Thymol_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Thymol perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Thymol_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.120073
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.119511
ZMYND8 zinc finger, MYND-type containing 8 0.0866827
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0860465
RUNX1 runt-related transcription factor 1 0.0814392
UBR2 ubiquitin protein ligase E3 component n-recognin 2 0.0745125
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0740869
EXT1 exostosin glycosyltransferase 1 0.0728981
RHOBTB3 Rho-related BTB domain containing 3 0.0666541
AOPEP aminopeptidase O (putative) 0.0636746
GCLC glutamate-cysteine ligase, catalytic subunit 0.0596898
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0578154
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0566044
ABHD2 abhydrolase domain containing 2 0.0544931
RNF149 ring finger protein 149 0.0536219
LMO7 LIM domain 7 0.0527503
TXNRD1 thioredoxin reductase 1 0.0524479
TSC22D1 TSC22 domain family, member 1 0.0518007
RNF43 ring finger protein 43 0.0512654
PTBP3 polypyrimidine tract binding protein 3 0.0499514
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0497421
TRIM2 tripartite motif containing 2 0.0485324
ITGA6 integrin, alpha 6 0.0456959
IFNGR1 interferon gamma receptor 1 0.0436538
KMT2E lysine (K)-specific methyltransferase 2E 0.0433653
IL20RA interleukin 20 receptor, alpha 0.0431591
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0426313
ANXA4 annexin A4 0.0421757
AHI1 Abelson helper integration site 1 0.0415347
MACC1 metastasis associated in colon cancer 1 0.0402123
FAT1 FAT atypical cadherin 1 0.0398135
TMEM51 transmembrane protein 51 0.0392116
NPEPPS aminopeptidase puromycin sensitive 0.0384366
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0374379
BICRAL BICRA like chromatin remodeling complex associated protein 0.0369559
SIPA1L2 signal-induced proliferation-associated 1 like 2 0.0363143
MYO1E myosin IE 0.0362969
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0362907
XPO1 exportin 1 0.035903
ALCAM activated leukocyte cell adhesion molecule 0.0358051
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0354087
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0352884
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0351574
PHF3 PHD finger protein 3 0.0348355
TMC5 transmembrane channel-like 5 0.0347954
AFF1 AF4/FMR2 family, member 1 0.0343054
FTH1 ferritin, heavy polypeptide 1 0.0338924
NRIP1 nuclear receptor interacting protein 1 0.03353
MYO10 myosin X 0.0331845
PRSS3 protease, serine, 3 0.0331099
ARGLU1 arginine and glutamate rich 1 0.0330703
TXNIP thioredoxin interacting protein 0.0320756
KLF5 Kruppel-like factor 5 (intestinal) 0.0309214
DUSP16 dual specificity phosphatase 16 0.0305767
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 0.0303281
PPARG peroxisome proliferator-activated receptor gamma 0.0302885
SAMD12 sterile alpha motif domain containing 12 0.0302578
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 0.0301747
CSNK1A1 casein kinase 1, alpha 1 0.0299043
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0297608
MEIS2 Meis homeobox 2 0.0297405
TMPRSS4 transmembrane protease, serine 4 0.0290383
CTNND1 catenin (cadherin-associated protein), delta 1 0.0289884
SH3PXD2A SH3 and PX domains 2A 0.0287305
BACE2 beta-site APP-cleaving enzyme 2 0.0285979
ETV6 ets variant 6 0.0281594
DENND4C DENN/MADD domain containing 4C 0.0281502
RBM47 RNA binding motif protein 47 0.0281263
PDIA3 protein disulfide isomerase family A, member 3 0.0281056
CREB3L2 cAMP responsive element binding protein 3-like 2 0.0277904
ARHGAP12 Rho GTPase activating protein 12 0.0276471
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0276326
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0268972
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0263142
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0261623
PLS1 plastin 1 0.0260896
TOX3 TOX high mobility group box family member 3 0.0260357
RREB1 ras responsive element binding protein 1 0.0253604
CMPK1 cytidine monophosphate (UMP-CMP) kinase 1, cytosolic 0.0253583
UBAC2 UBA domain containing 2 0.0251081
RASSF6 Ras association (RalGDS/AF-6) domain family member 6 0.0248637
SPG11 spastic paraplegia 11 (autosomal recessive) 0.0248545
ESYT2 extended synaptotagmin-like protein 2 0.0246568
GCC2 GRIP and coiled-coil domain containing 2 0.0244633
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.0242569
CEP350 centrosomal protein 350kDa 0.0240242
EHF ets homologous factor 0.0240221
TPR translocated promoter region, nuclear basket protein 0.0240151
MATR3 matrin 3 0.0239695
MAP3K20 mitogen-activated protein kinase kinase kinase 20 0.0238889
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.0238334
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0238271
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 0.0238032
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) 0.023801
