Tetracycline (hydrochloride)_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tetracycline (hydrochloride) perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

196 genes differentially expressed following the Tetracycline (hydrochloride)_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VIM vimentin 0.191635
PDE4D phosphodiesterase 4D, cAMP-specific 0.155301
EXT1 exostosin glycosyltransferase 1 0.124146
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.09546
ASPH aspartate beta-hydroxylase 0.0944759
CDH13 cadherin 13 0.0854892
EFNA5 ephrin-A5 0.07968
TPT1 tumor protein, translationally-controlled 1 0.0769882
PDE10A phosphodiesterase 10A 0.0754308
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0725203
NAP1L1 nucleosome assembly protein 1-like 1 0.0711538
DST dystonin 0.0673208
RPL23 ribosomal protein L23 0.066748
FLNB filamin B, beta 0.0640786
RPL12 ribosomal protein L12 0.0636326
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0631882
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0625648
CSNK1A1 casein kinase 1, alpha 1 0.0601382
PSD3 pleckstrin and Sec7 domain containing 3 0.0599402
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0587424
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0581429
WAC WW domain containing adaptor with coiled-coil 0.0569556
FAM13A family with sequence similarity 13, member A 0.0560411
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0557463
NBAS neuroblastoma amplified sequence 0.0542515
GOLGA4 golgin A4 0.0524683
PKM pyruvate kinase, muscle 0.0517214
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0507533
RPLP2 ribosomal protein, large, P2 0.0482748
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0466515
PRELID2 PRELI domain containing 2 0.0454982
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0445988
COG5 component of oligomeric golgi complex 5 0.0432052
PGK1 phosphoglycerate kinase 1 0.0421638
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0409211
S100A6 S100 calcium binding protein A6 0.0391218
TXNRD1 thioredoxin reductase 1 0.0385178
AKAP9 A kinase (PRKA) anchor protein 9 0.0381676
KMT2C lysine (K)-specific methyltransferase 2C 0.0372444
RAB7A RAB7A, member RAS oncogene family 0.0371297
RPS12 ribosomal protein S12 0.0366292
MAML2 mastermind-like 2 (Drosophila) 0.0362959
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0360812
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0358892
RBM39 RNA binding motif protein 39 0.0341399
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0338958
TRIO trio Rho guanine nucleotide exchange factor 0.0329851
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0316096
NAMPT nicotinamide phosphoribosyltransferase 0.031558
ZBTB20 zinc finger and BTB domain containing 20 0.0314816
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0308498
LDHA lactate dehydrogenase A 0.0307396
SBF2 SET binding factor 2 0.0303961
MAP4 microtubule-associated protein 4 0.0298338
FTL ferritin, light polypeptide 0.0294768
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.0289344
NDRG1 N-myc downstream regulated 1 0.0287882
SRRM2 serine/arginine repetitive matrix 2 0.0287836
RBM25 RNA binding motif protein 25 0.0276484
H3-3B H3.3 histone B 0.0270431
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0257005
RPL30 ribosomal protein L30 0.0256978
GLS2 glutaminase 2 (liver, mitochondrial) 0.0238969
EGR1 early growth response 1 0.023509
COPA coatomer protein complex, subunit alpha 0.0234447
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 0.0224204
PTK2 protein tyrosine kinase 2 0.0222718
ACTN4 actinin, alpha 4 0.0221595
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0216626
TIMP3 TIMP metallopeptidase inhibitor 3 0.0212687
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0198609
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0185446
FMN1 formin 1 0.017504
ZNF292 zinc finger protein 292 0.0169485
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0166564
TMSB10 thymosin beta 10 0.0163656
ENO1 enolase 1, (alpha) 0.0160433
CCNI cyclin I 0.0157231
POTEF POTE ankyrin domain family, member F 0.0151219
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0137424
KDM3A lysine (K)-specific demethylase 3A 0.0129256
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0126479
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.00987674
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.00971106
TNRC6B trinucleotide repeat containing 6B 0.00958467
ADAM9 ADAM metallopeptidase domain 9 0.00951588
SLC38A1 solute carrier family 38, member 1 0.00944908
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.00890109
NUP58 nucleoporin 58 0.00801001
MYOF myoferlin 0.00756114
SRPK2 SRSF protein kinase 2 0.00626354
GPHN gephyrin 0.00560848
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) 0.0055606
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.00526971
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.00483071
RICTOR RPTOR independent companion of MTOR, complex 2 0.00254474
PIAS1 protein inhibitor of activated STAT, 1 0.00133453
PTMA prothymosin, alpha 0.00122665
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.00117563
USP34 ubiquitin specific peptidase 34 0.00102895

