Thymol_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Thymol perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Thymol_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FNDC3B fibronectin type III domain containing 3B 0.0709874
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0695018
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0618246
RAD51B RAD51 paralog B 0.0604859
GRB10 growth factor receptor-bound protein 10 0.0592869
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0574984
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0574046
EFNA5 ephrin-A5 0.0566079
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0562985
SMAD3 SMAD family member 3 0.0553545
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0548718
ZEB2 zinc finger E-box binding homeobox 2 0.0547514
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0528039
NAV2 neuron navigator 2 0.0524528
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0506005
CD44 CD44 molecule (Indian blood group) 0.0483472
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0456395
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0441554
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0433843
HMGA2 high mobility group AT-hook 2 0.0428223
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0420034
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0419111
KYNU kynureninase 0.0418286
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0404994
TGM2 transglutaminase 2 0.040017
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0399695
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0396349
AKAP9 A kinase (PRKA) anchor protein 9 0.0396287
EGFR epidermal growth factor receptor 0.0396018
VEGFA vascular endothelial growth factor A 0.0388462
PDE4D phosphodiesterase 4D, cAMP-specific 0.0387154
EHBP1 EH domain binding protein 1 0.0385923
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0379336
USP34 ubiquitin specific peptidase 34 0.0376414
DOCK5 dedicator of cytokinesis 5 0.0362695
NRP1 neuropilin 1 0.0356128
MAML2 mastermind-like 2 (Drosophila) 0.0355113
PARP8 poly (ADP-ribose) polymerase family, member 8 0.0354841
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0354187
NTN4 netrin 4 0.0347837
IL6ST interleukin 6 signal transducer 0.0346506
ANTXR2 anthrax toxin receptor 2 0.0337695
HIPK2 homeodomain interacting protein kinase 2 0.0335104
PELI1 pellino E3 ubiquitin protein ligase 1 0.0334653
PDLIM5 PDZ and LIM domain 5 0.0330056
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 0.0325989
ANKRD28 ankyrin repeat domain 28 0.0324932
IRAK2 interleukin-1 receptor-associated kinase 2 0.0324523
MBNL1 muscleblind-like splicing regulator 1 0.0323077
PCBP2 poly(rC) binding protein 2 0.0318512
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0318487
LHFPL2 lipoma HMGIC fusion partner-like 2 0.031598
ECE1 endothelin converting enzyme 1 0.0311873
STK38L serine/threonine kinase 38 like 0.0308117
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0307841
TRIO trio Rho guanine nucleotide exchange factor 0.0307249
VEGFC vascular endothelial growth factor C 0.0303466
DPYSL3 dihydropyrimidinase-like 3 0.0294742
LRMDA leucine rich melanocyte differentiation associated 0.0292558
ATP13A3 ATPase type 13A3 0.0291741
GLCCI1 glucocorticoid induced 1 0.0286624
GRIK5 glutamate receptor, ionotropic, kainate 5 0.02751
ZBTB20 zinc finger and BTB domain containing 20 0.0268302
RAB27B RAB27B, member RAS oncogene family 0.0266551
PTK2 protein tyrosine kinase 2 0.0264667
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0264577
UBA6 ubiquitin-like modifier activating enzyme 6 0.0263698
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0262661
TJP1 tight junction protein 1 0.0262074
SVIL supervillin 0.0260075
VMP1 vacuole membrane protein 1 0.0257951
RUNX1 runt-related transcription factor 1 0.0256586
SIK3 SIK family kinase 3 0.0252454
RAP1B RAP1B, member of RAS oncogene family 0.0248692
RARB retinoic acid receptor, beta 0.0246492
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 0.0243551
MAST4 microtubule associated serine/threonine kinase family member 4 0.0243101
ADD3 adducin 3 (gamma) 0.0241599
ATXN10 ataxin 10 0.0236814
DSCAM Down syndrome cell adhesion molecule 0.0235445
RICTOR RPTOR independent companion of MTOR, complex 2 0.0234052
SYAP1 synapse associated protein 1 0.0232684
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0230649
KDM2A lysine (K)-specific demethylase 2A 0.02303
PTPRM protein tyrosine phosphatase, receptor type, M 0.0229321
MEIS2 Meis homeobox 2 0.0223187
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0221592
ESYT2 extended synaptotagmin-like protein 2 0.0220739
ALCAM activated leukocyte cell adhesion molecule 0.0220575
DST dystonin 0.0220388
GREB1L growth regulation by estrogen in breast cancer-like 0.0218658
KSR1 kinase suppressor of ras 1 0.0214937
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.021426
WLS wntless Wnt ligand secretion mediator 0.0213772
ITGAV integrin, alpha V 0.0212313
