Tetracycline (hydrochloride)_A498 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tetracycline (hydrochloride) perturbation in A498 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tetracycline (hydrochloride)_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CCL2 chemokine (C-C motif) ligand 2 0.139659
NRP2 neuropilin 2 0.11535
FTH1 ferritin, heavy polypeptide 1 0.101132
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0935257
CSF1 colony stimulating factor 1 (macrophage) 0.0931585
ZFP36L1 ZFP36 ring finger protein-like 1 0.0913227
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0853803
DDIT4 DNA-damage-inducible transcript 4 0.0781731
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0688517
VCAM1 vascular cell adhesion molecule 1 0.0677314
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0601754
PLK2 polo-like kinase 2 0.0537913
TPM3 tropomyosin 3 0.0517438
CENPF centromere protein F, 350/400kDa 0.0511462
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0484228
STAT1 signal transducer and activator of transcription 1, 91kDa 0.048119
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0465726
UBA6 ubiquitin-like modifier activating enzyme 6 0.0464531
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.04254
SRSF11 serine/arginine-rich splicing factor 11 0.0403297
UGCG UDP-glucose ceramide glucosyltransferase 0.0384536
MKI67 marker of proliferation Ki-67 0.0382636
VMP1 vacuole membrane protein 1 0.0380772
HMGB2 high mobility group box 2 0.0376047
MSN moesin 0.0375795
RTN4 reticulon 4 0.0370528
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0362024
CA12 carbonic anhydrase XII 0.035378
DIAPH3 diaphanous-related formin 3 0.0352379
ADAM10 ADAM metallopeptidase domain 10 0.0346198
P3H2 prolyl 3-hydroxylase 2 0.0345543
SLTM SAFB-like, transcription modulator 0.0343389
PDIA3 protein disulfide isomerase family A, member 3 0.0341704
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0337649
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0336198
AKAP9 A kinase (PRKA) anchor protein 9 0.0331991
MLEC malectin 0.0310756
RAI14 retinoic acid induced 14 0.0307365
TGFB2 transforming growth factor, beta 2 0.0307357
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0305675
IRS2 insulin receptor substrate 2 0.0303752
RNF220 ring finger protein 220 0.0303053
MYADM myeloid-associated differentiation marker 0.0300581
LDHA lactate dehydrogenase A 0.0299959
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 0.0298026
SRRM2 serine/arginine repetitive matrix 2 0.0292067
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0290075
GOLPH3 golgi phosphoprotein 3 (coat-protein) 0.0286997
RIPK2 receptor-interacting serine-threonine kinase 2 0.0278717
DLG1 discs, large homolog 1 (Drosophila) 0.0278126
VCAN versican 0.0277905
PTBP3 polypyrimidine tract binding protein 3 0.027591
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0275414
CHMP5 charged multivesicular body protein 5 0.0274246
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0273684
SET SET nuclear proto-oncogene 0.0273614
ANLN anillin, actin binding protein 0.0272257
NRIP1 nuclear receptor interacting protein 1 0.0271446
ADAM17 ADAM metallopeptidase domain 17 0.0269753
COL4A1 collagen, type IV, alpha 1 0.0267155
MYH9 myosin, heavy chain 9, non-muscle 0.0264755
ITGAV integrin, alpha V 0.0262959
KDM6A lysine (K)-specific demethylase 6A 0.026157
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0256916
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 0.0253019
SMC4 structural maintenance of chromosomes 4 0.025022
ANXA1 annexin A1 0.0247989
NFE2L1 nuclear factor, erythroid 2-like 1 0.0247671
TPR translocated promoter region, nuclear basket protein 0.024712
SRRM1 serine/arginine repetitive matrix 1 0.0244376
SKAP2 src kinase associated phosphoprotein 2 0.0242613
GOLGA4 golgin A4 0.0240024
NUCB2 nucleobindin 2 0.0239692
RPS7 ribosomal protein S7 0.0239183
CPAP centrosome assembly and centriole elongation protein 0.0238006
EML4 echinoderm microtubule associated protein like 4 0.0235512
CD46 CD46 molecule, complement regulatory protein 0.0235249
B2M beta-2-microglobulin 0.0234396
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0232134
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0229345
FAT1 FAT atypical cadherin 1 0.0227869
PKM pyruvate kinase, muscle 0.0227258
MYO10 myosin X 0.0227073
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 0.0226187
PFN1 profilin 1 0.0225847
CSNK1A1 casein kinase 1, alpha 1 0.022535
PAX8 paired box 8 0.0222652
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) 0.0220168
RPS3 ribosomal protein S3 0.0218886
MX1 MX dynamin-like GTPase 1 0.0217729
EHD4 EH-domain containing 4 0.02173
RALB v-ral simian leukemia viral oncogene homolog B 0.0216425
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) 0.0215593
VIRMA vir like m6A methyltransferase associated 0.0214093
NFIB nuclear factor I/B 0.0213748
