Tetracycline (hydrochloride)_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tetracycline (hydrochloride) perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tetracycline (hydrochloride)_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VIM vimentin 0.192924
HILPDA hypoxia inducible lipid droplet-associated 0.0621483
RPL23 ribosomal protein L23 0.059304
SMC4 structural maintenance of chromosomes 4 0.0574986
RACK1 receptor for activated C kinase 1 0.0446097
RPS3 ribosomal protein S3 0.0437211
BZW1 basic leucine zipper and W2 domains 1 0.0433838
PKM pyruvate kinase, muscle 0.0420099
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0416626
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0408304
AKAP13 A kinase (PRKA) anchor protein 13 0.0403655
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0403377
RNF145 ring finger protein 145 0.0399734
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0396741
FTH1 ferritin, heavy polypeptide 1 0.0396257
DIAPH3 diaphanous-related formin 3 0.0389362
CSDE1 cold shock domain containing E1, RNA-binding 0.0385834
TPI1 triosephosphate isomerase 1 0.0383602
NAMPT nicotinamide phosphoribosyltransferase 0.0375311
CSNK1A1 casein kinase 1, alpha 1 0.0374318
KIAA1958 KIAA1958 0.0371922
DGKD diacylglycerol kinase, delta 130kDa 0.0370721
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.0363648
MAP3K20 mitogen-activated protein kinase kinase kinase 20 0.0354558
ENO1 enolase 1, (alpha) 0.0353674
RPS12 ribosomal protein S12 0.035356
BRAF B-Raf proto-oncogene, serine/threonine kinase 0.0347848
PNISR PNN-interacting serine/arginine-rich protein 0.0342354
RPS17 ribosomal protein S17 0.0340668
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 0.0334752
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0328359
HMGB1 high mobility group box 1 0.0321933
PDE8A phosphodiesterase 8A 0.0319748
TPM4 tropomyosin 4 0.0319101
NBAS neuroblastoma amplified sequence 0.03179
UBAC2 UBA domain containing 2 0.0312451
PRC1 protein regulator of cytokinesis 1 0.0312321
EEF2 eukaryotic translation elongation factor 2 0.0312048
RPL35 ribosomal protein L35 0.0310669
HLTF helicase-like transcription factor 0.0308052
RPL12 ribosomal protein L12 0.030755
NUP58 nucleoporin 58 0.0304727
RPL7 ribosomal protein L7 0.030341
FTL ferritin, light polypeptide 0.0302498
SKP1 S-phase kinase-associated protein 1 0.030232
CEP295 centrosomal protein 295kDa 0.0299696
NACA nascent polypeptide-associated complex alpha subunit 0.0299524
CAVIN1 caveolae associated protein 1 0.0290511
TOP1 topoisomerase (DNA) I 0.0289781
JMJD1C jumonji domain containing 1C 0.028759
APP amyloid beta (A4) precursor protein 0.0285114
SEPTIN2 septin 2 0.0283305
LCORL ligand dependent nuclear receptor corepressor-like 0.028153
GPR107 G protein-coupled receptor 107 0.0280746
MKI67 marker of proliferation Ki-67 0.0280455
SEC13 SEC13 homolog (S. cerevisiae) 0.0279578
RAD23B RAD23 homolog B (S. cerevisiae) 0.0277765
KIAA1328 KIAA1328 0.027756
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0277111
VDAC1 voltage-dependent anion channel 1 0.0271611
ATXN2L ataxin 2-like 0.0268707
RSF1 remodeling and spacing factor 1 0.02679
TTK TTK protein kinase 0.0265758
TM9SF4 transmembrane 9 superfamily protein member 4 0.0264799
ARHGAP21 Rho GTPase activating protein 21 0.0263065
TUBA1B tubulin, alpha 1b 0.0262757
BRWD3 bromodomain and WD repeat domain containing 3 0.0261048
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.025888
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.0256975
ALKBH5 AlkB family member 5, RNA demethylase 0.0254011
MNAT1 MNAT CDK-activating kinase assembly factor 1 0.0252173
SET SET nuclear proto-oncogene 0.0250438
FAM193A family with sequence similarity 193, member A 0.0250159
TMSB10 thymosin beta 10 0.0249021
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0245935
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.024159
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.023992
RPL13A ribosomal protein L13a 0.0239366
PDIA3 protein disulfide isomerase family A, member 3 0.0239028
CSE1L CSE1 chromosome segregation 1-like (yeast) 0.0238466
RNF213 ring finger protein 213 0.0235846
KDM3A lysine (K)-specific demethylase 3A 0.0235317
FAM216A family with sequence similarity 216, member A 0.0234744
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3 0.023397
SUCO SUN domain containing ossification factor 0.0233581
ZMYND8 zinc finger, MYND-type containing 8 0.0233069
C6ORF62 chromosome 6 open reading frame 62 0.0233015
CREBBP CREB binding protein 0.0232601
RALA v-ral simian leukemia viral oncogene homolog A (ras related) 0.0231844
MED13L mediator complex subunit 13-like 0.0231266
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0231161
TNPO3 transportin 3 0.0230983
RPS8 ribosomal protein S8 0.0229253
RPS28 ribosomal protein S28 0.0228821
SLF1 SMC5-SMC6 complex localization factor 1 0.0226144
CDC25C cell division cycle 25C 0.0225116
CUL3 cullin 3 0.0223741
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0223612
