Thymol_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Thymol perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Thymol_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.30214
TXNRD1 thioredoxin reductase 1 0.163521
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.117866
GRAMD1B GRAM domain containing 1B 0.115788
ERRFI1 ERBB receptor feedback inhibitor 1 0.104143
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0980379
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0830914
XPO1 exportin 1 0.0767724
TPM3 tropomyosin 3 0.074852
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0720513
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0685253
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0629383
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.0618166
MKI67 marker of proliferation Ki-67 0.0615974
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0614843
KTN1 kinectin 1 (kinesin receptor) 0.0562365
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0529257
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0524825
SCAF11 SR-related CTD-associated factor 11 0.0495208
ADAR adenosine deaminase, RNA-specific 0.0466377
ENO1 enolase 1, (alpha) 0.0433258
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.0428908
KIF5B kinesin family member 5B 0.0428819
KDM2A lysine (K)-specific demethylase 2A 0.042833
TFPI2 tissue factor pathway inhibitor 2 0.0418387
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.040362
MMP12 matrix metallopeptidase 12 0.0397752
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0395065
KPNB1 karyopherin (importin) beta 1 0.0390597
CCT3 chaperonin containing TCP1, subunit 3 (gamma) 0.0385365
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0380251
VIM vimentin 0.0380045
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0375774
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 0.0364096
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0358782
SRP72 signal recognition particle 72kDa 0.0356251
CAMKMT calmodulin-lysine N-methyltransferase 0.03557
TLK1 tousled-like kinase 1 0.0352377
SPAG9 sperm associated antigen 9 0.0351744
ZFAND3 zinc finger, AN1-type domain 3 0.0350016
CSNK1A1 casein kinase 1, alpha 1 0.0347914
TLN1 talin 1 0.0346076
ANXA5 annexin A5 0.0344337
GOLGB1 golgin B1 0.0339038
NIPBL Nipped-B homolog (Drosophila) 0.0336628
CENPF centromere protein F, 350/400kDa 0.0336091
GOLGA4 golgin A4 0.0333504
ZFR zinc finger RNA binding protein 0.0333124
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0331638
IL6ST interleukin 6 signal transducer 0.0328984
CSDE1 cold shock domain containing E1, RNA-binding 0.0324723
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0324699
CANX calnexin 0.0320556
SINHCAF SIN3-HDAC complex associated factor 0.0320104
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0320008
GLO1 glyoxalase I 0.0319715
EML4 echinoderm microtubule associated protein like 4 0.0317757
PGK1 phosphoglycerate kinase 1 0.0311587
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0310807
MATR3 matrin 3 0.0310383
NAMPT nicotinamide phosphoribosyltransferase 0.0308675
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0304995
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.030433
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0302546
ZCCHC7 zinc finger, CCHC domain containing 7 0.0301866
WNK1 WNK lysine deficient protein kinase 1 0.029559
PHF20 PHD finger protein 20 0.0295382
PDIA6 protein disulfide isomerase family A, member 6 0.0294637
UBE2K ubiquitin-conjugating enzyme E2K 0.0292441
AKAP9 A kinase (PRKA) anchor protein 9 0.0291659
YBX1 Y box binding protein 1 0.0290768
MAP3K20 mitogen-activated protein kinase kinase kinase 20 0.0289925
RAB10 RAB10, member RAS oncogene family 0.0289503
RSL1D1 ribosomal L1 domain containing 1 0.0289416
SERBP1 SERPINE1 mRNA binding protein 1 0.0288247
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.0284348
ZNF292 zinc finger protein 292 0.0284245
BRAF B-Raf proto-oncogene, serine/threonine kinase 0.0281834
RNF169 ring finger protein 169 0.0281297
ARHGAP5 Rho GTPase activating protein 5 0.0280326
ANXA2 annexin A2 0.0279398
PYGL phosphorylase, glycogen, liver 0.027816
RUSC2 RUN and SH3 domain containing 2 0.0276777
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.0275152
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae) 0.027467
R3HDM2 R3H domain containing 2 0.0273118
STK4 serine/threonine kinase 4 0.0271636
TAOK1 TAO kinase 1 0.0270812
SBNO1 strawberry notch homolog 1 (Drosophila) 0.0270575
TBC1D5 TBC1 domain family, member 5 0.0269957
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0268178
ARID1A AT rich interactive domain 1A (SWI-like) 0.0268129
COG5 component of oligomeric golgi complex 5 0.0268019
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0267857
TULP3 tubby like protein 3 0.0266476
