| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/941651 |
| Similar Terms | |
| Downloads & Tools |
199 proteins with high or low expression in Thiothixene relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NDFIP1 | Nedd4 family interacting protein 1 | 3.09 |
| APOB | apolipoprotein B | 2.8 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | 2.64 |
| NCOA4 | nuclear receptor coactivator 4 | 2.6 |
| NDFIP2 | Nedd4 family interacting protein 2 | 2.56 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 2.54 |
| LAPTM4A | lysosomal protein transmembrane 4 alpha | 2.29 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | 2.25 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 2.12 |
| ITM2B | integral membrane protein 2B | 2.04 |
| MSMO1 | methylsterol monooxygenase 1 | 1.96 |
| FGFBP1 | fibroblast growth factor binding protein 1 | 1.9 |
| IDI1 | isopentenyl-diphosphate delta isomerase 1 | 1.86 |
| TMEM59 | transmembrane protein 59 | 1.83 |
| SQLE | squalene epoxidase | 1.83 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | 1.78 |
| NBR1 | neighbor of BRCA1 gene 1 | 1.7 |
| PCSK9 | proprotein convertase subtilisin/kexin type 9 | 1.67 |
| ACSS2 | acyl-CoA synthetase short-chain family member 2 | 1.65 |
| ITM2C | integral membrane protein 2C | 1.65 |
| SBSN | suprabasin | 1.63 |
| RNF130 | ring finger protein 130 | 1.63 |
| TMEM200A | transmembrane protein 200A | 1.63 |
| IFNGR1 | interferon gamma receptor 1 | 1.58 |
| KCNK5 | potassium channel, two pore domain subfamily K, member 5 | 1.55 |
| LRP10 | low density lipoprotein receptor-related protein 10 | 1.53 |
| FGFR4 | fibroblast growth factor receptor 4 | 1.48 |
| LDLR | low density lipoprotein receptor | 1.42 |
| APOE | apolipoprotein E | 1.42 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | 1.39 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 1.39 |
| RNF149 | ring finger protein 149 | 1.38 |
| LSS | lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) | 1.38 |
| F2RL1 | coagulation factor II (thrombin) receptor-like 1 | 1.37 |
| PSAP | prosaposin | 1.32 |
| SQSTM1 | sequestosome 1 | 1.29 |
| MVK | mevalonate kinase | 1.28 |
| MAP1LC3B2 | microtubule-associated protein 1 light chain 3 beta 2 | 1.27 |
| DHCR7 | 7-dehydrocholesterol reductase | 1.27 |
| HSD17B7 | hydroxysteroid (17-beta) dehydrogenase 7 | 1.27 |
| IL6ST | interleukin 6 signal transducer | 1.26 |
| CYP51A1 | cytochrome P450, family 51, subfamily A, polypeptide 1 | 1.25 |
| CDKN1C | cyclin-dependent kinase inhibitor 1C (p57, Kip2) | 1.23 |
| RNF13 | ring finger protein 13 | 1.22 |
| ACAT2 | acetyl-CoA acetyltransferase 2 | 1.21 |
| TMEM248 | transmembrane protein 248 | 1.17 |
| CALCOCO2 | calcium binding and coiled-coil domain 2 | 1.15 |
| LPIN1 | lipin 1 | 1.15 |
| FDPS | farnesyl diphosphate synthase | 1.13 |
| HGFAC | HGF activator | 1.05 |
| MYRF | myelin regulatory factor | 1.04 |
| ALDOC | aldolase C, fructose-bisphosphate | 1.04 |
| MVD | mevalonate (diphospho) decarboxylase | 1.03 |
| ERG28 | ergosterol biosynthesis 28 homolog | 1.02 |
| NEU1 | sialidase 1 (lysosomal sialidase) | 1.01 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | 1.01 |
| SLC38A2 | solute carrier family 38, member 2 | 1.01 |
| PRF1 | perforin 1 (pore forming protein) | 0.97 |
| UST | uronyl-2-sulfotransferase | 0.97 |
| TSPAN3 | tetraspanin 3 | 0.96 |
| SPINT2 | serine peptidase inhibitor, Kunitz type, 2 | 0.95 |
| SDCBP | syndecan binding protein (syntenin) | 0.94 |
| OSMR | oncostatin M receptor | 0.93 |
| HMOX1 | heme oxygenase 1 | 0.93 |
| ACVR2A | activin A receptor, type IIA | 0.92 |
| FADS1 | fatty acid desaturase 1 | 0.92 |
| PTPRS | protein tyrosine phosphatase, receptor type, S | 0.92 |
