Thymol_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Thymol perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Thymol_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EGFR epidermal growth factor receptor 0.174483
GRAMD1B GRAM domain containing 1B 0.0971046
CES1 carboxylesterase 1 0.0894699
SLTM SAFB-like, transcription modulator 0.0793466
ELL2 elongation factor, RNA polymerase II, 2 0.0755694
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0688052
SPAG9 sperm associated antigen 9 0.0572507
ERRFI1 ERBB receptor feedback inhibitor 1 0.0512373
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0497308
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.048315
CEMIP cell migration inducing protein, hyaluronan binding 0.0476741
DOCK5 dedicator of cytokinesis 5 0.047394
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0469387
AGO2 argonaute RISC catalytic component 2 0.0459206
FAM13A family with sequence similarity 13, member A 0.0445447
SAMD4A sterile alpha motif domain containing 4A 0.0437856
RUNX1 runt-related transcription factor 1 0.0430603
TOP1 topoisomerase (DNA) I 0.0429948
NAMPT nicotinamide phosphoribosyltransferase 0.0421737
PDE4D phosphodiesterase 4D, cAMP-specific 0.0393565
DSCAM Down syndrome cell adhesion molecule 0.0392096
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 0.0384496
USP34 ubiquitin specific peptidase 34 0.0379468
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0365194
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0360401
FNDC3A fibronectin type III domain containing 3A 0.0356162
EXT1 exostosin glycosyltransferase 1 0.0338886
PM20D1 peptidase M20 domain containing 1 0.0336101
MCTP1 multiple C2 domains, transmembrane 1 0.0334793
JMJD1C jumonji domain containing 1C 0.0333762
HOMER1 homer scaffolding protein 1 0.0314473
BMP6 bone morphogenetic protein 6 0.0311868
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0311657
MCL1 myeloid cell leukemia 1 0.0299386
BCAR3 breast cancer anti-estrogen resistance 3 0.0291493
TBC1D22A TBC1 domain family, member 22A 0.0287131
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.028635
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.0273151
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0272589
RAD51B RAD51 paralog B 0.026488
DTNA dystrobrevin, alpha 0.0258894
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0250576
FRY furry homolog (Drosophila) 0.0250435
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0250396
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0244062
KMT2E lysine (K)-specific methyltransferase 2E 0.0239665
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0235267
EXOC6B exocyst complex component 6B 0.0233581
LRP12 low density lipoprotein receptor-related protein 12 0.0232857
SLC35F5 solute carrier family 35, member F5 0.022466
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0223605
STC1 stanniocalcin 1 0.022349
MED13L mediator complex subunit 13-like 0.0212627
ANXA5 annexin A5 0.0212094
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) 0.0209967
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3 0.0207985
AFF1 AF4/FMR2 family, member 1 0.0207839
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0207813
ATP13A3 ATPase type 13A3 0.0207297
HELZ helicase with zinc finger 0.0201978
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides 0.0198947
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0196591
EPAS1 endothelial PAS domain protein 1 0.0195115
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0193462
FNIP1 folliculin interacting protein 1 0.0192952
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0192299
GPATCH2L G patch domain containing 2-like 0.0191358
SEC31A SEC31 homolog A (S. cerevisiae) 0.019069
IRS2 insulin receptor substrate 2 0.0190015
INTS6 integrator complex subunit 6 0.0188605
LYST lysosomal trafficking regulator 0.0186474
ATOSA atos homolog A 0.0186013
SIK3 SIK family kinase 3 0.0185206
SOD2 superoxide dismutase 2, mitochondrial 0.0184514
ARB2A ARB2 cotranscriptional regulator A 0.0184056
EP300 E1A binding protein p300 0.0183644
ZNF638 zinc finger protein 638 0.018246
MAST4 microtubule associated serine/threonine kinase family member 4 0.0181729
NGLY1 N-glycanase 1 0.0180984
YAP1 Yes-associated protein 1 0.0180818
EYA2 EYA transcriptional coactivator and phosphatase 2 0.0178988
HBP1 HMG-box transcription factor 1 0.0175383
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0174037
CYLD cylindromatosis (turban tumor syndrome) 0.0173863
OFD1 oral-facial-digital syndrome 1 0.0173098
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0171318
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0171203
ATP11A ATPase, class VI, type 11A 0.0170989
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.0170629
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0169352
KIAA1217 KIAA1217 0.0168599
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0167598
CAMTA1 calmodulin binding transcription activator 1 0.0167077
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0166279
