Tetracycline (hydrochloride)_SW480 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tetracycline (hydrochloride) perturbation in SW480 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tetracycline (hydrochloride)_SW480 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RPS3 ribosomal protein S3 0.0870077
NKD1 naked cuticle homolog 1 (Drosophila) 0.0855446
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0822004
MAML2 mastermind-like 2 (Drosophila) 0.0813574
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0804687
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0775465
OXR1 oxidation resistance 1 0.0761433
RUNX1 runt-related transcription factor 1 0.0752232
EEF2 eukaryotic translation elongation factor 2 0.0706628
ENO1 enolase 1, (alpha) 0.0678757
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0658961
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0653397
PDE4D phosphodiesterase 4D, cAMP-specific 0.0629968
CEMIP2 cell migration inducing hyaluronidase 2 0.0626887
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0622963
PCLO piccolo presynaptic cytomatrix protein 0.061964
CD46 CD46 molecule, complement regulatory protein 0.0605065
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.058556
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0547962
RPS12 ribosomal protein S12 0.0543095
MYH9 myosin, heavy chain 9, non-muscle 0.052828
DSPP dentin sialophosphoprotein 0.0514784
SPRED2 sprouty-related, EVH1 domain containing 2 0.0506855
MKI67 marker of proliferation Ki-67 0.0503093
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0497105
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0475866
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.046723
ZNF292 zinc finger protein 292 0.0466875
CENPF centromere protein F, 350/400kDa 0.046284
SMC4 structural maintenance of chromosomes 4 0.045313
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0444936
AKAP9 A kinase (PRKA) anchor protein 9 0.0440418
AOPEP aminopeptidase O (putative) 0.0435776
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0434143
CDK8 cyclin-dependent kinase 8 0.0420161
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0419269
PRELID2 PRELI domain containing 2 0.0403493
CDK19 cyclin-dependent kinase 19 0.0384907
DCUN1D3 DCN1, defective in cullin neddylation 1, domain containing 3 0.0368341
PROX1 prospero homeobox 1 0.0358988
PCM1 pericentriolar material 1 0.0358468
PCBP2 poly(rC) binding protein 2 0.0357522
BRWD3 bromodomain and WD repeat domain containing 3 0.0349358
GARS1 glycyl-tRNA synthetase 1 0.0348006
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.03369
HMGB2 high mobility group box 2 0.0329134
KMT2C lysine (K)-specific methyltransferase 2C 0.0324356
PGK1 phosphoglycerate kinase 1 0.0323781
UTRN utrophin 0.0315847
ABHD2 abhydrolase domain containing 2 0.0311593
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.0306942
TXNIP thioredoxin interacting protein 0.0306676
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0305565
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0303926
PEAK1 pseudopodium-enriched atypical kinase 1 0.0300754
PHF3 PHD finger protein 3 0.0300246
WDFY2 WD repeat and FYVE domain containing 2 0.0296528
DDIT4 DNA-damage-inducible transcript 4 0.0296362
RASSF6 Ras association (RalGDS/AF-6) domain family member 6 0.0295066
RPL18 ribosomal protein L18 0.0294511
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0287404
DST dystonin 0.0284788
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0284737
YEATS2 YEATS domain containing 2 0.0284504
RNF43 ring finger protein 43 0.0284386
CCDC82 coiled-coil domain containing 82 0.0282119
EFNB2 ephrin-B2 0.0281891
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.026978
SESN3 sestrin 3 0.0268889
ARGLU1 arginine and glutamate rich 1 0.0266152
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0265531
VGLL4 vestigial-like family member 4 0.0264632
ERRFI1 ERBB receptor feedback inhibitor 1 0.0264382
WDR26 WD repeat domain 26 0.0262621
RPL13A ribosomal protein L13a 0.0260573
WSB1 WD repeat and SOCS box containing 1 0.0260365
ZNF608 zinc finger protein 608 0.0259497
ATXN1 ataxin 1 0.0258936
KIZ kizuna centrosomal protein 0.0255889
USP9X ubiquitin specific peptidase 9, X-linked 0.0254289
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0253467
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0251309
KDM7A lysine (K)-specific demethylase 7A 0.0250798
FOXP1 forkhead box P1 0.0250541
MACC1 metastasis associated in colon cancer 1 0.0249153
ANLN anillin, actin binding protein 0.0248756
YME1L1 YME1-like 1 ATPase 0.024775
LDHA lactate dehydrogenase A 0.0247746
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0245726
MACF1 microtubule-actin crosslinking factor 1 0.0245158
RPS7 ribosomal protein S7 0.0242768
CEMIP cell migration inducing protein, hyaluronan binding 0.0242715
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0242551
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0241663
