Tetracycline (hydrochloride)_A549 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tetracycline (hydrochloride) perturbation in A549 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tetracycline (hydrochloride)_A549 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.233896
SPTBN1 spectrin, beta, non-erythrocytic 1 0.16369
AKAP12 A kinase (PRKA) anchor protein 12 0.138844
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.101527
STAT1 signal transducer and activator of transcription 1, 91kDa 0.10058
CA12 carbonic anhydrase XII 0.0876089
EFNA5 ephrin-A5 0.0811498
FTH1 ferritin, heavy polypeptide 1 0.0784023
FNDC3B fibronectin type III domain containing 3B 0.0741865
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0733772
PDE10A phosphodiesterase 10A 0.0659474
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.063646
GRB10 growth factor receptor-bound protein 10 0.0600518
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0600072
LDHA lactate dehydrogenase A 0.0589285
ANXA2 annexin A2 0.058279
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0566037
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0554841
ARHGAP26 Rho GTPase activating protein 26 0.0493132
DGKD diacylglycerol kinase, delta 130kDa 0.0469567
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0450873
MT2A metallothionein 2A 0.0444964
BASP1 brain abundant, membrane attached signal protein 1 0.0441192
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0437445
RNF213 ring finger protein 213 0.0431245
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0424593
MYO1E myosin IE 0.0417132
PSD3 pleckstrin and Sec7 domain containing 3 0.0410613
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0410401
EHBP1 EH domain binding protein 1 0.0403316
ANGPTL4 angiopoietin-like 4 0.0399444
MAML3 mastermind-like 3 (Drosophila) 0.0394605
FLNB filamin B, beta 0.0388414
FAM13A family with sequence similarity 13, member A 0.0388167
ASPH aspartate beta-hydroxylase 0.0385653
AUTS2 autism susceptibility candidate 2 0.0380477
STC1 stanniocalcin 1 0.0369106
SMAD3 SMAD family member 3 0.0363874
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0344855
FMNL2 formin-like 2 0.0343114
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.034258
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.033956
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0329678
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0325912
ENO1 enolase 1, (alpha) 0.0323886
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0321623
HILPDA hypoxia inducible lipid droplet-associated 0.0317096
NPAS2 neuronal PAS domain protein 2 0.0315891
FA2H fatty acid 2-hydroxylase 0.0315466
GPC6 glypican 6 0.0312346
PHF21A PHD finger protein 21A 0.031105
SOD2 superoxide dismutase 2, mitochondrial 0.0305796
EGFR epidermal growth factor receptor 0.0304407
RPS3 ribosomal protein S3 0.0303514
RPL18 ribosomal protein L18 0.0301067
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0293765
RB1CC1 RB1-inducible coiled-coil 1 0.0293078
EXT1 exostosin glycosyltransferase 1 0.029083
RIN2 Ras and Rab interactor 2 0.0286174
NRIP1 nuclear receptor interacting protein 1 0.0282144
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.0280981
TBC1D5 TBC1 domain family, member 5 0.027912
ERRFI1 ERBB receptor feedback inhibitor 1 0.0272733
ABTB3 ankyrin repeat and BTB domain containing 3 0.0268585
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0266895
SH3KBP1 SH3-domain kinase binding protein 1 0.0263372
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.025754
CMIP c-Maf inducing protein 0.0255526
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.025466
DOCK5 dedicator of cytokinesis 5 0.025204
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0251942
MCL1 myeloid cell leukemia 1 0.0251926
KDM7A lysine (K)-specific demethylase 7A 0.0250721
RAI1 retinoic acid induced 1 0.0249231
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0246483
DDIT4 DNA-damage-inducible transcript 4 0.0244351
PDE4B phosphodiesterase 4B, cAMP-specific 0.0242685
RPS7 ribosomal protein S7 0.024141
SLTM SAFB-like, transcription modulator 0.0240813
SKAP2 src kinase associated phosphoprotein 2 0.0239668
SPAG9 sperm associated antigen 9 0.0239291
ZFP36L1 ZFP36 ring finger protein-like 1 0.0238124
AXL AXL receptor tyrosine kinase 0.023644
DENND4C DENN/MADD domain containing 4C 0.0235799
AGFG1 ArfGAP with FG repeats 1 0.0234054
PARD3 par-3 family cell polarity regulator 0.0233782
MKI67 marker of proliferation Ki-67 0.0230369
RTN4 reticulon 4 0.0228206
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0227812
HIPK2 homeodomain interacting protein kinase 2 0.0227629
RAD51B RAD51 paralog B 0.0223426
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0222222
RIGI RNA sensor RIG-I 0.0221122
VMP1 vacuole membrane protein 1 0.0220156
C1D C1D nuclear receptor corepressor 0.0219899
USP34 ubiquitin specific peptidase 34 0.0218572