KMT2A lysine (K)-specific methyltransferase 2A 0.0265829
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0264183
BRCA1 breast cancer 1, early onset 0.0263331
SENP6 SUMO1/sentrin specific peptidase 6 0.0261982
IQGAP1 IQ motif containing GTPase activating protein 1 0.0261788

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.180557
MCL1 myeloid cell leukemia 1 -0.106045
RPS21 ribosomal protein S21 -0.0822575
TPT1 tumor protein, translationally-controlled 1 -0.0799385
HLA-B major histocompatibility complex, class I, B -0.0671754
RPS3 ribosomal protein S3 -0.0655761
ACTG1 actin gamma 1 -0.0608906
MT2A metallothionein 2A -0.059523
RPL26 ribosomal protein L26 -0.0562669
RPL37A ribosomal protein L37a -0.0551313
OSMR oncostatin M receptor -0.0526079
PTMA prothymosin, alpha -0.0448305
PRELID2 PRELI domain containing 2 -0.0445408
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0428688
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0420553
IFI6 interferon, alpha-inducible protein 6 -0.041858
RPS19 ribosomal protein S19 -0.0412325
RPL34 ribosomal protein L34 -0.0410597
WNT2B wingless-type MMTV integration site family, member 2B -0.0403784
RPL23 ribosomal protein L23 -0.040089
YBX3 Y box binding protein 3 -0.0380305
RPS24 ribosomal protein S24 -0.0378509
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0370361
RPL9 ribosomal protein L9 -0.036557
EGR1 early growth response 1 -0.0364386
RPL36 ribosomal protein L36 -0.0360831
RYR3 ryanodine receptor 3 -0.035518
RPL35A ribosomal protein L35a -0.0344174
INTS6 integrator complex subunit 6 -0.0337178
AEBP2 AE binding protein 2 -0.033423
PDE10A phosphodiesterase 10A -0.0326645
NEK10 NIMA-related kinase 10 -0.0322692
RPS10 ribosomal protein S10 -0.0314215
FMNL2 formin-like 2 -0.0286859
IER3 immediate early response 3 -0.028626
RPS15 ribosomal protein S15 -0.0282854
RPL37 ribosomal protein L37 -0.0276782
RPS27A ribosomal protein S27a -0.0270984
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0264603
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0263107
RPLP2 ribosomal protein, large, P2 -0.0259464
RPL28 ribosomal protein L28 -0.0256954
CCNL1 cyclin L1 -0.0254567
RPL11 ribosomal protein L11 -0.0254184
NABP1 nucleic acid binding protein 1 -0.0251038
SDK1 sidekick cell adhesion molecule 1 -0.024206
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0241354
LRRC23 leucine rich repeat containing 23 -0.0239516
THSD4 thrombospondin, type I, domain containing 4 -0.0237951
RPS23 ribosomal protein S23 -0.0237092
PRKCE protein kinase C, epsilon -0.023474
NDRG1 N-myc downstream regulated 1 -0.0233877
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0231599
RPS12 ribosomal protein S12 -0.0231595
RPL38 ribosomal protein L38 -0.023075
RPL27 ribosomal protein L27 -0.0229707
MYL12B myosin, light chain 12B, regulatory -0.0228749
EXT1 exostosin glycosyltransferase 1 -0.02263
RPL32 ribosomal protein L32 -0.0224532
PRH1 proline-rich protein HaeIII subfamily 1 -0.0223415
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0220132
FMN1 formin 1 -0.0214479
TRIM59 tripartite motif containing 59 -0.0211503
RPL36A ribosomal protein L36a -0.0209808
RPS17 ribosomal protein S17 -0.0207436
NTSR1 neurotensin receptor 1 (high affinity) -0.0203325
BRD2 bromodomain containing 2 -0.0203156
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0195418
DNAH14 dynein, axonemal, heavy chain 14 -0.0195209
STYK1 serine/threonine/tyrosine kinase 1 -0.0194519
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.0192924
RPS8 ribosomal protein S8 -0.019158
MT1X metallothionein 1X -0.0188377
RPS29 ribosomal protein S29 -0.0184164
GSTP1 glutathione S-transferase pi 1 -0.0182177
RIMS2 regulating synaptic membrane exocytosis 2 -0.018143
RPL19 ribosomal protein L19 -0.0181398
RPS4X ribosomal protein S4, X-linked -0.0180005
RPS13 ribosomal protein S13 -0.0178244
RAB7A RAB7A, member RAS oncogene family -0.0176904
RPL8 ribosomal protein L8 -0.0176157
NCOA7 nuclear receptor coactivator 7 -0.0175473
RPL31 ribosomal protein L31 -0.0175441
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B -0.0174389
RCC1 regulator of chromosome condensation 1 -0.0173275
GPX4 glutathione peroxidase 4 -0.0173239
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0172779
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0171699
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0170686
POTEF POTE ankyrin domain family, member F -0.0170018
SRSF6 serine/arginine-rich splicing factor 6 -0.016988
FTL ferritin, light polypeptide -0.0168689
VCL vinculin -0.0168658
SLC25A51 solute carrier family 25, member 51 -0.0168012
FUS FUS RNA binding protein -0.016702
PPP1R10 protein phosphatase 1, regulatory subunit 10 -0.0166413
MIDN midnolin -0.0165688
ARMH4 armadillo like helical domain containing 4 -0.0164223
KDM4B lysine (K)-specific demethylase 4B -0.0160487
TPM2 tropomyosin 2 (beta) -0.0158816