0.0467009 |
| RAD51B | RAD51 paralog B | -0.0462647 |
| TPM4 | tropomyosin 4 | -0.0457373 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0457169 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0455756 |
| RPS10 | ribosomal protein S10 | -0.0451271 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0447314 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0443891 |
| RPL19 | ribosomal protein L19 | -0.0437687 |
| RPL38 | ribosomal protein L38 | -0.0435348 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0433137 |
| ATXN1 | ataxin 1 | -0.0430672 |
| TPM2 | tropomyosin 2 (beta) | -0.0425652 |
| VCL | vinculin | -0.0421378 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0400515 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0397087 |
| MT2A | metallothionein 2A | -0.0395752 |
| RRM2 | ribonucleotide reductase M2 | -0.0389115 |
| RPLP2 | ribosomal protein, large, P2 | -0.038366 |
| WWOX | WW domain containing oxidoreductase | -0.0376283 |
| RPS6 | ribosomal protein S6 | -0.0375663 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.03666 |
| AFF3 | AF4/FMR2 family, member 3 | -0.0352782 |
| HMGA2 | high mobility group AT-hook 2 | -0.0352605 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0351903 |
| RPL8 | ribosomal protein L8 | -0.0349222 |
| RPLP1 | ribosomal protein, large, P1 | -0.0347869 |
| AHNAK | AHNAK nucleoprotein | -0.0338765 |
| RPL32 | ribosomal protein L32 | -0.0337879 |
| IER3 | immediate early response 3 | -0.0335707 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0332542 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0331883 |
| RPS24 | ribosomal protein S24 | -0.0330829 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0324627 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0320409 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | -0.0317823 |
| RPS27A | ribosomal protein S27a | -0.0316641 |
| PHF20 | PHD finger protein 20 | -0.0314251 |
| FMN1 | formin 1 | -0.0299402 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0298978 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0295011 |
| DEK | DEK proto-oncogene | -0.0293778 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0291591 |
| POTEF | POTE ankyrin domain family, member F | -0.0290641 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0287101 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0285615 |
| H3-3B | H3.3 histone B | -0.0284507 |
| EGR1 | early growth response 1 | -0.0284384 |
| RPL35A | ribosomal protein L35a | -0.0278062 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0274314 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0271074 |
| RPL36A | ribosomal protein L36a | -0.0269252 |
| RPLP0 | ribosomal protein, large, P0 | -0.0267805 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | -0.0260572 |
| RPL12 | ribosomal protein L12 | -0.0257009 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0254887 |
| SSH2 | slingshot protein phosphatase 2 | -0.0254738 |
| TPM1 | tropomyosin 1 (alpha) | -0.0254492 |
| RPS25 | ribosomal protein S25 | -0.0253285 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0252236 |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | -0.025087 |
| S100A10 | S100 calcium binding protein A10 | -0.0247026 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.024127 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0239391 |
| PRRC2B | proline-rich coiled-coil 2B | -0.0237402 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0236649 |
| BMP5 | bone morphogenetic protein 5 | -0.023564 |
| CUX1 | cut-like homeobox 1 | -0.0235477 |
| H1-0 | H1.0 linker histone | -0.0234756 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0234527 |
| ITSN1 | intersectin 1 (SH3 domain protein) | -0.0233326 |
| TCEAL4 | transcription elongation factor A (SII)-like 4 | -0.0231339 |
| RPS23 | ribosomal protein S23 | -0.0231098 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | -0.0228053 |
| FLOT1 | flotillin 1 | -0.0227941 |
| CD2AP | CD2-associated protein | -0.0227487 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0226627 |
| RPL7A | ribosomal protein L7a | -0.0224325 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0223974 |
