| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/13769 |
| Similar Terms | |
| Downloads & Tools |
199 proteins with high or low expression in Testolactone relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| OSGIN1 | oxidative stress induced growth inhibitor 1 | 3.47 |
| HMOX1 | heme oxygenase 1 | 2.6 |
| SRXN1 | sulfiredoxin 1 | 2.27 |
| MDM1 | Mdm1 nuclear protein homolog (mouse) | 2.14 |
| CYP4F11 | cytochrome P450, family 4, subfamily F, polypeptide 11 | 2.07 |
| FTL | ferritin, light polypeptide | 1.83 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 1.52 |
| GCLM | glutamate-cysteine ligase, modifier subunit | 1.38 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 1.37 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 1.33 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | 1.32 |
| SQSTM1 | sequestosome 1 | 1.26 |
| DES | desmin | 1.19 |
| KIAA1107 | KIAA1107 | 1.18 |
| GPC1 | glypican 1 | 1.14 |
| CCDC15 | coiled-coil domain containing 15 | 1.12 |
| ANKRD18B | ankyrin repeat domain 18B | 1.03 |
| TXNRD1 | thioredoxin reductase 1 | 1.0 |
| ABHD4 | abhydrolase domain containing 4 | 0.99 |
| KMT2B | lysine (K)-specific methyltransferase 2B | 0.98 |
| GSR | glutathione reductase | 0.95 |
| TRIM16 | tripartite motif containing 16 | 0.93 |
| ABCB6 | ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) | 0.9 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.88 |
| KDM4D | lysine (K)-specific demethylase 4D | 0.86 |
| UGDH | UDP-glucose 6-dehydrogenase | 0.86 |
| MAP2 | microtubule-associated protein 2 | 0.85 |
| KSR2 | kinase suppressor of ras 2 | 0.84 |
| ME1 | malic enzyme 1, NADP(+)-dependent, cytosolic | 0.84 |
| NAV3 | neuron navigator 3 | 0.82 |
| PIR | pirin (iron-binding nuclear protein) | 0.8 |
| RAP1GAP | RAP1 GTPase activating protein | 0.79 |
| TRIM29 | tripartite motif containing 29 | 0.79 |
| TTLL4 | tubulin tyrosine ligase-like family member 4 | 0.79 |
| ALAS1 | 5'-aminolevulinate synthase 1 | 0.78 |
| AKR1C3 | aldo-keto reductase family 1, member C3 | 0.76 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.73 |
| CBR3 | carbonyl reductase 3 | 0.73 |
| CTSL | cathepsin L | 0.72 |
| BAHCC1 | BAH domain and coiled-coil containing 1 | 0.72 |
| ASF1A | anti-silencing function 1A histone chaperone | 0.7 |
| CTNND2 | catenin (cadherin-associated protein), delta 2 | 0.7 |
| CLU | clusterin | 0.65 |
| GPN3 | GPN-loop GTPase 3 | 0.62 |
| CA8 | carbonic anhydrase VIII | 0.62 |
| POLR1D | polymerase (RNA) I polypeptide D, 16kDa | 0.61 |
| ANKRD10 | ankyrin repeat domain 10 | 0.6 |
| G6PD | glucose-6-phosphate dehydrogenase | 0.58 |
| FBXO30 | F-box protein 30 | 0.57 |
| ABCC2 | ATP-binding cassette, sub-family C (CFTR/MRP), member 2 | 0.57 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.56 |
| MYH6 | myosin, heavy chain 6, cardiac muscle, alpha | 0.56 |
| IFRD1 | interferon-related developmental regulator 1 | 0.55 |
| FUBP1 | far upstream element (FUSE) binding protein 1 | 0.55 |
| NUMBL | numb homolog (Drosophila)-like | 0.55 |
| DNAJB4 | DnaJ (Hsp40) homolog, subfamily B, member 4 | 0.54 |
| MAFG | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G | 0.53 |
| NQO2 | NAD(P)H dehydrogenase, quinone 2 | 0.52 |
| SYTL3 | synaptotagmin-like 3 | 0.52 |
| LRP8 | low density lipoprotein receptor-related protein 8, apolipoprotein e receptor | 0.51 |
| NOP10 | NOP10 ribonucleoprotein | 0.51 |
| EPHX1 | epoxide hydrolase 1, microsomal (xenobiotic) | 0.51 |
| PALB2 | partner and localizer of BRCA2 | 0.49 |
| SFN | stratifin | 0.49 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | 0.49 |
