Tetracycline (hydrochloride)_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tetracycline (hydrochloride) perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tetracycline (hydrochloride)_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SOD2 superoxide dismutase 2, mitochondrial 0.116456
FTH1 ferritin, heavy polypeptide 1 0.0839734
LDHA lactate dehydrogenase A 0.0820459
PLIN2 perilipin 2 0.0753287
FTL ferritin, light polypeptide 0.0691561
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0655413
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0644715
MYOF myoferlin 0.0627257
RPS12 ribosomal protein S12 0.061731
RPS3 ribosomal protein S3 0.0616571
MKI67 marker of proliferation Ki-67 0.0614021
ELL2 elongation factor, RNA polymerase II, 2 0.0598809
FRMD4A FERM domain containing 4A 0.056986
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0558822
PDE10A phosphodiesterase 10A 0.050308
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0491253
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0482453
ZNF608 zinc finger protein 608 0.0456112
LRRC7 leucine rich repeat containing 7 0.044819
VCAN versican 0.0447764
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0439191
TENT5A terminal nucleotidyltransferase 5A 0.0439038
EGR1 early growth response 1 0.0429106
ENO1 enolase 1, (alpha) 0.0422834
DEPP1 DEPP autophagy regulator 1 0.0398253
ZFP36L1 ZFP36 ring finger protein-like 1 0.0370756
IFI6 interferon, alpha-inducible protein 6 0.0368868
DDIT4 DNA-damage-inducible transcript 4 0.0367023
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0360871
CENPF centromere protein F, 350/400kDa 0.0359524
COL8A1 collagen, type VIII, alpha 1 0.0354667
C3 complement component 3 0.0350209
SQSTM1 sequestosome 1 0.0349958
HILPDA hypoxia inducible lipid droplet-associated 0.0346547
FRMPD4 FERM and PDZ domain containing 4 0.034451
ICAM1 intercellular adhesion molecule 1 0.0337692
KIF4A kinesin family member 4A 0.0333357
KDM5B lysine (K)-specific demethylase 5B 0.0325237
FNDC3B fibronectin type III domain containing 3B 0.0322759
VCL vinculin 0.031232
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0306589
ZNF292 zinc finger protein 292 0.0302059
HDAC9 histone deacetylase 9 0.0301109
CSDE1 cold shock domain containing E1, RNA-binding 0.0291508
MXI1 MAX interactor 1, dimerization protein 0.0287293
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 0.028416
CLIC4 chloride intracellular channel 4 0.0279912
BABAM2 BRISC and BRCA1 A complex member 2 0.0266103
SMC4 structural maintenance of chromosomes 4 0.0261141
PSD3 pleckstrin and Sec7 domain containing 3 0.0261076
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0253978
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.025149
RTN4 reticulon 4 0.0251046
MYLK myosin light chain kinase 0.025049
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0247994
FBXO32 F-box protein 32 0.0244043
IGFBP7 insulin-like growth factor binding protein 7 0.0241615
PTPRF protein tyrosine phosphatase, receptor type, F 0.02413
PRKCSH protein kinase C substrate 80K-H 0.023829
TPX2 TPX2, microtubule-associated 0.0235165
RNASEH2A ribonuclease H2, subunit A 0.0232851
RAD51B RAD51 paralog B 0.0231231
C6ORF62 chromosome 6 open reading frame 62 0.0230777
NRN1 neuritin 1 0.0229467
SDK1 sidekick cell adhesion molecule 1 0.0220827
BHLHE41 basic helix-loop-helix family, member e41 0.0219807
ZHX2 zinc fingers and homeoboxes 2 0.021856
CD109 CD109 molecule 0.0216333
GBP2 guanylate binding protein 2, interferon-inducible 0.0216228
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0215549
ASXL1 additional sex combs like transcriptional regulator 1 0.0214457
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0212797
BRWD3 bromodomain and WD repeat domain containing 3 0.0211671
NAV2 neuron navigator 2 0.0210609
PRR16 proline rich 16 0.0210279
PHF3 PHD finger protein 3 0.0209188
FHIT fragile histidine triad 0.0208474
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0203687
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0202362
RPS2 ribosomal protein S2 0.0201736
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0201094
MBNL1 muscleblind-like splicing regulator 1 0.0200855
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0200506
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0199868
CADM1 cell adhesion molecule 1 0.01963
TPM3 tropomyosin 3 0.019412
ANO6 anoctamin 6 0.0189134
RPS7 ribosomal protein S7 0.0186161
RPS17 ribosomal protein S17 0.0185438
ANXA2 annexin A2 0.0184003
RNF213 ring finger protein 213 0.0182411
DDIT3 DNA-damage-inducible transcript 3 0.0180826
CTSA cathepsin A 0.0180008
USP9X ubiquitin specific peptidase 9, X-linked 0.0177186
UBE2L6 ubiquitin-conjugating enzyme E2L 6 0.0176777
XRN1 5'-3' exoribonuclease 1 0.0175983
CCNL1 cyclin L1 0.0175827
HMMR hyaluronan-mediated motility receptor (RHAMM) 0.0175714
