Tetracycline (hydrochloride)_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tetracycline (hydrochloride) perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tetracycline (hydrochloride)_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.342075
IGF2 insulin-like growth factor 2 0.181753
MT2A metallothionein 2A 0.0885314
TF transferrin 0.0492387
RPS12 ribosomal protein S12 0.0447294
AHSG alpha-2-HS-glycoprotein 0.0414291
ERRFI1 ERBB receptor feedback inhibitor 1 0.0405747
FTL ferritin, light polypeptide 0.0405425
APOA1 apolipoprotein A-I 0.0403102
DDIT4 DNA-damage-inducible transcript 4 0.037985
RPL11 ribosomal protein L11 0.0353154
RPS3 ribosomal protein S3 0.0337687
PLIN2 perilipin 2 0.0307757
CPE carboxypeptidase E 0.028735
RPLP0 ribosomal protein, large, P0 0.0286768
RPL37A ribosomal protein L37a 0.0278341
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0260999
TPT1 tumor protein, translationally-controlled 1 0.0242748
CP ceruloplasmin (ferroxidase) 0.0234843
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0221132
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0219671
RPS6 ribosomal protein S6 0.0205295
TIMP1 TIMP metallopeptidase inhibitor 1 0.0202008
RPS17 ribosomal protein S17 0.0201356
RPS8 ribosomal protein S8 0.0199885
SEC62 SEC62 homolog (S. cerevisiae) 0.0199132
ISG15 ISG15 ubiquitin-like modifier 0.0197469
RPS7 ribosomal protein S7 0.0195288
HP1BP3 heterochromatin protein 1, binding protein 3 0.0187888
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.0185378
RPL31 ribosomal protein L31 0.018351
RPL21 ribosomal protein L21 0.0178858
RNASEH2A ribonuclease H2, subunit A 0.0178009
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0176099
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0174406
RPL12 ribosomal protein L12 0.0166585
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0166542
RPLP2 ribosomal protein, large, P2 0.016404
RPL27A ribosomal protein L27a 0.0160239
RPL26 ribosomal protein L26 0.0160211
RPL27 ribosomal protein L27 0.0158492
RPS2 ribosomal protein S2 0.0155834
RPS16 ribosomal protein S16 0.0154831
PTBP3 polypyrimidine tract binding protein 3 0.0151516
APOC1 apolipoprotein C-I 0.0146957
APOH apolipoprotein H (beta-2-glycoprotein I) 0.0146424
CXXC5 CXXC finger protein 5 0.0146074
PHYHIPL phytanoyl-CoA 2-hydroxylase interacting protein-like 0.0144726
RPL36 ribosomal protein L36 0.0143426
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0143115
PTPRM protein tyrosine phosphatase, receptor type, M 0.0139877
DTNA dystrobrevin, alpha 0.0133155
SETD5 SET domain containing 5 0.0131638
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0131359
FTH1 ferritin, heavy polypeptide 1 0.0130483
IFITM3 interferon induced transmembrane protein 3 0.0129854
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.012708
RPL35 ribosomal protein L35 0.0127044
MXI1 MAX interactor 1, dimerization protein 0.0124468
SERF2 small EDRK-rich factor 2 0.0124464
SRSF11 serine/arginine-rich splicing factor 11 0.0124381
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 0.0123353
RPL13A ribosomal protein L13a 0.0121251
TPI1 triosephosphate isomerase 1 0.011892
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) 0.0118477
IFI6 interferon, alpha-inducible protein 6 0.0117557
RPS27 ribosomal protein S27 0.0115865
PDIA3 protein disulfide isomerase family A, member 3 0.0114982
BPIFB2 BPI fold containing family B, member 2 0.0114889
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 0.0114395
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 0.0113868
KIF5B kinesin family member 5B 0.0113499
CAVIN1 caveolae associated protein 1 0.0112678
CSTB cystatin B (stefin B) 0.0111853
S100A9 S100 calcium binding protein A9 0.0111377
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.011023
BHLHE40 basic helix-loop-helix family, member e40 0.0109323
KPNB1 karyopherin (importin) beta 1 0.0109254
RPL37 ribosomal protein L37 0.0108592
RPL9 ribosomal protein L9 0.0108397
TMEM45B transmembrane protein 45B 0.010824
RPL7 ribosomal protein L7 0.0107863
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 0.0105161
MKI67 marker of proliferation Ki-67 0.0104828
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) 0.0104449
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0104003
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0103076
APOA2 apolipoprotein A-II 0.0102502
VIM vimentin 0.0102421
APOC2 apolipoprotein C-II 0.0102173
HMGA1 high mobility group AT-hook 1 0.0102009
RDX radixin 0.0100464
IFITM2 interferon induced transmembrane protein 2 0.0100332
CCNL1 cyclin L1 0.0100248
ESYT2 extended synaptotagmin-like protein 2 0.00993687
IRF2BP2 interferon regulatory factor 2 binding protein 2 0.00990913
RPLP1 ribosomal protein, large, P1 0.00988956
FAM13A family with sequence similarity 13, member A 0.00982802
WDFY2 WD repeat and FYVE domain containing 2 0.00977677
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.00973689

decreased expression

Symbol Name Standardized Value
UBC ubiquitin C -0.110576
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0943008
