Thymol_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Thymol perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Thymol_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PM20D1 peptidase M20 domain containing 1 0.154239
MT2A metallothionein 2A 0.133826
PDE4D phosphodiesterase 4D, cAMP-specific 0.10968
GRAMD1B GRAM domain containing 1B 0.105969
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.104836
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.104386
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0987802
FTH1 ferritin, heavy polypeptide 1 0.0951292
WAC WW domain containing adaptor with coiled-coil 0.0943452
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0835804
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0753116
RICTOR RPTOR independent companion of MTOR, complex 2 0.0750436
ZFAND3 zinc finger, AN1-type domain 3 0.0749188
ELL2 elongation factor, RNA polymerase II, 2 0.0730424
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0730155
IL6 interleukin 6 0.0652522
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.064813
RBM25 RNA binding motif protein 25 0.0609543
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0583245
PDLIM5 PDZ and LIM domain 5 0.0572571
COPA coatomer protein complex, subunit alpha 0.0570741
ZNF207 zinc finger protein 207 0.0557113
RBM39 RNA binding motif protein 39 0.0525134
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0519379
ITCH itchy E3 ubiquitin protein ligase 0.0502464
IGFBP3 insulin-like growth factor binding protein 3 0.0501932
ANXA5 annexin A5 0.0493801
FMNL2 formin-like 2 0.0486042
P4HB prolyl 4-hydroxylase, beta polypeptide 0.048543
VEZT vezatin, adherens junctions transmembrane protein 0.0474909
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0473268
UGCG UDP-glucose ceramide glucosyltransferase 0.0472018
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0467612
GLG1 golgi glycoprotein 1 0.0457289
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0453177
CDCP1 CUB domain containing protein 1 0.0448417
FLNB filamin B, beta 0.0447235
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0437564
PDIA6 protein disulfide isomerase family A, member 6 0.0425132
PUM2 pumilio RNA-binding family member 2 0.0423261
UBA6 ubiquitin-like modifier activating enzyme 6 0.0422207
FNDC3B fibronectin type III domain containing 3B 0.0419738
TJP1 tight junction protein 1 0.0409308
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0408965
AKAP13 A kinase (PRKA) anchor protein 13 0.0403519
RNF145 ring finger protein 145 0.0399298
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0391405
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0386316
CSNK1A1 casein kinase 1, alpha 1 0.038497
KMT2E lysine (K)-specific methyltransferase 2E 0.0383045
WWOX WW domain containing oxidoreductase 0.0382329
NOP58 NOP58 ribonucleoprotein 0.0381812
ERRFI1 ERBB receptor feedback inhibitor 1 0.0381284
PTBP2 polypyrimidine tract binding protein 2 0.0379087
HLA-B major histocompatibility complex, class I, B 0.0374966
PARD3 par-3 family cell polarity regulator 0.0374821
PUM1 pumilio RNA-binding family member 1 0.037435
ITGB5 integrin, beta 5 0.0371752
NRG1 neuregulin 1 0.0371308
MAP3K20 mitogen-activated protein kinase kinase kinase 20 0.0369719
TOP1 topoisomerase (DNA) I 0.0368047
ATXN1 ataxin 1 0.0367751
SLMAP sarcolemma associated protein 0.0367708
NPEPPS aminopeptidase puromycin sensitive 0.0366577
SETD5 SET domain containing 5 0.0363336
CHD1 chromodomain helicase DNA binding protein 1 0.0362697
SEC23A Sec23 homolog A (S. cerevisiae) 0.0356494
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0355489
CDC73 cell division cycle 73 0.0354183
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0353949
MCL1 myeloid cell leukemia 1 0.0353721
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0348683
SNX9 sorting nexin 9 0.0348155
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0347368
PCBP2 poly(rC) binding protein 2 0.0346232
STRN3 striatin, calmodulin binding protein 3 0.0342549
BAIAP2L1 BAI1-associated protein 2-like 1 0.0341559
SPAG9 sperm associated antigen 9 0.0338135
SRP54 signal recognition particle 54kDa 0.0334974
FNBP1L formin binding protein 1-like 0.0334191
NCKAP1 NCK-associated protein 1 0.0328051
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0327527
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0323573
HIBADH 3-hydroxyisobutyrate dehydrogenase 0.0323177
BCAR3 breast cancer anti-estrogen resistance 3 0.0320065
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0318657
BMP6 bone morphogenetic protein 6 0.0316483
CUL3 cullin 3 0.031589
GSK3B glycogen synthase kinase 3 beta 0.0314807
GGNBP2 gametogenetin binding protein 2 0.0312653
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0311842
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.0310725
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0308817
HMGA1 high mobility group AT-hook 1 0.0308428
