Thymol_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Thymol perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Thymol_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.136679
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.127966
AREG amphiregulin 0.119244
VMP1 vacuole membrane protein 1 0.118207
TMEM41B transmembrane protein 41B 0.117044
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.116796
JMJD1C jumonji domain containing 1C 0.102866
MMP12 matrix metallopeptidase 12 0.0996181
ANXA1 annexin A1 0.0976273
PDE4D phosphodiesterase 4D, cAMP-specific 0.0905946
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 0.0653451
ERRFI1 ERBB receptor feedback inhibitor 1 0.0649802
NR5A2 nuclear receptor subfamily 5, group A, member 2 0.063485
TXNRD1 thioredoxin reductase 1 0.0621771
RTN4 reticulon 4 0.0616682
ATP11A ATPase, class VI, type 11A 0.0553252
CSNK1A1 casein kinase 1, alpha 1 0.0539595
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0538918
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0522686
XPO1 exportin 1 0.0502471
SPATS2 spermatogenesis associated, serine-rich 2 0.0497173
PDGFC platelet derived growth factor C 0.0492381
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0490019
USP34 ubiquitin specific peptidase 34 0.0465982
TPM3 tropomyosin 3 0.045022
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0442455
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0441345
RPS12 ribosomal protein S12 0.0438743
EDARADD EDAR-associated death domain 0.0433595
ARL15 ADP-ribosylation factor-like 15 0.0419749
PDE4B phosphodiesterase 4B, cAMP-specific 0.0416219
YAP1 Yes-associated protein 1 0.0412935
STARD4 StAR-related lipid transfer (START) domain containing 4 0.0392302
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0388811
NEBL nebulette 0.0388754
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0378156
MBNL1 muscleblind-like splicing regulator 1 0.035623
ANKRD17 ankyrin repeat domain 17 0.0349879
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0344311
ZBTB20 zinc finger and BTB domain containing 20 0.0341915
CARD16 caspase recruitment domain family, member 16 0.033322
RABGAP1L RAB GTPase activating protein 1-like 0.0332918
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.0331961
PCDH9 protocadherin 9 0.032039
MARCHF4 membrane associated ring-CH-type finger 4 0.0320263
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0317549
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0311716
FBXO11 F-box protein 11 0.0309237
ANXA5 annexin A5 0.0306194
PHF21A PHD finger protein 21A 0.0305242
NCEH1 neutral cholesterol ester hydrolase 1 0.0299275
TBC1D5 TBC1 domain family, member 5 0.0298788
ERBIN erbb2 interacting protein 0.0295436
OSMR oncostatin M receptor 0.0286595
PRKCI protein kinase C, iota 0.0284462
CAMKMT calmodulin-lysine N-methyltransferase 0.028294
SPIRE1 spire-type actin nucleation factor 1 0.0280801
SBF2 SET binding factor 2 0.0272169
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0264441
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 0.0264209
NFE2L1 nuclear factor, erythroid 2-like 1 0.0260978
RAB6A RAB6A, member RAS oncogene family 0.025824
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0257659
TJP1 tight junction protein 1 0.0248624
LGALS12 lectin, galactoside-binding, soluble, 12 0.0247793
WWOX WW domain containing oxidoreductase 0.0246012
EZR ezrin 0.0245584
BCAS3 breast carcinoma amplified sequence 3 0.024224
RPS2 ribosomal protein S2 0.0240127
TBK1 TANK-binding kinase 1 0.0238044
PDIA6 protein disulfide isomerase family A, member 6 0.0237998
PPP4R1 protein phosphatase 4, regulatory subunit 1 0.0237816
NIBAN1 niban apoptosis regulator 1 0.023743
ZFAND3 zinc finger, AN1-type domain 3 0.0237101
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0236619
EXOC6B exocyst complex component 6B 0.023656
TNPO1 transportin 1 0.023341
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0233368
SESN2 sestrin 2 0.0232875
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0230752
WSB1 WD repeat and SOCS box containing 1 0.0229745
CDC42SE2 CDC42 small effector 2 0.0229067
ANKRD28 ankyrin repeat domain 28 0.0228927
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0227367
XPOT exportin, tRNA 0.0226813
EHBP1 EH domain binding protein 1 0.0224722
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0224687
ANKRD12 ankyrin repeat domain 12 0.0223653
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0220988
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1 0.0218835
HIPK3 homeodomain interacting protein kinase 3 0.0218379
TUBB6 tubulin, beta 6 class V 0.0217413
WWTR1 WW domain containing transcription regulator 1 0.0216857
UBE2G1 ubiquitin-conjugating enzyme E2G 1 0.0215736
NUP58 nucleoporin 58 0.0215424
KIF18B kinesin family member 18B 0.0215412
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0214937
CTNND1 catenin (cadherin-associated protein), delta 1 0.0213265
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0212057