VMP1 vacuole membrane protein 1 0.0165164
SMYD3 SET and MYND domain containing 3 0.0164753
MYO1E myosin IE 0.0164591
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.0164322
ZSWIM6 zinc finger, SWIM-type containing 6 0.0163904
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.0163634

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.293977
ASPH aspartate beta-hydroxylase -0.190802
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.113286
CAV1 caveolin 1, caveolae protein, 22kDa -0.111252
ACTG1 actin gamma 1 -0.106482
PTPRM protein tyrosine phosphatase, receptor type, M -0.0917361
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0899093
KRT18 keratin 18, type I -0.074628
KRT7 keratin 7, type II -0.0716847
LDHA lactate dehydrogenase A -0.0707735
AHNAK AHNAK nucleoprotein -0.0622579
PKM pyruvate kinase, muscle -0.0590194
TPT1 tumor protein, translationally-controlled 1 -0.0578839
CST3 cystatin C -0.0574169
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0568763
S100A10 S100 calcium binding protein A10 -0.0564458
FTL ferritin, light polypeptide -0.0558521
SEC61G Sec61 gamma subunit -0.054748
PTMA prothymosin, alpha -0.0539472
LAMC2 laminin, gamma 2 -0.0538079
KRT8 keratin 8, type II -0.0537531
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0521285
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0516998
EGR1 early growth response 1 -0.0513605
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0509562
IFI6 interferon, alpha-inducible protein 6 -0.0477926
IGFBP5 insulin-like growth factor binding protein 5 -0.0446295
AKR1C1 aldo-keto reductase family 1, member C1 -0.0446213
B2M beta-2-microglobulin -0.0442636
PGK1 phosphoglycerate kinase 1 -0.0432945
H1-0 H1.0 linker histone -0.0430335
ZMYND8 zinc finger, MYND-type containing 8 -0.0423942
THSD4 thrombospondin, type I, domain containing 4 -0.0408217
LOC112694756 uncharaterized LOC112694756 -0.0402842
RPL35A ribosomal protein L35a -0.039735
S100A6 S100 calcium binding protein A6 -0.0367507
TPM4 tropomyosin 4 -0.0365849
KRT19 keratin 19, type I -0.0363403
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0342242
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0327312
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0325652
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0320576
POTEF POTE ankyrin domain family, member F -0.031742
PATJ PATJ crumbs cell polarity complex component -0.0301456
IGFBP3 insulin-like growth factor binding protein 3 -0.0293512
S100A11 S100 calcium binding protein A11 -0.0292653
GNAS GNAS complex locus -0.0288015
ENO1 enolase 1, (alpha) -0.0281247
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.028024
RPS24 ribosomal protein S24 -0.0275243
WDR1 WD repeat domain 1 -0.0258396
SDC1 syndecan 1 -0.0256249
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0254138
MYL12B myosin, light chain 12B, regulatory -0.0250717
RPL37A ribosomal protein L37a -0.0248557
AKAP12 A kinase (PRKA) anchor protein 12 -0.0248024
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0247316
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0247199
HLA-B major histocompatibility complex, class I, B -0.0243061
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -0.0242264
STC2 stanniocalcin 2 -0.0237917
SDC4 syndecan 4 -0.0237644
CTSL cathepsin L -0.023597
S100A9 S100 calcium binding protein A9 -0.0233801
CCND1 cyclin D1 -0.0231675
FLNB filamin B, beta -0.0230846
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.0229236
TNS3 tensin 3 -0.0228358
PLEC plectin -0.0227767
GM2A GM2 ganglioside activator -0.0223964
OSMR oncostatin M receptor -0.0223822
NR4A1 nuclear receptor subfamily 4, group A, member 1 -0.0223799
RPL34 ribosomal protein L34 -0.0223674
RPL11 ribosomal protein L11 -0.0221902
SLC38A1 solute carrier family 38, member 1 -0.022097
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0219242
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0218789
LAMB3 laminin, beta 3 -0.0217586
VCL vinculin -0.0209298
PDIA3 protein disulfide isomerase family A, member 3 -0.0208229
RHOV ras homolog family member V -0.0206592
LOC102724023 ES1 protein homolog, mitochondrial -0.0204799
MYO1D myosin ID -0.020452
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0200025
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0197404
RPS19 ribosomal protein S19 -0.0196627
MT1X metallothionein 1X -0.0196322
IFI27 interferon, alpha-inducible protein 27 -0.0195853
ATF4 activating transcription factor 4 -0.0195467
IER3 immediate early response 3 -0.0191803
MAGEA4 melanoma antigen family A4 -0.0191783
RPS27A ribosomal protein S27a -0.0191625
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0189852
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.0189825
RPS25 ribosomal protein S25 -0.0189384
RAB27B RAB27B, member RAS oncogene family -0.018824
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -0.0187879
RPS14 ribosomal protein S14 -0.0186792
RPS21 ribosomal protein S21 -0.0184697
UGDH UDP-glucose 6-dehydrogenase -0.0183464