Tetracycline (hydrochloride)_H4 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tetracycline (hydrochloride) perturbation in H4 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tetracycline (hydrochloride)_H4 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide 0.205948
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.108023
FAM13A family with sequence similarity 13, member A 0.0964343
MT2A metallothionein 2A 0.095206
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0883524
HILPDA hypoxia inducible lipid droplet-associated 0.0766227
SDK1 sidekick cell adhesion molecule 1 0.0711629
VIM vimentin 0.0700609
LDHA lactate dehydrogenase A 0.0614809
TMSB10 thymosin beta 10 0.0613359
PTMA prothymosin, alpha 0.0602443
PDIA3 protein disulfide isomerase family A, member 3 0.0587657
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0586882
NDRG1 N-myc downstream regulated 1 0.0581698
HELZ helicase with zinc finger 0.0572359
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0571367
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0539621
ENO1 enolase 1, (alpha) 0.0505263
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0483328
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0452194
TIMP3 TIMP metallopeptidase inhibitor 3 0.0446747
DDIT4 DNA-damage-inducible transcript 4 0.0439769
CALR calreticulin 0.0438233
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0431802
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0427702
RPLP2 ribosomal protein, large, P2 0.0424364
PKM pyruvate kinase, muscle 0.0422086
NFE2L1 nuclear factor, erythroid 2-like 1 0.0416942
RPS3 ribosomal protein S3 0.0402628
EYA1 EYA transcriptional coactivator and phosphatase 1 0.0399732
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0386819
B2M beta-2-microglobulin 0.0371126
RPS12 ribosomal protein S12 0.036707
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0361902
MXI1 MAX interactor 1, dimerization protein 0.0354673
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0346017
SRP54 signal recognition particle 54kDa 0.034103
KMT2E lysine (K)-specific methyltransferase 2E 0.033895
ZNF395 zinc finger protein 395 0.0335677
UBA6 ubiquitin-like modifier activating enzyme 6 0.0334627
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0333496
FTH1 ferritin, heavy polypeptide 1 0.0333198
HYOU1 hypoxia up-regulated 1 0.0332894
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0313483
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0311058
RNF220 ring finger protein 220 0.0306931
PLIN2 perilipin 2 0.0306742
RPS8 ribosomal protein S8 0.0305402
ENO2 enolase 2 (gamma, neuronal) 0.0304471
ANLN anillin, actin binding protein 0.0303527
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0302283
RPL37A ribosomal protein L37a 0.0300481
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0297301
TPI1 triosephosphate isomerase 1 0.0295715
RPS17 ribosomal protein S17 0.0291354
CCNL1 cyclin L1 0.0290355
CDK19 cyclin-dependent kinase 19 0.0285183
SETD5 SET domain containing 5 0.028187
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 0.0279528
MYOF myoferlin 0.0278387
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0264279
RPL7A ribosomal protein L7a 0.0263258
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0262986
CENPF centromere protein F, 350/400kDa 0.0259298
YEATS2 YEATS domain containing 2 0.025894
GOLGA4 golgin A4 0.0257461
RPL7 ribosomal protein L7 0.0257399
KTN1 kinectin 1 (kinesin receptor) 0.0257346
ADM adrenomedullin 0.0253313
NAV2 neuron navigator 2 0.0250935
ESYT2 extended synaptotagmin-like protein 2 0.0245925
MYO1B myosin IB 0.024224
MCL1 myeloid cell leukemia 1 0.0242162
GPC6 glypican 6 0.0241545
TXNIP thioredoxin interacting protein 0.0239915
TPM3 tropomyosin 3 0.0238704
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) 0.0238582
FOSL1 FOS-like antigen 1 0.023553
MEF2A myocyte enhancer factor 2A 0.0234435
PLAUR plasminogen activator, urokinase receptor 0.0225875
ADAM17 ADAM metallopeptidase domain 17 0.0224656
LIMCH1 LIM and calponin homology domains 1 0.0224314
HOOK2 hook microtubule-tethering protein 2 0.022249
PCBP2 poly(rC) binding protein 2 0.0220376
RPL37 ribosomal protein L37 0.0219553
VEGFA vascular endothelial growth factor A 0.0219074
HMGB2 high mobility group box 2 0.0218933
ANXA1 annexin A1 0.0218614
SRRM2 serine/arginine repetitive matrix 2 0.0218297
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.021829
ANXA2 annexin A2 0.0217514
SQSTM1 sequestosome 1 0.0216523
RPS2 ribosomal protein S2 0.0216495
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0216359
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0215527
RAB6A RAB6A, member RAS oncogene family 0.0214595
FAM162A family with sequence similarity 162, member A 0.0214524
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0214228
RAI1 retinoic acid induced 1 0.021227
RPS25 ribosomal protein S25 0.0211465

