Terfenadine_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Terfenadine perturbation in NCI-H596 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Terfenadine_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EFNA5 ephrin-A5 0.149725
USP34 ubiquitin specific peptidase 34 0.131044
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.129241
IGFBP3 insulin-like growth factor binding protein 3 0.119823
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.112249
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.101278
AKAP12 A kinase (PRKA) anchor protein 12 0.0981362
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0973853
CLTC clathrin, heavy chain (Hc) 0.0956042
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0931173
DST dystonin 0.0928469
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0907551
PRELID2 PRELI domain containing 2 0.09068
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0884595
MED13 mediator complex subunit 13 0.0875974
MAML3 mastermind-like 3 (Drosophila) 0.0822286
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0816432
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0812357
EZR ezrin 0.0783106
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0774719
NPAS2 neuronal PAS domain protein 2 0.07461
ATXN1 ataxin 1 0.0712452
FGFR2 fibroblast growth factor receptor 2 0.0712308
FMN1 formin 1 0.0692493
SEC31A SEC31 homolog A (S. cerevisiae) 0.0689663
ASPH aspartate beta-hydroxylase 0.0675194
ACTG1 actin gamma 1 0.0667048
RPS3 ribosomal protein S3 0.0622025
NAV2 neuron navigator 2 0.0616808
PDE4D phosphodiesterase 4D, cAMP-specific 0.0569092
PICALM phosphatidylinositol binding clathrin assembly protein 0.0519011
DSCAM Down syndrome cell adhesion molecule 0.0485946
FTL ferritin, light polypeptide 0.0483039
FNDC3B fibronectin type III domain containing 3B 0.0470306
NAV1 neuron navigator 1 0.0469221
HELZ helicase with zinc finger 0.0444169
CALR calreticulin 0.0413622
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0386317
EXT1 exostosin glycosyltransferase 1 0.0379766
VIM vimentin 0.0363474
MYOF myoferlin 0.0359262
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0355986
SBF2 SET binding factor 2 0.0353143
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0334379
SRPK2 SRSF protein kinase 2 0.0332739
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0325778
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0323359
RORA RAR-related orphan receptor A 0.0322442
FNDC3A fibronectin type III domain containing 3A 0.0316851
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0316497
RPLP0 ribosomal protein, large, P0 0.0309377
SLC38A1 solute carrier family 38, member 1 0.0302157
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0291915
RAB1A RAB1A, member RAS oncogene family 0.0288696
LOX lysyl oxidase 0.027674
OGA O-GlcNAcase 0.0273503
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0271966
SMAD3 SMAD family member 3 0.0264855
NDRG1 N-myc downstream regulated 1 0.0250218
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0244385
SND1 staphylococcal nuclease and tudor domain containing 1 0.023929
FRMD4A FERM domain containing 4A 0.0239092
NRG3 neuregulin 3 0.0238595
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.022772
FAM13A family with sequence similarity 13, member A 0.0207736
NKD1 naked cuticle homolog 1 (Drosophila) 0.0206063
EIF1 eukaryotic translation initiation factor 1 0.0203242
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0202267
B2M beta-2-microglobulin 0.0200062
STAG2 stromal antigen 2 0.0179914
RPL23 ribosomal protein L23 0.0179586
CDK6 cyclin-dependent kinase 6 0.0167362
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0157729
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0155971
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0153034
PSD3 pleckstrin and Sec7 domain containing 3 0.0151922
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0151578
HMGA2 high mobility group AT-hook 2 0.012698
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0117974
RAD51B RAD51 paralog B 0.0116419
ZSWIM6 zinc finger, SWIM-type containing 6 0.0108856
FN1 fibronectin 1 0.0103236
TPT1 tumor protein, translationally-controlled 1 0.00950518
TMSB10 thymosin beta 10 0.00930323
PDLIM5 PDZ and LIM domain 5 0.00907454
FMNL2 formin-like 2 0.00860053
RASA3 RAS p21 protein activator 3 0.00854808
BIRC6 baculoviral IAP repeat containing 6 0.00849518
LDHA lactate dehydrogenase A 0.00755519
BPTF bromodomain PHD finger transcription factor 0.00742357
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.00656953
MT2A metallothionein 2A 0.00628486
NPC1 Niemann-Pick disease, type C1 0.00616173
SRRM2 serine/arginine repetitive matrix 2 0.00474644
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.0046264
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.00414291
RAB10 RAB10, member RAS oncogene family 0.00382919
PRRC2B proline-rich coiled-coil 2B 0.00307121
ANKRD17 ankyrin repeat domain 17 0.00293852
KTN1 kinectin 1 (kinesin receptor) 0.00291844

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.128224