PTEN phosphatase and tensin homolog 0.024037
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0240357
SVIL supervillin 0.0240309
MED13L mediator complex subunit 13-like 0.0238735
RACK1 receptor for activated C kinase 1 0.023787
WDPCP WD repeat containing planar cell polarity effector 0.0235731

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.134412
CCND1 cyclin D1 -0.132714
RPL35A ribosomal protein L35a -0.124743
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.122667
ACTG1 actin gamma 1 -0.11611
AKAP12 A kinase (PRKA) anchor protein 12 -0.0995361
TPT1 tumor protein, translationally-controlled 1 -0.0956938
NAV2 neuron navigator 2 -0.0815552
ANO1 anoctamin 1, calcium activated chloride channel -0.0719627
TMSB4X thymosin beta 4, X-linked -0.0713473
SDK1 sidekick cell adhesion molecule 1 -0.0702958
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0680859
AHNAK AHNAK nucleoprotein -0.0661702
KRT8 keratin 8, type II -0.0608699
FRMD5 FERM domain containing 5 -0.0524211
S100A10 S100 calcium binding protein A10 -0.0507272
RPS6 ribosomal protein S6 -0.0503872
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0495054
RPS23 ribosomal protein S23 -0.0478423
GMDS GDP-mannose 4,6-dehydratase -0.0474982
CDH13 cadherin 13 -0.0459144
MRPS6 mitochondrial ribosomal protein S6 -0.0453731
HMGA1 high mobility group AT-hook 1 -0.0450582
CDK6 cyclin-dependent kinase 6 -0.0450431
RBP1 retinol binding protein 1, cellular -0.0442653
INTS6 integrator complex subunit 6 -0.0431401
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0417812
EMP1 epithelial membrane protein 1 -0.0407954
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) -0.0401543
DEK DEK proto-oncogene -0.0400123
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0393026
SERBP1 SERPINE1 mRNA binding protein 1 -0.0389054
IPO7 importin 7 -0.0387
RPS19 ribosomal protein S19 -0.0380541
RPS21 ribosomal protein S21 -0.0379946
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.037767
PERP PERP, TP53 apoptosis effector -0.03715
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0371375
SQSTM1 sequestosome 1 -0.0361889
NOP56 NOP56 ribonucleoprotein -0.0356359
UBAP2 ubiquitin associated protein 2 -0.0353957
CD44 CD44 molecule (Indian blood group) -0.0353593
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0353542
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 -0.0343355
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0343152
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.0341551
ASPH aspartate beta-hydroxylase -0.0339972
RPL8 ribosomal protein L8 -0.0338402
RPS24 ribosomal protein S24 -0.0338236
FLNB filamin B, beta -0.0333781
RPS5 ribosomal protein S5 -0.0328488
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0323208
SLC38A2 solute carrier family 38, member 2 -0.032267
ATP5F1B ATP synthase F1 subunit beta -0.0322641
RBMX RNA binding motif protein, X-linked -0.0322135
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0320931
VIM vimentin -0.0320315
RPS8 ribosomal protein S8 -0.0315497
CUX1 cut-like homeobox 1 -0.0312533
UBC ubiquitin C -0.0305091
BACE2 beta-site APP-cleaving enzyme 2 -0.0301786
RPL34 ribosomal protein L34 -0.028897
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.028661
SDC4 syndecan 4 -0.0286379
ASTN2 astrotactin 2 -0.028568
IGFBP3 insulin-like growth factor binding protein 3 -0.0283669
NAP1L4 nucleosome assembly protein 1-like 4 -0.0276255
COBL cordon-bleu WH2 repeat protein -0.0275353
GNL3 guanine nucleotide binding protein-like 3 (nucleolar) -0.0273401
RPL38 ribosomal protein L38 -0.0273079
GSPT1 G1 to S phase transition 1 -0.0271466
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0271139
SF3B3 splicing factor 3b, subunit 3, 130kDa -0.0270071
SKAP1 src kinase associated phosphoprotein 1 -0.0269278
RSL1D1 ribosomal L1 domain containing 1 -0.0267583
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0267474
NPR2 natriuretic peptide receptor 2 -0.0266789
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) -0.026574
TPM4 tropomyosin 4 -0.0261577
VDAC1 voltage-dependent anion channel 1 -0.0260131
WDR43 WD repeat domain 43 -0.0259759
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0257697
PUS7 pseudouridylate synthase 7 (putative) -0.0255704
EIF5B eukaryotic translation initiation factor 5B -0.0255224
NOLC1 nucleolar and coiled-body phosphoprotein 1 -0.0254655
YBX1 Y box binding protein 1 -0.0253149
HMGB1 high mobility group box 1 -0.025292
GLG1 golgi glycoprotein 1 -0.02524
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -0.0251217
NPAS2 neuronal PAS domain protein 2 -0.0250962
YY1 YY1 transcription factor -0.0250415
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.0250145
CBX3 chromobox homolog 3 -0.0250064
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0249732
RPS15 ribosomal protein S15 -0.0249601
UBE3C ubiquitin protein ligase E3C -0.0249067
RPL39 ribosomal protein L39 -0.0247094
VCL vinculin -0.0247047
TFRC transferrin receptor -0.0245775
TUBA1B tubulin, alpha 1b -0.0244128