FOXO3 forkhead box O3 0.0307947
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0305913
NUP58 nucleoporin 58 0.0305832
FBXL20 F-box and leucine-rich repeat protein 20 0.0304704
HELZ helicase with zinc finger 0.0303722
BRWD1 bromodomain and WD repeat domain containing 1 0.0303271

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.190626
ASPH aspartate beta-hydroxylase -0.0966687
BICC1 BicC family RNA binding protein 1 -0.094838
PTMA prothymosin, alpha -0.0927682
TFPI2 tissue factor pathway inhibitor 2 -0.08547
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0844523
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0840884
ACTG1 actin gamma 1 -0.0804988
AHNAK AHNAK nucleoprotein -0.072478
CAVIN1 caveolae associated protein 1 -0.0688192
NQO1 NAD(P)H dehydrogenase, quinone 1 -0.0651898
TXNRD1 thioredoxin reductase 1 -0.0610841
TPT1 tumor protein, translationally-controlled 1 -0.0605276
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0576213
DST dystonin -0.0561685
IER3 immediate early response 3 -0.0549287
CANX calnexin -0.0530616
FGB fibrinogen beta chain -0.0504555
VIM vimentin -0.0489632
RPL19 ribosomal protein L19 -0.0469959
RPL4 ribosomal protein L4 -0.0465468
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0462257
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0456394
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0420198
RAD21 RAD21 homolog (S. pombe) -0.0398976
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0398591
RPS21 ribosomal protein S21 -0.0393213
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0368879
RPS2 ribosomal protein S2 -0.0368588
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0368031
MYH9 myosin, heavy chain 9, non-muscle -0.0356381
SLC35F3 solute carrier family 35, member F3 -0.0353485
MYL12B myosin, light chain 12B, regulatory -0.0349947
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0345747
APP amyloid beta (A4) precursor protein -0.0343987
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.033346
SQSTM1 sequestosome 1 -0.031782
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.031572
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0315234
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0307821
CENPF centromere protein F, 350/400kDa -0.0300047
RPL7 ribosomal protein L7 -0.0296315
RPL35A ribosomal protein L35a -0.0293021
HDAC9 histone deacetylase 9 -0.0292234
RPS19 ribosomal protein S19 -0.0291655
IGF1R insulin-like growth factor 1 receptor -0.0289001
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 -0.0288526
ZFHX3 zinc finger homeobox 3 -0.028237
MAP1B microtubule-associated protein 1B -0.0282133
S100A6 S100 calcium binding protein A6 -0.0267421
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) -0.0266155
TMSB4X thymosin beta 4, X-linked -0.0265744
EHBP1 EH domain binding protein 1 -0.0265546
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0263151
MKI67 marker of proliferation Ki-67 -0.0256744
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0255632
UTRN utrophin -0.0254939
NR4A1 nuclear receptor subfamily 4, group A, member 1 -0.0252672
PKM pyruvate kinase, muscle -0.0246642
ATP5F1B ATP synthase F1 subunit beta -0.0244847
BABAM2 BRISC and BRCA1 A complex member 2 -0.0241495
RPL11 ribosomal protein L11 -0.0238653
AK1 adenylate kinase 1 -0.0237851
CDK12 cyclin-dependent kinase 12 -0.0236351
THBS1 thrombospondin 1 -0.0236221
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0233814
PPP1R10 protein phosphatase 1, regulatory subunit 10 -0.0229939
RPS24 ribosomal protein S24 -0.0229906
SDC4 syndecan 4 -0.0228556
RPLP0 ribosomal protein, large, P0 -0.0227452
PLEC plectin -0.0226788
HLA-C major histocompatibility complex, class I, C -0.022491
ACACA acetyl-CoA carboxylase alpha -0.0224403
LMNA lamin A/C -0.0223887
EFNA5 ephrin-A5 -0.0222813
TNS3 tensin 3 -0.0221132
NABP1 nucleic acid binding protein 1 -0.0217543
RPS27A ribosomal protein S27a -0.0217106
RPL41 ribosomal protein L41 -0.0214996
GNAS GNAS complex locus -0.0213784
TPM1 tropomyosin 1 (alpha) -0.0211849
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0209941
EGR1 early growth response 1 -0.02097
RPL34 ribosomal protein L34 -0.0204751
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0204011
SERF2 small EDRK-rich factor 2 -0.0203889
RACK1 receptor for activated C kinase 1 -0.0202494
KANSL1L KAT8 regulatory NSL complex subunit 1-like -0.0200084
BICD1 bicaudal D homolog 1 (Drosophila) -0.0200002
STMN1 stathmin 1 -0.0198948
EIF1 eukaryotic translation initiation factor 1 -0.0197905
SOX4 SRY (sex determining region Y)-box 4 -0.0197565
RPL3 ribosomal protein L3 -0.0194525
PFDN2 prefoldin subunit 2 -0.0193262
HMGB2 high mobility group box 2 -0.0189311
LAMB1 laminin, beta 1 -0.0187966
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0187874
IGFBP4 insulin-like growth factor binding protein 4 -0.0187599
RPL23 ribosomal protein L23 -0.0187462
LOC112694756 uncharaterized LOC112694756 -0.0185601