Theophylline Gene Set

Dataset CTD Gene-Chemical Interactions
Category physical interactions
Type chemical
Description A dimethylxanthine having the two methyl groups located at positions 1 and 3. It is structurally similar to caffeine and is found in green and black tea. (Chemical Entities of Biological Interest Ontology, CHEBI_28177)
External Link http://ctdbase.org/detail.go?type=chem&acc=D013806
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Genes

334 genes/proteins interacting with the chemical Theophylline from the curated CTD Gene-Chemical Interactions dataset.

Symbol Name
ABHD11 abhydrolase domain containing 11
ACAA1 acetyl-CoA acyltransferase 1
ACOT7 acyl-CoA thioesterase 7
ACTA2 actin, alpha 2, smooth muscle, aorta
ADAMTSL3 ADAMTS-like 3
ADORA1 adenosine A1 receptor
ADRBK2 adrenergic, beta, receptor kinase 2
AFF4 AF4/FMR2 family, member 4
AHCTF1 AT hook containing transcription factor 1
ALG9 ALG9, alpha-1,2-mannosyltransferase
ANKRD13C ankyrin repeat domain 13C
AOC1 amine oxidase, copper containing 1
ARF1 ADP-ribosylation factor 1
ARID2 AT rich interactive domain 2 (ARID, RFX-like)
ARMC8 armadillo repeat containing 8
ARNT aryl hydrocarbon receptor nuclear translocator
ARSB arylsulfatase B
ATPAF2 ATP synthase mitochondrial F1 complex assembly factor 2
ATRX alpha thalassemia/mental retardation syndrome X-linked
AURKB aurora kinase B
AZI2 5-azacytidine induced 2
B3GALNT2 beta-1,3-N-acetylgalactosaminyltransferase 2
B4GALT7 xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7
BAG5 BCL2-associated athanogene 5
BCL2 B-cell CLL/lymphoma 2
BCL7C B-cell CLL/lymphoma 7C
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRE brain and reproductive organ-expressed (TNFRSF1A modulator)
BTG3 BTG family, member 3
C16ORF62 chromosome 16 open reading frame 62
C1ORF43 chromosome 1 open reading frame 43
C2CD5 C2 calcium-dependent domain containing 5
C5 complement component 5
CAND1 cullin-associated and neddylation-dissociated 1
CASP2 caspase 2, apoptosis-related cysteine peptidase
CASP3 caspase 3, apoptosis-related cysteine peptidase
CAT catalase
CCDC130 coiled-coil domain containing 130
CCDC30 coiled-coil domain containing 30
CCDC82 coiled-coil domain containing 82
CCDC93 coiled-coil domain containing 93
CCL2 chemokine (C-C motif) ligand 2
CCND1 cyclin D1
CCSER2 coiled-coil serine-rich protein 2
CD33 CD33 molecule
CD4 CD4 molecule
CDK13 cyclin-dependent kinase 13
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CENPU centromere protein U
CEP63 centrosomal protein 63kDa
CEPT1 choline/ethanolamine phosphotransferase 1
CGA glycoprotein hormones, alpha polypeptide
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin
COQ4 coenzyme Q4
COX5B cytochrome c oxidase subunit Vb
CPM carboxypeptidase M
CPNE1 copine I
CRELD1 cysteine-rich with EGF-like domains 1
CRTC3 CREB regulated transcription coactivator 3
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CSF3 colony stimulating factor 3 (granulocyte)
CSNK1E casein kinase 1, epsilon
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DACT3 dishevelled-binding antagonist of beta-catenin 3
DCBLD1 discoidin, CUB and LCCL domain containing 1
DDI2 DNA-damage inducible 1 homolog 2 (S. cerevisiae)
DHX8 DEAH (Asp-Glu-Ala-His) box polypeptide 8
DLG1 discs, large homolog 1 (Drosophila)
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15
DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4
DOCK4 dedicator of cytokinesis 4
DOLK dolichol kinase
DUSP19 dual specificity phosphatase 19
EGLN3 egl-9 family hypoxia-inducible factor 3
ELP6 elongator acetyltransferase complex subunit 6
EMC3 ER membrane protein complex subunit 3
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
EPG5 ectopic P-granules autophagy protein 5 homolog (C. elegans)
EPS8L1 EPS8-like 1
ERCC5 excision repair cross-complementation group 5
ERF Ets2 repressor factor
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1
ERLIN1 ER lipid raft associated 1
ERLIN2 ER lipid raft associated 2
EXOSC3 exosome component 3
EXOSC4 exosome component 4
FADS3 fatty acid desaturase 3
FAM171B family with sequence similarity 171, member B
FAM194C family with sequence similarity 149 member C
FAM222B family with sequence similarity 222, member B
FBXO8 F-box protein 8
FCHSD2 FCH and double SH3 domains 2
FDXR ferredoxin reductase
FHL3 four and a half LIM domains 3
FIBP fibroblast growth factor (acidic) intracellular binding protein
FIP1L1 factor interacting with PAPOLA and CPSF1
