Tetracycline (hydrochloride)_BT-474 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tetracycline (hydrochloride) perturbation in BT-474 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tetracycline (hydrochloride)_BT-474 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTH1 ferritin, heavy polypeptide 1 0.132654
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0849598
RPS3 ribosomal protein S3 0.0625433
RPL23 ribosomal protein L23 0.0518863
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.040634
CEMIP cell migration inducing protein, hyaluronan binding 0.0382836
TMEM165 transmembrane protein 165 0.033708
NDRG1 N-myc downstream regulated 1 0.0333771
MT2A metallothionein 2A 0.031801
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0297897
RPL12 ribosomal protein L12 0.0294227
FTL ferritin, light polypeptide 0.0288596
ENO1 enolase 1, (alpha) 0.0284838
LDHA lactate dehydrogenase A 0.0283476
FAM13A family with sequence similarity 13, member A 0.0271447
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0255113
KMT2E lysine (K)-specific methyltransferase 2E 0.0238093
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0237332
TPT1 tumor protein, translationally-controlled 1 0.023482
RPS27 ribosomal protein S27 0.0231828
RPS12 ribosomal protein S12 0.022477
RPL9 ribosomal protein L9 0.0223337
RPS6 ribosomal protein S6 0.0218894
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0213622
RPS2 ribosomal protein S2 0.0210852
ZNF292 zinc finger protein 292 0.0208464
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0208252
ANXA2 annexin A2 0.0206541
ANKRD12 ankyrin repeat domain 12 0.0200059
HILPDA hypoxia inducible lipid droplet-associated 0.0196042
TMEM45B transmembrane protein 45B 0.0184021
RPL7 ribosomal protein L7 0.0183407
RPL35 ribosomal protein L35 0.01831
RPL13A ribosomal protein L13a 0.0180164
RPL18 ribosomal protein L18 0.0178096
ESYT2 extended synaptotagmin-like protein 2 0.0177774
COX6C cytochrome c oxidase subunit VIc 0.0177032
RPLP0 ribosomal protein, large, P0 0.0176835
RNASEH2A ribonuclease H2, subunit A 0.017085
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous) 0.016866
CD46 CD46 molecule, complement regulatory protein 0.0167362
S100A8 S100 calcium binding protein A8 0.0166712
MUCL1 mucin-like 1 0.0166521
UQCRB ubiquinol-cytochrome c reductase binding protein 0.0165961
RTN4 reticulon 4 0.0164203
AKAP9 A kinase (PRKA) anchor protein 9 0.0163174
RPS25 ribosomal protein S25 0.0162154
KMT5B lysine methyltransferase 5B 0.0160084
PRRC2C proline-rich coiled-coil 2C 0.0158656
ACSS2 acyl-CoA synthetase short-chain family member 2 0.0157641
TMSB10 thymosin beta 10 0.0156964
RAB6A RAB6A, member RAS oncogene family 0.0153289
EGR1 early growth response 1 0.0152851
DDIT4 DNA-damage-inducible transcript 4 0.015282
S100P S100 calcium binding protein P 0.0151853
RPLP2 ribosomal protein, large, P2 0.0147991
RPL11 ribosomal protein L11 0.0147931
RPL7A ribosomal protein L7a 0.0147778
RPL10A ribosomal protein L10a 0.0147745
RPL5 ribosomal protein L5 0.0147194
PRELID2 PRELI domain containing 2 0.0146851
HMGB2 high mobility group box 2 0.0146596
DHX40 DEAH (Asp-Glu-Ala-His) box polypeptide 40 0.0145959
MUC6 mucin 6, oligomeric mucus/gel-forming 0.0145547
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0145299
MKRN1 makorin ring finger protein 1 0.0142388
DHRS7 dehydrogenase/reductase (SDR family) member 7 0.01413
SERF2 small EDRK-rich factor 2 0.0141175
VMP1 vacuole membrane protein 1 0.0140605
VIM vimentin 0.0138666
RPL37 ribosomal protein L37 0.0137732
RPS8 ribosomal protein S8 0.0135086
NDUFA4 NDUFA4, mitochondrial complex associated 0.0133446
RPLP1 ribosomal protein, large, P1 0.0133345
WDR45B WD repeat domain 45B 0.0130507
RPL36 ribosomal protein L36 0.013016
ZBTB20 zinc finger and BTB domain containing 20 0.0129473
RPS13 ribosomal protein S13 0.0129068
MIEN1 migration and invasion enhancer 1 0.0127664
STC1 stanniocalcin 1 0.0127477
RPL21 ribosomal protein L21 0.0127036
JMY junction mediating and regulatory protein, p53 cofactor 0.0126719
FAM162A family with sequence similarity 162, member A 0.0125779
PHF3 PHD finger protein 3 0.0123741
WDR26 WD repeat domain 26 0.0123334
SRRM2 serine/arginine repetitive matrix 2 0.0122741
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 0.0122328
MIMS1 mitochondrial inner membrane scaffold 1 0.0121922
ZNRF2 zinc and ring finger 2, E3 ubiquitin protein ligase 0.0121699
WSB1 WD repeat and SOCS box containing 1 0.0121658
RNF24 ring finger protein 24 0.0121562
S100A14 S100 calcium binding protein A14 0.0121397
RAI1 retinoic acid induced 1 0.0120889
RACK1 receptor for activated C kinase 1 0.011985
KDM7A lysine (K)-specific demethylase 7A 0.011985
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.0116416
RPS17 ribosomal protein S17 0.0116309
TXNIP thioredoxin interacting protein 0.0116185
TMED2 transmembrane emp24 domain trafficking protein 2 0.0115264
RPS20 ribosomal protein S20 0.0112196

decreased expression

Symbol Name Standardized Value
CDK12 cyclin-dependent kinase 12 -0.18905
ACACA acetyl-CoA carboxylase alpha -0.101161
THSD4 thrombospondin, type I, domain containing 4 -0.0844075
