Thymol_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Thymol perturbation in HS-578T cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Thymol_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 0.370269
NDRG1 N-myc downstream regulated 1 0.139417
MT2A metallothionein 2A 0.134527
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.103421
TRIO trio Rho guanine nucleotide exchange factor 0.10168
VEGFA vascular endothelial growth factor A 0.0968648
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0933587
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0773895
CD44 CD44 molecule (Indian blood group) 0.07472
COL6A3 collagen, type VI, alpha 3 0.0645667
FNDC3B fibronectin type III domain containing 3B 0.0643514
ARRDC3 arrestin domain containing 3 0.0601678
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0586454
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0580189
ATP13A3 ATPase type 13A3 0.0574981
CADM1 cell adhesion molecule 1 0.0553509
NAV2 neuron navigator 2 0.0541857
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0500944
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0498042
RUNX1 runt-related transcription factor 1 0.0496857
ZNF292 zinc finger protein 292 0.046266
MYO10 myosin X 0.0457933
CXCL8 chemokine (C-X-C motif) ligand 8 0.0440304
JARID2 jumonji, AT rich interactive domain 2 0.0417918
EGFR epidermal growth factor receptor 0.0408322
LDHA lactate dehydrogenase A 0.038965
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0388637
LIMS1 LIM and senescent cell antigen-like domains 1 0.0386992
DLG1 discs, large homolog 1 (Drosophila) 0.0386801
MARCKS myristoylated alanine-rich protein kinase C substrate 0.0385127
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0384073
PDE10A phosphodiesterase 10A 0.0382354
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.036627
TRAM1 translocation associated membrane protein 1 0.0366228
ANXA5 annexin A5 0.036399
SPAG9 sperm associated antigen 9 0.0362031
RPS6 ribosomal protein S6 0.0355856
RICTOR RPTOR independent companion of MTOR, complex 2 0.0349684
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0349425
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0347436
PDIA6 protein disulfide isomerase family A, member 6 0.0347302
POSTN periostin, osteoblast specific factor 0.0344888
GRB10 growth factor receptor-bound protein 10 0.0343101
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0335774
ESYT2 extended synaptotagmin-like protein 2 0.0332597
VCAN versican 0.0331136
KMT2E lysine (K)-specific methyltransferase 2E 0.0330854
CDH13 cadherin 13 0.0327973
RND3 Rho family GTPase 3 0.0326298
UBA6 ubiquitin-like modifier activating enzyme 6 0.0319157
NFE2L1 nuclear factor, erythroid 2-like 1 0.0317362
TMEM165 transmembrane protein 165 0.0316865
PTK2 protein tyrosine kinase 2 0.0313819
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0308307
MED13L mediator complex subunit 13-like 0.0293929
ANXA2 annexin A2 0.0289003
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0286552
ELL2 elongation factor, RNA polymerase II, 2 0.0283285
SDC2 syndecan 2 0.0280412
FN1 fibronectin 1 0.0280178
HILPDA hypoxia inducible lipid droplet-associated 0.027575
FAM13A family with sequence similarity 13, member A 0.0274627
CXCL3 chemokine (C-X-C motif) ligand 3 0.0273225
RYBP RING1 and YY1 binding protein 0.0267496
ERRFI1 ERBB receptor feedback inhibitor 1 0.0265988
ALCAM activated leukocyte cell adhesion molecule 0.0265679
BHLHE40 basic helix-loop-helix family, member e40 0.026494
SETD5 SET domain containing 5 0.0264766
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 0.0263537
WWTR1 WW domain containing transcription regulator 1 0.0262709
YBX1 Y box binding protein 1 0.0262556
RLF rearranged L-myc fusion 0.0255255
B2M beta-2-microglobulin 0.0253755
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0251374
SNX9 sorting nexin 9 0.0249568
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0248939
FXR1 fragile X mental retardation, autosomal homolog 1 0.0248522
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0247072
MRTFA myocardin related transcription factor A 0.0241658
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0240739
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0239485
TLN1 talin 1 0.0239295
DSTN destrin (actin depolymerizing factor) 0.0237509
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0237203
HAS2 hyaluronan synthase 2 0.0234811
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0232518
SH3PXD2B SH3 and PX domains 2B 0.023235
SHB Src homology 2 domain containing adaptor protein B 0.0231088
HIPK2 homeodomain interacting protein kinase 2 0.0230664
QKI QKI, KH domain containing, RNA binding 0.022949
FTH1 ferritin, heavy polypeptide 1 0.0229001
FOSL1 FOS-like antigen 1 0.0228326
USP3 ubiquitin specific peptidase 3 0.0227167
DPYSL2 dihydropyrimidinase-like 2 0.0226946
FYN FYN proto-oncogene, Src family tyrosine kinase 0.0226697
RNF24 ring finger protein 24 0.0224221
