Thymol_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Thymol perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Thymol_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 0.279241
IGFBP1 insulin-like growth factor binding protein 1 0.182707
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.127258
ATXN1 ataxin 1 0.100754
SVIL supervillin 0.0929557
SAMD4A sterile alpha motif domain containing 4A 0.0891362
PDLIM5 PDZ and LIM domain 5 0.0844552
ERRFI1 ERBB receptor feedback inhibitor 1 0.0809112
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0779829
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0738295
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0735063
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0656996
HMGA1 high mobility group AT-hook 1 0.0647596
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0623054
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0616939
MBNL1 muscleblind-like splicing regulator 1 0.05684
FNDC3B fibronectin type III domain containing 3B 0.0559202
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0552834
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0541142
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.0527637
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 0.0523892
MBNL2 muscleblind-like splicing regulator 2 0.0514704
DTNA dystrobrevin, alpha 0.0510461
DLC1 DLC1 Rho GTPase activating protein 0.0500327
GK glycerol kinase 0.0477194
ANXA5 annexin A5 0.0465669
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0461213
SBF2 SET binding factor 2 0.0442558
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0415751
AHR aryl hydrocarbon receptor 0.0415464
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0409936
CCL20 chemokine (C-C motif) ligand 20 0.0405648
ZNF292 zinc finger protein 292 0.0403078
PAWR PRKC, apoptosis, WT1, regulator 0.0398572
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 0.039705
FAM13A family with sequence similarity 13, member A 0.039093
STK17A serine/threonine kinase 17a 0.0378158
KYNU kynureninase 0.0372437
FMNL2 formin-like 2 0.0364025
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0361995
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0359998
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0359902
TIMP1 TIMP metallopeptidase inhibitor 1 0.0358347
RASA2 RAS p21 protein activator 2 0.0356038
TRIO trio Rho guanine nucleotide exchange factor 0.035584
ITCH itchy E3 ubiquitin protein ligase 0.035308
ZFAND3 zinc finger, AN1-type domain 3 0.0351953
WWTR1 WW domain containing transcription regulator 1 0.034628
EPS8 epidermal growth factor receptor pathway substrate 8 0.0343602
RASGRF2 Ras protein-specific guanine nucleotide-releasing factor 2 0.0342831
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0342355
ENO1 enolase 1, (alpha) 0.0340306
KMT2E lysine (K)-specific methyltransferase 2E 0.0339944
BHLHE40 basic helix-loop-helix family, member e40 0.0339393
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0337881
EXT1 exostosin glycosyltransferase 1 0.0334969
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0331181
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0330709
PARD3 par-3 family cell polarity regulator 0.0327126
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0324928
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0324312
OSBPL10 oxysterol binding protein-like 10 0.0322665
FTH1 ferritin, heavy polypeptide 1 0.0320578
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0315728
MYO6 myosin VI 0.0313465
FAT1 FAT atypical cadherin 1 0.0313347
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0311796
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.030669
SCAF11 SR-related CTD-associated factor 11 0.0304417
AKAP13 A kinase (PRKA) anchor protein 13 0.0299035
AKAP9 A kinase (PRKA) anchor protein 9 0.0292965
ENAH enabled homolog (Drosophila) 0.0291725
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 0.0289837
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0289828
NDRG1 N-myc downstream regulated 1 0.0285797
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0285353
WWC2 WW and C2 domain containing 2 0.0283024
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0282472
ESYT2 extended synaptotagmin-like protein 2 0.0282263
UBE2R2 ubiquitin-conjugating enzyme E2R 2 0.0280283
BAIAP2L1 BAI1-associated protein 2-like 1 0.0278882
PALLD palladin, cytoskeletal associated protein 0.027268
RNF145 ring finger protein 145 0.0272425
RAI14 retinoic acid induced 14 0.0272038
RPL5 ribosomal protein L5 0.0268535
VEGFA vascular endothelial growth factor A 0.0267477
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0267436
RUNX1 runt-related transcription factor 1 0.0266537
WDFY2 WD repeat and FYVE domain containing 2 0.0266315
FOXP1 forkhead box P1 0.0264195
TRIM33 tripartite motif containing 33 0.026328
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0262488
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.026167
PTK2 protein tyrosine kinase 2 0.0260311