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0842396
APOB apolipoprotein B -0.0838876
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0802685
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0653778
SVIL supervillin -0.0616471
RPS27A ribosomal protein S27a -0.0610528
FN1 fibronectin 1 -0.059346
EEF2 eukaryotic translation elongation factor 2 -0.0567307
AKAP12 A kinase (PRKA) anchor protein 12 -0.0512946
TM4SF1 transmembrane 4 L six family member 1 -0.0455685
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0435747
SLC38A2 solute carrier family 38, member 2 -0.0425433
SDC4 syndecan 4 -0.041181
SAMD4A sterile alpha motif domain containing 4A -0.0404124
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0403651
ENO1 enolase 1, (alpha) -0.0382839
NKD1 naked cuticle homolog 1 (Drosophila) -0.0368746
AHNAK AHNAK nucleoprotein -0.0357106
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.035348
LOC112694756 uncharaterized LOC112694756 -0.0349895
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0345572
SMAD3 SMAD family member 3 -0.034326
DSCAM Down syndrome cell adhesion molecule -0.0338377
KRT8 keratin 8, type II -0.0338002
SOD2 superoxide dismutase 2, mitochondrial -0.032804
JUN jun proto-oncogene -0.032704
MYH9 myosin, heavy chain 9, non-muscle -0.032396
ANKRD11 ankyrin repeat domain 11 -0.0309178
ASPH aspartate beta-hydroxylase -0.0305946
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0304677
RRBP1 ribosome binding protein 1 -0.0301388
PCBP2 poly(rC) binding protein 2 -0.0300554
VMP1 vacuole membrane protein 1 -0.0294372
FAM107B family with sequence similarity 107, member B -0.0291303
UBASH3B ubiquitin associated and SH3 domain containing B -0.0280172
MACF1 microtubule-actin crosslinking factor 1 -0.0279863
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0277775
FOXP1 forkhead box P1 -0.0271186
IGF1R insulin-like growth factor 1 receptor -0.0270796
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0266332
ITGAV integrin, alpha V -0.0262773
FAT1 FAT atypical cadherin 1 -0.0260229
MCL1 myeloid cell leukemia 1 -0.0256387
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.025616
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0255757
FLNB filamin B, beta -0.0253486
GLG1 golgi glycoprotein 1 -0.0245461
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0241847
BCL2L1 BCL2-like 1 -0.024073
RPL23 ribosomal protein L23 -0.0237713
LRMDA leucine rich melanocyte differentiation associated -0.0236091
EPAS1 endothelial PAS domain protein 1 -0.0234658
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) -0.0232932
CANX calnexin -0.0231004
ABTB3 ankyrin repeat and BTB domain containing 3 -0.0226478
DIAPH1 diaphanous-related formin 1 -0.022563
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.022497
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0221802
CPEB4 cytoplasmic polyadenylation element binding protein 4 -0.0221609
FBF1 Fas (TNFRSF6) binding factor 1 -0.0216164
CRLS1 cardiolipin synthase 1 -0.0215177
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0214525
GPAM glycerol-3-phosphate acyltransferase, mitochondrial -0.0212484
MRTFA myocardin related transcription factor A -0.020953
ANO6 anoctamin 6 -0.0208918
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 -0.0208446
GPC3 glypican 3 -0.0204026
TBC1D22A TBC1 domain family, member 22A -0.0202868
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0199477
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 -0.0198822
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0198033
NAP1L1 nucleosome assembly protein 1-like 1 -0.0197183
EIF4A2 eukaryotic translation initiation factor 4A2 -0.0195733
TXNRD1 thioredoxin reductase 1 -0.0195594
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0192617
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18 -0.0192075
SKI SKI proto-oncogene -0.019101
DOCK5 dedicator of cytokinesis 5 -0.0190921
GSK3B glycogen synthase kinase 3 beta -0.0189219
TRIO trio Rho guanine nucleotide exchange factor -0.0188665
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.0188195
DNAH17 dynein, axonemal, heavy chain 17 -0.0185653
TRIP12 thyroid hormone receptor interactor 12 -0.0184861
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0184506
PDGFB platelet-derived growth factor beta polypeptide -0.0183995
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0181629
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) -0.0181491
KDM3A lysine (K)-specific demethylase 3A -0.0179915
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0179218
PPARD peroxisome proliferator-activated receptor delta -0.0178672
ZNF638 zinc finger protein 638 -0.0176386
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.0175426
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0174581
ZEB1 zinc finger E-box binding homeobox 1 -0.0173178
CALR calreticulin -0.0173095
ELL2 elongation factor, RNA polymerase II, 2 -0.0171114
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle -0.0170717
USP34 ubiquitin specific peptidase 34 -0.0170382