Terfenadine_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Terfenadine perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Terfenadine_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SOD2 superoxide dismutase 2, mitochondrial 0.118738
CD44 CD44 molecule (Indian blood group) 0.103747
EEF2 eukaryotic translation elongation factor 2 0.0975099
STC1 stanniocalcin 1 0.0947126
FTH1 ferritin, heavy polypeptide 1 0.0887313
UGCG UDP-glucose ceramide glucosyltransferase 0.083875
RND3 Rho family GTPase 3 0.0801974
LDHA lactate dehydrogenase A 0.0783244
HDAC9 histone deacetylase 9 0.0776973
NAV2 neuron navigator 2 0.0760459
HLA-E major histocompatibility complex, class I, E 0.0732485
NAMPT nicotinamide phosphoribosyltransferase 0.0719922
KYNU kynureninase 0.0679271
NDRG1 N-myc downstream regulated 1 0.067528
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.065672
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0629086
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0623096
ELL2 elongation factor, RNA polymerase II, 2 0.0619023
LOX lysyl oxidase 0.0573399
FNIP1 folliculin interacting protein 1 0.056152
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.052782
ZFP36L1 ZFP36 ring finger protein-like 1 0.0523983
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0505223
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0493825
ARRDC3 arrestin domain containing 3 0.0476829
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0473129
MXI1 MAX interactor 1, dimerization protein 0.046531
AKAP12 A kinase (PRKA) anchor protein 12 0.0459035
SFTPA2 surfactant protein A2 0.0454502
RPS2 ribosomal protein S2 0.0447579
ADM adrenomedullin 0.0435852
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0430105
TENT5A terminal nucleotidyltransferase 5A 0.0429147
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0423195
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0423154
NRIP1 nuclear receptor interacting protein 1 0.0415612
FLNB filamin B, beta 0.0405931
AHR aryl hydrocarbon receptor 0.0405784
PLIN2 perilipin 2 0.0398792
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0397409
CXCL8 chemokine (C-X-C motif) ligand 8 0.0396272
LAMP2 lysosomal-associated membrane protein 2 0.0388776
C3 complement component 3 0.0385302
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0380887
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0379337
ZBTB38 zinc finger and BTB domain containing 38 0.0378537
LOXL2 lysyl oxidase-like 2 0.0365966
APP amyloid beta (A4) precursor protein 0.0363797
PGK1 phosphoglycerate kinase 1 0.0356706
RBMS3 RNA binding motif, single stranded interacting protein 3 0.034772
PRELID2 PRELI domain containing 2 0.0346475
UBA6 ubiquitin-like modifier activating enzyme 6 0.0343329
SPAG9 sperm associated antigen 9 0.0341126
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.0340437
DOCK5 dedicator of cytokinesis 5 0.0339607
MMP12 matrix metallopeptidase 12 0.0338931
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0330009
ATP13A3 ATPase type 13A3 0.0328838
SOX9 SRY (sex determining region Y)-box 9 0.0326717
CDK19 cyclin-dependent kinase 19 0.0326563
ARFGEF3 ARFGEF family member 3 0.0325458
WDFY1 WD repeat and FYVE domain containing 1 0.032348
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0323425
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0321813
ICAM1 intercellular adhesion molecule 1 0.0321791
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0320606
FMNL2 formin-like 2 0.0317622
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0312397
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0310067
SQSTM1 sequestosome 1 0.0305507
HILPDA hypoxia inducible lipid droplet-associated 0.0302778
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0301279
NOTCH2 notch 2 0.0293572
TRAM2 translocation associated membrane protein 2 0.0291957
ARID5B AT rich interactive domain 5B (MRF1-like) 0.0283893
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0282605
AKAP13 A kinase (PRKA) anchor protein 13 0.0281397
ZMIZ1 zinc finger, MIZ-type containing 1 0.0281211
STC2 stanniocalcin 2 0.0278138
MSN moesin 0.0278072
MBNL1 muscleblind-like splicing regulator 1 0.0275215
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) 0.0273633
IRAK2 interleukin-1 receptor-associated kinase 2 0.0271561
NFE2L1 nuclear factor, erythroid 2-like 1 0.0267224
NT5C2 5'-nucleotidase, cytosolic II 0.0266129
MBNL2 muscleblind-like splicing regulator 2 0.0263444
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.0262607
CD109 CD109 molecule 0.0262442
IGFBP3 insulin-like growth factor binding protein 3 0.0262108
CALR calreticulin 0.0261746
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0260175
MINDY2 MINDY lysine 48 deubiquitinase 2 0.025633
BPTF bromodomain PHD finger transcription factor 0.0252305
YEATS2 YEATS domain containing 2 0.0251948
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.0251581
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.024808
