| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tetracycline (hydrochloride) perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Tetracycline (hydrochloride)_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ASPH | aspartate beta-hydroxylase | 0.116583 |
| EFNA5 | ephrin-A5 | 0.0982086 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0840498 |
| RPS12 | ribosomal protein S12 | 0.0676953 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0657567 |
| VIM | vimentin | 0.0608815 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0608402 |
| RPS3 | ribosomal protein S3 | 0.0575544 |
| LDHA | lactate dehydrogenase A | 0.0495557 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0482303 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.046617 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0460409 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.044059 |
| CTSC | cathepsin C | 0.0436496 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0433011 |
| PTMA | prothymosin, alpha | 0.0421696 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0390278 |
| TMSB10 | thymosin beta 10 | 0.0386516 |
| FTL | ferritin, light polypeptide | 0.0377282 |
| MCL1 | myeloid cell leukemia 1 | 0.0374853 |
| ENO1 | enolase 1, (alpha) | 0.0370955 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0366336 |
| EPB41L3 | erythrocyte membrane protein band 4.1-like 3 | 0.0365556 |
| RPL37A | ribosomal protein L37a | 0.035853 |
| NRCAM | neuronal cell adhesion molecule | 0.0352596 |
| RPL26 | ribosomal protein L26 | 0.035221 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0346263 |
| RACK1 | receptor for activated C kinase 1 | 0.0341851 |
| S100A6 | S100 calcium binding protein A6 | 0.0339923 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0336137 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0329914 |
| B2M | beta-2-microglobulin | 0.0291437 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0284256 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0278861 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0275574 |
| PDGFA | platelet-derived growth factor alpha polypeptide | 0.0274182 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.027179 |
| NEK7 | NIMA-related kinase 7 | 0.0270073 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0268395 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0266259 |
| FAM13A | family with sequence similarity 13, member A | 0.0248916 |
| SET | SET nuclear proto-oncogene | 0.0238699 |
| MKI67 | marker of proliferation Ki-67 | 0.0238433 |
| CANX | calnexin | 0.0236863 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0233729 |
| RTN4 | reticulon 4 | 0.0232317 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0228461 |
| PGK1 | phosphoglycerate kinase 1 | 0.0227615 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0227554 |
| RAI1 | retinoic acid induced 1 | 0.0227435 |
| RPL12 | ribosomal protein L12 | 0.0223748 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0222892 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0222646 |
| CENPF | centromere protein F, 350/400kDa | 0.0220468 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0219649 |
| ANXA2 | annexin A2 | 0.0217397 |
| RPL13A | ribosomal protein L13a | 0.0211349 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0208835 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0208628 |
| RPS8 | ribosomal protein S8 | 0.0206149 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0205902 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | 0.0204528 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0204175 |
| TPI1 | triosephosphate isomerase 1 | 0.0201639 |
| RPL9 | ribosomal protein L9 | 0.0197524 |
| RPS7 | ribosomal protein S7 | 0.0197022 |
| RPS17 | ribosomal protein S17 | 0.0193713 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0190722 |
| RPS25 | ribosomal protein S25 | 0.0190614 |
| RPS2 | ribosomal protein S2 | 0.0189834 |
| HYOU1 | hypoxia up-regulated 1 | 0.0189339 |
| FLNB | filamin B, beta | 0.0189123 |
| ZNF292 | zinc finger protein 292 | 0.0187193 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0186577 |
| PFN1 | profilin 1 | 0.018649 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0186202 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0183351 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0183335 |
| AP1S3 | adaptor-related protein complex 1, sigma 3 subunit | 0.0182576 |
| RPL18 | ribosomal protein L18 | 0.0182501 |
| MORF4L2 | mortality factor 4 like 2 | 0.0182412 |
| MT2A | metallothionein 2A | 0.017776 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0177385 |
| ANXA1 | annexin A1 | 0.0177349 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0177309 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.01768 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0173249 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 0.0171905 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0171267 |
| SLC25A5 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | 0.0171083 |
| MYOF | myoferlin | 0.0167874 |
| WDFY2 | WD repeat and FYVE domain containing 2 | 0.0167712 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0167123 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0166843 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0165442 |
| PRDX1 | peroxiredoxin 1 | 0.0165395 |
| LMNA | lamin A/C | 0.016425 |