TMBIM4 transmembrane BAX inhibitor motif containing 4 0.0223461
ATL2 atlastin GTPase 2 0.0222113

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.283397
MACF1 microtubule-actin crosslinking factor 1 -0.096675
DST dystonin -0.077126
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.071348
RBM39 RNA binding motif protein 39 -0.0686375
ATM ATM serine/threonine kinase -0.062764
IGFBP3 insulin-like growth factor binding protein 3 -0.0591365
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0587459
SLC38A2 solute carrier family 38, member 2 -0.0574918
UGCG UDP-glucose ceramide glucosyltransferase -0.0566196
CD44 CD44 molecule (Indian blood group) -0.0559754
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0548423
N4BP2L2 NEDD4 binding protein 2-like 2 -0.054391
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0541451
SAMD4A sterile alpha motif domain containing 4A -0.0535519
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0525231
SPAG9 sperm associated antigen 9 -0.0523532
ERBIN erbb2 interacting protein -0.0521909
PALM2AKAP2 PALM2 and AKAP2 fusion -0.051783
AKAP12 A kinase (PRKA) anchor protein 12 -0.0510893
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -0.0505411
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0502272
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0473312
BIRC3 baculoviral IAP repeat containing 3 -0.0472102
IGF2 insulin-like growth factor 2 -0.0472016
ANKRD12 ankyrin repeat domain 12 -0.0458507
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0455744
OSMR oncostatin M receptor -0.0453166
FMNL2 formin-like 2 -0.0451791
GOLGA4 golgin A4 -0.0447709
IARS1 isoleucyl-tRNA synthetase 1 -0.0444439
GOLGB1 golgin B1 -0.0441781
RIGI RNA sensor RIG-I -0.0441353
WNK1 WNK lysine deficient protein kinase 1 -0.0440852
CENPF centromere protein F, 350/400kDa -0.043789
CPNE1 copine I -0.0433014
YBX3 Y box binding protein 3 -0.0422487
TAS2R14 taste receptor, type 2, member 14 -0.0416529
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0412069
TAOK1 TAO kinase 1 -0.0408937
NCEH1 neutral cholesterol ester hydrolase 1 -0.0406482
DOCK4 dedicator of cytokinesis 4 -0.0402383
KMT2A lysine (K)-specific methyltransferase 2A -0.0391842
PICALM phosphatidylinositol binding clathrin assembly protein -0.0391594
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0385257
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0382778
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0377396
ARHGAP26 Rho GTPase activating protein 26 -0.037568
NALCN sodium leak channel, non selective -0.0372189
DDX24 DEAD (Asp-Glu-Ala-Asp) box helicase 24 -0.0371984
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.036983
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 -0.0369463
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0365767
FLNB filamin B, beta -0.0363845
ATP9B ATPase, class II, type 9B -0.0363558
S100A10 S100 calcium binding protein A10 -0.0356566
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0355655
NT5E 5'-nucleotidase, ecto (CD73) -0.0355595
TJP2 tight junction protein 2 -0.0349714
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0347583
PRKCA protein kinase C, alpha -0.0345858
POTEF POTE ankyrin domain family, member F -0.0344938
PTK2 protein tyrosine kinase 2 -0.0342606
OSBPL6 oxysterol binding protein-like 6 -0.0339734
NDRG1 N-myc downstream regulated 1 -0.0339615
GLS2 glutaminase 2 (liver, mitochondrial) -0.0337694
MBNL2 muscleblind-like splicing regulator 2 -0.0336894
AHNAK AHNAK nucleoprotein -0.0336445
SMAD3 SMAD family member 3 -0.0336354
GPC5 glypican 5 -0.0335774
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0334279
FN1 fibronectin 1 -0.0332611
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0332606
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0331023
EXT1 exostosin glycosyltransferase 1 -0.0330953
SETD5 SET domain containing 5 -0.0330934
LMO7 LIM domain 7 -0.032891
CEMIP2 cell migration inducing hyaluronidase 2 -0.0325519
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.032183
FBXL7 F-box and leucine-rich repeat protein 7 -0.0318211
ZBTB38 zinc finger and BTB domain containing 38 -0.0317799
SENP6 SUMO1/sentrin specific peptidase 6 -0.0311346
RAI14 retinoic acid induced 14 -0.031067
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0308842
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0308771
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0304463
MYO9B myosin IXB -0.0303984
FUS FUS RNA binding protein -0.0301652
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0301553
FBXL20 F-box and leucine-rich repeat protein 20 -0.0301355
ANO6 anoctamin 6 -0.0300825
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0299896
EFL1 elongation factor like GTPase 1 -0.0299726
CD2AP CD2-associated protein -0.029944
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.0299087
NRDC nardilysin convertase -0.0298642
JARID2 jumonji, AT rich interactive domain 2 -0.0295431
FOXO3 forkhead box O3 -0.0293516
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0293141
ARFGEF3 ARFGEF family member 3 -0.0292341