IGF2 insulin-like growth factor 2 -0.126368
CADM2 cell adhesion molecule 2 -0.118196
PEG10 paternally expressed 10 -0.102193
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D -0.098681
ZNF608 zinc finger protein 608 -0.0958543
TENM3 teneurin transmembrane protein 3 -0.0941401
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0921425
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0840495
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.081175
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0775019
GMDS GDP-mannose 4,6-dehydratase -0.0774272
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0752713
RPLP1 ribosomal protein, large, P1 -0.0740306
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 -0.0710859
LPP LIM domain containing preferred translocation partner in lipoma -0.0685682
RBM25 RNA binding motif protein 25 -0.0683725
LAMB3 laminin, beta 3 -0.0681827
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0660324
ARRDC3 arrestin domain containing 3 -0.0630353
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.06188
ATP11A ATPase, class VI, type 11A -0.0618205
MBNL1 muscleblind-like splicing regulator 1 -0.0599654
GOLGB1 golgin B1 -0.0595275
PRKCA protein kinase C, alpha -0.0591416
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0570095
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0568575
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0563587
CPEB4 cytoplasmic polyadenylation element binding protein 4 -0.0547139
ZFAND3 zinc finger, AN1-type domain 3 -0.0543764
TRIO trio Rho guanine nucleotide exchange factor -0.0543002
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) -0.0541893
PDE10A phosphodiesterase 10A -0.0541048
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0539333
NALF1 NALCN channel auxiliary factor 1 -0.0538749
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0509835
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0501561
MEF2A myocyte enhancer factor 2A -0.0497086
RPS16 ribosomal protein S16 -0.0478752
GPC6 glypican 6 -0.0467414
SNX9 sorting nexin 9 -0.0464192
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0443285
EGR1 early growth response 1 -0.0436957
UBE2Z ubiquitin-conjugating enzyme E2Z -0.0427439
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0427388
RPLP2 ribosomal protein, large, P2 -0.0418972
IGFBP5 insulin-like growth factor binding protein 5 -0.0395916
RSRC1 arginine/serine-rich coiled-coil 1 -0.039245
ANXA2 annexin A2 -0.0386765
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0381681
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0379034
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0378162
KMT2C lysine (K)-specific methyltransferase 2C -0.0374254
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0348515
MON2 MON2 homolog (S. cerevisiae) -0.0346098
SPAG9 sperm associated antigen 9 -0.0330163
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.032375
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0323185
CARD16 caspase recruitment domain family, member 16 -0.0316955
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0308817
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0302245
JMJD1C jumonji domain containing 1C -0.0302124
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.029673
RPL37 ribosomal protein L37 -0.0292759
MXD1 MAX dimerization protein 1 -0.0290665
EGFR epidermal growth factor receptor -0.0276685
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0275178
NF1 neurofibromin 1 -0.0271234
PARD3 par-3 family cell polarity regulator -0.0268228
VCL vinculin -0.0261283
MYO5B myosin VB -0.0261199
PRRC2C proline-rich coiled-coil 2C -0.0260301
CEMIP cell migration inducing protein, hyaluronan binding -0.0256994
DTNA dystrobrevin, alpha -0.0256771
SMYD3 SET and MYND domain containing 3 -0.0251175
RPS8 ribosomal protein S8 -0.0246126
SPATA13 spermatogenesis associated 13 -0.0239424
SP100 SP100 nuclear antigen -0.0236316
NFIA nuclear factor I/A -0.0221093
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.0213832
WWP2 WW domain containing E3 ubiquitin protein ligase 2 -0.0209881
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.0209545
NCOA3 nuclear receptor coactivator 3 -0.0208825
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0204998
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.0196497
RPL26 ribosomal protein L26 -0.0188793
ARHGAP32 Rho GTPase activating protein 32 -0.0187756
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0185361
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -0.0183095
AREG amphiregulin -0.0181926
ITGA6 integrin, alpha 6 -0.018002
UBE2K ubiquitin-conjugating enzyme E2K -0.0178488
WASF2 WAS protein family, member 2 -0.0177705
KDM5B lysine (K)-specific demethylase 5B -0.0177203
ZBTB20 zinc finger and BTB domain containing 20 -0.0174656
PTK2 protein tyrosine kinase 2 -0.0174164
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0171345
ANKRD12 ankyrin repeat domain 12 -0.0156945
MACF1 microtubule-actin crosslinking factor 1 -0.0146464
LMO7 LIM domain 7 -0.0145243