| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Terfenadine perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Terfenadine_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.140088 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.118188 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.102318 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0921719 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.09215 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.085147 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0749143 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0747047 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0688771 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.0678538 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0656926 |
| EFNA5 | ephrin-A5 | 0.0637722 |
| DNER | delta/notch-like EGF repeat containing | 0.0622861 |
| RPS12 | ribosomal protein S12 | 0.0615932 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0593869 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0593668 |
| PYGL | phosphorylase, glycogen, liver | 0.0513092 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0491996 |
| VIM | vimentin | 0.0486907 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0477187 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0465918 |
| NDRG1 | N-myc downstream regulated 1 | 0.0449872 |
| FMNL2 | formin-like 2 | 0.0448473 |
| INTS6 | integrator complex subunit 6 | 0.0443908 |
| DST | dystonin | 0.0434709 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | 0.0434098 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.042871 |
| MT2A | metallothionein 2A | 0.0425482 |
| PDE10A | phosphodiesterase 10A | 0.0421133 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 0.0413359 |
| COL4A5 | collagen, type IV, alpha 5 | 0.0404309 |
| CD44 | CD44 molecule (Indian blood group) | 0.0398433 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0391722 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0385487 |
| KYNU | kynureninase | 0.038374 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | 0.0382072 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0381084 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0367704 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0367431 |
| STC1 | stanniocalcin 1 | 0.0364936 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0363744 |
| RAD51B | RAD51 paralog B | 0.0357253 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0356728 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.0344878 |
| SMAD2 | SMAD family member 2 | 0.0343253 |
| RACK1 | receptor for activated C kinase 1 | 0.0343105 |
| COL4A6 | collagen, type IV, alpha 6 | 0.0340708 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0335577 |
| RPL37A | ribosomal protein L37a | 0.0332937 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0326177 |
| RPS3 | ribosomal protein S3 | 0.0324895 |
| PRELID2 | PRELI domain containing 2 | 0.0323192 |
| CTBP2 | C-terminal binding protein 2 | 0.0321003 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0318618 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.031459 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0312532 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0308612 |
| AUTS2 | autism susceptibility candidate 2 | 0.0307593 |
| CTIF | CBP80/20-dependent translation initiation factor | 0.0306231 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.030519 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0303279 |
| FLNA | filamin A, alpha | 0.0302275 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0300005 |
| LAMA5 | laminin, alpha 5 | 0.0287594 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0285738 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0270178 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.0269606 |
| COL8A1 | collagen, type VIII, alpha 1 | 0.0263565 |
| PCBP2 | poly(rC) binding protein 2 | 0.026266 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0261229 |
| HDAC4 | histone deacetylase 4 | 0.0256179 |
| MCL1 | myeloid cell leukemia 1 | 0.0255258 |
| NHSL1 | NHS-like 1 | 0.0240492 |
| LMAN1 | lectin, mannose-binding, 1 | 0.0240459 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.0236183 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0236136 |
| PRKAA2 | protein kinase, AMP-activated, alpha 2 catalytic subunit | 0.0235477 |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | 0.02349 |
| GPC6 | glypican 6 | 0.0233293 |
| CALR | calreticulin | 0.0232078 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0229795 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0229729 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0229028 |
| COPA | coatomer protein complex, subunit alpha | 0.0228513 |
| EPHA4 | EPH receptor A4 | 0.0228478 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.022845 |
| TMEM144 | transmembrane protein 144 | 0.0227639 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0220486 |
| AP1S3 | adaptor-related protein complex 1, sigma 3 subunit | 0.0217427 |
| DPYSL2 | dihydropyrimidinase-like 2 | 0.0215412 |
| GLRX | glutaredoxin (thioltransferase) | 0.0215214 |
| RPS8 | ribosomal protein S8 | 0.0215037 |
| UBAP2L | ubiquitin associated protein 2-like | 0.0208672 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0205183 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0204958 |
| RPS27 | ribosomal protein S27 | 0.0201092 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0201056 |
| CREB5 | cAMP responsive element binding protein 5 | 0.0198308 |