| SGCE | sarcoglycan, epsilon | 0.9 |
| SLC16A6 | solute carrier family 16, member 6 | 0.89 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.89 |
| AREG | amphiregulin | 0.89 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | 0.88 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.86 |
| SCNN1A | sodium channel, non voltage gated 1 alpha subunit | 0.86 |
| DHCR24 | 24-dehydrocholesterol reductase | 0.86 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.85 |
| MFGE8 | milk fat globule-EGF factor 8 protein | 0.85 |
| TM7SF2 | transmembrane 7 superfamily member 2 | 0.84 |
| MCL1 | myeloid cell leukemia 1 | 0.84 |
| TMEM185B | transmembrane protein 185B | 0.84 |
| SC5D | sterol-C5-desaturase | 0.83 |
| TMEM135 | transmembrane protein 135 | 0.82 |
| CASP10 | caspase 10, apoptosis-related cysteine peptidase | 0.81 |
| SGMS2 | sphingomyelin synthase 2 | 0.8 |
| PDE9A | phosphodiesterase 9A | 0.8 |
| KCNN4 | potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 | 0.8 |
| SERINC1 | serine incorporator 1 | 0.8 |
| BMPR1A | bone morphogenetic protein receptor, type IA | 0.79 |
| NSDHL | NAD(P) dependent steroid dehydrogenase-like | 0.79 |
| MICA | MHC class I polypeptide-related sequence A | 0.79 |
| DCHS1 | dachsous cadherin-related 1 | 0.78 |
| LYPD3 | LY6/PLAUR domain containing 3 | 0.77 |
| HRH1 | histamine receptor H1 | 0.76 |
| JAG1 | jagged 1 | 0.76 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.76 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.75 |
| DDR1 | discoidin domain receptor tyrosine kinase 1 | 0.75 |
| NPDC1 | neural proliferation, differentiation and control, 1 | 0.75 |
| PRXL2A | peroxiredoxin like 2A | 0.75 |
| ABCB1 | ATP-binding cassette, sub-family B (MDR/TAP), member 1 | 0.74 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ASTE1 | asteroid homolog 1 (Drosophila) | -1.53 |
| ASAH1 | N-acylsphingosine amidohydrolase (acid ceramidase) 1 | -1.08 |
| TLL2 | tolloid-like 2 | -0.94 |
| PMF1 | polyamine-modulated factor 1 | -0.9 |
| CLN5 | ceroid-lipofuscinosis, neuronal 5 | -0.86 |
| RND3 | Rho family GTPase 3 | -0.86 |
| ANKRD39 | ankyrin repeat domain 39 | -0.86 |
| ZNF12 | zinc finger protein 12 | -0.83 |
| PCLO | piccolo presynaptic cytomatrix protein | -0.8 |
| NDUFAF6 | NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 | -0.74 |
| BCL2L12 | BCL2-like 12 (proline rich) | -0.73 |
| SPAG5 | sperm associated antigen 5 | -0.73 |
| SETD9 | SET domain containing 9 | -0.73 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.68 |
| BOD1 | biorientation of chromosomes in cell division 1 | -0.66 |
| CDCA4 | cell division cycle associated 4 | -0.66 |
| CEBPA | CCAAT/enhancer binding protein (C/EBP), alpha | -0.66 |
| COQ7 | coenzyme Q7 homolog, ubiquinone (yeast) | -0.65 |
| YPEL5 | yippee-like 5 (Drosophila) | -0.64 |
| ATP9B | ATPase, class II, type 9B | -0.64 |
| UBE2L6 | ubiquitin-conjugating enzyme E2L 6 | -0.63 |
| ITGB5 | integrin, beta 5 | -0.63 |
| ENO1 | enolase 1, (alpha) | -0.63 |
| ABCA3 | ATP-binding cassette, sub-family A (ABC1), member 3 | -0.62 |
| DONSON | downstream neighbor of SON | -0.62 |
| SET | SET nuclear proto-oncogene | -0.62 |
| HAUS7 | HAUS augmin-like complex, subunit 7 | -0.61 |
| HSBP1 | heat shock factor binding protein 1 | -0.61 |
| ARSK | arylsulfatase family, member K | -0.59 |
| PDSS1 | prenyl (decaprenyl) diphosphate synthase, subunit 1 | -0.58 |
| ISCA2 | iron-sulfur cluster assembly 2 | -0.57 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.57 |
| SIVA1 | SIVA1, apoptosis-inducing factor | -0.56 |
| C12ORF57 | chromosome 12 open reading frame 57 | -0.55 |
| COX10 | COX10 heme A:farnesyltransferase cytochrome c oxidase assembly factor | -0.55 |
