Thymol_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Thymol perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Thymol_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NALF1 NALCN channel auxiliary factor 1 0.240697
LSAMP limbic system-associated membrane protein 0.177984
NRG1 neuregulin 1 0.126369
ATXN1 ataxin 1 0.0895111
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0892688
MEF2A myocyte enhancer factor 2A 0.0888364
LINGO2 leucine rich repeat and Ig domain containing 2 0.0797026
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0787827
SMYD3 SET and MYND domain containing 3 0.0782392
PTPRM protein tyrosine phosphatase, receptor type, M 0.0736763
VCL vinculin 0.0696065
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0675066
NREP neuronal regeneration related protein 0.067074
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 0.0665258
DTNA dystrobrevin, alpha 0.0630536
HMGA2 high mobility group AT-hook 2 0.0629259
PTPRD protein tyrosine phosphatase, receptor type, D 0.0605401
FMN1 formin 1 0.0605158
LIMCH1 LIM and calponin homology domains 1 0.0602476
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0593616
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0590764
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0588423
PLAT plasminogen activator, tissue 0.0571359
CUX1 cut-like homeobox 1 0.0560382
PRKCA protein kinase C, alpha 0.0547338
IGFBP3 insulin-like growth factor binding protein 3 0.0537542
CDH10 cadherin 10, type 2 (T2-cadherin) 0.0535197
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0530338
FNDC3B fibronectin type III domain containing 3B 0.0520649
CPED1 cadherin-like and PC-esterase domain containing 1 0.0505304
RPL35A ribosomal protein L35a 0.0504664
PACS1 phosphofurin acidic cluster sorting protein 1 0.0503083
NPAS2 neuronal PAS domain protein 2 0.0501832
NDRG1 N-myc downstream regulated 1 0.0499053
RAD51B RAD51 paralog B 0.0495408
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.04789
PCDH9 protocadherin 9 0.0467476
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 0.0460001
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0446979
PCBP2 poly(rC) binding protein 2 0.0439872
UNC5B unc-5 homolog B (C. elegans) 0.0437915
CRH corticotropin releasing hormone 0.0434147
COL4A5 collagen, type IV, alpha 5 0.0433691
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0431965
RPL5 ribosomal protein L5 0.0427677
DCAF7 DDB1 and CUL4 associated factor 7 0.0423607
TIMP3 TIMP metallopeptidase inhibitor 3 0.0419024
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0418013
TCF12 transcription factor 12 0.0413083
PLPP1 phospholipid phosphatase 1 0.0401366
GATA3 GATA binding protein 3 0.039806
GSE1 Gse1 coiled-coil protein 0.0396889
SLIT2 slit homolog 2 (Drosophila) 0.0394281
CEMIP cell migration inducing protein, hyaluronan binding 0.0388764
ERRFI1 ERBB receptor feedback inhibitor 1 0.0387568
FN1 fibronectin 1 0.0382098
RPS3 ribosomal protein S3 0.0380934
PDS5A PDS5 cohesin associated factor A 0.037817
TBX2 T-box 2 0.0367542
KLHL13 kelch-like family member 13 0.036623
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0364728
TET1 tet methylcytosine dioxygenase 1 0.0363678
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0363487
ZSWIM6 zinc finger, SWIM-type containing 6 0.0361889
PDE4D phosphodiesterase 4D, cAMP-specific 0.0355643
RPS12 ribosomal protein S12 0.0351337
BPTF bromodomain PHD finger transcription factor 0.0350117
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.034647
DPH6 diphthamine biosynthesis 6 0.0341013
RPS8 ribosomal protein S8 0.0337538
TAOK3 TAO kinase 3 0.0337377
NCAM2 neural cell adhesion molecule 2 0.0336739
RPS17 ribosomal protein S17 0.03341
AKAP12 A kinase (PRKA) anchor protein 12 0.0333228
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0332501
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0331372
ADGRB3 adhesion G protein-coupled receptor B3 0.0331356
BBX bobby sox homolog (Drosophila) 0.0330002
RPLP0 ribosomal protein, large, P0 0.0325637
BCAS3 breast carcinoma amplified sequence 3 0.0325367
TRIO trio Rho guanine nucleotide exchange factor 0.0322718
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 0.0319553
CEP95 centrosomal protein 95kDa 0.0318758
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.031836
SDK1 sidekick cell adhesion molecule 1 0.0316848
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0316039
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.0314842
NPAS3 neuronal PAS domain protein 3 0.0312663
CEP112 centrosomal protein 112kDa 0.0312133
RPLP1 ribosomal protein, large, P1 0.0311649
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0311132
MBNL1 muscleblind-like splicing regulator 1 0.0309781
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0308202
THSD7A thrombospondin, type I, domain containing 7A 0.0306134
ENO1 enolase 1, (alpha) 0.0305829
ITGA1 integrin, alpha 1 0.030514
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.030293
FAM13A family with sequence similarity 13, member A 0.0302074
GPC5 glypican 5 0.0301504
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.029977

