Tetracycline (hydrochloride)_AsPC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tetracycline (hydrochloride) perturbation in AsPC-1 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Tetracycline (hydrochloride)_AsPC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VCAN versican 0.111386
PSD3 pleckstrin and Sec7 domain containing 3 0.103862
EGFR epidermal growth factor receptor 0.0736464
ITGA6 integrin, alpha 6 0.0717413
UBA6 ubiquitin-like modifier activating enzyme 6 0.0630715
FLNB filamin B, beta 0.0610397
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0584988
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0556975
ITPRID2 ITPR interacting domain containing 2 0.0536879
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0533973
EFNA5 ephrin-A5 0.0485048
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0451624
LAMA4 laminin, alpha 4 0.0448288
ITGB4 integrin, beta 4 0.0438355
PTPRR protein tyrosine phosphatase, receptor type, R 0.0436288
LDHA lactate dehydrogenase A 0.0431203
TRRAP transformation/transcription domain-associated protein 0.0427285
SLC35F3 solute carrier family 35, member F3 0.0424751
ARHGAP42 Rho GTPase activating protein 42 0.0424137
DOCK5 dedicator of cytokinesis 5 0.0414678
HMGA2 high mobility group AT-hook 2 0.041448
MUC17 mucin 17, cell surface associated 0.0412125
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0405295
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0387664
NPSR1 neuropeptide S receptor 1 0.038612
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0367231
SLK STE20-like kinase 0.0360934
PPARG peroxisome proliferator-activated receptor gamma 0.0349699
CAPRIN2 caprin family member 2 0.0336817
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0334737
ESYT2 extended synaptotagmin-like protein 2 0.0322411
RNASEH2A ribonuclease H2, subunit A 0.032075
SKAP2 src kinase associated phosphoprotein 2 0.0316293
GRB10 growth factor receptor-bound protein 10 0.0312998
PDE4D phosphodiesterase 4D, cAMP-specific 0.0311796
PICALM phosphatidylinositol binding clathrin assembly protein 0.0308647
AKAP13 A kinase (PRKA) anchor protein 13 0.0290783
PRELID2 PRELI domain containing 2 0.0283169
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.0282737
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 0.0282393
ANXA11 annexin A11 0.0278775
MPRIP myosin phosphatase Rho interacting protein 0.0270834
MAML2 mastermind-like 2 (Drosophila) 0.0269758
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0265738
RPS7 ribosomal protein S7 0.0264739
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0264044
ERRFI1 ERBB receptor feedback inhibitor 1 0.0262711
ANO6 anoctamin 6 0.0258584
PDLIM5 PDZ and LIM domain 5 0.0250566
KIF16B kinesin family member 16B 0.0248372
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0247311
SLTM SAFB-like, transcription modulator 0.0246826
AKAP12 A kinase (PRKA) anchor protein 12 0.0241862
SULF2 sulfatase 2 0.0241796
FTH1 ferritin, heavy polypeptide 1 0.0233126
RABGAP1L RAB GTPase activating protein 1-like 0.023171
EHBP1 EH domain binding protein 1 0.0230524
RPS2 ribosomal protein S2 0.0230515
FOXO1 forkhead box O1 0.0229803
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0228437
VCL vinculin 0.0226214
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0226018
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0225618
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.0224388
DIAPH2 diaphanous-related formin 2 0.022097
RALB v-ral simian leukemia viral oncogene homolog B 0.0220074
BAIAP2L1 BAI1-associated protein 2-like 1 0.0219982
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0219908
KIAA0040 KIAA0040 0.0219136
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.021672
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0214173
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) 0.0213931
FNDC3B fibronectin type III domain containing 3B 0.0213372
RCOR1 REST corepressor 1 0.0211822
TNRC18 trinucleotide repeat containing 18 0.0209993
TRIO trio Rho guanine nucleotide exchange factor 0.0208803
FAT1 FAT atypical cadherin 1 0.0206517
HP1BP3 heterochromatin protein 1, binding protein 3 0.0201469
ITCH itchy E3 ubiquitin protein ligase 0.0199838
STK39 serine threonine kinase 39 0.0199419
MYH9 myosin, heavy chain 9, non-muscle 0.0198925
PRSS3 protease, serine, 3 0.019795
CARD16 caspase recruitment domain family, member 16 0.0195896
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.0193093
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 0.0192823
YAP1 Yes-associated protein 1 0.0190063
DGKD diacylglycerol kinase, delta 130kDa 0.018951
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0186484
ARHGAP29 Rho GTPase activating protein 29 0.0186454
EIF4B eukaryotic translation initiation factor 4B 0.018545
KIRREL1 kirre like nephrin family adhesion molecule 1 0.0183697
PTEN phosphatase and tensin homolog 0.0183051
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0182824
NPAS2 neuronal PAS domain protein 2 0.0182121
