| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tetracycline (hydrochloride) perturbation in NCI-H2347 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Tetracycline (hydrochloride)_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.175478 |
| MYO6 | myosin VI | 0.0770314 |
| EFNA5 | ephrin-A5 | 0.0759063 |
| NDRG1 | N-myc downstream regulated 1 | 0.0729647 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0716158 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.0654664 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0621795 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0570535 |
| SEMA3B | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B | 0.0560592 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.052702 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0521792 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0521431 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0518304 |
| EXT1 | exostosin glycosyltransferase 1 | 0.050838 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.050333 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0502529 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0498731 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0478114 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0473858 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0463519 |
| DTNA | dystrobrevin, alpha | 0.0446237 |
| VMP1 | vacuole membrane protein 1 | 0.0441916 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | 0.0403149 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0394491 |
| PLEC | plectin | 0.0392639 |
| MYO1E | myosin IE | 0.0391715 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0382464 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0382287 |
| TMF1 | TATA element modulatory factor 1 | 0.0380573 |
| RALGPS2 | Ral GEF with PH domain and SH3 binding motif 2 | 0.0380243 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0378183 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0375152 |
| LAMB3 | laminin, beta 3 | 0.0372501 |
| FBXO32 | F-box protein 32 | 0.0371234 |
| MAP3K9 | mitogen-activated protein kinase kinase kinase 9 | 0.0365074 |
| TXNIP | thioredoxin interacting protein | 0.0364904 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0349394 |
| TMEM165 | transmembrane protein 165 | 0.0335505 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0333737 |
| MICAL3 | microtubule associated monooxygenase, calponin and LIM domain containing 3 | 0.0332842 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0332741 |
| SBF2 | SET binding factor 2 | 0.0332668 |
| ENO1 | enolase 1, (alpha) | 0.0327098 |
| JMJD1C | jumonji domain containing 1C | 0.0321658 |
| TJP2 | tight junction protein 2 | 0.0319665 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | 0.0319369 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0319035 |
| RCOR1 | REST corepressor 1 | 0.0317351 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.031441 |
| FLNA | filamin A, alpha | 0.0307614 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0307061 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | 0.0304448 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0303879 |
| ERBIN | erbb2 interacting protein | 0.0300018 |
| VGLL3 | vestigial-like family member 3 | 0.0296243 |
| MYO5B | myosin VB | 0.0294557 |
| CDCP1 | CUB domain containing protein 1 | 0.0292892 |
| NEK7 | NIMA-related kinase 7 | 0.0290786 |
| SMAD3 | SMAD family member 3 | 0.0288443 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0287336 |
| VCL | vinculin | 0.0287249 |
| GOLPH3 | golgi phosphoprotein 3 (coat-protein) | 0.0280604 |
| TUFT1 | tuftelin 1 | 0.0274656 |
| TUBB4B | tubulin, beta 4B class IVb | 0.0274473 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0273163 |
| FLNB | filamin B, beta | 0.0269636 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0268048 |
| BCL2L1 | BCL2-like 1 | 0.0267695 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0264183 |
| OCLN | occludin | 0.0260924 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0260876 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.026063 |
| BLZF1 | basic leucine zipper nuclear factor 1 | 0.0257066 |
| ST14 | suppression of tumorigenicity 14 (colon carcinoma) | 0.0255768 |
| FAM107B | family with sequence similarity 107, member B | 0.0250334 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | 0.024978 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.0249758 |
| MCTP2 | multiple C2 domains, transmembrane 2 | 0.0241602 |
| MKRN1 | makorin ring finger protein 1 | 0.023938 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.023886 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | 0.0237187 |
| MYO10 | myosin X | 0.0231305 |
| UBAP1 | ubiquitin associated protein 1 | 0.023096 |
| JUP | junction plakoglobin | 0.0230845 |
| RAB6A | RAB6A, member RAS oncogene family | 0.023082 |
| DUSP10 | dual specificity phosphatase 10 | 0.0226685 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0226678 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0225692 |
| TENT2 | terminal nucleotidyltransferase 2 | 0.022553 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0225367 |
| MCL1 | myeloid cell leukemia 1 | 0.0224751 |
| NPC1 | Niemann-Pick disease, type C1 | 0.0224015 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0223783 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.022372 |
| PLSCR1 | phospholipid scramblase 1 | 0.0223122 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0222954 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0222451 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0221979 |