ZMYND8 zinc finger, MYND-type containing 8 0.0217646
WWOX WW domain containing oxidoreductase 0.021286
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.0212551
SBF2 SET binding factor 2 0.0208626

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.276266
ACTG1 actin gamma 1 -0.197017
RPS19 ribosomal protein S19 -0.0901046
EIF1 eukaryotic translation initiation factor 1 -0.0764874
RPL35A ribosomal protein L35a -0.0673719
TM4SF1 transmembrane 4 L six family member 1 -0.0653019
S100A10 S100 calcium binding protein A10 -0.0652512
FTL ferritin, light polypeptide -0.0635216
RPS23 ribosomal protein S23 -0.0592493
KRT81 keratin 81, type II -0.0581804
RPLP1 ribosomal protein, large, P1 -0.0580806
POTEF POTE ankyrin domain family, member F -0.0572529
RPS6 ribosomal protein S6 -0.0531868
RPL23 ribosomal protein L23 -0.0455453
UBC ubiquitin C -0.0447338
RPL8 ribosomal protein L8 -0.043489
RPL28 ribosomal protein L28 -0.0409013
RPS11 ribosomal protein S11 -0.0399086
MT1X metallothionein 1X -0.0361762
TMSB10 thymosin beta 10 -0.0337809
RPL34 ribosomal protein L34 -0.0324556
IGFBP4 insulin-like growth factor binding protein 4 -0.0316561
RPS24 ribosomal protein S24 -0.0309427
TPT1 tumor protein, translationally-controlled 1 -0.030526
KRT7 keratin 7, type II -0.0282023
RPL38 ribosomal protein L38 -0.0272505
RPS29 ribosomal protein S29 -0.0267983
RPS8 ribosomal protein S8 -0.0258403
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0253072
RPS16 ribosomal protein S16 -0.0244244
RPS14 ribosomal protein S14 -0.0241514
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0239126
NAV2 neuron navigator 2 -0.0228583
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0228571
RPS15 ribosomal protein S15 -0.0224357
RPS21 ribosomal protein S21 -0.0211033
RPS27A ribosomal protein S27a -0.0209497
RPS5 ribosomal protein S5 -0.0208054
IARS1 isoleucyl-tRNA synthetase 1 -0.0207446
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0207404
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.020562
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -0.0203493
PALLD palladin, cytoskeletal associated protein -0.0193476
VDAC1 voltage-dependent anion channel 1 -0.0191748
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0190415
RPL32 ribosomal protein L32 -0.0190365
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0190277
RSL1D1 ribosomal L1 domain containing 1 -0.018788
AHNAK AHNAK nucleoprotein -0.0186575
RAB10 RAB10, member RAS oncogene family -0.0186272
TBCA tubulin folding cofactor A -0.0184806
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.018461
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0182993
FBXO11 F-box protein 11 -0.0182783
SAMD4A sterile alpha motif domain containing 4A -0.0180998
IGFBP3 insulin-like growth factor binding protein 3 -0.0179861
CDK12 cyclin-dependent kinase 12 -0.0179568
NAP1L4 nucleosome assembly protein 1-like 4 -0.0179522
GOLGB1 golgin B1 -0.0179048
FBXL2 F-box and leucine-rich repeat protein 2 -0.0176951
RPL19 ribosomal protein L19 -0.0173176
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0172162
WASF2 WAS protein family, member 2 -0.0171539
RPS13 ribosomal protein S13 -0.0170566
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0169259
DUSP5 dual specificity phosphatase 5 -0.0159466
EIF5B eukaryotic translation initiation factor 5B -0.0159462
C15ORF48 chromosome 15 open reading frame 48 -0.0156757
TMSB4X thymosin beta 4, X-linked -0.0156145
ASTN2 astrotactin 2 -0.0154485
DENND4A DENN/MADD domain containing 4A -0.0154058
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0151938
LMAN1 lectin, mannose-binding, 1 -0.0151746
KRT8 keratin 8, type II -0.0151243
ATP5F1B ATP synthase F1 subunit beta -0.0150728
ACTN4 actinin, alpha 4 -0.015055
IPO7 importin 7 -0.0150041
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0149018
RBMX RNA binding motif protein, X-linked -0.0146218
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.0145619
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0145374
CLINT1 clathrin interactor 1 -0.0144998
RPL27A ribosomal protein L27a -0.0144003
TPM1 tropomyosin 1 (alpha) -0.0143587
LARP4B La ribonucleoprotein domain family, member 4B -0.014296
PRRC2C proline-rich coiled-coil 2C -0.0138215
GLG1 golgi glycoprotein 1 -0.0138117
LDHB lactate dehydrogenase B -0.0138068
BIRC3 baculoviral IAP repeat containing 3 -0.0137861
UPP1 uridine phosphorylase 1 -0.0137861
RAB1A RAB1A, member RAS oncogene family -0.0137144
DSCAM Down syndrome cell adhesion molecule -0.013682
ETFA electron-transfer-flavoprotein, alpha polypeptide -0.0136459
RPL31 ribosomal protein L31 -0.0135747
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 -0.0135207
UBB ubiquitin B -0.0135029
ERBIN erbb2 interacting protein -0.0134896
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0133032
GPHN gephyrin -0.0131261
AADAC arylacetamide deacetylase -0.0130399