Thymol_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Thymol perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Thymol_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PABPC1 poly(A) binding protein, cytoplasmic 1 0.221344
NDRG1 N-myc downstream regulated 1 0.167384
IGFBP3 insulin-like growth factor binding protein 3 0.14139
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.129935
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.1195
TSC22D2 TSC22 domain family, member 2 0.116125
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.106894
FTH1 ferritin, heavy polypeptide 1 0.0958694
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0935931
VEGFA vascular endothelial growth factor A 0.0883511
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0813037
FNDC3B fibronectin type III domain containing 3B 0.0765561
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0736898
POTEF POTE ankyrin domain family, member F 0.0735868
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0722418
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0712486
MSN moesin 0.0709903
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0700076
GRB10 growth factor receptor-bound protein 10 0.0695289
ARRDC3 arrestin domain containing 3 0.0631427
TPM3 tropomyosin 3 0.0610881
ANXA5 annexin A5 0.0598278
FBXO32 F-box protein 32 0.0587216
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0571087
HMGA1 high mobility group AT-hook 1 0.0568271
FAM13A family with sequence similarity 13, member A 0.056619
SQSTM1 sequestosome 1 0.0551642
WSB1 WD repeat and SOCS box containing 1 0.0550708
LDHA lactate dehydrogenase A 0.0543247
BHLHE40 basic helix-loop-helix family, member e40 0.0538423
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0536661
UPP1 uridine phosphorylase 1 0.0526873
UBA6 ubiquitin-like modifier activating enzyme 6 0.0517684
PCBP2 poly(rC) binding protein 2 0.0496124
ERRFI1 ERBB receptor feedback inhibitor 1 0.0475809
RPS6 ribosomal protein S6 0.047282
RNF145 ring finger protein 145 0.0452746
PKM pyruvate kinase, muscle 0.0449119
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0448735
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0442074
NAMPT nicotinamide phosphoribosyltransferase 0.0441249
ZFP36L1 ZFP36 ring finger protein-like 1 0.0438209
DSPP dentin sialophosphoprotein 0.0433506
PTK2 protein tyrosine kinase 2 0.0411126
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0406789
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0405435
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0404356
RPS12 ribosomal protein S12 0.0398391
LPP LIM domain containing preferred translocation partner in lipoma 0.0385476
ELL2 elongation factor, RNA polymerase II, 2 0.0382398
ANXA1 annexin A1 0.0381797
MXD1 MAX dimerization protein 1 0.0378822
ENO1 enolase 1, (alpha) 0.0378254
PDIA6 protein disulfide isomerase family A, member 6 0.0377535
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 0.0374191
APLP2 amyloid beta (A4) precursor-like protein 2 0.0370686
TMEM165 transmembrane protein 165 0.0369639
DTNA dystrobrevin, alpha 0.0366724
IFI27 interferon, alpha-inducible protein 27 0.0354092
ZNF292 zinc finger protein 292 0.0351167
KMT2E lysine (K)-specific methyltransferase 2E 0.0346518
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0343575
RPS2 ribosomal protein S2 0.0343468
ARID4B AT rich interactive domain 4B (RBP1-like) 0.034028
RYBP RING1 and YY1 binding protein 0.0333178
SETD5 SET domain containing 5 0.0332238
HSPA8 heat shock 70kDa protein 8 0.0331207
CD109 CD109 molecule 0.0326382
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0326034
ZNF207 zinc finger protein 207 0.0325389
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0320053
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 0.0319808
XPO1 exportin 1 0.031438
BBX bobby sox homolog (Drosophila) 0.0313621
RALA v-ral simian leukemia viral oncogene homolog A (ras related) 0.0313461
KTN1 kinectin 1 (kinesin receptor) 0.0312567
SPAG9 sperm associated antigen 9 0.0306146
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0305692
ZNF148 zinc finger protein 148 0.0304431
MYO6 myosin VI 0.03037
RPL5 ribosomal protein L5 0.0301332
JUP junction plakoglobin 0.029878
GPBP1 GC-rich promoter binding protein 1 0.0298306
PDIA3 protein disulfide isomerase family A, member 3 0.029804
RAB7A RAB7A, member RAS oncogene family 0.0296322
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.0295782
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0291351
RAD51B RAD51 paralog B 0.0289729
FXR1 fragile X mental retardation, autosomal homolog 1 0.0288994
PELI1 pellino E3 ubiquitin protein ligase 1 0.0284991
CSNK1A1 casein kinase 1, alpha 1 0.02848
TJP2 tight junction protein 2 0.0283146
RAB6A RAB6A, member RAS oncogene family 0.0282518
RAB11FIP1 RAB11 family interacting protein 1 (class I) 0.028239
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0281829