| KLC1 | kinesin light chain 1 | 0.022181 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.022051 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.295999 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.164641 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.158947 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.154223 |
| PTMA | prothymosin, alpha | -0.131113 |
| POTEF | POTE ankyrin domain family, member F | -0.124533 |
| CANX | calnexin | -0.113115 |
| UBC | ubiquitin C | -0.0994045 |
| TMSB4X | thymosin beta 4, X-linked | -0.0938463 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0918997 |
| RPL35A | ribosomal protein L35a | -0.0801481 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0792277 |
| AHNAK | AHNAK nucleoprotein | -0.0743439 |
| FTL | ferritin, light polypeptide | -0.0717229 |
| HMGA1 | high mobility group AT-hook 1 | -0.0709541 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0646759 |
| S100A10 | S100 calcium binding protein A10 | -0.06194 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0618069 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0614219 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0612607 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0582073 |
| RPL8 | ribosomal protein L8 | -0.057519 |
| RPLP0 | ribosomal protein, large, P0 | -0.0574012 |
| S100A6 | S100 calcium binding protein A6 | -0.0541678 |
| YBX1 | Y box binding protein 1 | -0.0538263 |
| FN1 | fibronectin 1 | -0.0507765 |
| CCND1 | cyclin D1 | -0.0507647 |
| GNAS | GNAS complex locus | -0.0505176 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0492744 |
| RPS8 | ribosomal protein S8 | -0.0485288 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0483954 |
| H1-0 | H1.0 linker histone | -0.0480559 |
| RPS6 | ribosomal protein S6 | -0.0479437 |
| SQSTM1 | sequestosome 1 | -0.0464308 |
| KRT7 | keratin 7, type II | -0.0440523 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0440432 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0439974 |
| RPL34 | ribosomal protein L34 | -0.0438278 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | -0.0430328 |
| PLAU | plasminogen activator, urokinase | -0.0417707 |
| RHEB | Ras homolog enriched in brain | -0.0412713 |
| RPS24 | ribosomal protein S24 | -0.0402997 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0401964 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0395765 |
| TPM4 | tropomyosin 4 | -0.0394695 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0390698 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.038807 |
| EPCAM | epithelial cell adhesion molecule | -0.0384376 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0380969 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | -0.0378614 |
| TMEM123 | transmembrane protein 123 | -0.0368662 |
| DEK | DEK proto-oncogene | -0.0368367 |
| VIM | vimentin | -0.036167 |
| G0S2 | G0/G1 switch 2 | -0.0347131 |
| RPS14 | ribosomal protein S14 | -0.033779 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0334569 |
| RPS27A | ribosomal protein S27a | -0.033376 |
| ANXA2 | annexin A2 | -0.0332413 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0320882 |
| RYBP | RING1 and YY1 binding protein | -0.0320417 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0316106 |
| CD2AP | CD2-associated protein | -0.031335 |
| RPL14 | ribosomal protein L14 | -0.0299822 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | -0.0299188 |
| RPL12 | ribosomal protein L12 | -0.0299136 |
| RHOA | ras homolog family member A | -0.0298558 |
| QKI | QKI, KH domain containing, RNA binding | -0.0291599 |
| RPS13 | ribosomal protein S13 | -0.0291006 |
| RPLP1 | ribosomal protein, large, P1 | -0.0289422 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0289386 |
| SLC38A1 | solute carrier family 38, member 1 | -0.028933 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.0287744 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0285907 |
| HMGB1 | high mobility group box 1 | -0.0284791 |
| PGK1 | phosphoglycerate kinase 1 | -0.0282278 |
| ACTG1 | actin gamma 1 | -0.0277674 |
| TOP1 | topoisomerase (DNA) I | -0.0270123 |
| TKT | transketolase | -0.0269417 |
| RPS5 | ribosomal protein S5 | -0.0265419 |
| USP3 | ubiquitin specific peptidase 3 | -0.0263363 |
| TMEM263 | transmembrane protein 263 | -0.0263079 |
| SMG7 | SMG7 nonsense mediated mRNA decay factor | -0.0263076 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.026225 |
| RPL4 | ribosomal protein L4 | -0.0260905 |
| RPL19 | ribosomal protein L19 | -0.0258192 |
| NAP1L4 | nucleosome assembly protein 1-like 4 | -0.0256395 |
| TPI1 | triosephosphate isomerase 1 | -0.0255568 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | -0.0252263 |
| IRF1 | interferon regulatory factor 1 | -0.0251009 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0250865 |
| IFRD1 | interferon-related developmental regulator 1 | -0.0250057 |
| TUBA1B | tubulin, alpha 1b | -0.0248845 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0248767 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | -0.0248135 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0244504 |
| DDX24 | DEAD (Asp-Glu-Ala-Asp) box helicase 24 | -0.0244374 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | -0.0244234 |
| SLC34A2 | solute carrier family 34 (type II sodium/phosphate cotransporter), member 2 | -0.02433 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | -0.0242544 |
| RPS19 | ribosomal protein S19 | -0.0242524 |