FITM2 fat storage-inducing transmembrane protein 2
FLOT2 flotillin 2
FNBP4 formin binding protein 4
FNTB farnesyltransferase, CAAX box, beta
FOLR1 folate receptor 1 (adult)
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXF2 forkhead box F2
GABARAPL1 GABA(A) receptor-associated protein like 1
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GDF15 growth differentiation factor 15
GGPS1 geranylgeranyl diphosphate synthase 1
GLS glutaminase
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
GNAS GNAS complex locus
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1
GPATCH8 G patch domain containing 8
GRM1 glutamate receptor, metabotropic 1
GRM6 glutamate receptor, metabotropic 6
GSR glutathione reductase
HDAC1 histone deacetylase 1
HDAC2 histone deacetylase 2
HDAC3 histone deacetylase 3
HDC histidine decarboxylase
HELQ helicase, POLQ-like
HEMK1 HemK methyltransferase family member 1
HHLA3 HERV-H LTR-associating 3
HINT1 histidine triad nucleotide binding protein 1
HIST1H3E histone cluster 1, H3e
HIST2H2AA3 histone cluster 2, H2aa3
HIST4H4 histone cluster 4, H4
HM13 histocompatibility (minor) 13
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9)
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14
HTRA2 HtrA serine peptidase 2
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
ICE2 interactor of little elongation complex ELL subunit 2
IDUA iduronidase, alpha-L-
IER2 immediate early response 2
IFNA1 interferon, alpha 1
IFT122 intraflagellar transport 122
IFT57 intraflagellar transport 57
IFT88 intraflagellar transport 88
IKBIP IKBKB interacting protein
IL10 interleukin 10
IL12A interleukin 12A
IL12B interleukin 12B
IL13 interleukin 13
IL18 interleukin 18
IL1B interleukin 1, beta
IL2 interleukin 2
IL2RA interleukin 2 receptor, alpha
IL4 interleukin 4
IL6 interleukin 6
ILK integrin-linked kinase
INIP INTS3 and NABP interacting protein
ITFG1 integrin alpha FG-GAP repeat containing 1
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
ITM2B integral membrane protein 2B
JAK1 Janus kinase 1
KCNC3 potassium channel, voltage gated Shaw related subfamily C, member 3
KCNMB4 potassium channel subfamily M regulatory beta subunit 4
KDM4B lysine (K)-specific demethylase 4B
KIF1B kinesin family member 1B
KIN Kin17 DNA and RNA binding protein
KLHL7 kelch-like family member 7
LAMC1 laminin, gamma 1 (formerly LAMB2)
LHFP lipoma HMGIC fusion partner
LIMK1 LIM domain kinase 1
LIPE lipase, hormone-sensitive
LRRC23 leucine rich repeat containing 23
LSM8 LSM8 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LTB lymphotoxin beta (TNF superfamily, member 3)
LTC4S leukotriene C4 synthase
LTF lactotransferrin
LYPLAL1 lysophospholipase-like 1
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like
MAPK7 mitogen-activated protein kinase 7
MDH1 malate dehydrogenase 1, NAD (soluble)
MED13L mediator complex subunit 13-like
MED16 mediator complex subunit 16
METTL15 methyltransferase like 15
MFSD10 major facilitator superfamily domain containing 10
MGST2 microsomal glutathione S-transferase 2
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type
MPHOSPH6 M-phase phosphoprotein 6
MPO myeloperoxidase
MTG2 mitochondrial ribosome-associated GTPase 2
MTIF3 mitochondrial translational initiation factor 3
MTO1 mitochondrial tRNA translation optimization 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYO19 myosin XIX
N4BP2L2 NEDD4 binding protein 2-like 2
NAPEPLD N-acyl phosphatidylethanolamine phospholipase D
NBEAL1 neurobeachin-like 1
NCK2 NCK adaptor protein 2
NDUFB2 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NLK nemo-like kinase
NNT nicotinamide nucleotide transhydrogenase
NOMO1 NODAL modulator 1
NOS2 nitric oxide synthase 2, inducible
NQO2 NAD(P)H dehydrogenase, quinone 2
NUP50 nucleoporin 50kDa
OCIAD1 OCIA domain containing 1
OTP orthopedia homeobox
PAN3 PAN3 poly(A) specific ribonuclease subunit
PARP1 poly (ADP-ribose) polymerase 1
PCP4L1 Purkinje cell protein 4 like 1
PDSS2 prenyl (decaprenyl) diphosphate synthase, subunit 2
PEX7 peroxisomal biogenesis factor 7
PIAS1 protein inhibitor of activated STAT, 1
PIAS2 protein inhibitor of activated STAT, 2
PICALM phosphatidylinositol binding clathrin assembly protein
PIGC phosphatidylinositol glycan anchor biosynthesis, class C
PITPNB phosphatidylinositol transfer protein, beta
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
POLR1B polymerase (RNA) I polypeptide B, 128kDa
POLR2F polymerase (RNA) II (DNA directed) polypeptide F
