| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tetracycline (hydrochloride) perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Tetracycline (hydrochloride)_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.230058 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.095217 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.051907 |
| ERBIN | erbb2 interacting protein | 0.040401 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0389734 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0376783 |
| RAD51B | RAD51 paralog B | 0.0370843 |
| CMIP | c-Maf inducing protein | 0.0326642 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0317553 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0290701 |
| TTC28 | tetratricopeptide repeat domain 28 | 0.0290016 |
| RPS12 | ribosomal protein S12 | 0.0288686 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0284645 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0284402 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0279965 |
| NEBL | nebulette | 0.0272732 |
| EFNA5 | ephrin-A5 | 0.0270438 |
| HYOU1 | hypoxia up-regulated 1 | 0.0265012 |
| PRR16 | proline rich 16 | 0.025108 |
| RPS3 | ribosomal protein S3 | 0.0249389 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0246341 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0243707 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 0.0242444 |
| EIF5B | eukaryotic translation initiation factor 5B | 0.0224218 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | 0.022249 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0219148 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | 0.0218291 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | 0.0217587 |
| PARD3 | par-3 family cell polarity regulator | 0.0217269 |
| KIF5B | kinesin family member 5B | 0.0211785 |
| CABIN1 | calcineurin binding protein 1 | 0.0207144 |
| STRN3 | striatin, calmodulin binding protein 3 | 0.0206424 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0204495 |
| FMNL2 | formin-like 2 | 0.0198108 |
| FLNB | filamin B, beta | 0.0191278 |
| PRKCE | protein kinase C, epsilon | 0.0191012 |
| PHF20 | PHD finger protein 20 | 0.0190821 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0190324 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0188397 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0188396 |
| SBF2 | SET binding factor 2 | 0.0186435 |
| RAI1 | retinoic acid induced 1 | 0.0186079 |
| RPS17 | ribosomal protein S17 | 0.0184991 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0183298 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0183272 |
| EGR1 | early growth response 1 | 0.0182965 |
| PYGL | phosphorylase, glycogen, liver | 0.0182684 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0182447 |
| SPIRE1 | spire-type actin nucleation factor 1 | 0.0181686 |
| SNX14 | sorting nexin 14 | 0.0181363 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0180975 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0177289 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.0177227 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0177127 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0175319 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0174463 |
| WWOX | WW domain containing oxidoreductase | 0.0174427 |
| NUP153 | nucleoporin 153kDa | 0.0173406 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | 0.0171194 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0171193 |
| CDKAL1 | CDK5 regulatory subunit associated protein 1-like 1 | 0.0169433 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0168847 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.016811 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0164548 |
| SPIDR | scaffolding protein involved in DNA repair | 0.0163712 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0162343 |
| TPR | translocated promoter region, nuclear basket protein | 0.0160357 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0160165 |
| PPIG | peptidylprolyl isomerase G (cyclophilin G) | 0.0159634 |
| SP3 | Sp3 transcription factor | 0.0159579 |
| XPO1 | exportin 1 | 0.015857 |
| RAP1GAP2 | RAP1 GTPase activating protein 2 | 0.0157822 |
| STC1 | stanniocalcin 1 | 0.0157276 |
| IRF2BPL | interferon regulatory factor 2 binding protein-like | 0.0157214 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0156433 |
| PSMD7 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 | 0.0156007 |
| TGFB2 | transforming growth factor, beta 2 | 0.015561 |
| RPS7 | ribosomal protein S7 | 0.0155339 |
| MKI67 | marker of proliferation Ki-67 | 0.0151725 |
| SRPK2 | SRSF protein kinase 2 | 0.0151715 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0149839 |
| GOLGA4 | golgin A4 | 0.0149801 |
| SRSF11 | serine/arginine-rich splicing factor 11 | 0.0149154 |
| ARHGAP29 | Rho GTPase activating protein 29 | 0.0148635 |
| IWS1 | IWS1 homolog (S. cerevisiae) | 0.0148028 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | 0.0146802 |
| HDGF | hepatoma-derived growth factor | 0.0145365 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0145161 |
| WWC2 | WW and C2 domain containing 2 | 0.014488 |
| TMEM87A | transmembrane protein 87A | 0.0144673 |
| DDX46 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 | 0.0144038 |
| SMARCC1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 | 0.0142176 |
| RNASEH2A | ribonuclease H2, subunit A | 0.0141929 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | 0.0139549 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0138521 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0137879 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.013682 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0136585 |