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 0.0278007
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0277336
RIOK3 RIO kinase 3 0.0274989
DSTN destrin (actin depolymerizing factor) 0.0274889
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0272503

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.253299
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.159843
TPT1 tumor protein, translationally-controlled 1 -0.119621
ASPH aspartate beta-hydroxylase -0.116246
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0826598
LMO7 LIM domain 7 -0.081258
RPL35A ribosomal protein L35a -0.0664089
LAMB3 laminin, beta 3 -0.0639188
PTMA prothymosin, alpha -0.0636106
TMSB4X thymosin beta 4, X-linked -0.059572
ALCAM activated leukocyte cell adhesion molecule -0.0584435
TMEM263 transmembrane protein 263 -0.0581305
RPS19 ribosomal protein S19 -0.0580818
S100A6 S100 calcium binding protein A6 -0.0540499
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.052865
RPL32 ribosomal protein L32 -0.0491582
KRT7 keratin 7, type II -0.04914
SDC4 syndecan 4 -0.0487835
MT2A metallothionein 2A -0.0478073
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0436212
LAMC2 laminin, gamma 2 -0.0418774
ARF1 ADP-ribosylation factor 1 -0.0418248
RPL34 ribosomal protein L34 -0.0409336
HMGB2 high mobility group box 2 -0.0407197
RASAL2 RAS protein activator like 2 -0.0400959
RPLP1 ribosomal protein, large, P1 -0.0373659
TM4SF1 transmembrane 4 L six family member 1 -0.0359912
RAD21 RAD21 homolog (S. pombe) -0.0358049
KDM3A lysine (K)-specific demethylase 3A -0.0355617
KRT18 keratin 18, type I -0.0355376
RPS21 ribosomal protein S21 -0.0351543
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0341082
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0339439
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0331895
FN1 fibronectin 1 -0.0329766
AREG amphiregulin -0.0326874
RRBP1 ribosome binding protein 1 -0.0323536
RPLP2 ribosomal protein, large, P2 -0.0314217
PALM2AKAP2 PALM2 and AKAP2 fusion -0.031016
PGK1 phosphoglycerate kinase 1 -0.0308774
NPC2 Niemann-Pick disease, type C2 -0.030801
GNAS GNAS complex locus -0.0304277
MYL12B myosin, light chain 12B, regulatory -0.0303259
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0295161
CRABP2 cellular retinoic acid binding protein 2 -0.0293602
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0291909
TUBB4B tubulin, beta 4B class IVb -0.0291176
ARHGAP29 Rho GTPase activating protein 29 -0.0290424
RPS23 ribosomal protein S23 -0.0286867
S100A4 S100 calcium binding protein A4 -0.0274925
RPS4X ribosomal protein S4, X-linked -0.026723
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0265687
RPLP0 ribosomal protein, large, P0 -0.025758
KRT8 keratin 8, type II -0.0257468
RPL23 ribosomal protein L23 -0.0256007
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0255854
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.0254381
AHNAK AHNAK nucleoprotein -0.0253104
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0252069
VCL vinculin -0.0250767
LMNA lamin A/C -0.025076
CALU calumenin -0.0250696
ISG15 ISG15 ubiquitin-like modifier -0.0250468
PDLIM5 PDZ and LIM domain 5 -0.0250352
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0248674
PLAU plasminogen activator, urokinase -0.0248342
DLC1 DLC1 Rho GTPase activating protein -0.0248054
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0247593
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.024759
IER3 immediate early response 3 -0.0245316
LIMCH1 LIM and calponin homology domains 1 -0.0245137
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0243574
NABP1 nucleic acid binding protein 1 -0.0240594
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0236958
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0230038
OAZ1 ornithine decarboxylase antizyme 1 -0.022988
S100A11 S100 calcium binding protein A11 -0.0228242
RUNX1 runt-related transcription factor 1 -0.0227206
RPS14 ribosomal protein S14 -0.0225227
CD2AP CD2-associated protein -0.0219978
EIF4A2 eukaryotic translation initiation factor 4A2 -0.0218957
KLHL5 kelch-like family member 5 -0.0217111
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.021584
RPL28 ribosomal protein L28 -0.0215115
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0214911
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0213559
GLCCI1 glucocorticoid induced 1 -0.021286
SEC61G Sec61 gamma subunit -0.0212548
S100A10 S100 calcium binding protein A10 -0.0211787
SCEL sciellin -0.0211318
CCNI cyclin I -0.0210332
RPL19 ribosomal protein L19 -0.0209823
CD63 CD63 molecule -0.0204631
RPL36 ribosomal protein L36 -0.0200683
ARHGAP5 Rho GTPase activating protein 5 -0.0200067
TACSTD2 tumor-associated calcium signal transducer 2 -0.019879
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0198334
TRIO trio Rho guanine nucleotide exchange factor -0.0196303
GRAMD2B GRAM domain containing 2B -0.0196211
FBXL2 F-box and leucine-rich repeat protein 2 -0.019595