POLR3H polymerase (RNA) III (DNA directed) polypeptide H (22.9kD)
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
POMC proopiomelanocortin
PPARA peroxisome proliferator-activated receptor alpha
PPARG peroxisome proliferator-activated receptor gamma
PRIM2 primase, DNA, polypeptide 2 (58kDa)
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRKRA protein kinase, interferon-inducible double stranded RNA dependent activator
PRLR prolactin receptor
PRPF38B pre-mRNA processing factor 38B
PYCR2 pyrroline-5-carboxylate reductase family, member 2
RAB21 RAB21, member RAS oncogene family
RB1 retinoblastoma 1
RBM8A RNA binding motif protein 8A
RC3H1 ring finger and CCCH-type domains 1
RECK reversion-inducing-cysteine-rich protein with kazal motifs
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
REN renin
RFK riboflavin kinase
RFTN1 raftlin, lipid raft linker 1
RHNO1 RAD9-HUS1-RAD1 interacting nuclear orphan 1
RHOT2 ras homolog family member T2
RIC3 RIC3 acetylcholine receptor chaperone
RIPK3 receptor-interacting serine-threonine kinase 3
RMND5A required for meiotic nuclear division 5 homolog A (S. cerevisiae)
RNASET2 ribonuclease T2
SCO2 SCO2 cytochrome c oxidase assembly protein
SECISBP2 SECIS binding protein 2
SELL selectin L
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFTPB surfactant protein B
SH2D2A SH2 domain containing 2A
SH3RF1 SH3 domain containing ring finger 1
SHPRH SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase
SIRT2 sirtuin 2
SLC12A8 solute carrier family 12, member 8
SLC12A9 solute carrier family 12, member 9
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC25A24 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5
SLMAP sarcolemma associated protein
SMAD2 SMAD family member 2
SMAD5 SMAD family member 5
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SMIM7 small integral membrane protein 7
SNAP23 synaptosomal-associated protein, 23kDa
SNX13 sorting nexin 13
SRSF3 serine/arginine-rich splicing factor 3
SST somatostatin
ST3GAL3 ST3 beta-galactoside alpha-2,3-sialyltransferase 3
STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
STK24 serine/threonine kinase 24
STK35 serine/threonine kinase 35
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TAC1 tachykinin, precursor 1
TARS2 threonyl-tRNA synthetase 2, mitochondrial (putative)
TAS2R14 taste receptor, type 2, member 14
TBXAS1 thromboxane A synthase 1 (platelet)
TCF3 transcription factor 3
TEFM transcription elongation factor, mitochondrial
TGFB1 transforming growth factor, beta 1
TMC5 transmembrane channel-like 5
TMED4 transmembrane emp24 protein transport domain containing 4
TMEM106B transmembrane protein 106B
TMEM243 transmembrane protein 243, mitochondrial
TMEM260 transmembrane protein 260
TMEM80 transmembrane protein 80
TMEM87B transmembrane protein 87B
TNF tumor necrosis factor
TNFAIP8 tumor necrosis factor, alpha-induced protein 8
TPP2 tripeptidyl peptidase II
TRIM4 tripartite motif containing 4
TRMT10A tRNA methyltransferase 10 homolog A (S. cerevisiae)
TRMT61A tRNA methyltransferase 61A
TRPM7 transient receptor potential cation channel, subfamily M, member 7
TTC3 tetratricopeptide repeat domain 3
TTLL3 tubulin tyrosine ligase-like family member 3
TTN titin
TUBA1B tubulin, alpha 1b
TUBD1 tubulin, delta 1
UBFD1 ubiquitin family domain containing 1
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative)
UBTF upstream binding transcription factor, RNA polymerase I
UFM1 ubiquitin-fold modifier 1
UVRAG UV radiation resistance associated
VPS26A vacuolar protein sorting 26 homolog A (S. pombe)
VSX1 visual system homeobox 1
WBSCR16 Williams-Beuren syndrome chromosome region 16
WDR20 WD repeat domain 20
WDYHV1 WDYHV motif containing 1
WHAMMP3 WAS protein homolog associated with actin, golgi membranes and microtubules pseudogene 3
WHSC1L1 Wolf-Hirschhorn syndrome candidate 1-like 1
WTAP Wilms tumor 1 associated protein
WWOX WW domain containing oxidoreductase
XYLB xylulokinase homolog (H. influenzae)
YIPF4 Yip1 domain family, member 4
ZBTB18 zinc finger and BTB domain containing 18
ZBTB25 zinc finger and BTB domain containing 25
ZBTB45 zinc finger and BTB domain containing 45
ZCCHC10 zinc finger, CCHC domain containing 10
ZFAND3 zinc finger, AN1-type domain 3
ZFPL1 zinc finger protein-like 1
ZNF24 zinc finger protein 24
ZNF26 zinc finger protein 26
ZNF354A zinc finger protein 354A
ZNF510 zinc finger protein 510
ZNF542P zinc finger protein 542, pseudogene
ZNF700 zinc finger protein 700
ZXDC ZXD family zinc finger C