| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/46199646 |
| Similar Terms | |
| Downloads & Tools |
200 proteins with high or low expression in Tezacaftor relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| C14ORF93 | chromosome 14 open reading frame 93 | 2.89 |
| GRHL1 | grainyhead-like 1 (Drosophila) | 0.91 |
| PER2 | period circadian clock 2 | 0.71 |
| SGSH | N-sulfoglucosamine sulfohydrolase | 0.6 |
| SPTBN5 | spectrin, beta, non-erythrocytic 5 | 0.57 |
| COL6A6 | collagen, type VI, alpha 6 | 0.49 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.49 |
| PIP | prolactin-induced protein | 0.49 |
| JPT1 | Jupiter microtubule associated homolog 1 | 0.47 |
| CYP51A1 | cytochrome P450, family 51, subfamily A, polypeptide 1 | 0.45 |
| LYPLA2 | lysophospholipase II | 0.43 |
| ATXN2 | ataxin 2 | 0.42 |
| C6ORF62 | chromosome 6 open reading frame 62 | 0.41 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | 0.38 |
| TMEM39B | transmembrane protein 39B | 0.37 |
| PRELID3B | PRELI domain containing 3B | 0.35 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | 0.35 |
| ZNF888 | zinc finger protein 888 | 0.33 |
| TRMO | tRNA methyltransferase O | 0.32 |
| TMEM9B | TMEM9 domain family, member B | 0.31 |
| PARP16 | poly (ADP-ribose) polymerase family, member 16 | 0.29 |
| NOS3 | nitric oxide synthase 3 (endothelial cell) | 0.29 |
| HMGB2 | high mobility group box 2 | 0.29 |
| H3C1 | H3 clustered histone 1 | 0.29 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.28 |
| ELOVL6 | ELOVL fatty acid elongase 6 | 0.28 |
| MID1IP1 | MID1 interacting protein 1 | 0.28 |
| PWWP2B | PWWP domain containing 2B | 0.28 |
| USP12 | ubiquitin specific peptidase 12 | 0.28 |
| UBE2J2 | ubiquitin-conjugating enzyme E2, J2 | 0.27 |
| ZNF746 | zinc finger protein 746 | 0.27 |
| CHRNA5 | cholinergic receptor, nicotinic, alpha 5 (neuronal) | 0.27 |
| SMO | smoothened, frizzled class receptor | 0.27 |
| LAMA3 | laminin, alpha 3 | 0.26 |
| SLC3A2 | solute carrier family 3 (amino acid transporter heavy chain), member 2 | 0.26 |
| EIF5A2 | eukaryotic translation initiation factor 5A2 | 0.26 |
| PIMREG | PICALM interacting mitotic regulator | 0.26 |
| DOLK | dolichol kinase | 0.26 |
| STC2 | stanniocalcin 2 | 0.25 |
| TECR | trans-2,3-enoyl-CoA reductase | 0.25 |
| PROS1 | protein S (alpha) | 0.25 |
| SPPL2A | signal peptide peptidase like 2A | 0.25 |
| B4GALT4 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4 | 0.25 |
| ZCCHC24 | zinc finger, CCHC domain containing 24 | 0.24 |
| DNASE1L1 | deoxyribonuclease I-like 1 | 0.24 |
| FOXJ2 | forkhead box J2 | 0.24 |
| TNFRSF12A | tumor necrosis factor receptor superfamily, member 12A | 0.24 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | 0.24 |
| DCAF15 | DDB1 and CUL4 associated factor 15 | 0.23 |
| MICOS10 | mitochondrial contact site and cristae organizing system subunit 10 | 0.23 |
| SPCS1 | signal peptidase complex subunit 1 homolog (S. cerevisiae) | 0.23 |
| DEGS1 | delta(4)-desaturase, sphingolipid 1 | 0.23 |
| MTFP1 | mitochondrial fission process 1 | 0.23 |
| GAS6 | growth arrest-specific 6 | 0.23 |
| ALPK1 | alpha-kinase 1 | 0.23 |
| CMC4 | C-x(9)-C motif containing 4 | 0.23 |
| GNAZ | guanine nucleotide binding protein (G protein), alpha z polypeptide | 0.23 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.23 |
| ZFP36 | ZFP36 ring finger protein | 0.23 |
| FBXL2 | F-box and leucine-rich repeat protein 2 | 0.22 |
| ATP8B1 | ATPase, aminophospholipid transporter, class I, type 8B, member 1 | 0.22 |
| ABHD2 | abhydrolase domain containing 2 | 0.22 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.22 |
| GNG5 | guanine nucleotide binding protein (G protein), gamma 5 | 0.22 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | 0.22 |
