Tetracycline (hydrochloride)_LOX-IMVI Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tetracycline (hydrochloride) perturbation in LOX-IMVI cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tetracycline (hydrochloride)_LOX-IMVI drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide 0.115894
CD109 CD109 molecule 0.0822954
RPS3 ribosomal protein S3 0.072476
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0717947
GPC6 glypican 6 0.0696835
MT2A metallothionein 2A 0.0567981
RPS12 ribosomal protein S12 0.0547389
ELL2 elongation factor, RNA polymerase II, 2 0.0485704
TMSB10 thymosin beta 10 0.0481583
ALCAM activated leukocyte cell adhesion molecule 0.0474121
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0469412
RUNX1 runt-related transcription factor 1 0.0465458
MXI1 MAX interactor 1, dimerization protein 0.0465078
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0419377
ZNF292 zinc finger protein 292 0.0414102
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0398633
MMP12 matrix metallopeptidase 12 0.0390555
LDHA lactate dehydrogenase A 0.0383901
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0380628
RPL36 ribosomal protein L36 0.0372709
RPL13A ribosomal protein L13a 0.0371146
NLGN1 neuroligin 1 0.0363838
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0352982
RPS17 ribosomal protein S17 0.0343104
NRP2 neuropilin 2 0.0329709
KLF6 Kruppel-like factor 6 0.0324756
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0320614
RPLP0 ribosomal protein, large, P0 0.0314243
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0313772
DPYD dihydropyrimidine dehydrogenase 0.0312639
ESYT2 extended synaptotagmin-like protein 2 0.0306671
MALT1 MALT1 paracaspase 0.0302113
RPLP2 ribosomal protein, large, P2 0.0300565
TMPRSS15 transmembrane protease, serine 15 0.0300186
DDIT4 DNA-damage-inducible transcript 4 0.0299939
RPL21 ribosomal protein L21 0.0299292
LIMCH1 LIM and calponin homology domains 1 0.0292789
MYOF myoferlin 0.0287806
RPL7 ribosomal protein L7 0.0284761
TRIO trio Rho guanine nucleotide exchange factor 0.0280163
PHF21A PHD finger protein 21A 0.0276104
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0275114
HILPDA hypoxia inducible lipid droplet-associated 0.0272865
PRELID2 PRELI domain containing 2 0.0271242
PLIN2 perilipin 2 0.0266825
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0265181
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0263682
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0261122
TBC1D5 TBC1 domain family, member 5 0.0261076
FNDC3B fibronectin type III domain containing 3B 0.0254145
FLNA filamin A, alpha 0.0251299
TXNIP thioredoxin interacting protein 0.024938
CDK19 cyclin-dependent kinase 19 0.02466
ADGRB3 adhesion G protein-coupled receptor B3 0.024495
SMAD3 SMAD family member 3 0.0243068
CAV1 caveolin 1, caveolae protein, 22kDa 0.0239131
EYA1 EYA transcriptional coactivator and phosphatase 1 0.023888
VEZT vezatin, adherens junctions transmembrane protein 0.0238127
SERINC1 serine incorporator 1 0.0236785
BNC2 basonuclin 2 0.0235778
DIAPH3 diaphanous-related formin 3 0.0232807
MBNL1 muscleblind-like splicing regulator 1 0.0231663
RPL12 ribosomal protein L12 0.0226551
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0225848
TM4SF19 transmembrane 4 L six family member 19 0.0220131
RPS7 ribosomal protein S7 0.0219474
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0218622
BRWD3 bromodomain and WD repeat domain containing 3 0.0217569
NDRG1 N-myc downstream regulated 1 0.0216074
BDNF brain-derived neurotrophic factor 0.0215456
MEIS2 Meis homeobox 2 0.02147
RPL18 ribosomal protein L18 0.0214645
ARID1A AT rich interactive domain 1A (SWI-like) 0.0213688
PAX3 paired box 3 0.0213646
RPS2 ribosomal protein S2 0.0213027
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0212315
NALF1 NALCN channel auxiliary factor 1 0.0211388
ANXA2 annexin A2 0.0211321
RPL37A ribosomal protein L37a 0.0211152
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0207977
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0207807
KCMF1 potassium channel modulatory factor 1 0.0206503
PTMA prothymosin, alpha 0.0205571
ITSN2 intersectin 2 0.0203723
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0194938
FTH1 ferritin, heavy polypeptide 1 0.0193824
BABAM2 BRISC and BRCA1 A complex member 2 0.0192941
CAVIN1 caveolae associated protein 1 0.0192653
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0192463
PTPRD protein tyrosine phosphatase, receptor type, D 0.019125
KIAA1958 KIAA1958 0.019032
RPL27 ribosomal protein L27 0.0189496
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.018869
RARB retinoic acid receptor, beta 0.0184659
RPS27 ribosomal protein S27 0.0184111
DGKD diacylglycerol kinase, delta 130kDa 0.018205
RPS25 ribosomal protein S25 0.0182002
CSDE1 cold shock domain containing E1, RNA-binding 0.0179967
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0178645
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0177656

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.487591