AFF1 AF4/FMR2 family, member 1 0.0211339

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.234617
MYL12B myosin, light chain 12B, regulatory -0.101175
ACTG1 actin gamma 1 -0.0995379
PTMA prothymosin, alpha -0.0910687
RPL35A ribosomal protein L35a -0.0855819
TPT1 tumor protein, translationally-controlled 1 -0.0777326
NAP1L1 nucleosome assembly protein 1-like 1 -0.0723827
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0693671
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0670515
ATP5F1B ATP synthase F1 subunit beta -0.0657209
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0570436
IFIH1 interferon induced with helicase C domain 1 -0.0534855
RPS24 ribosomal protein S24 -0.0498831
AHNAK AHNAK nucleoprotein -0.0491789
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0458543
RPS21 ribosomal protein S21 -0.0451794
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0440517
ADIPOR2 adiponectin receptor 2 -0.0432423
RPS19 ribosomal protein S19 -0.0429256
RAB7A RAB7A, member RAS oncogene family -0.0424827
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.0418568
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.041568
RPL23 ribosomal protein L23 -0.0409298
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0395421
H1-0 H1.0 linker histone -0.038249
RPL34 ribosomal protein L34 -0.0359472
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0342242
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0342047
EIF4A2 eukaryotic translation initiation factor 4A2 -0.0335888
CENPF centromere protein F, 350/400kDa -0.0335377
RPL19 ribosomal protein L19 -0.033396
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0328006
RPL11 ribosomal protein L11 -0.0327175
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0323838
EGR1 early growth response 1 -0.0323833
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) -0.0322407
GNAS GNAS complex locus -0.0311588
RPS14 ribosomal protein S14 -0.0309969
PTMS parathymosin -0.0304987
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) -0.0303295
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0295392
HMGA2 high mobility group AT-hook 2 -0.0294675
RPLP0 ribosomal protein, large, P0 -0.0289691
RPS27A ribosomal protein S27a -0.0287717
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0286829
LMO7 LIM domain 7 -0.0286068
INTS6 integrator complex subunit 6 -0.0274864
ECT2 epithelial cell transforming 2 -0.0271919
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0271562
HSPB1 heat shock 27kDa protein 1 -0.0267365
KHSRP KH-type splicing regulatory protein -0.0265305
DST dystonin -0.0265179
TM4SF1 transmembrane 4 L six family member 1 -0.0264212
NOLC1 nucleolar and coiled-body phosphoprotein 1 -0.0258391
RPL12 ribosomal protein L12 -0.0254888
HMGB1 high mobility group box 1 -0.0251468
RPLP1 ribosomal protein, large, P1 -0.0250538
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0242693
RPL9 ribosomal protein L9 -0.0239621
YBX1 Y box binding protein 1 -0.0239132
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.023843
CANX calnexin -0.0236499
KDM3A lysine (K)-specific demethylase 3A -0.0233801
LARP4B La ribonucleoprotein domain family, member 4B -0.0231496
RPS4X ribosomal protein S4, X-linked -0.0231353
CCDC47 coiled-coil domain containing 47 -0.0230889
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0230838
LOC102724023 ES1 protein homolog, mitochondrial -0.0230141
TUBA1B tubulin, alpha 1b -0.0228164
RAD21 RAD21 homolog (S. pombe) -0.0227844
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0224468
CUBN cubilin (intrinsic factor-cobalamin receptor) -0.0223885
RPL32 ribosomal protein L32 -0.0223803
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0223635
RPS9 ribosomal protein S9 -0.021633
RPS5 ribosomal protein S5 -0.0216308
MARCHF6 membrane associated ring-CH-type finger 6 -0.0216029
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.0215459
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.021344
CLPTM1L CLPTM1-like -0.0213023
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0211884
RPL8 ribosomal protein L8 -0.0210358
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit -0.0208745
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0205197
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0204633
CDV3 CDV3 homolog (mouse) -0.0202897
VDAC1 voltage-dependent anion channel 1 -0.0200135
LRRC23 leucine rich repeat containing 23 -0.0199712
RSL1D1 ribosomal L1 domain containing 1 -0.0198814
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0195133
TCP1 t-complex 1 -0.0192729
RPL38 ribosomal protein L38 -0.0192571
MSRB3 methionine sulfoxide reductase B3 -0.0192281
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0190276
TUBB tubulin, beta class I -0.0188986
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.0188335
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0187953
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 -0.0187877
POU2F1 POU class 2 homeobox 1 -0.0187581
AXIN2 axin 2 -0.0187237