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.0833527
TLE4 transducin-like enhancer of split 4 -0.0639764
LPIN1 lipin 1 -0.0622308
TENT5A terminal nucleotidyltransferase 5A -0.0549163
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0546966
COL1A1 collagen, type I, alpha 1 -0.0532994
RIGI RNA sensor RIG-I -0.05085
CANX calnexin -0.0502428
CLTC clathrin, heavy chain (Hc) -0.0499939
IGF2 insulin-like growth factor 2 -0.0475105
LMNA lamin A/C -0.0464682
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0462299
KDM3A lysine (K)-specific demethylase 3A -0.0451902
KMT2C lysine (K)-specific methyltransferase 2C -0.0441101
DSCAM Down syndrome cell adhesion molecule -0.0438681
PRRC2C proline-rich coiled-coil 2C -0.0435671
GOLGA4 golgin A4 -0.0416677
IARS1 isoleucyl-tRNA synthetase 1 -0.0405332
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.039865
ITPRID2 ITPR interacting domain containing 2 -0.0397269
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0392837
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.039189
TNRC6B trinucleotide repeat containing 6B -0.0391673
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0388844
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.0375075
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0370467
OXSR1 oxidative stress responsive 1 -0.0365228
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0354793
MYH9 myosin, heavy chain 9, non-muscle -0.0341511
NPEPPS aminopeptidase puromycin sensitive -0.0339966
WDR43 WD repeat domain 43 -0.033784
SP100 SP100 nuclear antigen -0.0337731
SF3B3 splicing factor 3b, subunit 3, 130kDa -0.0335747
TMSB10 thymosin beta 10 -0.0331492
ZFC3H1 zinc finger, C3H1-type containing -0.0330737
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0325519
CD46 CD46 molecule, complement regulatory protein -0.0324654
NUP160 nucleoporin 160kDa -0.0324308
HAND2 heart and neural crest derivatives expressed 2 -0.0322951
SRRM2 serine/arginine repetitive matrix 2 -0.0314815
PSME4 proteasome (prosome, macropain) activator subunit 4 -0.031434
ARF1 ADP-ribosylation factor 1 -0.031289
TLN1 talin 1 -0.0312006
EPRS1 glutamyl-prolyl-tRNA synthetase 1 -0.0310396
XPO1 exportin 1 -0.0303301
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 -0.0301299
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0296371
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 -0.0295042
HMGB2 high mobility group box 2 -0.0292894
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0291303
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0288257
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase -0.0288123
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0284381
APP amyloid beta (A4) precursor protein -0.0284101
RBM39 RNA binding motif protein 39 -0.0284039
FCHSD2 FCH and double SH3 domains 2 -0.0280421
DUSP10 dual specificity phosphatase 10 -0.028021
AHNAK AHNAK nucleoprotein -0.0277834
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0276569
CCDC47 coiled-coil domain containing 47 -0.0276218
TMF1 TATA element modulatory factor 1 -0.0273084
PSD3 pleckstrin and Sec7 domain containing 3 -0.027094
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 -0.0270254
EIF4A2 eukaryotic translation initiation factor 4A2 -0.0268396
TARS1 threonyl-tRNA synthetase 1 -0.0265276
SYT1 synaptotagmin I -0.0264595
MON2 MON2 homolog (S. cerevisiae) -0.0264317
ELF2 E74-like factor 2 (ets domain transcription factor) -0.0262018
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.0261428
THBS1 thrombospondin 1 -0.0259484
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0256031
FTO fat mass and obesity associated -0.0255194
GATAD2B GATA zinc finger domain containing 2B -0.0253151
SNX14 sorting nexin 14 -0.0253121
LTN1 listerin E3 ubiquitin protein ligase 1 -0.0252788
ACIN1 apoptotic chromatin condensation inducer 1 -0.0250168
KMT2E lysine (K)-specific methyltransferase 2E -0.0249468
RPL38 ribosomal protein L38 -0.0249342
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.0248709
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) -0.0248591
YME1L1 YME1-like 1 ATPase -0.0248021
PPP1R15B protein phosphatase 1, regulatory subunit 15B -0.0247782
PDIA3 protein disulfide isomerase family A, member 3 -0.0247763
HDLBP high density lipoprotein binding protein -0.0246348
AUTS2 autism susceptibility candidate 2 -0.0244503
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0240999
RB1CC1 RB1-inducible coiled-coil 1 -0.0240681
SCARB2 scavenger receptor class B, member 2 -0.0239789
UBA2 ubiquitin-like modifier activating enzyme 2 -0.0238487
EPHA7 EPH receptor A7 -0.023588
MARCHF6 membrane associated ring-CH-type finger 6 -0.0234491
SRSF1 serine/arginine-rich splicing factor 1 -0.0234044
RAB21 RAB21, member RAS oncogene family -0.0233612
NIPBL Nipped-B homolog (Drosophila) -0.023326
RPL6 ribosomal protein L6 -0.0232977
LMAN1 lectin, mannose-binding, 1 -0.0231387
NFX1 nuclear transcription factor, X-box binding 1 -0.0230938
AUH AU RNA binding protein/enoyl-CoA hydratase -0.0230344
GRB2 growth factor receptor-bound protein 2 -0.0230049
MAP1B microtubule-associated protein 1B -0.0229641