PRKN parkin RBR E3 ubiquitin protein ligase 0.0172872
CTNND1 catenin (cadherin-associated protein), delta 1 0.0171773

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.241231
HLA-B major histocompatibility complex, class I, B -0.140347
MARCKS myristoylated alanine-rich protein kinase C substrate -0.137511
IGFBP3 insulin-like growth factor binding protein 3 -0.130527
CD44 CD44 molecule (Indian blood group) -0.12848
AKAP12 A kinase (PRKA) anchor protein 12 -0.119109
ACTG1 actin gamma 1 -0.102436
IER3 immediate early response 3 -0.0879665
GLIS3 GLIS family zinc finger 3 -0.0867655
RPL35A ribosomal protein L35a -0.0863795
RPS23 ribosomal protein S23 -0.0793472
ZFAND3 zinc finger, AN1-type domain 3 -0.0707992
TPT1 tumor protein, translationally-controlled 1 -0.0688914
NAMPT nicotinamide phosphoribosyltransferase -0.0635112
COL1A1 collagen, type I, alpha 1 -0.0633652
UBC ubiquitin C -0.0616406
TMSB10 thymosin beta 10 -0.0590375
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0576405
NDRG1 N-myc downstream regulated 1 -0.0565102
CDH13 cadherin 13 -0.0560999
RPS6 ribosomal protein S6 -0.0556679
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0555114
DEK DEK proto-oncogene -0.0533388
TMSB4X thymosin beta 4, X-linked -0.0523753
MYH9 myosin, heavy chain 9, non-muscle -0.0522443
HMGA2 high mobility group AT-hook 2 -0.0518028
PPARD peroxisome proliferator-activated receptor delta -0.0516998
EIF1 eukaryotic translation initiation factor 1 -0.0498335
SLC38A1 solute carrier family 38, member 1 -0.0494705
UGCG UDP-glucose ceramide glucosyltransferase -0.0485629
THBS1 thrombospondin 1 -0.0472052
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0469851
VIM vimentin -0.0466112
LOC112694756 uncharaterized LOC112694756 -0.0461739
SRGN serglycin -0.0443114
RPS24 ribosomal protein S24 -0.0442288
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0438937
EXT1 exostosin glycosyltransferase 1 -0.0428225
POTEF POTE ankyrin domain family, member F -0.0420591
RPL23 ribosomal protein L23 -0.0420527
CANX calnexin -0.0416344
PARD3 par-3 family cell polarity regulator -0.0412859
RPLP1 ribosomal protein, large, P1 -0.0404811
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0398581
RPS21 ribosomal protein S21 -0.039777
VEGFA vascular endothelial growth factor A -0.0396553
NAP1L4 nucleosome assembly protein 1-like 4 -0.0390888
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0381426
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0375305
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0371542
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0371184
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0370435
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0369637
ZBTB38 zinc finger and BTB domain containing 38 -0.0368463
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0367799
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0366476
INHBA inhibin, beta A -0.0362364
RPL32 ribosomal protein L32 -0.0362032
AHNAK AHNAK nucleoprotein -0.0356933
TPM4 tropomyosin 4 -0.0354168
GOLGA4 golgin A4 -0.0352485
CD63 CD63 molecule -0.0351125
RRBP1 ribosome binding protein 1 -0.0346319
CELF1 CUGBP, Elav-like family member 1 -0.0337197
PHIP pleckstrin homology domain interacting protein -0.0336786
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0335734
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0330118
TPM1 tropomyosin 1 (alpha) -0.032937
RHOBTB3 Rho-related BTB domain containing 3 -0.0325361
RPL34 ribosomal protein L34 -0.032055
SNX9 sorting nexin 9 -0.0320103
RPS15 ribosomal protein S15 -0.0318691
ATP13A3 ATPase type 13A3 -0.0317784
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0317618
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0314406
CD99 CD99 molecule -0.0305274
RPL8 ribosomal protein L8 -0.0304635
CTSB cathepsin B -0.0303634
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -0.0303194
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0300319
MT1X metallothionein 1X -0.0299309
NT5C2 5'-nucleotidase, cytosolic II -0.0298309
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0298069
SFTPA2 surfactant protein A2 -0.0294655
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0290908
RPL28 ribosomal protein L28 -0.0290852
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0289258
RPL38 ribosomal protein L38 -0.0285408
RPS11 ribosomal protein S11 -0.0284606
RPL5 ribosomal protein L5 -0.0282696
CALR calreticulin -0.0282399
CLMP CXADR-like membrane protein -0.0281187
IARS1 isoleucyl-tRNA synthetase 1 -0.0281038
NAP1L1 nucleosome assembly protein 1-like 1 -0.0279569
ASTN2 astrotactin 2 -0.0277107
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0273926
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.0272784
IL6 interleukin 6 -0.0272675
TAOK1 TAO kinase 1 -0.0271985
GGNBP2 gametogenetin binding protein 2 -0.0271496