Thrombocytopenia Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A blood platelet disease characterized by low a platelet count in the blood. (Human Disease Ontology, DOID_1588)
External Link https://www.disgenet.org/browser/0/1/0/C0857305
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Genes

157 genes associated with the disease Thrombocytopenia in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ACTB actin, beta
ADAM10 ADAM metallopeptidase domain 10
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13
ANKRD26 ankyrin repeat domain 26
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
APOH apolipoprotein H (beta-2-glycoprotein I)
AQP4 aquaporin 4
ASGR1 asialoglycoprotein receptor 1
BDNF brain-derived neurotrophic factor
BFSP2 beaded filament structural protein 2, phakinin
BMI1 BMI1 proto-oncogene, polycomb ring finger
C6ORF25 chromosome 6 open reading frame 25
CARD9 caspase recruitment domain family, member 9
CAT catalase
CCL2 chemokine (C-C motif) ligand 2
CCR6 chemokine (C-C motif) receptor 6
CD19 CD19 molecule
CD34 CD34 molecule
CD40LG CD40 ligand
CD44 CD44 molecule (Indian blood group)
CD47 CD47 molecule
CD72 CD72 molecule
CD86 CD86 molecule
CIB1 calcium and integrin binding 1 (calmyrin)
CLEC1B C-type lectin domain family 1, member B
CNR1 cannabinoid receptor 1 (brain)
CNR2 cannabinoid receptor 2 (macrophage)
COMMD3-BMI1 COMMD3-BMI1 readthrough
CRP C-reactive protein, pentraxin-related
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL12 chemokine (C-X-C motif) ligand 12
CYCS cytochrome c, somatic
ENG endoglin
ERBB2 erb-b2 receptor tyrosine kinase 2
ETV6 ets variant 6
F2RL3 coagulation factor II (thrombin) receptor-like 3
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64)
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FLI1 Fli-1 proto-oncogene, ETS transcription factor
FLNA filamin A, alpha
FOXP3 forkhead box P3
FYB1 FYN binding protein 1
GATA1 GATA binding protein 1 (globin transcription factor 1)
GATA3 GATA binding protein 3
GEM GTP binding protein overexpressed in skeletal muscle
GFI1B growth factor independent 1B transcription repressor
GP1BA glycoprotein Ib (platelet), alpha polypeptide
GP1BB glycoprotein Ib (platelet), beta polypeptide
GP5 glycoprotein V (platelet)
GP6 glycoprotein VI (platelet)
GP9 glycoprotein IX (platelet)
GRN granulin
HAVCR2 hepatitis A virus cellular receptor 2
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HLA-DOA major histocompatibility complex, class II, DO alpha
HMOX1 heme oxygenase 1
HOXA10 homeobox A10
HOXA11 homeobox A11
HOXD11 homeobox D11
HOXD13 homeobox D13
HPSE heparanase
IDO1 indoleamine 2,3-dioxygenase 1
IFNG interferon, gamma
IL10 interleukin 10
IL11 interleukin 11
IL16 interleukin 16
IL17A interleukin 17A
IL17D interleukin 17D
IL17F interleukin 17F
IL18 interleukin 18
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
IL2 interleukin 2
IL21 interleukin 21
IL23A interleukin 23, alpha subunit p19
IL23R interleukin 23 receptor
IL27 interleukin 27
IL33 interleukin 33
IL37 interleukin 37
IL4 interleukin 4
IL4R interleukin 4 receptor
IL6 interleukin 6
IL9 interleukin 9
INTS8 integrator complex subunit 8
IRAK1 interleukin-1 receptor-associated kinase 1
IRF4 interferon regulatory factor 4
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
JAK2 Janus kinase 2
KIF15 kinesin family member 15
KIR2DS1 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1
KIR2DS5 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 5
KIR3DL1 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1
KIR3DL2 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2
KRT20 keratin 20, type I
LTA lymphotoxin alpha
MASTL microtubule associated serine/threonine kinase-like
MBD2 methyl-CpG binding domain protein 2
MBD4 methyl-CpG binding domain protein 4
MPL MPL proto-oncogene, thrombopoietin receptor
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MYDGF myeloid-derived growth factor
MYH9 myosin, heavy chain 9, non-muscle
NCAM1 neural cell adhesion molecule 1
NELFCD negative elongation factor complex member C/D
NFE2L2 nuclear factor, erythroid 2-like 2
NLRP3 NLR family, pyrin domain containing 3
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
PAEP progestagen-associated endometrial protein
PDCD1 programmed cell death 1
PF4 platelet factor 4
PPARA peroxisome proliferator-activated receptor alpha
PTEN phosphatase and tensin homolog
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTPA protein phosphatase 2 phosphatase activator
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
RBM8A RNA binding motif protein 8A
RHD Rh blood group, D antigen
RUNX1 runt-related transcription factor 1
RUNX3 runt-related transcription factor 3
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SMOC1 SPARC related modular calcium binding 1
SOD1 superoxide dismutase 1, soluble
SON SON DNA binding protein
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT5B signal transducer and activator of transcription 5B
SYK spleen tyrosine kinase
TBX21 T-box 21
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
TG thyroglobulin
TGFB1 transforming growth factor, beta 1
TGFB3 transforming growth factor, beta 3
THPO thrombopoietin
TIMP1 TIMP metallopeptidase inhibitor 1
TLR4 toll-like receptor 4
TNF tumor necrosis factor
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TNFRSF4 tumor necrosis factor receptor superfamily, member 4
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TPO thyroid peroxidase
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VWF von Willebrand factor
WAS Wiskott-Aldrich syndrome
WIPF1 WAS/WASL interacting protein family, member 1
ZFPM1 zinc finger protein, FOG family member 1