| KIF5B | kinesin family member 5B | 0.0163547 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.016284 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0162621 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.162413 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.158935 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.125184 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0837565 |
| PDE10A | phosphodiesterase 10A | -0.0667523 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0544753 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0484453 |
| DPP10 | dipeptidyl-peptidase 10 (non-functional) | -0.0419994 |
| ADGRD1 | adhesion G protein-coupled receptor D1 | -0.0400209 |
| RPS23 | ribosomal protein S23 | -0.0384561 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.038448 |
| RPL35A | ribosomal protein L35a | -0.0371729 |
| P3H2 | prolyl 3-hydroxylase 2 | -0.0361874 |
| GDA | guanine deaminase | -0.0359088 |
| CDH13 | cadherin 13 | -0.0323782 |
| FN1 | fibronectin 1 | -0.0312367 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | -0.0291086 |
| TBXT | T-box transcription factor T | -0.027535 |
| ACTG1 | actin gamma 1 | -0.0274676 |
| UBC | ubiquitin C | -0.0274238 |
| S100A10 | S100 calcium binding protein A10 | -0.02657 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0263461 |
| GRAMD1B | GRAM domain containing 1B | -0.0244216 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0240818 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | -0.0238707 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0227069 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0222697 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | -0.0218701 |
| KIAA0825 | KIAA0825 | -0.0215314 |
| FMNL2 | formin-like 2 | -0.020332 |
| SVIL | supervillin | -0.0196332 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0195423 |
| PM20D1 | peptidase M20 domain containing 1 | -0.0192848 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0187748 |
| ASTN2 | astrotactin 2 | -0.0187321 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0179047 |
| RPS19 | ribosomal protein S19 | -0.0178196 |
| RPL34 | ribosomal protein L34 | -0.0176792 |
| RPS21 | ribosomal protein S21 | -0.017626 |
| EXT1 | exostosin glycosyltransferase 1 | -0.017416 |
| ITPK1 | inositol-tetrakisphosphate 1-kinase | -0.0171279 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0170266 |
| PDE1A | phosphodiesterase 1A, calmodulin-dependent | -0.0165377 |
| TENM2 | teneurin transmembrane protein 2 | -0.0162024 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0161481 |
| AGTPBP1 | ATP/GTP binding protein 1 | -0.0159712 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.01593 |
| CADM2 | cell adhesion molecule 2 | -0.0159146 |
| RPL8 | ribosomal protein L8 | -0.0157587 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | -0.0155854 |
| TENM3 | teneurin transmembrane protein 3 | -0.0154639 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0152823 |
| RPS15 | ribosomal protein S15 | -0.015237 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0151141 |
| CUX1 | cut-like homeobox 1 | -0.014718 |
| UNC5D | unc-5 homolog D (C. elegans) | -0.0146638 |
| RPL32 | ribosomal protein L32 | -0.0145754 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0145085 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0144801 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0143378 |
| TXNRD1 | thioredoxin reductase 1 | -0.0142612 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0142552 |
| ANTXR1 | anthrax toxin receptor 1 | -0.0142418 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.0139505 |
| RPH3AL | rabphilin 3A-like (without C2 domains) | -0.0139291 |
| MAP7 | microtubule-associated protein 7 | -0.0138979 |
| SMYD3 | SET and MYND domain containing 3 | -0.0138036 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0137252 |
| SMAD2 | SMAD family member 2 | -0.0136868 |
| LSAMP | limbic system-associated membrane protein | -0.0135912 |
| PCDH9 | protocadherin 9 | -0.0135117 |
| OXSR1 | oxidative stress responsive 1 | -0.0135108 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0132674 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0132567 |
| STEAP1B | STEAP family member 1B | -0.0131991 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0128706 |
| NTN4 | netrin 4 | -0.0128112 |
| AHNAK | AHNAK nucleoprotein | -0.0126925 |
| AEBP2 | AE binding protein 2 | -0.0126802 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0123976 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0123273 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0122955 |
| RPL38 | ribosomal protein L38 | -0.0122561 |
| MGST1 | microsomal glutathione S-transferase 1 | -0.0118952 |
| XPR1 | xenotropic and polytropic retrovirus receptor 1 | -0.0116311 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0116185 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0115345 |
| RBM39 | RNA binding motif protein 39 | -0.0113482 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0113476 |
| AUTS2 | autism susceptibility candidate 2 | -0.0113035 |
| MFSD12 | major facilitator superfamily domain containing 12 | -0.011295 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | -0.0109735 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0109645 |
| SORBS2 | sorbin and SH3 domain containing 2 | -0.0107696 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | -0.0107086 |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 | -0.0106816 |
| RBMX | RNA binding motif protein, X-linked | -0.0106062 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0105796 |
| FSTL4 | follistatin-like 4 | -0.0105084 |
| ALPK2 | alpha-kinase 2 | -0.0103796 |