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0247704
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0246437
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0243772
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0243189

decreased expression

Symbol Name Standardized Value
FRMD4A FERM domain containing 4A -0.203586
TMSB10 thymosin beta 10 -0.18698
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.109939
RPS6 ribosomal protein S6 -0.099305
FTL ferritin, light polypeptide -0.0948914
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0865243
PTMA prothymosin, alpha -0.083709
MT2A metallothionein 2A -0.082772
TPT1 tumor protein, translationally-controlled 1 -0.0755209
RPLP2 ribosomal protein, large, P2 -0.0705154
GLIS3 GLIS family zinc finger 3 -0.0621641
RPS19 ribosomal protein S19 -0.058482
RPS24 ribosomal protein S24 -0.0584742
RPS23 ribosomal protein S23 -0.0584356
MARCKS myristoylated alanine-rich protein kinase C substrate -0.058036
RPLP1 ribosomal protein, large, P1 -0.0551183
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0529864
RPS21 ribosomal protein S21 -0.0517904
BICC1 BicC family RNA binding protein 1 -0.0512133
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0508945
IER3 immediate early response 3 -0.0498609
CDH13 cadherin 13 -0.0484684
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0483356
RPL32 ribosomal protein L32 -0.0475593
RPL19 ribosomal protein L19 -0.047525
COL1A1 collagen, type I, alpha 1 -0.0460219
QKI QKI, KH domain containing, RNA binding -0.0450643
PTPRK protein tyrosine phosphatase, receptor type, K -0.0430662
S100A9 S100 calcium binding protein A9 -0.0425032
RRBP1 ribosome binding protein 1 -0.0417873
DLG1 discs, large homolog 1 (Drosophila) -0.0401522
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0400864
WSB1 WD repeat and SOCS box containing 1 -0.0399835
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0393671
RPS13 ribosomal protein S13 -0.0392359
SOX5 SRY (sex determining region Y)-box 5 -0.0388533
RPL36A ribosomal protein L36a -0.0388167
VCL vinculin -0.0383285
VIM vimentin -0.0375975
HLA-B major histocompatibility complex, class I, B -0.0375141
ZMYND8 zinc finger, MYND-type containing 8 -0.0372983
ZFAND3 zinc finger, AN1-type domain 3 -0.0371634
EXT1 exostosin glycosyltransferase 1 -0.0368834
IFITM3 interferon induced transmembrane protein 3 -0.0367181
RPL35 ribosomal protein L35 -0.036171
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.035542
RBM39 RNA binding motif protein 39 -0.034824
FRMPD4 FERM and PDZ domain containing 4 -0.0341518
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0336712
RPS10 ribosomal protein S10 -0.0335415
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0332096
DEK DEK proto-oncogene -0.0328804
SBF2 SET binding factor 2 -0.0324961
IFITM1 interferon induced transmembrane protein 1 -0.032491
FRMD5 FERM domain containing 5 -0.03249
ARF4 ADP-ribosylation factor 4 -0.0324292
RPS14 ribosomal protein S14 -0.0324029
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.032295
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0321233
RPL11 ribosomal protein L11 -0.032097
FAM20C family with sequence similarity 20, member C -0.0319882
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0315324
RPL35A ribosomal protein L35a -0.031303
RPL36 ribosomal protein L36 -0.0308198
CADM1 cell adhesion molecule 1 -0.0305766
RPL23 ribosomal protein L23 -0.030227
EIF4A1 eukaryotic translation initiation factor 4A1 -0.030023
ISG15 ISG15 ubiquitin-like modifier -0.0295247
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0293298
CLMP CXADR-like membrane protein -0.0292837
RPL38 ribosomal protein L38 -0.0285633
SLC35F3 solute carrier family 35, member F3 -0.0282676
MYH9 myosin, heavy chain 9, non-muscle -0.028179
TMEM132D transmembrane protein 132D -0.0279322
RPL12 ribosomal protein L12 -0.0278571
AHNAK AHNAK nucleoprotein -0.0278485
COL1A2 collagen, type I, alpha 2 -0.0275876
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0268812
RPL8 ribosomal protein L8 -0.0267063
AFF3 AF4/FMR2 family, member 3 -0.0264955
NAV1 neuron navigator 1 -0.0263389
COL7A1 collagen, type VII, alpha 1 -0.0263365
RPL31 ribosomal protein L31 -0.0260348
CHD6 chromodomain helicase DNA binding protein 6 -0.0256208
ARID1B AT rich interactive domain 1B (SWI1-like) -0.025531
RPS4X ribosomal protein S4, X-linked -0.0255254
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0254235
HMGA1 high mobility group AT-hook 1 -0.0253636
SHOC2 soc-2 suppressor of clear homolog (C. elegans) -0.0253288
UTRN utrophin -0.0251939
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0250975
DIAPH2 diaphanous-related formin 2 -0.0250162
RPS29 ribosomal protein S29 -0.0249235
RPS11 ribosomal protein S11 -0.0248662
BNC2 basonuclin 2 -0.0247222
DHFR dihydrofolate reductase -0.0246765
IARS1 isoleucyl-tRNA synthetase 1 -0.0242017
ZNF609 zinc finger protein 609 -0.0236124
HDLBP high density lipoprotein binding protein -0.023598
ASTN2 astrotactin 2 -0.0235958