IGFBP5 insulin-like growth factor binding protein 5 -0.0731808
UBC ubiquitin C -0.0727315
AHNAK AHNAK nucleoprotein -0.0711706
PTPRK protein tyrosine phosphatase, receptor type, K -0.0697154
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0695543
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0633001
ACTG1 actin gamma 1 -0.0628397
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0619948
CATSPERB catsper channel auxiliary subunit beta -0.0618509
CCND1 cyclin D1 -0.0615509
ITCH itchy E3 ubiquitin protein ligase -0.0606908
LASP1 LIM and SH3 protein 1 -0.0602571
VCP valosin containing protein -0.0556961
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.052963
ZMYND8 zinc finger, MYND-type containing 8 -0.0523068
TRPS1 trichorhinophalangeal syndrome I -0.052011
EHMT1 euchromatic histone-lysine N-methyltransferase 1 -0.0495915
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0488658
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0464779
LPP LIM domain containing preferred translocation partner in lipoma -0.0464063
ENAH enabled homolog (Drosophila) -0.0453833
TMSB4X thymosin beta 4, X-linked -0.0449653
KRT8 keratin 8, type II -0.0448324
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0444661
TRIO trio Rho guanine nucleotide exchange factor -0.0439199
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0437103
DNAH14 dynein, axonemal, heavy chain 14 -0.0428865
PRRC2B proline-rich coiled-coil 2B -0.042152
PBX1 pre-B-cell leukemia homeobox 1 -0.0420963
MLLT6 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 -0.0418671
SP100 SP100 nuclear antigen -0.041122
ANKRD11 ankyrin repeat domain 11 -0.0396489
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 -0.0395779
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.0389898
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.038282
KIAA1217 KIAA1217 -0.0378081
ZFAND3 zinc finger, AN1-type domain 3 -0.0373869
PATJ PATJ crumbs cell polarity complex component -0.0372477
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0367653
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0361995
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0351231
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0346915
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0341195
DENND1A DENN/MADD domain containing 1A -0.033851
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0338239
RRBP1 ribosome binding protein 1 -0.0337459
GSE1 Gse1 coiled-coil protein -0.0334354
NRIP1 nuclear receptor interacting protein 1 -0.0332634
RBM47 RNA binding motif protein 47 -0.0332492
PLSCR1 phospholipid scramblase 1 -0.0330669
STAU1 staufen double-stranded RNA binding protein 1 -0.0330442
ZNFX1 zinc finger, NFX1-type containing 1 -0.033031
PDLIM5 PDZ and LIM domain 5 -0.0320196
KRT7 keratin 7, type II -0.0318551
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0314837
PTK2 protein tyrosine kinase 2 -0.0312276
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0311828
DUSP16 dual specificity phosphatase 16 -0.0305145
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0301548
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0299097
RIMS2 regulating synaptic membrane exocytosis 2 -0.0298081
GRB7 growth factor receptor-bound protein 7 -0.0296709
POTEF POTE ankyrin domain family, member F -0.0294205
SETX senataxin -0.0292403
LARP4B La ribonucleoprotein domain family, member 4B -0.0289981
HLA-C major histocompatibility complex, class I, C -0.0286856
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 -0.0285082
GMDS GDP-mannose 4,6-dehydratase -0.0284403
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0283566
IFIH1 interferon induced with helicase C domain 1 -0.0275114
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0274588
ACTN4 actinin, alpha 4 -0.0270627
NCOA6 nuclear receptor coactivator 6 -0.0268596
PARD3 par-3 family cell polarity regulator -0.0268051
IFI6 interferon, alpha-inducible protein 6 -0.0267571
SMYD3 SET and MYND domain containing 3 -0.0266889
EFNA5 ephrin-A5 -0.0264417
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0264356
MSI2 musashi RNA-binding protein 2 -0.0263913
PRKCA protein kinase C, alpha -0.026016
CCSER1 coiled-coil serine-rich protein 1 -0.02556
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0255431
MBD4 methyl-CpG binding domain protein 4 -0.0248401
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 -0.0247496
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0247149
MYH9 myosin, heavy chain 9, non-muscle -0.0246055
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 -0.0245479
CD164 CD164 molecule, sialomucin -0.024239
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit -0.0241547
PAWR PRKC, apoptosis, WT1, regulator -0.0240366
LGALS12 lectin, galactoside-binding, soluble, 12 -0.0239495
MYO5B myosin VB -0.0238524
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0237212
H1-0 H1.0 linker histone -0.0232553
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) -0.0231058
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0230709
ZHX2 zinc fingers and homeoboxes 2 -0.0229613