Tetracycline (hydrochloride)_SHP-77 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tetracycline (hydrochloride) perturbation in SHP-77 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tetracycline (hydrochloride)_SHP-77 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE10A phosphodiesterase 10A 0.322453
TENM1 teneurin transmembrane protein 1 0.12037
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.0882633
CENPF centromere protein F, 350/400kDa 0.0825423
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0814967
KCND2 potassium channel, voltage gated Shal related subfamily D, member 2 0.0768659
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.075277
PEG10 paternally expressed 10 0.0739864
ENO1 enolase 1, (alpha) 0.0703771
PDE4D phosphodiesterase 4D, cAMP-specific 0.0693155
NCKAP5 NCK-associated protein 5 0.0634787
SMOC1 SPARC related modular calcium binding 1 0.0620043
FAT1 FAT atypical cadherin 1 0.0588104
RIT2 Ras-like without CAAX 2 0.0575851
CDH12 cadherin 12, type 2 (N-cadherin 2) 0.0555154
TOX thymocyte selection-associated high mobility group box 0.0543832
NALF1 NALCN channel auxiliary factor 1 0.0531282
PCSK1 proprotein convertase subtilisin/kexin type 1 0.0478218
SASH1 SAM and SH3 domain containing 1 0.0475812
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 0.0471804
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0468181
PDE4B phosphodiesterase 4B, cAMP-specific 0.0466357
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0443589
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0436787
RAD51B RAD51 paralog B 0.0424036
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.0410207
NLGN1 neuroligin 1 0.0407486
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0385183
IRS2 insulin receptor substrate 2 0.0384838
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0366007
VGF VGF nerve growth factor inducible 0.0362787
BCAS3 breast carcinoma amplified sequence 3 0.0354783
RIMS2 regulating synaptic membrane exocytosis 2 0.0353603
CA8 carbonic anhydrase VIII 0.03478
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.0340284
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) 0.0337476
GRAMD4 GRAM domain containing 4 0.0327199
FHIT fragile histidine triad 0.031368
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0312148
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.0310534
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0307422
ESRRG estrogen-related receptor gamma 0.029668
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0290689
LSAMP limbic system-associated membrane protein 0.0284384
WWOX WW domain containing oxidoreductase 0.0282786
GRIK1 glutamate receptor, ionotropic, kainate 1 0.0274944
NKAIN2 Na+/K+ transporting ATPase interacting 2 0.0274795
ASCL1 achaete-scute family bHLH transcription factor 1 0.0272075
NRXN1 neurexin 1 0.0267391
MTMR7 myotubularin related protein 7 0.0264413
RALYL RALY RNA binding protein-like 0.0263132
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0262739
KCNH7 potassium channel, voltage gated eag related subfamily H, member 7 0.0260564
MKI67 marker of proliferation Ki-67 0.0254756
FGF14 fibroblast growth factor 14 0.0251557
DENND1A DENN/MADD domain containing 1A 0.0248816
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0246774
SMC1A structural maintenance of chromosomes 1A 0.0242651
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae) 0.0241489
RPS7 ribosomal protein S7 0.0240056
CADM1 cell adhesion molecule 1 0.0239961
SMYD3 SET and MYND domain containing 3 0.0238923
PBX3 pre-B-cell leukemia homeobox 3 0.0238295
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0234196
SMAD9 SMAD family member 9 0.0230144
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0229194
AOPEP aminopeptidase O (putative) 0.0228751
EFNA5 ephrin-A5 0.0228085
KCNMB3 potassium channel subfamily M regulatory beta subunit 3 0.0227692
TBC1D5 TBC1 domain family, member 5 0.0224864
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0223615
HMGB2 high mobility group box 2 0.0223194
PCBP3 poly(rC) binding protein 3 0.0222464
FKBP9 FK506 binding protein 9, 63 kDa 0.0220098
ARHGAP26 Rho GTPase activating protein 26 0.0218655
TMEM255B transmembrane protein 255B 0.0216995
MACF1 microtubule-actin crosslinking factor 1 0.0212711
RPS3 ribosomal protein S3 0.0212431
AP1S3 adaptor-related protein complex 1, sigma 3 subunit 0.0211778
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0210815
FOXP2 forkhead box P2 0.0208977
NYAP2 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2 0.0208397
SUMF1 sulfatase modifying factor 1 0.0208327
ELL2 elongation factor, RNA polymerase II, 2 0.0207461
SLCO3A1 solute carrier organic anion transporter family, member 3A1 0.0205404
KANTR KDM5C adjacent non-coding transcript 0.0202656
SNAP25 synaptosomal-associated protein, 25kDa 0.020227
GPRIN3 GPRIN family member 3 0.0200316
PCCA propionyl CoA carboxylase, alpha polypeptide 0.019833
AGBL4 ATP/GTP binding protein-like 4 0.0196324
DST dystonin 0.0194552
UBE2QL1 ubiquitin-conjugating enzyme E2Q family-like 1 0.0193498
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.019318