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.229686
NALF1 NALCN channel auxiliary factor 1 -0.150428
KYNU kynureninase -0.138643
IGFBP3 insulin-like growth factor binding protein 3 -0.137402
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.134563
CXCL8 chemokine (C-X-C motif) ligand 8 -0.128627
CD44 CD44 molecule (Indian blood group) -0.124498
EXT1 exostosin glycosyltransferase 1 -0.0959421
AHNAK AHNAK nucleoprotein -0.094642
INHBA inhibin, beta A -0.0785402
GLIS3 GLIS family zinc finger 3 -0.0724421
FNDC3B fibronectin type III domain containing 3B -0.0689109
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0632021
OSMR oncostatin M receptor -0.0603819
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0602286
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0596786
VCL vinculin -0.0517451
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.050949
COL6A3 collagen, type VI, alpha 3 -0.050906
TNS3 tensin 3 -0.0500043
NAMPT nicotinamide phosphoribosyltransferase -0.0499737
SLC38A2 solute carrier family 38, member 2 -0.0491873
ASPH aspartate beta-hydroxylase -0.0477704
NAV1 neuron navigator 1 -0.0472883
DST dystonin -0.0472226
FAF1 Fas (TNFRSF6) associated factor 1 -0.0470078
TNNC1 troponin C type 1 (slow) -0.0464316
ZFAND3 zinc finger, AN1-type domain 3 -0.0461494
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0446054
ANTXR2 anthrax toxin receptor 2 -0.0440965
PTPRG protein tyrosine phosphatase, receptor type, G -0.0438863
CALD1 caldesmon 1 -0.0437126
FAM20C family with sequence similarity 20, member C -0.0408636
HLA-B major histocompatibility complex, class I, B -0.0401537
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0401357
PTK2 protein tyrosine kinase 2 -0.0398991
LMAN1 lectin, mannose-binding, 1 -0.0397111
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0384824
PDLIM5 PDZ and LIM domain 5 -0.0371119
FBXL17 F-box and leucine-rich repeat protein 17 -0.0363521
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0346985
IL6ST interleukin 6 signal transducer -0.0343237
FSTL1 follistatin-like 1 -0.0342606
PHF14 PHD finger protein 14 -0.0341424
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0341364
ACTN4 actinin, alpha 4 -0.0323685
TXNRD1 thioredoxin reductase 1 -0.0321281
WWTR1 WW domain containing transcription regulator 1 -0.0320839
HIBADH 3-hydroxyisobutyrate dehydrogenase -0.0316924
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0316859
ANKRD11 ankyrin repeat domain 11 -0.0314768
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 -0.0314013
LYPD6B LY6/PLAUR domain containing 6B -0.0307089
BBS9 Bardet-Biedl syndrome 9 -0.0305912
NAV3 neuron navigator 3 -0.0304138
ZBTB20 zinc finger and BTB domain containing 20 -0.0302078
MYO10 myosin X -0.0301612
CARS1 cysteinyl-tRNA synthetase 1 -0.0300933
OR51B5 olfactory receptor, family 51, subfamily B, member 5 -0.0292416
NABP1 nucleic acid binding protein 1 -0.0291495
TRIM56 tripartite motif containing 56 -0.0290571
NCOA7 nuclear receptor coactivator 7 -0.0287544
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.028743
PDE4D phosphodiesterase 4D, cAMP-specific -0.0285655
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0285582
TUSC3 tumor suppressor candidate 3 -0.0283635
LRRC49 leucine rich repeat containing 49 -0.028138
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0281028
GFPT2 glutamine-fructose-6-phosphate transaminase 2 -0.0277861
MCTP2 multiple C2 domains, transmembrane 2 -0.0276932
MB21D2 Mab-21 domain containing 2 -0.0273958
CDK6 cyclin-dependent kinase 6 -0.0273137
VEGFC vascular endothelial growth factor C -0.0272052
SCFD2 sec1 family domain containing 2 -0.0271647
TNPO1 transportin 1 -0.0269936
RPL35A ribosomal protein L35a -0.0267487
FN1 fibronectin 1 -0.0261625
TPTE transmembrane phosphatase with tensin homology -0.0261428
CDK14 cyclin-dependent kinase 14 -0.0257462
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0256322
RNF213 ring finger protein 213 -0.0253894
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0252161
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0250036
AKAP12 A kinase (PRKA) anchor protein 12 -0.0249565
ATM ATM serine/threonine kinase -0.0248255
ANKMY1 ankyrin repeat and MYND domain containing 1 -0.0245766
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0245065
ZNF804A zinc finger protein 804A -0.0244221
NIBAN1 niban apoptosis regulator 1 -0.024402
RFX8 RFX family member 8, lacking RFX DNA binding domain -0.0243994
PTPRK protein tyrosine phosphatase, receptor type, K -0.0243757
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -0.0243449
TENM3 teneurin transmembrane protein 3 -0.0243198
IARS1 isoleucyl-tRNA synthetase 1 -0.0242746
CANX calnexin -0.024023
ETV6 ets variant 6 -0.0238645
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.023786
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0234405
AOPEP aminopeptidase O (putative) -0.0233552
BMERB1 bMERB domain containing 1 -0.0232861