Thymol_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Thymol perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Thymol_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.234939
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0978966
FNDC3B fibronectin type III domain containing 3B 0.092154
TENM3 teneurin transmembrane protein 3 0.0906725
COL11A1 collagen, type XI, alpha 1 0.0903539
TRIO trio Rho guanine nucleotide exchange factor 0.087523
ITGAV integrin, alpha V 0.085386
MED13L mediator complex subunit 13-like 0.0720022
PLPP1 phospholipid phosphatase 1 0.066172
ANK2 ankyrin 2, neuronal 0.0654718
SRPK2 SRSF protein kinase 2 0.0643674
ZNF292 zinc finger protein 292 0.0636364
KMT2C lysine (K)-specific methyltransferase 2C 0.0635457
PCLO piccolo presynaptic cytomatrix protein 0.0624655
JMJD1C jumonji domain containing 1C 0.0620672
PRKD1 protein kinase D1 0.0607094
ZFAND3 zinc finger, AN1-type domain 3 0.060255
WSB1 WD repeat and SOCS box containing 1 0.0595902
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0574454
TSC22D2 TSC22 domain family, member 2 0.0567566
ERBB4 erb-b2 receptor tyrosine kinase 4 0.0559721
HDAC9 histone deacetylase 9 0.0547003
GPBP1 GC-rich promoter binding protein 1 0.054201
ZEB2 zinc finger E-box binding homeobox 2 0.0525434
CENPF centromere protein F, 350/400kDa 0.0522111
GPHN gephyrin 0.0516273
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0509651
PHIP pleckstrin homology domain interacting protein 0.0499193
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0487166
PEG10 paternally expressed 10 0.0485469
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0479283
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.047883
ZMYM2 zinc finger, MYM-type 2 0.0476114
PARD3 par-3 family cell polarity regulator 0.0457826
N4BP2L2 NEDD4 binding protein 2-like 2 0.0452254
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6 0.0446149
TMEM165 transmembrane protein 165 0.0442969
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0432283
PUM1 pumilio RNA-binding family member 1 0.0432275
KIF13A kinesin family member 13A 0.0430168
KCTD16 potassium channel tetramerization domain containing 16 0.0428228
PDGFC platelet derived growth factor C 0.04275
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0424762
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 0.0419947
AKAP9 A kinase (PRKA) anchor protein 9 0.0418235
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0416862
OGA O-GlcNAcase 0.0413732
ENAH enabled homolog (Drosophila) 0.0412471
PDIA6 protein disulfide isomerase family A, member 6 0.0405446
ZFR zinc finger RNA binding protein 0.0401656
TJP1 tight junction protein 1 0.038296
ANXA5 annexin A5 0.0379157
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.0370528
RAI1 retinoic acid induced 1 0.0367776
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0363217
MATR3 matrin 3 0.0356965
ANKRD33B ankyrin repeat domain 33B 0.0354872
CHD1 chromodomain helicase DNA binding protein 1 0.0353799
ADAM9 ADAM metallopeptidase domain 9 0.0349241
EXT1 exostosin glycosyltransferase 1 0.0347988
PICALM phosphatidylinositol binding clathrin assembly protein 0.0347514
KMT2E lysine (K)-specific methyltransferase 2E 0.0342552
ANKRD12 ankyrin repeat domain 12 0.0341076
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0336964
NIPBL Nipped-B homolog (Drosophila) 0.033468
SMC4 structural maintenance of chromosomes 4 0.0330692
BRAF B-Raf proto-oncogene, serine/threonine kinase 0.033027
SETD5 SET domain containing 5 0.0329682
TPX2 TPX2, microtubule-associated 0.0329095
VMP1 vacuole membrane protein 1 0.0328526
RNF145 ring finger protein 145 0.0327603
AVL9 AVL9 homolog (S. cerevisiase) 0.0326927
TLK2 tousled-like kinase 2 0.0325772
UVRAG UV radiation resistance associated 0.0324763
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0324484
MAML2 mastermind-like 2 (Drosophila) 0.0319188
ZNF638 zinc finger protein 638 0.0319137
NRG1 neuregulin 1 0.0317588
CCNY cyclin Y 0.0316567
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0316277
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.031625
SEC62 SEC62 homolog (S. cerevisiae) 0.0314511
RABGAP1L RAB GTPase activating protein 1-like 0.0307963
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) 0.030411
TAOK1 TAO kinase 1 0.0302493
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 0.0302229
GOLPH3 golgi phosphoprotein 3 (coat-protein) 0.03018
GPC4 glypican 4 0.0301568
TLK1 tousled-like kinase 1 0.0300242
RCOR1 REST corepressor 1 0.0299972
HIBCH 3-hydroxyisobutyryl-CoA hydrolase 0.0298673
XPO1 exportin 1 0.0298411
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0296085
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0296078
SNX6 sorting nexin 6 0.0295638
ARL15 ADP-ribosylation factor-like 15 0.0293875
SMYD3 SET and MYND domain containing 3 0.0291201
SCAF11 SR-related CTD-associated factor 11 0.0290674
KDM6A lysine (K)-specific demethylase 6A 0.0288931
