Thymol_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Thymol perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Thymol_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SLTM SAFB-like, transcription modulator 0.168897
LMO7 LIM domain 7 0.127056
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.120513
BACE2 beta-site APP-cleaving enzyme 2 0.0970297
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0944572
EGFR epidermal growth factor receptor 0.0931649
HSPH1 heat shock 105kDa/110kDa protein 1 0.0830751
SAMD4A sterile alpha motif domain containing 4A 0.0792858
FN1 fibronectin 1 0.0738254
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0733435
ANXA1 annexin A1 0.0722374
AKAP13 A kinase (PRKA) anchor protein 13 0.0702688
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.069241
DPYD dihydropyrimidine dehydrogenase 0.063011
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0605921
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0605059
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0593734
HSPA8 heat shock 70kDa protein 8 0.0566007
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0553243
MYO1E myosin IE 0.0543949
MACF1 microtubule-actin crosslinking factor 1 0.0537023
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0535101
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.0533026
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0499717
OSMR oncostatin M receptor 0.0499636
GRB10 growth factor receptor-bound protein 10 0.0493793
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0489859
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0471057
ASPH aspartate beta-hydroxylase 0.0458567
KMT2E lysine (K)-specific methyltransferase 2E 0.0457299
PTPRM protein tyrosine phosphatase, receptor type, M 0.0451104
UBA6 ubiquitin-like modifier activating enzyme 6 0.0450179
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0447502
ITPRID2 ITPR interacting domain containing 2 0.0446332
AHNAK AHNAK nucleoprotein 0.0445258
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 0.0435448
ADGRB3 adhesion G protein-coupled receptor B3 0.0429654
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 0.0428066
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0411249
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0410023
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.0401159
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0400737
PDE4D phosphodiesterase 4D, cAMP-specific 0.0399167
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0391401
NPEPPS aminopeptidase puromycin sensitive 0.0390801
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0389729
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0383122
CSNK1A1 casein kinase 1, alpha 1 0.0383029
IGF1R insulin-like growth factor 1 receptor 0.0382751
SMAD3 SMAD family member 3 0.0380533
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 0.0379743
SOS1 son of sevenless homolog 1 (Drosophila) 0.0370788
FLNB filamin B, beta 0.0365529
ATOSA atos homolog A 0.0349105
SVIL supervillin 0.0348531
NPTN neuroplastin 0.034725
S100P S100 calcium binding protein P 0.0342457
CLTC clathrin, heavy chain (Hc) 0.0341771
PKM pyruvate kinase, muscle 0.0339617
MYOF myoferlin 0.0337557
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0336086
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0334272
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0329713
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0327669
N4BP2L2 NEDD4 binding protein 2-like 2 0.032761
RAB7A RAB7A, member RAS oncogene family 0.0326208
RUNX1 runt-related transcription factor 1 0.0325501
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.0315724
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0310511
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0309025
TM4SF1 transmembrane 4 L six family member 1 0.0306761
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.0305393
BCL2L1 BCL2-like 1 0.0304454
TMEM87A transmembrane protein 87A 0.0300935
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0298392
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.0296615
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0294699
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0294239
TSC22D2 TSC22 domain family, member 2 0.0291264
TJP2 tight junction protein 2 0.0291158
ERRFI1 ERBB receptor feedback inhibitor 1 0.0288247
CDCP1 CUB domain containing protein 1 0.0279639
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.027948
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 0.0268837
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0261389
LRP12 low density lipoprotein receptor-related protein 12 0.0252906
SGMS2 sphingomyelin synthase 2 0.0252039
ACTN4 actinin, alpha 4 0.0251913
SRRM2 serine/arginine repetitive matrix 2 0.025141
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 0.024994
MBNL1 muscleblind-like splicing regulator 1 0.0248061
JARID2 jumonji, AT rich interactive domain 2 0.0241087
ESYT2 extended synaptotagmin-like protein 2 0.0239643
TTC3 tetratricopeptide repeat domain 3 0.0233255
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0231086
JMJD1C jumonji domain containing 1C 0.0230714