| ARMH3 | armadillo like helical domain containing 3 | 0.22 |
| PFDN1 | prefoldin subunit 1 | 0.22 |
| ZNF480 | zinc finger protein 480 | 0.22 |
| ZNF544 | zinc finger protein 544 | 0.21 |
| FAAH2 | fatty acid amide hydrolase 2 | 0.21 |
| PPP3CC | protein phosphatase 3, catalytic subunit, gamma isozyme | 0.21 |
| ERCC6 | excision repair cross-complementation group 6 | 0.21 |
| TM2D3 | TM2 domain containing 3 | 0.21 |
| MARCHF7 | membrane associated ring-CH-type finger 7 | 0.21 |
| DALRD3 | DALR anticodon binding domain containing 3 | 0.21 |
| S100A10 | S100 calcium binding protein A10 | 0.21 |
| N6AMT1 | N-6 adenine-specific DNA methyltransferase 1 (putative) | 0.21 |
| ALG14 | ALG14, UDP-N-acetylglucosaminyltransferase subunit | 0.21 |
| TMEM129 | transmembrane protein 129, E3 ubiquitin protein ligase | 0.21 |
| DCLRE1C | DNA cross-link repair 1C | 0.21 |
| ZNF14 | zinc finger protein 14 | 0.21 |
| C12ORF45 | chromosome 12 open reading frame 45 | 0.21 |
| NIPA1 | non imprinted in Prader-Willi/Angelman syndrome 1 | 0.2 |
| ZNRD1 | zinc ribbon domain containing 1 | 0.2 |
| ATXN7 | ataxin 7 | 0.2 |
| CPA4 | carboxypeptidase A4 | 0.2 |
| AREG | amphiregulin | 0.2 |
| LAMTOR1 | late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 | 0.2 |
| CARD8 | caspase recruitment domain family, member 8 | 0.2 |
| TIMM10B | translocase of inner mitochondrial membrane 10 homolog B (yeast) | 0.2 |
| C2CD3 | C2 calcium-dependent domain containing 3 | 0.2 |
| NKAP | NFKB activating protein | 0.2 |
| LIN37 | lin-37 DREAM MuvB core complex component | 0.19 |
| MKNK2 | MAP kinase interacting serine/threonine kinase 2 | 0.19 |
| C1ORF50 | chromosome 1 open reading frame 50 | 0.19 |
| MCFD2 | multiple coagulation factor deficiency 2 | 0.19 |
| POLH | polymerase (DNA directed), eta | 0.19 |
| COMMD5 | COMM domain containing 5 | 0.19 |
| PDLIM3 | PDZ and LIM domain 3 | 0.19 |
| HSPA1L | heat shock 70kDa protein 1-like | 0.19 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ACTBL2 | actin, beta-like 2 | -0.76 |
| DBNL | drebrin-like | -0.74 |
| DNAH5 | dynein, axonemal, heavy chain 5 | -0.73 |
| PIM1 | Pim-1 proto-oncogene, serine/threonine kinase | -0.7 |
| FGFR2 | fibroblast growth factor receptor 2 | -0.68 |
| CNNM1 | cyclin and CBS domain divalent metal cation transport mediator 1 | -0.59 |
| CCDC73 | coiled-coil domain containing 73 | -0.59 |
| HEXD | hexosaminidase D | -0.57 |
| LRRC58 | leucine rich repeat containing 58 | -0.52 |
| SP140 | SP140 nuclear body protein | -0.51 |
| GJC1 | gap junction protein, gamma 1, 45kDa | -0.46 |
| MTRF1 | mitochondrial translational release factor 1 | -0.43 |
| HEMK1 | HemK methyltransferase family member 1 | -0.43 |
| RNF145 | ring finger protein 145 | -0.43 |
| PROSER3 | proline and serine rich 3 | -0.41 |
| TRAK2 | trafficking protein, kinesin binding 2 | -0.41 |
| KMT2B | lysine (K)-specific methyltransferase 2B | -0.41 |
| CENPI | centromere protein I | -0.4 |
| DISP2 | dispatched homolog 2 (Drosophila) | -0.4 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | -0.4 |
| FBXO10 | F-box protein 10 | -0.4 |
| TMEM65 | transmembrane protein 65 | -0.39 |
| TPM4 | tropomyosin 4 | -0.39 |
| PEX26 | peroxisomal biogenesis factor 26 | -0.39 |
| ASB1 | ankyrin repeat and SOCS box containing 1 | -0.39 |
| PRF1 | perforin 1 (pore forming protein) | -0.38 |
| MED10 | mediator complex subunit 10 | -0.38 |
| SH2B3 | SH2B adaptor protein 3 | -0.37 |
| OGFOD3 | 2-oxoglutarate and iron-dependent oxygenase domain containing 3 | -0.37 |
| BORCS5 | BLOC-1 related complex subunit 5 | -0.37 |
| ANKRD12 | ankyrin repeat domain 12 | -0.37 |