PKM pyruvate kinase, muscle 0.0224186
ZFAND3 zinc finger, AN1-type domain 3 0.0223985
LOX lysyl oxidase 0.0223712
SOD2 superoxide dismutase 2, mitochondrial 0.0223423

decreased expression

Symbol Name Standardized Value
COL1A1 collagen, type I, alpha 1 -0.256062
TMSB10 thymosin beta 10 -0.108233
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.083115
TPT1 tumor protein, translationally-controlled 1 -0.0576485
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.05486
RPL35A ribosomal protein L35a -0.0519783
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0509028
PTMA prothymosin, alpha -0.0467748
VCL vinculin -0.0461371
IER3 immediate early response 3 -0.0424669
RRBP1 ribosome binding protein 1 -0.0421916
AHNAK AHNAK nucleoprotein -0.0388398
HLA-B major histocompatibility complex, class I, B -0.0374003
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0361586
F3 coagulation factor III (thromboplastin, tissue factor) -0.0350195
EXT1 exostosin glycosyltransferase 1 -0.0346921
CLIC4 chloride intracellular channel 4 -0.0341955
PDE4D phosphodiesterase 4D, cAMP-specific -0.0336682
TPM4 tropomyosin 4 -0.0336078
DPYD dihydropyrimidine dehydrogenase -0.0332054
TRPS1 trichorhinophalangeal syndrome I -0.032134
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0305184
COL7A1 collagen, type VII, alpha 1 -0.0298939
PRELID2 PRELI domain containing 2 -0.0295429
RPS24 ribosomal protein S24 -0.0284916
CAVIN1 caveolae associated protein 1 -0.0274787
PALLD palladin, cytoskeletal associated protein -0.026564
FBN1 fibrillin 1 -0.0265381
COL5A1 collagen, type V, alpha 1 -0.0259163
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0258298
PSD3 pleckstrin and Sec7 domain containing 3 -0.0250725
PDIA5 protein disulfide isomerase family A, member 5 -0.0250099
COL3A1 collagen, type III, alpha 1 -0.0248419
TMSB4X thymosin beta 4, X-linked -0.0246063
EGR1 early growth response 1 -0.0243499
CALD1 caldesmon 1 -0.0242856
RPS25 ribosomal protein S25 -0.0239779
ASPH aspartate beta-hydroxylase -0.0235898
PDLIM5 PDZ and LIM domain 5 -0.0234972
PTPRF protein tyrosine phosphatase, receptor type, F -0.0234559
EBF1 early B-cell factor 1 -0.0226304
CD63 CD63 molecule -0.0222396
GOLGB1 golgin B1 -0.0218962
RPL34 ribosomal protein L34 -0.0216476
COL6A2 collagen, type VI, alpha 2 -0.0215928
ENO2 enolase 2 (gamma, neuronal) -0.0213937
SLC38A2 solute carrier family 38, member 2 -0.0213103
CANX calnexin -0.0210593
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0208459
TM4SF1 transmembrane 4 L six family member 1 -0.020577
HMGA2 high mobility group AT-hook 2 -0.0202828
RPS13 ribosomal protein S13 -0.0201958
COL1A2 collagen, type I, alpha 2 -0.0189019
TMEM263 transmembrane protein 263 -0.0187017
OSMR oncostatin M receptor -0.0186794
ACTG1 actin gamma 1 -0.0181854
SPDYA speedy/RINGO cell cycle regulator family member A -0.0181531
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0181205
MYDGF myeloid-derived growth factor -0.0180351
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0180143
WNT2B wingless-type MMTV integration site family, member 2B -0.0179138
FAM20C family with sequence similarity 20, member C -0.0178735
GLRX glutaredoxin (thioltransferase) -0.0174026
GLIS3 GLIS family zinc finger 3 -0.0171364
PLEC plectin -0.0170602
NREP neuronal regeneration related protein -0.0169686
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0167496
SEC61G Sec61 gamma subunit -0.0166221
MYO1E myosin IE -0.0165764
LMNA lamin A/C -0.0165737
HM13 histocompatibility (minor) 13 -0.0165604
BBS9 Bardet-Biedl syndrome 9 -0.0165069
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0164477
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.016202
ATG7 autophagy related 7 -0.0161336
INTS6 integrator complex subunit 6 -0.0160494
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0157206
PGK1 phosphoglycerate kinase 1 -0.0155861
CCDC47 coiled-coil domain containing 47 -0.0155563
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0154646
HLA-C major histocompatibility complex, class I, C -0.0154344
ATF4 activating transcription factor 4 -0.0153498
COL5A2 collagen, type V, alpha 2 -0.0153099
RPS8 ribosomal protein S8 -0.0151507
LAMB3 laminin, beta 3 -0.0150023
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0148766
RPL9 ribosomal protein L9 -0.0148481
FHL2 four and a half LIM domains 2 -0.014705
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0145551
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0143545
VIM vimentin -0.0143543
TNS3 tensin 3 -0.0143386
IFI6 interferon, alpha-inducible protein 6 -0.0143154
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.014297
KDM4B lysine (K)-specific demethylase 4B -0.0142435
RPL23 ribosomal protein L23 -0.0141844
GANAB glucosidase, alpha; neutral AB -0.0141738
GNAS GNAS complex locus -0.0141223
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 -0.0140057
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0139961