| INHBA | inhibin, beta A | 0.019782 |
| FLNB | filamin B, beta | 0.0196365 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | -0.141381 |
| PTMA | prothymosin, alpha | -0.122846 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.116005 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.110017 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0861784 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0791228 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.076732 |
| ASPH | aspartate beta-hydroxylase | -0.0747124 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0652056 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0633335 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0628717 |
| RPS24 | ribosomal protein S24 | -0.0617959 |
| GDA | guanine deaminase | -0.0617381 |
| COL5A2 | collagen, type V, alpha 2 | -0.0561687 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0554608 |
| MYOF | myoferlin | -0.0522384 |
| TMSB10 | thymosin beta 10 | -0.0491379 |
| RBM39 | RNA binding motif protein 39 | -0.0489132 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0485036 |
| PCBP3 | poly(rC) binding protein 3 | -0.0447737 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0446674 |
| SRGN | serglycin | -0.0441073 |
| PTGR1 | prostaglandin reductase 1 | -0.0440913 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0440851 |
| NRCAM | neuronal cell adhesion molecule | -0.0423183 |
| RPS6 | ribosomal protein S6 | -0.0417809 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0410133 |
| NEK7 | NIMA-related kinase 7 | -0.0407551 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0403805 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0400315 |
| SMYD3 | SET and MYND domain containing 3 | -0.038568 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.0384975 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.038425 |
| PALLD | palladin, cytoskeletal associated protein | -0.0373472 |
| RPL38 | ribosomal protein L38 | -0.0370323 |
| RPS21 | ribosomal protein S21 | -0.0367199 |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 | -0.0365663 |
| CENPF | centromere protein F, 350/400kDa | -0.0354621 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | -0.0353916 |
| HNRNPK | heterogeneous nuclear ribonucleoprotein K | -0.0349385 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0343188 |
| CTSL | cathepsin L | -0.0339192 |
| RPL36A | ribosomal protein L36a | -0.0338869 |
| FTL | ferritin, light polypeptide | -0.0336584 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0333977 |
| TNPO1 | transportin 1 | -0.0326917 |
| RGS2 | regulator of G-protein signaling 2 | -0.0325594 |
| TENM3 | teneurin transmembrane protein 3 | -0.0322851 |
| PRKD3 | protein kinase D3 | -0.0319609 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0319119 |
| RPLP1 | ribosomal protein, large, P1 | -0.0313827 |
| MFF | mitochondrial fission factor | -0.0311633 |
| MATR3 | matrin 3 | -0.031134 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0302331 |
| FOXC1 | forkhead box C1 | -0.028848 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.028435 |
| RPL19 | ribosomal protein L19 | -0.0283413 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0278013 |
| PRDX1 | peroxiredoxin 1 | -0.0276954 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.0268061 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0266361 |
| TBXT | T-box transcription factor T | -0.0265497 |
| PRRC2B | proline-rich coiled-coil 2B | -0.0251741 |
| ANLN | anillin, actin binding protein | -0.0249527 |
| XPO1 | exportin 1 | -0.0248139 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0247443 |
| AGFG1 | ArfGAP with FG repeats 1 | -0.0247259 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0246016 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.024086 |
| MKI67 | marker of proliferation Ki-67 | -0.0240493 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | -0.0240419 |
| PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | -0.024014 |
| SEPTIN10 | septin 10 | -0.0237693 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0236678 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | -0.0231758 |
| H3-3B | H3.3 histone B | -0.0230764 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0229551 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0228088 |
| B2M | beta-2-microglobulin | -0.0224932 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0223807 |
| SLC16A6 | solute carrier family 16, member 6 | -0.0223377 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.0223275 |
| TNIP1 | TNFAIP3 interacting protein 1 | -0.022258 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0222417 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0221799 |
| RPL7A | ribosomal protein L7a | -0.0221775 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.022094 |
| DHX9 | DEAH (Asp-Glu-Ala-His) box helicase 9 | -0.0220637 |
| RAB10 | RAB10, member RAS oncogene family | -0.0220245 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0220008 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0217411 |
| RPLP0 | ribosomal protein, large, P0 | -0.0217371 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.021631 |
| RPS23 | ribosomal protein S23 | -0.0215671 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0214011 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0213886 |
| RAN | RAN, member RAS oncogene family | -0.0213714 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | -0.0212881 |
| TUBA1B | tubulin, alpha 1b | -0.021089 |
| TMSB4X | thymosin beta 4, X-linked | -0.02107 |