| RPE | ribulose-5-phosphate-3-epimerase | 0.48 |
| TKT | transketolase | 0.48 |
| HOXA9 | homeobox A9 | 0.48 |
| CCND3 | cyclin D3 | 0.47 |
| KIAA0232 | KIAA0232 | 0.47 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.47 |
| FAM110C | family with sequence similarity 110, member C | 0.46 |
| PPP2R3A | protein phosphatase 2, regulatory subunit B'', alpha | 0.46 |
| MAGEA6 | melanoma antigen family A6 | 0.45 |
| TXN | thioredoxin | 0.45 |
| ALDH3A2 | aldehyde dehydrogenase 3 family, member A2 | 0.45 |
| KIAA1217 | KIAA1217 | 0.44 |
| CHP1 | calcineurin-like EF-hand protein 1 | 0.44 |
| TNFSF9 | tumor necrosis factor (ligand) superfamily, member 9 | 0.44 |
| CCDC32 | coiled-coil domain containing 32 | 0.43 |
| TSKU | tsukushi, small leucine rich proteoglycan | 0.43 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | 0.43 |
| CAMKK1 | calcium/calmodulin-dependent protein kinase kinase 1, alpha | 0.43 |
| SLC6A17 | solute carrier family 6 (neutral amino acid transporter), member 17 | 0.42 |
| HSBP1 | heat shock factor binding protein 1 | 0.42 |
| RFFL | ring finger and FYVE-like domain containing E3 ubiquitin protein ligase | 0.42 |
| GLA | galactosidase, alpha | 0.42 |
| SLC3A2 | solute carrier family 3 (amino acid transporter heavy chain), member 2 | 0.41 |
| LIN7A | lin-7 homolog A (C. elegans) | 0.41 |
| PRR14L | proline rich 14-like | 0.41 |
| ZNF697 | zinc finger protein 697 | 0.41 |
| PALM3 | paralemmin 3 | 0.41 |
| DCHS1 | dachsous cadherin-related 1 | 0.41 |
| CCDC170 | coiled-coil domain containing 170 | 0.4 |
| TMEM173 | transmembrane protein 173 | 0.4 |
| HYPK | huntingtin interacting protein K | 0.4 |
| GDF15 | growth differentiation factor 15 | 0.4 |
| LRRC58 | leucine rich repeat containing 58 | 0.4 |
| IL27RA | interleukin 27 receptor, alpha | 0.4 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.91 |
| GREB1L | growth regulation by estrogen in breast cancer-like | -0.91 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | -0.89 |
| MXRA7 | matrix-remodelling associated 7 | -0.87 |
| ENO1 | enolase 1, (alpha) | -0.77 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | -0.72 |
| LAMC2 | laminin, gamma 2 | -0.69 |
| ADGRF1 | adhesion G protein-coupled receptor F1 | -0.67 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | -0.66 |
| ARHGAP28 | Rho GTPase activating protein 28 | -0.65 |
| DPYD | dihydropyrimidine dehydrogenase | -0.65 |
| ZC3H6 | zinc finger CCCH-type containing 6 | -0.63 |
| ESAM | endothelial cell adhesion molecule | -0.61 |
| ARSG | arylsulfatase G | -0.59 |
| RAB26 | RAB26, member RAS oncogene family | -0.58 |
| ZNF362 | zinc finger protein 362 | -0.57 |
| WNT16 | wingless-type MMTV integration site family, member 16 | -0.56 |
| COL13A1 | collagen, type XIII, alpha 1 | -0.54 |
| MEGF8 | multiple EGF-like-domains 8 | -0.53 |
| METTL7A | methyltransferase like 7A | -0.53 |
| RGN | regucalcin | -0.53 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.53 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.52 |
| TRIM46 | tripartite motif containing 46 | -0.52 |
| GAS6 | growth arrest-specific 6 | -0.52 |
| HOXB8 | homeobox B8 | -0.51 |
| TMEM231 | transmembrane protein 231 | -0.51 |
| CYP51A1 | cytochrome P450, family 51, subfamily A, polypeptide 1 | -0.51 |
| HS3ST1 | heparan sulfate (glucosamine) 3-O-sulfotransferase 1 | -0.51 |
| NCAM1 | neural cell adhesion molecule 1 | -0.5 |
| FAM122B | family with sequence similarity 122B | -0.49 |
| ENTR1 | endosome associated trafficking regulator 1 | -0.49 |
| DUSP22 | dual specificity phosphatase 22 | -0.49 |
| NT5E | 5'-nucleotidase, ecto (CD73) | -0.48 |
