Thymol_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Thymol perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Thymol_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MEF2A myocyte enhancer factor 2A 0.159118
NDRG1 N-myc downstream regulated 1 0.155251
MTSS1 metastasis suppressor 1 0.136227
CLU clusterin 0.11079
LMO7 LIM domain 7 0.107329
MYOF myoferlin 0.105912
CD44 CD44 molecule (Indian blood group) 0.102477
MSN moesin 0.101689
FLNB filamin B, beta 0.0990353
MBNL1 muscleblind-like splicing regulator 1 0.0932973
TRIO trio Rho guanine nucleotide exchange factor 0.0854309
RICTOR RPTOR independent companion of MTOR, complex 2 0.0829674
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0820639
FOXO1 forkhead box O1 0.0790812
TGM2 transglutaminase 2 0.0737834
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0728198
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0699968
SULF1 sulfatase 1 0.0658766
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0648173
PLS3 plastin 3 0.0628133
ESYT2 extended synaptotagmin-like protein 2 0.0623432
ANXA1 annexin A1 0.0614606
KTN1 kinectin 1 (kinesin receptor) 0.0570337
KMT2E lysine (K)-specific methyltransferase 2E 0.0565905
TXNIP thioredoxin interacting protein 0.0558705
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0535784
FTH1 ferritin, heavy polypeptide 1 0.0535071
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.052873
RNASEH2A ribonuclease H2, subunit A 0.0528376
EMP1 epithelial membrane protein 1 0.0517896
GOLGA4 golgin A4 0.0515464
ITCH itchy E3 ubiquitin protein ligase 0.0514777
PTK2 protein tyrosine kinase 2 0.0502585
ENO1 enolase 1, (alpha) 0.0502115
ITGA6 integrin, alpha 6 0.0495547
SAMD9 sterile alpha motif domain containing 9 0.049007
FOXP1 forkhead box P1 0.0472092
BCL2L1 BCL2-like 1 0.0459406
AKAP9 A kinase (PRKA) anchor protein 9 0.0458182
EZR ezrin 0.0452085
RIN2 Ras and Rab interactor 2 0.0432079
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0428361
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0426309
ARRDC3 arrestin domain containing 3 0.0425837
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0421867
STC1 stanniocalcin 1 0.0416602
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0413484
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0411144
DOK5 docking protein 5 0.0406786
LOC112694756 uncharaterized LOC112694756 0.0402984
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0402843
AOPEP aminopeptidase O (putative) 0.039807
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.039499
FN1 fibronectin 1 0.0394056
TPM3 tropomyosin 3 0.0393652
SBF2 SET binding factor 2 0.0388091
ANXA5 annexin A5 0.0386424
SLK STE20-like kinase 0.0386403
EXT1 exostosin glycosyltransferase 1 0.0377738
SULF2 sulfatase 2 0.037643
ACTN4 actinin, alpha 4 0.0375546
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.037286
ARHGAP29 Rho GTPase activating protein 29 0.0369271
BHLHE40 basic helix-loop-helix family, member e40 0.0369084
FNDC3B fibronectin type III domain containing 3B 0.0365313
PDE4D phosphodiesterase 4D, cAMP-specific 0.0364667
NAMPT nicotinamide phosphoribosyltransferase 0.0364131
CDKN2A cyclin-dependent kinase inhibitor 2A 0.0362067
CSNK1A1 casein kinase 1, alpha 1 0.0361922
PARP4 poly (ADP-ribose) polymerase family, member 4 0.0360759
CALB1 calbindin 1, 28kDa 0.0356301
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 0.0356117
LNPEP leucyl/cystinyl aminopeptidase 0.0354067
DPYD dihydropyrimidine dehydrogenase 0.0353319
SMAD3 SMAD family member 3 0.0352789
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.034872
ARHGAP21 Rho GTPase activating protein 21 0.0341609
CAV1 caveolin 1, caveolae protein, 22kDa 0.0337002
AKAP13 A kinase (PRKA) anchor protein 13 0.0332216
KLF5 Kruppel-like factor 5 (intestinal) 0.0332044
MBNL2 muscleblind-like splicing regulator 2 0.0330197
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.03295
PALLD palladin, cytoskeletal associated protein 0.0328349
ANXA2 annexin A2 0.0328075
MYO10 myosin X 0.0327319
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0326742
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0325002
ZNF292 zinc finger protein 292 0.0324964
PGK1 phosphoglycerate kinase 1 0.0323895
TAGLN2 transgelin 2 0.0323002
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0320437
HSPG2 heparan sulfate proteoglycan 2 0.0318378
FOSL1 FOS-like antigen 1 0.0318341
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0317845
DSTN destrin (actin depolymerizing factor) 0.0315444
MYADM myeloid-associated differentiation marker 0.0313967
MARCKS myristoylated alanine-rich protein kinase C substrate 0.0312823
SQLE squalene epoxidase 0.0311709
RNF217 ring finger protein 217 0.0311286
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0309683