decreased expression

Symbol Name Standardized Value
EGFR epidermal growth factor receptor -0.185163
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.119321
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.114512
ITGA6 integrin, alpha 6 -0.0987274
SLTM SAFB-like, transcription modulator -0.0950689
LPP LIM domain containing preferred translocation partner in lipoma -0.093014
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0919113
PRKCA protein kinase C, alpha -0.0857641
THSD4 thrombospondin, type I, domain containing 4 -0.083375
MCL1 myeloid cell leukemia 1 -0.0806445
ATP11A ATPase, class VI, type 11A -0.0745414
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0735028
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0720991
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0703062
MYO1E myosin IE -0.0694309
PDE8A phosphodiesterase 8A -0.0656516
GSK3B glycogen synthase kinase 3 beta -0.0650339
ANKRD12 ankyrin repeat domain 12 -0.0629376
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0628322
FMNL2 formin-like 2 -0.0614993
LMO7 LIM domain 7 -0.0592655
FTH1 ferritin, heavy polypeptide 1 -0.0589018
MYH9 myosin, heavy chain 9, non-muscle -0.058592
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0573994
HLA-B major histocompatibility complex, class I, B -0.0530319
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0527785
TTC3 tetratricopeptide repeat domain 3 -0.0511538
KTN1 kinectin 1 (kinesin receptor) -0.0505423
UBC ubiquitin C -0.050413
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0502672
TMEM165 transmembrane protein 165 -0.0496467
OSMR oncostatin M receptor -0.0492846
SEC31A SEC31 homolog A (S. cerevisiae) -0.047876
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0476477
RPLP1 ribosomal protein, large, P1 -0.0472054
PCBP2 poly(rC) binding protein 2 -0.0454083
ARHGAP5 Rho GTPase activating protein 5 -0.044687
RPL31 ribosomal protein L31 -0.0434995
FN1 fibronectin 1 -0.0433122
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0421331
RPS6 ribosomal protein S6 -0.0407778
ACTG1 actin gamma 1 -0.0390436
MYO10 myosin X -0.0361117
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0352624
ANKRD11 ankyrin repeat domain 11 -0.0347693
B2M beta-2-microglobulin -0.0321704
ANXA2 annexin A2 -0.0318183
JMJD1C jumonji domain containing 1C -0.0310544
VCL vinculin -0.0305207
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0274533
NIPBL Nipped-B homolog (Drosophila) -0.0273606
ARRDC3 arrestin domain containing 3 -0.0261994
ADAM10 ADAM metallopeptidase domain 10 -0.0261118
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0258412
MYO6 myosin VI -0.0249554
CNOT4 CCR4-NOT transcription complex, subunit 4 -0.024328
RLF rearranged L-myc fusion -0.0241883
HDAC9 histone deacetylase 9 -0.0236508
DSCAM Down syndrome cell adhesion molecule -0.0229023
ATXN1 ataxin 1 -0.0204214
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0201272
AKAP12 A kinase (PRKA) anchor protein 12 -0.019942
RUNX1 runt-related transcription factor 1 -0.0197235
SMAD3 SMAD family member 3 -0.019651
EEF2 eukaryotic translation elongation factor 2 -0.0191135
MT2A metallothionein 2A -0.0189523
SMYD3 SET and MYND domain containing 3 -0.0188207
PARD3 par-3 family cell polarity regulator -0.0183736
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0165468
ZFAND3 zinc finger, AN1-type domain 3 -0.0160633
ELOF1 elongation factor 1 homolog (S. cerevisiae) -0.014678
GPC6 glypican 6 -0.0144412
MACF1 microtubule-actin crosslinking factor 1 -0.0141261
RTN4 reticulon 4 -0.0139992
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0130496
HMGA2 high mobility group AT-hook 2 -0.0129198
RPS27A ribosomal protein S27a -0.0118445
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.010928
TPM4 tropomyosin 4 -0.0108884
CD44 CD44 molecule (Indian blood group) -0.0106575
MED13L mediator complex subunit 13-like -0.0101302
ELL2 elongation factor, RNA polymerase II, 2 -0.0100986
RNF213 ring finger protein 213 -0.00972226
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.00954349
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.00854266
YBX3 Y box binding protein 3 -0.00804523
RPS8 ribosomal protein S8 -0.00769891
ARID1B AT rich interactive domain 1B (SWI1-like) -0.00739506
SETD5 SET domain containing 5 -0.00442645
FNDC3B fibronectin type III domain containing 3B -0.00280797
RPS3 ribosomal protein S3 -0.00259306
PRRC2C proline-rich coiled-coil 2C -0.00123608
BIRC6 baculoviral IAP repeat containing 6 -8.70579E-4
PABPC1 poly(A) binding protein, cytoplasmic 1 -7.78918E-4
DOCK5 dedicator of cytokinesis 5 -6.31097E-4
RPL37A ribosomal protein L37a -4.71201E-4