| CYP4V2 | cytochrome P450, family 4, subfamily V, polypeptide 2 | -0.46 |
| C15ORF61 | chromosome 15 open reading frame 61 | -0.46 |
| FAM171A2 | family with sequence similarity 171, member A2 | -0.46 |
| TADA2A | transcriptional adaptor 2A | -0.46 |
| RAPGEF5 | Rap guanine nucleotide exchange factor (GEF) 5 | -0.45 |
| SUCLG2 | succinate-CoA ligase, GDP-forming, beta subunit | -0.45 |
| SOX13 | SRY (sex determining region Y)-box 13 | -0.45 |
| ZNF3 | zinc finger protein 3 | -0.44 |
| HEXD | hexosaminidase D | -0.44 |
| MPV17 | MpV17 mitochondrial inner membrane protein | -0.44 |
| TP53 | tumor protein p53 | -0.44 |
| MT2A | metallothionein 2A | -0.43 |
| SLC26A2 | solute carrier family 26 (anion exchanger), member 2 | -0.43 |
| PARP9 | poly (ADP-ribose) polymerase family, member 9 | -0.42 |
| SLC12A4 | solute carrier family 12 (potassium/chloride transporter), member 4 | -0.42 |
| RCAN1 | regulator of calcineurin 1 | -0.41 |
| CBX7 | chromobox homolog 7 | -0.41 |
| HBA1 | hemoglobin, alpha 1 | -0.41 |
| TULP3 | tubby like protein 3 | -0.41 |
| TP53I3 | tumor protein p53 inducible protein 3 | -0.4 |
| FBXL8 | F-box and leucine-rich repeat protein 8 | -0.4 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.4 |
| CHID1 | chitinase domain containing 1 | -0.4 |
| TBC1D25 | TBC1 domain family, member 25 | -0.4 |
| HGH1 | HGH1 homolog (S. cerevisiae) | -0.4 |
| KIAA0556 | KIAA0556 | -0.4 |
| TANGO2 | transport and golgi organization 2 homolog (Drosophila) | -0.4 |
| SEMA4G | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G | -0.39 |
| SELENOH | selenoprotein H | -0.39 |
| SELENOW | selenoprotein W | -0.39 |
| EIF2B4 | eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa | -0.39 |
| MYH16 | myosin, heavy chain 16 pseudogene | -0.39 |
| NOVA1 | neuro-oncological ventral antigen 1 | -0.39 |
| AASS | aminoadipate-semialdehyde synthase | -0.39 |
| OSBPL7 | oxysterol binding protein-like 7 | -0.38 |
| AXL | AXL receptor tyrosine kinase | -0.38 |
| RNF185 | ring finger protein 185 | -0.38 |
| CNKSR1 | connector enhancer of kinase suppressor of Ras 1 | -0.38 |
| LIME1 | Lck interacting transmembrane adaptor 1 | -0.38 |
| INHBA | inhibin, beta A | -0.38 |
| F10 | coagulation factor X | -0.38 |
| ZNF658 | zinc finger protein 658 | -0.37 |
| TMUB2 | transmembrane and ubiquitin-like domain containing 2 | -0.37 |
| ABHD10 | abhydrolase domain containing 10 | -0.37 |
| ST5 | suppression of tumorigenicity 5 | -0.37 |
| ZFP62 | ZFP62 zinc finger protein | -0.37 |
| MT1L | metallothionein 1L (gene/pseudogene) | -0.37 |
| ZBTB4 | zinc finger and BTB domain containing 4 | -0.37 |
| VIM | vimentin | -0.37 |
| DOP1A | DOP1 leucine zipper like protein A | -0.36 |
| SLC16A6 | solute carrier family 16, member 6 | -0.36 |
| NUDT6 | nudix (nucleoside diphosphate linked moiety X)-type motif 6 | -0.36 |
| ITGB4 | integrin, beta 4 | -0.36 |
| KCNN4 | potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 | -0.36 |
| ZNF446 | zinc finger protein 446 | -0.36 |
| LAMA5 | laminin, alpha 5 | -0.36 |
| COL14A1 | collagen, type XIV, alpha 1 | -0.36 |
| GPX1 | glutathione peroxidase 1 | -0.36 |
| ALDH1A3 | aldehyde dehydrogenase 1 family, member A3 | -0.36 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.36 |
| RALGAPA1 | Ral GTPase activating protein, alpha subunit 1 (catalytic) | -0.35 |
| SLC11A2 | solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 | -0.35 |
| RIOX1 | ribosomal oxygenase 1 | -0.35 |
| COL6A2 | collagen, type VI, alpha 2 | -0.35 |
| PEX7 | peroxisomal biogenesis factor 7 | -0.35 |
| ARHGEF17 | Rho guanine nucleotide exchange factor (GEF) 17 | -0.35 |