LMNB1 lamin B1 0.0193116
ASPH aspartate beta-hydroxylase 0.0193051
MBNL2 muscleblind-like splicing regulator 2 0.0192673
IGF1R insulin-like growth factor 1 receptor 0.0191563
CNKSR3 CNKSR family member 3 0.0190966
PCLO piccolo presynaptic cytomatrix protein 0.0190158
POU6F2 POU class 6 homeobox 2 0.0189149

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.141321
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.135771
CALCA calcitonin-related polypeptide alpha -0.135628
ACTG1 actin gamma 1 -0.0929559
NDRG1 N-myc downstream regulated 1 -0.0918506
RPL8 ribosomal protein L8 -0.0694525
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0692443
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0690886
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0675482
STC1 stanniocalcin 1 -0.0653333
RPS21 ribosomal protein S21 -0.0622029
EGR1 early growth response 1 -0.059808
TMSB4X thymosin beta 4, X-linked -0.0594774
RPS6 ribosomal protein S6 -0.0554521
NCOR1 nuclear receptor corepressor 1 -0.0486921
S100A9 S100 calcium binding protein A9 -0.0461693
EIF4A1 eukaryotic translation initiation factor 4A1 -0.046165
PKM pyruvate kinase, muscle -0.0454287
MCL1 myeloid cell leukemia 1 -0.043913
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0434918
KTN1 kinectin 1 (kinesin receptor) -0.042834
UBB ubiquitin B -0.0425511
RBM25 RNA binding motif protein 25 -0.0417411
SEZ6L2 seizure related 6 homolog (mouse)-like 2 -0.0408816
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0403143
RSRC2 arginine/serine-rich coiled-coil 2 -0.0395487
FTL ferritin, light polypeptide -0.039464
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0389876
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0385237
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.037951
NOP58 NOP58 ribonucleoprotein -0.0372649
EIF1 eukaryotic translation initiation factor 1 -0.0371248
LOC112694756 uncharaterized LOC112694756 -0.0366845
RPS23 ribosomal protein S23 -0.0365413
RPL26 ribosomal protein L26 -0.0361201
IARS1 isoleucyl-tRNA synthetase 1 -0.0360669
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.0354226
RPL35A ribosomal protein L35a -0.0350851
RPL37A ribosomal protein L37a -0.034861
MAP1B microtubule-associated protein 1B -0.0346584
RPS8 ribosomal protein S8 -0.0345139
NAP1L1 nucleosome assembly protein 1-like 1 -0.0339134
RPL32 ribosomal protein L32 -0.0339114
RPL5 ribosomal protein L5 -0.0337855
RPS15 ribosomal protein S15 -0.0337656
RPS11 ribosomal protein S11 -0.0336034
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0328234
RPS19 ribosomal protein S19 -0.0326984
TPD52 tumor protein D52 -0.0326067
TPT1 tumor protein, translationally-controlled 1 -0.0325995
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0323533
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0321431
NIPBL Nipped-B homolog (Drosophila) -0.0314654
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0313067
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0308377
RSL1D1 ribosomal L1 domain containing 1 -0.030742
RPL34 ribosomal protein L34 -0.0307212
DEK DEK proto-oncogene -0.0298921
WAC WW domain containing adaptor with coiled-coil -0.0296746
MT2A metallothionein 2A -0.0296744
NR4A1 nuclear receptor subfamily 4, group A, member 1 -0.0292784
PTK2 protein tyrosine kinase 2 -0.0291436
RPL11 ribosomal protein L11 -0.0289455
BCL2 B-cell CLL/lymphoma 2 -0.0286124
IGFBP2 insulin-like growth factor binding protein 2, 36kDa -0.028412
ATP5F1B ATP synthase F1 subunit beta -0.0281581
UBC ubiquitin C -0.0278441
RPL38 ribosomal protein L38 -0.0276729
SCG2 secretogranin II -0.0276144
MARCHF6 membrane associated ring-CH-type finger 6 -0.027475
GNAS GNAS complex locus -0.0269843
SOX4 SRY (sex determining region Y)-box 4 -0.0269663
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0268986
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.026706
TRIO trio Rho guanine nucleotide exchange factor -0.0266632
TTC19 tetratricopeptide repeat domain 19 -0.0265085
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.0264255
RPL30 ribosomal protein L30 -0.0262434
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0260837
NRG1 neuregulin 1 -0.0259844
TMSB10 thymosin beta 10 -0.0259671
CHGA chromogranin A -0.0259416
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0258692
PSME4 proteasome (prosome, macropain) activator subunit 4 -0.0256843
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -0.025482
WDR45B WD repeat domain 45B -0.0254615
STXBP5L syntaxin binding protein 5-like -0.0251563
RPLP1 ribosomal protein, large, P1 -0.0250187
CELF1 CUGBP, Elav-like family member 1 -0.0246751
EMSY EMSY transcriptional repressor, BRCA2 interacting -0.0245764
RPL7 ribosomal protein L7 -0.0245004
KPNB1 karyopherin (importin) beta 1 -0.0241631
PDIA6 protein disulfide isomerase family A, member 6 -0.0241272
RSF1 remodeling and spacing factor 1 -0.0236936
CCNI cyclin I -0.0236663
JUN jun proto-oncogene -0.0235187
KCTD9 potassium channel tetramerization domain containing 9 -0.0232112
RPL7A ribosomal protein L7a -0.0232002
NPR2 natriuretic peptide receptor 2 -0.0230712
TNRC6B trinucleotide repeat containing 6B -0.0230545