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0260168
ARHGAP21 Rho GTPase activating protein 21 0.0259573
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 0.0257623
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0257582
LRRC1 leucine rich repeat containing 1 0.0256863
FAM107B family with sequence similarity 107, member B 0.0256314

decreased expression

Symbol Name Standardized Value
APOB apolipoprotein B -0.202774
C3 complement component 3 -0.165525
TMSB10 thymosin beta 10 -0.098291
APOA2 apolipoprotein A-II -0.0909244
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0820266
RBM39 RNA binding motif protein 39 -0.0742738
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0655685
PEG3 paternally expressed 3 -0.0648068
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0592901
SDC4 syndecan 4 -0.0588245
MYH9 myosin, heavy chain 9, non-muscle -0.0575767
NKD1 naked cuticle homolog 1 (Drosophila) -0.0548174
PDGFB platelet-derived growth factor beta polypeptide -0.0526939
FN1 fibronectin 1 -0.0524632
RPS21 ribosomal protein S21 -0.0516945
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0492852
GPC3 glypican 3 -0.0492747
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.045488
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0451569
RPL11 ribosomal protein L11 -0.0446581
PTMA prothymosin, alpha -0.0443407
RIGI RNA sensor RIG-I -0.0431796
CANX calnexin -0.0415976
TRIM26 tripartite motif containing 26 -0.0413069
GPAM glycerol-3-phosphate acyltransferase, mitochondrial -0.0402713
EGR1 early growth response 1 -0.0402583
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0396349
MBNL3 muscleblind-like splicing regulator 3 -0.0386059
TM9SF3 transmembrane 9 superfamily member 3 -0.038263
RRBP1 ribosome binding protein 1 -0.0382628
TPT1 tumor protein, translationally-controlled 1 -0.0381696
RPS12 ribosomal protein S12 -0.0375712
CLTC clathrin, heavy chain (Hc) -0.0366448
RNF213 ring finger protein 213 -0.0360532
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0345145
APOE apolipoprotein E -0.0343148
ISG15 ISG15 ubiquitin-like modifier -0.0342227
RPL3 ribosomal protein L3 -0.0338075
GPC6 glypican 6 -0.0324521
RPL26 ribosomal protein L26 -0.0321695
DNAH17 dynein, axonemal, heavy chain 17 -0.031433
RPS2 ribosomal protein S2 -0.0310355
AMBP alpha-1-microglobulin/bikunin precursor -0.0309895
GMDS GDP-mannose 4,6-dehydratase -0.0309306
AHNAK AHNAK nucleoprotein -0.0308514
A2M alpha-2-macroglobulin -0.0308479
RPL9 ribosomal protein L9 -0.0301348
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0300202
CP ceruloplasmin (ferroxidase) -0.0300024
SEPTIN9 septin 9 -0.0292163
LYZ lysozyme -0.0290942
CTSB cathepsin B -0.0283465
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 -0.0281914
PAPOLA poly(A) polymerase alpha -0.0281086
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0278605
MT1X metallothionein 1X -0.0268392
MAPK13 mitogen-activated protein kinase 13 -0.0266219
RPL23 ribosomal protein L23 -0.0265921
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 -0.0265613
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.0264945
CFB complement factor B -0.0264046
WNK1 WNK lysine deficient protein kinase 1 -0.0261568
ABTB3 ankyrin repeat and BTB domain containing 3 -0.0261522
RPS19 ribosomal protein S19 -0.0259903
MX2 MX dynamin-like GTPase 2 -0.0257159
RPL4 ribosomal protein L4 -0.0256479
IFI6 interferon, alpha-inducible protein 6 -0.025379
RNASET2 ribonuclease T2 -0.0253323
FBF1 Fas (TNFRSF6) binding factor 1 -0.02514
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.0248487
H1-0 H1.0 linker histone -0.0247681
TUFT1 tuftelin 1 -0.0246712
CALD1 caldesmon 1 -0.0245538
RPL19 ribosomal protein L19 -0.0243033
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0242003
DSPP dentin sialophosphoprotein -0.0238355
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.0237079
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0232734
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.0230345
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.0230123
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0228736
ICAM1 intercellular adhesion molecule 1 -0.0224915
SET SET nuclear proto-oncogene -0.022484
SLC38A2 solute carrier family 38, member 2 -0.0224709
JUN jun proto-oncogene -0.0224692
PROS1 protein S (alpha) -0.0222171
EIF1 eukaryotic translation initiation factor 1 -0.0221009
PRRC2B proline-rich coiled-coil 2B -0.0219181
PEG10 paternally expressed 10 -0.0216985
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -0.0214244
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -0.0213916
ENO2 enolase 2 (gamma, neuronal) -0.0213489
RPL38 ribosomal protein L38 -0.0211455
SDC2 syndecan 2 -0.0211053
LMCD1 LIM and cysteine-rich domains 1 -0.0210361
SRSF11 serine/arginine-rich splicing factor 11 -0.0210208
LARP4B La ribonucleoprotein domain family, member 4B -0.0209592
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like -0.0207918
MT2A metallothionein 2A -0.0205918
ATP5F1B ATP synthase F1 subunit beta -0.0204872