ARB2A ARB2 cotranscriptional regulator A 0.0229685
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.0223578
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0218581
KRT17 keratin 17, type I 0.0217522

decreased expression

Symbol Name Standardized Value
SPAG9 sperm associated antigen 9 -0.146624
IFIH1 interferon induced with helicase C domain 1 -0.107556
RIGI RNA sensor RIG-I -0.097577
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.086323
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.085369
EGR1 early growth response 1 -0.078729
OASL 2'-5'-oligoadenylate synthetase-like -0.0765389
LSAMP limbic system-associated membrane protein -0.0753329
XPR1 xenotropic and polytropic retrovirus receptor 1 -0.0725887
NDRG1 N-myc downstream regulated 1 -0.0713989
PRRC2C proline-rich coiled-coil 2C -0.0703285
NAMPT nicotinamide phosphoribosyltransferase -0.0702584
AKAP12 A kinase (PRKA) anchor protein 12 -0.0681053
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0670851
NRG1 neuregulin 1 -0.0668394
PARD3 par-3 family cell polarity regulator -0.0667126
WSB1 WD repeat and SOCS box containing 1 -0.0666206
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0653701
IGF2 insulin-like growth factor 2 -0.0643403
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0640646
GOLGA4 golgin A4 -0.0639467
RNF145 ring finger protein 145 -0.0638094
RTN4 reticulon 4 -0.0627788
TXNRD1 thioredoxin reductase 1 -0.0618207
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.061649
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0610659
TJP1 tight junction protein 1 -0.0610171
TRIO trio Rho guanine nucleotide exchange factor -0.059467
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0589786
CANX calnexin -0.0586614
SMYD3 SET and MYND domain containing 3 -0.0571246
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0564051
GPC6 glypican 6 -0.0558047
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0554423
NF1 neurofibromin 1 -0.0541541
B2M beta-2-microglobulin -0.0531511
EIF1 eukaryotic translation initiation factor 1 -0.0517915
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0495374
CHD1 chromodomain helicase DNA binding protein 1 -0.0481937
LAMB3 laminin, beta 3 -0.0468619
FTL ferritin, light polypeptide -0.0467473
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0461516
VIM vimentin -0.045957
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0456087
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0454
TMSB10 thymosin beta 10 -0.044185
FMNL2 formin-like 2 -0.0437155
STK17A serine/threonine kinase 17a -0.0434532
RPL12 ribosomal protein L12 -0.0427285
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0421845
ENO1 enolase 1, (alpha) -0.0410751
LDHA lactate dehydrogenase A -0.040372
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0397842
PDE10A phosphodiesterase 10A -0.0395298
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0395027
KDM6A lysine (K)-specific demethylase 6A -0.0394513
KYNU kynureninase -0.0384711
PAPOLA poly(A) polymerase alpha -0.0382649
PTMA prothymosin, alpha -0.0374004
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 -0.0365774
VMP1 vacuole membrane protein 1 -0.0362372
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 -0.036026
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0344872
FAT1 FAT atypical cadherin 1 -0.0341854
KPNB1 karyopherin (importin) beta 1 -0.0335472
BRWD1 bromodomain and WD repeat domain containing 1 -0.0325652
LPP LIM domain containing preferred translocation partner in lipoma -0.0325595
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0316713
AKAP9 A kinase (PRKA) anchor protein 9 -0.0307372
EZR ezrin -0.030252
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0294938
KMT2C lysine (K)-specific methyltransferase 2C -0.0293879
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0288488
TPT1 tumor protein, translationally-controlled 1 -0.0287939
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.0287601
KTN1 kinectin 1 (kinesin receptor) -0.0287176
AFF4 AF4/FMR2 family, member 4 -0.0283332
MED13 mediator complex subunit 13 -0.027907
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0276312
MAST4 microtubule associated serine/threonine kinase family member 4 -0.0267471
DOCK4 dedicator of cytokinesis 4 -0.0264568
SQSTM1 sequestosome 1 -0.0260374
HLA-B major histocompatibility complex, class I, B -0.0254667
GSK3B glycogen synthase kinase 3 beta -0.0246117
MCL1 myeloid cell leukemia 1 -0.0246044
COPA coatomer protein complex, subunit alpha -0.0245713
GARS1 glycyl-tRNA synthetase 1 -0.0242135
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0241116
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0234827
ZNF292 zinc finger protein 292 -0.0234574
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 -0.0232327
H3-3B H3.3 histone B -0.0230682
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0225881
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0224953
DSCAM Down syndrome cell adhesion molecule -0.0217497
LIMCH1 LIM and calponin homology domains 1 -0.0217335
STC1 stanniocalcin 1 -0.0214459
PGK1 phosphoglycerate kinase 1 -0.0213911
JUN jun proto-oncogene -0.0212073
LAMC2 laminin, gamma 2 -0.0211918