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.0178291
SVIL supervillin 0.0177666
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0177555
GLS2 glutaminase 2 (liver, mitochondrial) 0.0177513
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0174136
DPYSL2 dihydropyrimidinase-like 2 0.0172983

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.267879
TMSB10 thymosin beta 10 -0.204241
S100A10 S100 calcium binding protein A10 -0.177405
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -0.169123
TPT1 tumor protein, translationally-controlled 1 -0.145575
PTMA prothymosin, alpha -0.125775
UBC ubiquitin C -0.124448
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa -0.110661
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.108021
ACTG1 actin gamma 1 -0.0974531
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0951916
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0925003
RPL35A ribosomal protein L35a -0.0922302
AHNAK AHNAK nucleoprotein -0.0858493
IGFBP3 insulin-like growth factor binding protein 3 -0.0836436
LAMB3 laminin, beta 3 -0.0779279
RPL8 ribosomal protein L8 -0.0773624
TM4SF1 transmembrane 4 L six family member 1 -0.0771229
EIF1 eukaryotic translation initiation factor 1 -0.076274
TXNRD1 thioredoxin reductase 1 -0.0707719
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0674854
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0669528
VIM vimentin -0.0660476
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0649316
SDC4 syndecan 4 -0.0638485
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0613035
HMGA1 high mobility group AT-hook 1 -0.0607307
RPS21 ribosomal protein S21 -0.060012
RPLP1 ribosomal protein, large, P1 -0.0570433
RPL34 ribosomal protein L34 -0.0568969
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0560368
RPS23 ribosomal protein S23 -0.0559767
S100A6 S100 calcium binding protein A6 -0.0520404
RRBP1 ribosome binding protein 1 -0.0503514
DSG2 desmoglein 2 -0.0499354
RBM39 RNA binding motif protein 39 -0.0496359
KDM3A lysine (K)-specific demethylase 3A -0.0492627
FTL ferritin, light polypeptide -0.0483763
RAB1A RAB1A, member RAS oncogene family -0.0480812
IER3 immediate early response 3 -0.047851
DHRS9 dehydrogenase/reductase (SDR family) member 9 -0.0477792
TMSB4X thymosin beta 4, X-linked -0.0477418
EMP1 epithelial membrane protein 1 -0.0475677
CANX calnexin -0.0475163
RPS24 ribosomal protein S24 -0.0463523
LOC112694756 uncharaterized LOC112694756 -0.0452364
RPL32 ribosomal protein L32 -0.0442669
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0435639
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0428443
SQSTM1 sequestosome 1 -0.042814
LY6E lymphocyte antigen 6 complex, locus E -0.0408536
RPL12 ribosomal protein L12 -0.0406939
RSL1D1 ribosomal L1 domain containing 1 -0.0402568
RPS13 ribosomal protein S13 -0.0400612
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0398082
RAD21 RAD21 homolog (S. pombe) -0.0393059
STAU1 staufen double-stranded RNA binding protein 1 -0.0385716
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0383067
RPS19 ribosomal protein S19 -0.0377615
RPS8 ribosomal protein S8 -0.0375924
CD63 CD63 molecule -0.0375584
RPS6 ribosomal protein S6 -0.0374344
RIOK3 RIO kinase 3 -0.0370661
EXT1 exostosin glycosyltransferase 1 -0.0358177
RPL28 ribosomal protein L28 -0.035538
CD2AP CD2-associated protein -0.0355266
RPL23 ribosomal protein L23 -0.0355249
EPCAM epithelial cell adhesion molecule -0.0351219
TMEM263 transmembrane protein 263 -0.0348569
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0348392
B2M beta-2-microglobulin -0.0338822
PGK1 phosphoglycerate kinase 1 -0.0338538
EGR1 early growth response 1 -0.0338483
RPLP2 ribosomal protein, large, P2 -0.0335115
RPL31 ribosomal protein L31 -0.0333451
H1-0 H1.0 linker histone -0.0331708
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0331687
RPS15 ribosomal protein S15 -0.0328783
TXNIP thioredoxin interacting protein -0.0325803
WSB1 WD repeat and SOCS box containing 1 -0.0325105
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0322382
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0319271
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0317021
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0316394
HDLBP high density lipoprotein binding protein -0.0315998
CCNI cyclin I -0.0315551
ANXA2 annexin A2 -0.0313259
MDK midkine (neurite growth-promoting factor 2) -0.0312675
RPL26 ribosomal protein L26 -0.0312657
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.0310702
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0306231
MYL12B myosin, light chain 12B, regulatory -0.0305666
CALU calumenin -0.0304658
RPS14 ribosomal protein S14 -0.0303532
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0302666
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0301089
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0299408
ARF1 ADP-ribosylation factor 1 -0.029452
RPS29 ribosomal protein S29 -0.0294401
SPAG9 sperm associated antigen 9 -0.0291721