AKAP12 A kinase (PRKA) anchor protein 12 -0.169628
EXT1 exostosin glycosyltransferase 1 -0.129488
ACTG1 actin gamma 1 -0.125347
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.110755
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.106435
AHNAK AHNAK nucleoprotein -0.0989297
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.094312
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0877196
DTNA dystrobrevin, alpha -0.0790653
VIM vimentin -0.0780796
SAMD3 sterile alpha motif domain containing 3 -0.0726515
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0686658
SAMD4A sterile alpha motif domain containing 4A -0.0676822
UBC ubiquitin C -0.066212
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0629796
PTK2 protein tyrosine kinase 2 -0.0569165
SDCCAG8 serologically defined colon cancer antigen 8 -0.0554382
NTM neurotrimin -0.0546528
EIF1 eukaryotic translation initiation factor 1 -0.0521945
LOC112694756 uncharaterized LOC112694756 -0.0518035
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0495435
DOCK4 dedicator of cytokinesis 4 -0.0493715
RPL35A ribosomal protein L35a -0.0490005
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0479235
PHACTR1 phosphatase and actin regulator 1 -0.0471308
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0471088
MYO10 myosin X -0.0470629
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0460441
GLS2 glutaminase 2 (liver, mitochondrial) -0.0454391
TM4SF1 transmembrane 4 L six family member 1 -0.043868
NAV3 neuron navigator 3 -0.0437865
MAPKAP1 mitogen-activated protein kinase associated protein 1 -0.0431832
RPS27A ribosomal protein S27a -0.0429475
TSC22D2 TSC22 domain family, member 2 -0.042893
ASPH aspartate beta-hydroxylase -0.0405767
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) -0.0402612
LSAMP limbic system-associated membrane protein -0.0389588
HMGA2 high mobility group AT-hook 2 -0.0381205
CANX calnexin -0.0374495
MCTP1 multiple C2 domains, transmembrane 1 -0.0363139
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0362847
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0357737
RPL8 ribosomal protein L8 -0.0354297
ANTXR2 anthrax toxin receptor 2 -0.0345885
SLC38A2 solute carrier family 38, member 2 -0.0341233
ADAM19 ADAM metallopeptidase domain 19 -0.0340652
RAD21 RAD21 homolog (S. pombe) -0.0328055
NETO1 neuropilin (NRP) and tolloid (TLL)-like 1 -0.032783
KIAA1217 KIAA1217 -0.0325454
NABP1 nucleic acid binding protein 1 -0.0323048
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0320341
JMJD1C jumonji domain containing 1C -0.0319124
CDK6 cyclin-dependent kinase 6 -0.0319049
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.0314975
DSCAM Down syndrome cell adhesion molecule -0.0313701
CDK17 cyclin-dependent kinase 17 -0.0311167
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.0304962
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0300635
ESM1 endothelial cell-specific molecule 1 -0.0297632
USP34 ubiquitin specific peptidase 34 -0.0291792
RASA2 RAS p21 protein activator 2 -0.0286669
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0284814
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0282991
MAML2 mastermind-like 2 (Drosophila) -0.0282499
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0279085
WDR43 WD repeat domain 43 -0.0275617
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme -0.0275196
ZNF207 zinc finger protein 207 -0.027287
RTN4 reticulon 4 -0.0271183
EIF3H eukaryotic translation initiation factor 3, subunit H -0.0269958
INTS6 integrator complex subunit 6 -0.0269669
POTEF POTE ankyrin domain family, member F -0.0267632
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0265613
EIF4A2 eukaryotic translation initiation factor 4A2 -0.0265152
EEF2 eukaryotic translation elongation factor 2 -0.0263129
HDAC9 histone deacetylase 9 -0.0263034
PTPRK protein tyrosine phosphatase, receptor type, K -0.0262494
KYNU kynureninase -0.0260714
RPL4 ribosomal protein L4 -0.0260537
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0260477
PARD3 par-3 family cell polarity regulator -0.0259231
YES1 YES proto-oncogene 1, Src family tyrosine kinase -0.0258588
SEPTIN7 septin 7 -0.0258062
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0255804
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0255269
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0255012
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0254634
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0247261
IARS1 isoleucyl-tRNA synthetase 1 -0.0244575
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0244503
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0243079
ZNF638 zinc finger protein 638 -0.0241417
EIF3E eukaryotic translation initiation factor 3, subunit E -0.0240942
RSRC2 arginine/serine-rich coiled-coil 2 -0.0238594
DEK DEK proto-oncogene -0.0238533
RPL34 ribosomal protein L34 -0.0237943
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0236536
ZNF804A zinc finger protein 804A -0.0235166
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0234435