FNDC3A fibronectin type III domain containing 3A 0.0237521
MEF2A myocyte enhancer factor 2A 0.0234513
PARP4 poly (ADP-ribose) polymerase family, member 4 0.023392
PUM2 pumilio RNA-binding family member 2 0.0232896
CLCN3 chloride channel, voltage-sensitive 3 0.0232124
ATP10B ATPase, class V, type 10B 0.0231607

decreased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 -0.135986
VCL vinculin -0.129804
INTS6 integrator complex subunit 6 -0.12955
EGR1 early growth response 1 -0.123647
RIGI RNA sensor RIG-I -0.118904
LYZ lysozyme -0.118164
STAT1 signal transducer and activator of transcription 1, 91kDa -0.115624
EPSTI1 epithelial stromal interaction 1 (breast) -0.0962004
SP100 SP100 nuclear antigen -0.0960358
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0921577
PTMA prothymosin, alpha -0.0883318
RNF213 ring finger protein 213 -0.0837564
RAB7A RAB7A, member RAS oncogene family -0.0832595
AREG amphiregulin -0.0772797
GMDS GDP-mannose 4,6-dehydratase -0.0724362
TMSB10 thymosin beta 10 -0.0709894
PLSCR1 phospholipid scramblase 1 -0.0682348
IFI6 interferon, alpha-inducible protein 6 -0.0666611
ANKRD10 ankyrin repeat domain 10 -0.0657052
EZR ezrin -0.0646885
PLSCR2 phospholipid scramblase 2 -0.0642843
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 -0.0637278
MX2 MX dynamin-like GTPase 2 -0.061538
TSHZ2 teashirt zinc finger homeobox 2 -0.0604004
TM4SF19 transmembrane 4 L six family member 19 -0.0597393
MX1 MX dynamin-like GTPase 1 -0.0596209
NPSR1 neuropeptide S receptor 1 -0.0587712
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0579607
JUN jun proto-oncogene -0.0571512
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0565327
ANXA2 annexin A2 -0.0553685
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -0.0544549
PMP22 peripheral myelin protein 22 -0.052772
MCL1 myeloid cell leukemia 1 -0.0517784
RABGAP1L RAB GTPase activating protein 1-like -0.0514882
C6ORF132 chromosome 6 open reading frame 132 -0.0507464
TUFT1 tuftelin 1 -0.0499445
RPL35A ribosomal protein L35a -0.0461817
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0417733
IFI27 interferon, alpha-inducible protein 27 -0.0412877
CATSPERB catsper channel auxiliary subunit beta -0.0407958
FBXO39 F-box protein 39 -0.0406159
MCTP1 multiple C2 domains, transmembrane 1 -0.0399512
RPS24 ribosomal protein S24 -0.0390659
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0380296
NABP1 nucleic acid binding protein 1 -0.0379342
TM4SF1 transmembrane 4 L six family member 1 -0.0377306
TNS4 tensin 4 -0.0371675
FOSL1 FOS-like antigen 1 -0.0368459
ACTG1 actin gamma 1 -0.0367282
DDIT3 DNA-damage-inducible transcript 3 -0.0366428
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -0.0346845
RPS19 ribosomal protein S19 -0.0344768
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -0.0339349
XAF1 XIAP associated factor 1 -0.0326605
POTEF POTE ankyrin domain family, member F -0.0325415
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0321737
CCNL1 cyclin L1 -0.0320308
SLC25A25 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25 -0.0319582
RPL23 ribosomal protein L23 -0.0314438
SDC4 syndecan 4 -0.0314147
TJP1 tight junction protein 1 -0.0305656
APOL6 apolipoprotein L, 6 -0.030463
SETX senataxin -0.0301604
CMPK2 cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial -0.0299115
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -0.0296781
GOLGB1 golgin B1 -0.0296524
OASL 2'-5'-oligoadenylate synthetase-like -0.0295861
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0292715
CTSD cathepsin D -0.0288515
RPL34 ribosomal protein L34 -0.0287824
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 -0.0287707
ERBIN erbb2 interacting protein -0.0285165
POU2F2 POU class 2 homeobox 2 -0.0283486
IFIH1 interferon induced with helicase C domain 1 -0.028012
RPLP0 ribosomal protein, large, P0 -0.0279542
KRT18 keratin 18, type I -0.0273499
IFITM3 interferon induced transmembrane protein 3 -0.0271673
HLA-C major histocompatibility complex, class I, C -0.0270147
MORF4L2 mortality factor 4 like 2 -0.0270051
HLA-B major histocompatibility complex, class I, B -0.0264311
KLF6 Kruppel-like factor 6 -0.0263649
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0255
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0254492
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -0.0253429
RPL37 ribosomal protein L37 -0.0251234
HLA-A major histocompatibility complex, class I, A -0.024951
UBC ubiquitin C -0.0248634
RPL9 ribosomal protein L9 -0.0248508
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0247525
SERF2 small EDRK-rich factor 2 -0.0245627
RPL11 ribosomal protein L11 -0.0245438
PERP PERP, TP53 apoptosis effector -0.0244237
SHB Src homology 2 domain containing adaptor protein B -0.0235945
TMSB4X thymosin beta 4, X-linked -0.0234498
RPLP1 ribosomal protein, large, P1 -0.0232844
TUBB4B tubulin, beta 4B class IVb -0.0230194
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0226446
ACTN4 actinin, alpha 4 -0.0226369
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae) -0.0225807