decreased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 -0.127292
PTMA prothymosin, alpha -0.126692
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0832464
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0748056
HLA-B major histocompatibility complex, class I, B -0.0720325
RPS24 ribosomal protein S24 -0.0706757
RPL35A ribosomal protein L35a -0.0672989
INTS6 integrator complex subunit 6 -0.0522608
RPL34 ribosomal protein L34 -0.0506898
TMSB10 thymosin beta 10 -0.050411
RPS25 ribosomal protein S25 -0.0485766
RPL37A ribosomal protein L37a -0.0482946
RPS21 ribosomal protein S21 -0.0465905
RPL36A ribosomal protein L36a -0.0436029
RPLP2 ribosomal protein, large, P2 -0.0432583
RPS27A ribosomal protein S27a -0.0428031
RPL31 ribosomal protein L31 -0.0425923
RPL26 ribosomal protein L26 -0.0401251
RPLP1 ribosomal protein, large, P1 -0.040078
IFI6 interferon, alpha-inducible protein 6 -0.0369036
TMSB4X thymosin beta 4, X-linked -0.0362689
CAVIN1 caveolae associated protein 1 -0.0362044
RPL11 ribosomal protein L11 -0.0361603
RPS8 ribosomal protein S8 -0.0335536
ACTG1 actin gamma 1 -0.0318153
RPL9 ribosomal protein L9 -0.0315534
VDAC1 voltage-dependent anion channel 1 -0.031093
AHNAK AHNAK nucleoprotein -0.0291838
BLCAP bladder cancer associated protein -0.0289582
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0286092
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A -0.0274938
RPS29 ribosomal protein S29 -0.0274873
RPS23 ribosomal protein S23 -0.0271923
RPL12 ribosomal protein L12 -0.0270877
HM13 histocompatibility (minor) 13 -0.026997
IER3 immediate early response 3 -0.0268
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0264405
ADIRF adipogenesis regulatory factor -0.0259689
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0254708
VIM vimentin -0.0251234
FTL ferritin, light polypeptide -0.0246059
RPS11 ribosomal protein S11 -0.0244827
RPS13 ribosomal protein S13 -0.0244632
RPS19 ribosomal protein S19 -0.0243571
RPS27 ribosomal protein S27 -0.0243436
SPINK5 serine peptidase inhibitor, Kazal type 5 -0.0239443
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0230794
RPL7A ribosomal protein L7a -0.0229645
RPL27A ribosomal protein L27a -0.0226942
TRA2A transformer 2 alpha homolog (Drosophila) -0.0225434
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0224776
NAP1L1 nucleosome assembly protein 1-like 1 -0.0220796
RPS3 ribosomal protein S3 -0.0220177
ATP5F1E ATP synthase F1 subunit epsilon -0.0219345
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0216427
MGP matrix Gla protein -0.0212417
SP100 SP100 nuclear antigen -0.0212225
ARF1 ADP-ribosylation factor 1 -0.0211481
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0208411
SYN3 synapsin III -0.0205414
TUBB4B tubulin, beta 4B class IVb -0.0200707
RPL23 ribosomal protein L23 -0.0198876
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -0.019839
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0196395
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0192754
IFIH1 interferon induced with helicase C domain 1 -0.0192609
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0192092
RPL19 ribosomal protein L19 -0.0191447
FOXC1 forkhead box C1 -0.0188295
DDIT3 DNA-damage-inducible transcript 3 -0.0187056
SELENOK selenoprotein K -0.0186351
RPS10 ribosomal protein S10 -0.0184822
NT5C2 5'-nucleotidase, cytosolic II -0.0184254
KDM3A lysine (K)-specific demethylase 3A -0.0182713
DLG1 discs, large homolog 1 (Drosophila) -0.0182136
UQCRQ ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa -0.018113
TM4SF1 transmembrane 4 L six family member 1 -0.0180434
MYL12B myosin, light chain 12B, regulatory -0.0179934
RPL38 ribosomal protein L38 -0.0178521
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.0175064
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0174291
ZMYND8 zinc finger, MYND-type containing 8 -0.0173923
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0173055
GNAS GNAS complex locus -0.0172797
THBD thrombomodulin -0.0172754
CUX1 cut-like homeobox 1 -0.0171499
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.017139
ZNFX1 zinc finger, NFX1-type containing 1 -0.0168793
ZBTB7A zinc finger and BTB domain containing 7A -0.0168793
RPS14 ribosomal protein S14 -0.0168245
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0166433
ENO2 enolase 2 (gamma, neuronal) -0.0165638
RPS20 ribosomal protein S20 -0.0165234
IFI27 interferon, alpha-inducible protein 27 -0.0165169
TOMM7 translocase of outer mitochondrial membrane 7 homolog (yeast) -0.0161831
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0161114
VCL vinculin -0.0159238
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0155995
HLA-A major histocompatibility complex, class I, A -0.0155911
AHRR aryl-hydrocarbon receptor repressor -0.0154916