SYNJ2 synaptojanin 2 0.0211421
DOCK4 dedicator of cytokinesis 4 0.0210955
WWTR1 WW domain containing transcription regulator 1 0.0210085
SYT1 synaptotagmin I 0.0208413
ANKH ANKH inorganic pyrophosphate transport regulator 0.020616

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.219358
CXCL8 chemokine (C-X-C motif) ligand 8 -0.108231
FAM20C family with sequence similarity 20, member C -0.100159
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0915685
VIM vimentin -0.0892424
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0759452
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0727687
PTMA prothymosin, alpha -0.0719461
TPT1 tumor protein, translationally-controlled 1 -0.071836
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.063898
FTL ferritin, light polypeptide -0.0540003
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0493717
FN1 fibronectin 1 -0.0480341
TFPI2 tissue factor pathway inhibitor 2 -0.0466623
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0444982
MTSS1 metastasis suppressor 1 -0.0439107
TMSB4X thymosin beta 4, X-linked -0.043553
RAB1A RAB1A, member RAS oncogene family -0.0420731
EIF1 eukaryotic translation initiation factor 1 -0.0417003
RBM39 RNA binding motif protein 39 -0.041028
CANX calnexin -0.0410142
IER3 immediate early response 3 -0.0409113
AHNAK AHNAK nucleoprotein -0.0398699
KDM3A lysine (K)-specific demethylase 3A -0.0348242
IFI6 interferon, alpha-inducible protein 6 -0.0335539
RPL35A ribosomal protein L35a -0.033378
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0329162
S100A6 S100 calcium binding protein A6 -0.0325896
MT2A metallothionein 2A -0.0318591
RPS21 ribosomal protein S21 -0.0314655
IGFBP3 insulin-like growth factor binding protein 3 -0.0300106
SAMD9 sterile alpha motif domain containing 9 -0.0295587
DDIT3 DNA-damage-inducible transcript 3 -0.0291884
NRG1 neuregulin 1 -0.0284682
RPL32 ribosomal protein L32 -0.0277213
IL1B interleukin 1, beta -0.0277183
PGK1 phosphoglycerate kinase 1 -0.0273567
UBC ubiquitin C -0.0270242
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0263428
RPS19 ribosomal protein S19 -0.0260627
STAT1 signal transducer and activator of transcription 1, 91kDa -0.025585
RPL34 ribosomal protein L34 -0.0253975
TM4SF1 transmembrane 4 L six family member 1 -0.0253126
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0253065
CALR calreticulin -0.0250742
GNAS GNAS complex locus -0.0250624
NDRG1 N-myc downstream regulated 1 -0.0249066
HLA-B major histocompatibility complex, class I, B -0.0248937
H1-0 H1.0 linker histone -0.0247495
DLG1 discs, large homolog 1 (Drosophila) -0.0246246
STC1 stanniocalcin 1 -0.0245649
SOX4 SRY (sex determining region Y)-box 4 -0.0245597
THBD thrombomodulin -0.0245018
LOX lysyl oxidase -0.024109
HDLBP high density lipoprotein binding protein -0.0239363
ATG7 autophagy related 7 -0.0238174
RPL31 ribosomal protein L31 -0.0235712
CP ceruloplasmin (ferroxidase) -0.0229688
RPL36 ribosomal protein L36 -0.0229417
S100A10 S100 calcium binding protein A10 -0.0228099
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0224413
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0224052
EFCAB13 EF-hand calcium binding domain 13 -0.0223715
TMEM263 transmembrane protein 263 -0.0221844
RAI1 retinoic acid induced 1 -0.021842
RPL19 ribosomal protein L19 -0.0217146
RPLP1 ribosomal protein, large, P1 -0.0216553
RPS24 ribosomal protein S24 -0.0216432
CDH13 cadherin 13 -0.0215962
TGFB1 transforming growth factor, beta 1 -0.0215791
BTG1 B-cell translocation gene 1, anti-proliferative -0.0208764
RPS29 ribosomal protein S29 -0.0208101
ENO2 enolase 2 (gamma, neuronal) -0.020242
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0201229
ZMYND8 zinc finger, MYND-type containing 8 -0.0195565
RPL11 ribosomal protein L11 -0.0193827
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0192823
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0191076
HLA-C major histocompatibility complex, class I, C -0.0190743
RPL37A ribosomal protein L37a -0.0190652
COL12A1 collagen, type XII, alpha 1 -0.0187673
ALDH1A3 aldehyde dehydrogenase 1 family, member A3 -0.0187179
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0187115
RPLP2 ribosomal protein, large, P2 -0.0185744
SDC4 syndecan 4 -0.0184661
C15ORF48 chromosome 15 open reading frame 48 -0.0183674
PRRX1 paired related homeobox 1 -0.0182638
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0178114
ANKRD11 ankyrin repeat domain 11 -0.0177648
ZNF804A zinc finger protein 804A -0.0177538
RPL23 ribosomal protein L23 -0.0175498
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 -0.0172326
COL7A1 collagen, type VII, alpha 1 -0.0171829
SQSTM1 sequestosome 1 -0.0170509
RPL38 ribosomal protein L38 -0.0170456
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 -0.0170368
HLA-A major histocompatibility complex, class I, A -0.0167074
SDK1 sidekick cell adhesion molecule 1 -0.0166761
PDIA3 protein disulfide isomerase family A, member 3 -0.0166223
NAV3 neuron navigator 3 -0.0166025