CDC14A cell division cycle 14A 0.0286957

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.132117
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.111964
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0954389
AHNAK AHNAK nucleoprotein -0.0883094
THBS1 thrombospondin 1 -0.0736056
PTMA prothymosin, alpha -0.0724518
EMP1 epithelial membrane protein 1 -0.0605448
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0589528
VIM vimentin -0.0584128
NTM neurotrimin -0.0583865
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0578441
CTNNA3 catenin (cadherin-associated protein), alpha 3 -0.0577301
RPS27A ribosomal protein S27a -0.0570167
TMSB4X thymosin beta 4, X-linked -0.0554224
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0512662
UBC ubiquitin C -0.047315
NPAS3 neuronal PAS domain protein 3 -0.0438838
VGLL3 vestigial-like family member 3 -0.0432635
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0421673
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0391907
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0391123
CALR calreticulin -0.0388432
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0369349
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 -0.0355012
COL3A1 collagen, type III, alpha 1 -0.0352447
RPLP1 ribosomal protein, large, P1 -0.0343499
POTEF POTE ankyrin domain family, member F -0.0342113
S100A10 S100 calcium binding protein A10 -0.0340984
TUBA1B tubulin, alpha 1b -0.0340797
SOX5 SRY (sex determining region Y)-box 5 -0.034025
ACTG1 actin gamma 1 -0.0334613
YBX1 Y box binding protein 1 -0.033334
RACK1 receptor for activated C kinase 1 -0.0321233
H1-0 H1.0 linker histone -0.0312125
CALCR calcitonin receptor -0.0311119
RPS21 ribosomal protein S21 -0.0309574
RPS19 ribosomal protein S19 -0.0309115
HMCN1 hemicentin 1 -0.030418
RPL23 ribosomal protein L23 -0.0295731
BMPR1A bone morphogenetic protein receptor, type IA -0.0295723
SORBS2 sorbin and SH3 domain containing 2 -0.0294195
RPS4X ribosomal protein S4, X-linked -0.0292473
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) -0.0292456
MARS1 methionyl-tRNA synthetase 1 -0.0290401
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.0289918
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0289048
RBM39 RNA binding motif protein 39 -0.0288206
BAZ1A bromodomain adjacent to zinc finger domain, 1A -0.0286431
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle -0.0282772
DMD dystrophin -0.0282046
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase -0.0279776
LOC112694756 uncharaterized LOC112694756 -0.0277238
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) -0.0276466
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) -0.0273254
RPL12 ribosomal protein L12 -0.0272204
CUL4B cullin 4B -0.0271313
PDIA4 protein disulfide isomerase family A, member 4 -0.0268869
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0268119
TSPAN12 tetraspanin 12 -0.0266797
RPS10 ribosomal protein S10 -0.0266371
CADM2 cell adhesion molecule 2 -0.0262694
MED12L mediator complex subunit 12-like -0.0261528
YAP1 Yes-associated protein 1 -0.026068
RPL19 ribosomal protein L19 -0.0254623
LDHA lactate dehydrogenase A -0.0254602
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0253361
RPS14 ribosomal protein S14 -0.0252937
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0250693
FN1 fibronectin 1 -0.024529
RTN3 reticulon 3 -0.0244432
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.024409
RPL4 ribosomal protein L4 -0.0239942
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme -0.0239558
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.023839
S100A6 S100 calcium binding protein A6 -0.0237265
COTL1 coactosin-like F-actin binding protein 1 -0.0237018
SET SET nuclear proto-oncogene -0.0235768
COL5A2 collagen, type V, alpha 2 -0.0235728
LMNA lamin A/C -0.0235716
CSDE1 cold shock domain containing E1, RNA-binding -0.0234513
ATP5F1A ATP synthase F1 subunit alpha -0.0234133
RPS15 ribosomal protein S15 -0.0233474
RCC1 regulator of chromosome condensation 1 -0.0233067
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) -0.0231787
MMP1 matrix metallopeptidase 1 -0.0231322
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 -0.0231282
EEF1G eukaryotic translation elongation factor 1 gamma -0.0230161
ANXA2 annexin A2 -0.0228517
ZFP30 ZFP30 zinc finger protein -0.0225777
PCDH17 protocadherin 17 -0.0224938
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0224485
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 -0.0224425
KCMF1 potassium channel modulatory factor 1 -0.0222694
PCBP2 poly(rC) binding protein 2 -0.0222506
RPS3 ribosomal protein S3 -0.0222173
CAVIN1 caveolae associated protein 1 -0.022142
CCDC47 coiled-coil domain containing 47 -0.0219771
SRRM2 serine/arginine repetitive matrix 2 -0.0218471
ATP5F1B ATP synthase F1 subunit beta -0.0217239
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase -0.0216343