FNDC3B fibronectin type III domain containing 3B 0.0213468
HDGF hepatoma-derived growth factor 0.0212837
MKRN1 makorin ring finger protein 1 0.0210886
ADAM9 ADAM metallopeptidase domain 9 0.0210761
RPS2 ribosomal protein S2 0.0209804

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.230776
IGFBP3 insulin-like growth factor binding protein 3 -0.219825
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.19905
FRMD4A FERM domain containing 4A -0.166629
RPL35A ribosomal protein L35a -0.113234
HLA-B major histocompatibility complex, class I, B -0.10908
UBC ubiquitin C -0.0882245
ACTG1 actin gamma 1 -0.0830323
TPT1 tumor protein, translationally-controlled 1 -0.0809795
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0788823
NAMPT nicotinamide phosphoribosyltransferase -0.0739164
EIF1 eukaryotic translation initiation factor 1 -0.0727174
TMSB10 thymosin beta 10 -0.067504
EXT1 exostosin glycosyltransferase 1 -0.0633173
RPL34 ribosomal protein L34 -0.0618313
RPL8 ribosomal protein L8 -0.0545049
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0538863
S100A10 S100 calcium binding protein A10 -0.0534879
RPS19 ribosomal protein S19 -0.0524294
RPLP1 ribosomal protein, large, P1 -0.0515508
HSPB1 heat shock 27kDa protein 1 -0.050577
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0472668
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0471007
RPS24 ribosomal protein S24 -0.0449533
RRBP1 ribosome binding protein 1 -0.0433747
INTS6 integrator complex subunit 6 -0.0433107
RPS23 ribosomal protein S23 -0.0413698
CD63 CD63 molecule -0.0413254
CP ceruloplasmin (ferroxidase) -0.0412132
RSL1D1 ribosomal L1 domain containing 1 -0.0403499
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0399172
CTSD cathepsin D -0.0395724
HLA-C major histocompatibility complex, class I, C -0.0385107
AHNAK AHNAK nucleoprotein -0.0384738
RPL23 ribosomal protein L23 -0.038398
RND3 Rho family GTPase 3 -0.0377498
PALLD palladin, cytoskeletal associated protein -0.0375014
APOL1 apolipoprotein L, 1 -0.037325
RPS15 ribosomal protein S15 -0.0372106
RPS6 ribosomal protein S6 -0.0360395
TFPI2 tissue factor pathway inhibitor 2 -0.0354591
CANX calnexin -0.0352837
TMEM263 transmembrane protein 263 -0.034934
RPL28 ribosomal protein L28 -0.0346056
RPS11 ribosomal protein S11 -0.0342142
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0340988
G0S2 G0/G1 switch 2 -0.0338886
LOC112694756 uncharaterized LOC112694756 -0.0334449
KYNU kynureninase -0.0332367
ARF1 ADP-ribosylation factor 1 -0.0331985
OAZ1 ornithine decarboxylase antizyme 1 -0.0331809
NDRG1 N-myc downstream regulated 1 -0.033099
CDK12 cyclin-dependent kinase 12 -0.0328285
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0327721
RPS21 ribosomal protein S21 -0.0325658
FUS FUS RNA binding protein -0.0321314
RIGI RNA sensor RIG-I -0.031846
IFIH1 interferon induced with helicase C domain 1 -0.0315675
RPL19 ribosomal protein L19 -0.0306791
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0300619
VIM vimentin -0.0298447
TSHZ2 teashirt zinc finger homeobox 2 -0.029277
IARS1 isoleucyl-tRNA synthetase 1 -0.0292266
SPECC1 sperm antigen with calponin homology and coiled-coil domains 1 -0.0290809
HLA-E major histocompatibility complex, class I, E -0.0288793
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0275688
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0274828
SEC31A SEC31 homolog A (S. cerevisiae) -0.0272351
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0270316
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0266308
RPL38 ribosomal protein L38 -0.0265973
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0265415
RPS5 ribosomal protein S5 -0.0264587
PTMA prothymosin, alpha -0.0263969
EPAS1 endothelial PAS domain protein 1 -0.0263295
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0256111
ZSWIM6 zinc finger, SWIM-type containing 6 -0.025533
UBB ubiquitin B -0.0254381
LMNA lamin A/C -0.0247447
NUP98 nucleoporin 98kDa -0.0246633
RPS20 ribosomal protein S20 -0.024496
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) -0.0244557
FMNL2 formin-like 2 -0.0244492
CCNI cyclin I -0.0243912
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0239702
POTEF POTE ankyrin domain family, member F -0.0238948
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.023703
RPS4X ribosomal protein S4, X-linked -0.0234641
RAB1A RAB1A, member RAS oncogene family -0.0234476
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0233448
RPL31 ribosomal protein L31 -0.023301
OSMR oncostatin M receptor -0.0232788
FSTL1 follistatin-like 1 -0.023179
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0228183
SDC4 syndecan 4 -0.0227338
IFRD1 interferon-related developmental regulator 1 -0.0226966
LMAN1 lectin, mannose-binding, 1 -0.0224483
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) -0.0223611
RPS14 ribosomal protein S14 -0.0219407
PDLIM5 PDZ and LIM domain 5 -0.0218871