| GALNT13 | polypeptide N-acetylgalactosaminyltransferase 13 | -0.36 |
| SLC49A4 | solute carrier family 49 member 4 | -0.36 |
| CMC1 | C-x(9)-C motif containing 1 | -0.36 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | -0.35 |
| DIPK1B | divergent protein kinase domain 1B | -0.35 |
| NOTCH3 | notch 3 | -0.34 |
| CACNB3 | calcium channel, voltage-dependent, beta 3 subunit | -0.33 |
| FZD1 | frizzled class receptor 1 | -0.33 |
| SUSD1 | sushi domain containing 1 | -0.33 |
| TDRD9 | tudor domain containing 9 | -0.32 |
| ANKRD13B | ankyrin repeat domain 13B | -0.32 |
| KDELR1 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 | -0.32 |
| FAM117B | family with sequence similarity 117, member B | -0.32 |
| NAT1 | N-acetyltransferase 1 (arylamine N-acetyltransferase) | -0.32 |
| ZGRF1 | zinc finger, GRF-type containing 1 | -0.32 |
| CCDC91 | coiled-coil domain containing 91 | -0.31 |
| ZBTB45 | zinc finger and BTB domain containing 45 | -0.31 |
| DXO | decapping exoribonuclease | -0.31 |
| BLOC1S6 | biogenesis of lysosomal organelles complex-1, subunit 6, pallidin | -0.31 |
| CEP44 | centrosomal protein 44kDa | -0.31 |
| RNF115 | ring finger protein 115 | -0.3 |
| C2ORF72 | chromosome 2 open reading frame 72 | -0.3 |
| ZDHHC2 | zinc finger, DHHC-type containing 2 | -0.3 |
| HMBOX1 | homeobox containing 1 | -0.3 |
| CBR3 | carbonyl reductase 3 | -0.3 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.3 |
| ZNF394 | zinc finger protein 394 | -0.29 |
| KHK | ketohexokinase (fructokinase) | -0.29 |
| ZKSCAN2 | zinc finger with KRAB and SCAN domains 2 | -0.29 |
| KIAA0513 | KIAA0513 | -0.29 |
| B4GALNT1 | beta-1,4-N-acetyl-galactosaminyl transferase 1 | -0.29 |
| SH3RF2 | SH3 domain containing ring finger 2 | -0.29 |
| FBXW8 | F-box and WD repeat domain containing 8 | -0.28 |
| FJX1 | four jointed box 1 (Drosophila) | -0.28 |
| SLC12A8 | solute carrier family 12, member 8 | -0.28 |
| B3GNT3 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 | -0.28 |
| BMP1 | bone morphogenetic protein 1 | -0.28 |
| ZNF200 | zinc finger protein 200 | -0.27 |
| MRPL32 | mitochondrial ribosomal protein L32 | -0.27 |
| NOL3 | nucleolar protein 3 (apoptosis repressor with CARD domain) | -0.27 |
| AGPAT1 | 1-acylglycerol-3-phosphate O-acyltransferase 1 | -0.27 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.27 |
| MCOLN3 | mucolipin 3 | -0.27 |
| FAM89A | family with sequence similarity 89, member A | -0.27 |
| NEIL1 | nei endonuclease VIII-like 1 (E. coli) | -0.26 |
| RUFY3 | RUN and FYVE domain containing 3 | -0.26 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.26 |
| HRH1 | histamine receptor H1 | -0.26 |
| PLEKHG5 | pleckstrin homology domain containing, family G (with RhoGef domain) member 5 | -0.26 |
| CXXC5 | CXXC finger protein 5 | -0.26 |
| TNFAIP1 | tumor necrosis factor, alpha-induced protein 1 (endothelial) | -0.26 |
| CLTCL1 | clathrin, heavy chain-like 1 | -0.26 |
| PALB2 | partner and localizer of BRCA2 | -0.26 |
| CDK18 | cyclin-dependent kinase 18 | -0.26 |
| TSPYL2 | TSPY-like 2 | -0.26 |
| DPY30 | dpy-30 homolog (C. elegans) | -0.25 |
| HOXB4 | homeobox B4 | -0.25 |
| ANXA1 | annexin A1 | -0.25 |
| TSPAN9 | tetraspanin 9 | -0.25 |
| TSPAN3 | tetraspanin 3 | -0.25 |
| DHDDS | dehydrodolichyl diphosphate synthase | -0.25 |
| CHRD | chordin | -0.25 |
| ARHGAP22 | Rho GTPase activating protein 22 | -0.25 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | -0.25 |
| GTF2A1 | general transcription factor IIA, 1, 19/37kDa | -0.25 |
| MYH6 | myosin, heavy chain 6, cardiac muscle, alpha | -0.25 |
| EI24 | etoposide induced 2.4 | -0.24 |
| BDH2 | 3-hydroxybutyrate dehydrogenase, type 2 | -0.24 |
| CLTA | clathrin, light chain A | -0.24 |