| PRDX1 | peroxiredoxin 1 | 0.0135769 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0135356 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.478539 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.160295 |
| ACTG1 | actin gamma 1 | -0.152869 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.13397 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.117662 |
| UBC | ubiquitin C | -0.100635 |
| IER3 | immediate early response 3 | -0.0935865 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0922149 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0862481 |
| S100A10 | S100 calcium binding protein A10 | -0.0854583 |
| PM20D1 | peptidase M20 domain containing 1 | -0.080596 |
| RPL23 | ribosomal protein L23 | -0.0801607 |
| FTL | ferritin, light polypeptide | -0.0719595 |
| FGB | fibrinogen beta chain | -0.0711368 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0653631 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0638347 |
| POTEF | POTE ankyrin domain family, member F | -0.0635592 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0624735 |
| DENND4A | DENN/MADD domain containing 4A | -0.0622646 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0603753 |
| AHNAK | AHNAK nucleoprotein | -0.0583029 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0575527 |
| RPL8 | ribosomal protein L8 | -0.0574508 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0562121 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0548504 |
| RPL35A | ribosomal protein L35a | -0.0545735 |
| PTMA | prothymosin, alpha | -0.0538741 |
| RPLP1 | ribosomal protein, large, P1 | -0.0535937 |
| RPS27A | ribosomal protein S27a | -0.0525219 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0515038 |
| RPL19 | ribosomal protein L19 | -0.0504778 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0475566 |
| USP3 | ubiquitin specific peptidase 3 | -0.0466998 |
| RPS23 | ribosomal protein S23 | -0.0466362 |
| RPS21 | ribosomal protein S21 | -0.0458035 |
| YBX1 | Y box binding protein 1 | -0.0449496 |
| S100A6 | S100 calcium binding protein A6 | -0.0441954 |
| RPS15 | ribosomal protein S15 | -0.0436696 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | -0.0428782 |
| MT2A | metallothionein 2A | -0.0428448 |
| GRAMD1B | GRAM domain containing 1B | -0.0425834 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0425463 |
| RPL4 | ribosomal protein L4 | -0.0420564 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | -0.0419781 |
| FAM168A | family with sequence similarity 168, member A | -0.0410058 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0395084 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.038709 |
| VIM | vimentin | -0.0385004 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0379627 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0377799 |
| TFG | TRK-fused gene | -0.0375656 |
| ANXA2 | annexin A2 | -0.0375336 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0372316 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0369093 |
| CALR | calreticulin | -0.03674 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0365917 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | -0.0360713 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | -0.0359204 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | -0.0358393 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | -0.0358352 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0358303 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.035815 |
| OSBPL9 | oxysterol binding protein-like 9 | -0.0353691 |
| RPS19 | ribosomal protein S19 | -0.035235 |
| TRMT112 | tRNA methyltransferase 11-2 homolog (S. cerevisiae) | -0.035167 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0349928 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0349819 |
| JAK1 | Janus kinase 1 | -0.0347554 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0346174 |
| ASPH | aspartate beta-hydroxylase | -0.0342685 |
| TMSB10 | thymosin beta 10 | -0.0341474 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0340297 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0338996 |
| SDC4 | syndecan 4 | -0.0335373 |
| RPL34 | ribosomal protein L34 | -0.0333877 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0333121 |
| ASTN2 | astrotactin 2 | -0.0331244 |
| RPS29 | ribosomal protein S29 | -0.0327273 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | -0.0325908 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0324533 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | -0.0320076 |
| RBM39 | RNA binding motif protein 39 | -0.0318578 |
| CANX | calnexin | -0.031843 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0314642 |
| SRGN | serglycin | -0.031162 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0310234 |
| RPS5 | ribosomal protein S5 | -0.0306099 |
| RPL32 | ribosomal protein L32 | -0.0304806 |
| ZNF292 | zinc finger protein 292 | -0.0304274 |
| RPS11 | ribosomal protein S11 | -0.0300026 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.029811 |
| IFRD1 | interferon-related developmental regulator 1 | -0.029372 |
| TXNRD1 | thioredoxin reductase 1 | -0.0293418 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0291206 |
| DEK | DEK proto-oncogene | -0.0287929 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.0282128 |
| OLA1 | Obg-like ATPase 1 | -0.0280829 |
| RHEB | Ras homolog enriched in brain | -0.0278417 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0278039 |
| HLA-B | major histocompatibility complex, class I, B | -0.0270756 |