| FOXRED2 | FAD-dependent oxidoreductase domain containing 2 | -0.55 |
| CCN1 | cellular communication network factor 1 | -0.54 |
| THAP9 | THAP domain containing 9 | -0.54 |
| MIEN1 | migration and invasion enhancer 1 | -0.54 |
| ANTKMT | adenine nucleotide translocase lysine methyltransferase | -0.54 |
| MALSU1 | mitochondrial assembly of ribosomal large subunit 1 | -0.54 |
| ATP5F1D | ATP synthase F1 subunit delta | -0.53 |
| FANCG | Fanconi anemia, complementation group G | -0.53 |
| ZMYND19 | zinc finger, MYND-type containing 19 | -0.53 |
| NUDT18 | nudix (nucleoside diphosphate linked moiety X)-type motif 18 | -0.52 |
| ZNF57 | zinc finger protein 57 | -0.52 |
| CMC4 | C-x(9)-C motif containing 4 | -0.52 |
| FAM126B | family with sequence similarity 126, member B | -0.52 |
| ANAPC16 | anaphase promoting complex subunit 16 | -0.52 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.52 |
| MTRF1L | mitochondrial translational release factor 1-like | -0.52 |
| TOR1AIP2 | torsin A interacting protein 2 | -0.52 |
| RAD51 | RAD51 recombinase | -0.51 |
| COA4 | cytochrome c oxidase assembly factor 4 homolog (S. cerevisiae) | -0.51 |
| HSCB | HscB mitochondrial iron-sulfur cluster co-chaperone | -0.51 |
| UPRT | uracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae) | -0.5 |
| RNASEH2C | ribonuclease H2, subunit C | -0.5 |
| NAAA | N-acylethanolamine acid amidase | -0.5 |
| CBY1 | chibby homolog 1 (Drosophila) | -0.49 |
| EPDR1 | ependymin related 1 | -0.49 |
| CKS2 | CDC28 protein kinase regulatory subunit 2 | -0.49 |
| SON | SON DNA binding protein | -0.48 |
| CEP72 | centrosomal protein 72kDa | -0.48 |
| MORC4 | MORC family CW-type zinc finger 4 | -0.48 |
| MCOLN3 | mucolipin 3 | -0.48 |
| LCMT1 | leucine carboxyl methyltransferase 1 | -0.47 |
| TRMT112 | tRNA methyltransferase 11-2 homolog (S. cerevisiae) | -0.47 |
| KNSTRN | kinetochore-localized astrin/SPAG5 binding protein | -0.47 |
| MRM2 | mitochondrial rRNA methyltransferase 2 | -0.46 |
| CCNB1 | cyclin B1 | -0.46 |
| USP22 | ubiquitin specific peptidase 22 | -0.46 |
| NUDT8 | nudix (nucleoside diphosphate linked moiety X)-type motif 8 | -0.46 |
| CHTF8 | CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae) | -0.46 |
| E2F7 | E2F transcription factor 7 | -0.46 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.45 |
| ACAD10 | acyl-CoA dehydrogenase family, member 10 | -0.45 |
| BID | BH3 interacting domain death agonist | -0.45 |
| RASSF5 | Ras association (RalGDS/AF-6) domain family member 5 | -0.45 |
| ITGB3BP | integrin beta 3 binding protein (beta3-endonexin) | -0.45 |
| MEST | mesoderm specific transcript | -0.45 |
| ADM | adrenomedullin | -0.44 |
| SYTL2 | synaptotagmin-like 2 | -0.44 |
| TOP1MT | topoisomerase (DNA) I, mitochondrial | -0.44 |
| ZSCAN25 | zinc finger and SCAN domain containing 25 | -0.44 |
| NDUFAF3 | NADH dehydrogenase (ubiquinone) complex I, assembly factor 3 | -0.44 |
| CDK6 | cyclin-dependent kinase 6 | -0.43 |
| TYMS | thymidylate synthetase | -0.43 |
| DESI1 | desumoylating isopeptidase 1 | -0.43 |
| CDC20 | cell division cycle 20 | -0.43 |
| USPL1 | ubiquitin specific peptidase like 1 | -0.43 |
| GALNT5 | polypeptide N-acetylgalactosaminyltransferase 5 | -0.43 |
| LPCAT2 | lysophosphatidylcholine acyltransferase 2 | -0.42 |
| DNAAF2 | dynein, axonemal, assembly factor 2 | -0.42 |
| NEK2 | NIMA-related kinase 2 | -0.42 |
| RCHY1 | ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase | -0.42 |
| NDRG2 | NDRG family member 2 | -0.42 |
| SYTL3 | synaptotagmin-like 3 | -0.42 |
| ZCCHC10 | zinc finger, CCHC domain containing 10 | -0.42 |
| ATPAF1 | ATP synthase mitochondrial F1 complex assembly factor 1 | -0.41 |
