Thymol_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Thymol perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Thymol_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ADAM10 ADAM metallopeptidase domain 10 0.144825
PKM pyruvate kinase, muscle 0.115986
PDE4D phosphodiesterase 4D, cAMP-specific 0.110157
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0901381
HDAC9 histone deacetylase 9 0.0869501
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0820369
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0786039
PDGFC platelet derived growth factor C 0.0721825
FLNB filamin B, beta 0.0703381
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0693443
ZNF292 zinc finger protein 292 0.0676878
GOLGA4 golgin A4 0.0675971
PYGB phosphorylase, glycogen; brain 0.0669729
EGFR epidermal growth factor receptor 0.06668
TXNIP thioredoxin interacting protein 0.0664926
DSCAM Down syndrome cell adhesion molecule 0.0638266
RTN4 reticulon 4 0.0605088
ARL4C ADP-ribosylation factor-like 4C 0.0598929
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0571212
TJP1 tight junction protein 1 0.0552995
SPATS2L spermatogenesis associated, serine-rich 2-like 0.054075
TXNRD1 thioredoxin reductase 1 0.0531121
JMJD1C jumonji domain containing 1C 0.049071
NBEA neurobeachin 0.0486581
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.048506
NCEH1 neutral cholesterol ester hydrolase 1 0.0474643
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0460141
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 0.0459588
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0455086
QKI QKI, KH domain containing, RNA binding 0.0444026
EML4 echinoderm microtubule associated protein like 4 0.0426312
KMT2E lysine (K)-specific methyltransferase 2E 0.0403919
MATR3 matrin 3 0.0402045
ZBTB20 zinc finger and BTB domain containing 20 0.0399729
MACROD2 MACRO domain containing 2 0.0383188
USP34 ubiquitin specific peptidase 34 0.0382792
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0380501
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.036439
NCKAP1 NCK-associated protein 1 0.0359913
ANKRD12 ankyrin repeat domain 12 0.035477
EZR ezrin 0.0346991
ANK2 ankyrin 2, neuronal 0.0333256
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0331051
SETD5 SET domain containing 5 0.0318861
HMGA1 high mobility group AT-hook 1 0.0317172
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 0.0316458
WAC WW domain containing adaptor with coiled-coil 0.0314892
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.031473
NUP58 nucleoporin 58 0.0314521
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0312836
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0312733
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0307244
KTN1 kinectin 1 (kinesin receptor) 0.0304875
GSK3B glycogen synthase kinase 3 beta 0.0303414
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0303068
SQSTM1 sequestosome 1 0.0300764
PRRC2C proline-rich coiled-coil 2C 0.0299985
SMC3 structural maintenance of chromosomes 3 0.0297429
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0297304
PTBP2 polypyrimidine tract binding protein 2 0.0294261
CNOT6L CCR4-NOT transcription complex, subunit 6-like 0.0293348
NQO1 NAD(P)H dehydrogenase, quinone 1 0.0293205
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0291487
BRWD1 bromodomain and WD repeat domain containing 1 0.0290913
BIRC6 baculoviral IAP repeat containing 6 0.0289077
TMEM65 transmembrane protein 65 0.0288132
NBAS neuroblastoma amplified sequence 0.0287227
ARID1A AT rich interactive domain 1A (SWI-like) 0.0286238
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0285297
SCAF11 SR-related CTD-associated factor 11 0.028321
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0282878
VCL vinculin 0.0281632
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0279245
RHOA ras homolog family member A 0.0276341
ZMYM2 zinc finger, MYM-type 2 0.0275024
MAP3K14 mitogen-activated protein kinase kinase kinase 14 0.0274785
NAMPT nicotinamide phosphoribosyltransferase 0.0272333
ZNF608 zinc finger protein 608 0.0264389
KDM4C lysine (K)-specific demethylase 4C 0.0261698
MXI1 MAX interactor 1, dimerization protein 0.0260415
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.0258906
ADAM9 ADAM metallopeptidase domain 9 0.0256583
PLK2 polo-like kinase 2 0.0255036
DUSP4 dual specificity phosphatase 4 0.0253876
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0247337
ZEB1 zinc finger E-box binding homeobox 1 0.0247103
RBM25 RNA binding motif protein 25 0.0246312
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0245154
RAB6A RAB6A, member RAS oncogene family 0.0240115
PNISR PNN-interacting serine/arginine-rich protein 0.0239348
EEF2 eukaryotic translation elongation factor 2 0.0239244
FAM13A family with sequence similarity 13, member A 0.0239093
RPS2 ribosomal protein S2 0.0238121
SEC23A Sec23 homolog A (S. cerevisiae) 0.0237129
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2 0.0237039
TGFBR3 transforming growth factor, beta receptor III 0.023511
TBK1 TANK-binding kinase 1 0.0233913
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0233183
TRIM24 tripartite motif containing 24 0.0230298
CDC27 cell division cycle 27 0.0229786

decreased expression

Symbol Name Standardized Value
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.133614
PDE4B phosphodiesterase 4B, cAMP-specific -0.125224
AHNAK AHNAK nucleoprotein -0.110685
TPT1 tumor protein, translationally-controlled 1 -0.1052
PTMA prothymosin, alpha -0.102615
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0871474
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0832663
BMP10 bone morphogenetic protein 10 -0.0743773
GLI3 GLI family zinc finger 3 -0.071241
TMSB10 thymosin beta 10 -0.0634386
DLG1 discs, large homolog 1 (Drosophila) -0.0607933
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0505373
PDE7B phosphodiesterase 7B -0.0443477
RFC3 replication factor C (activator 1) 3, 38kDa -0.0435523
VIM vimentin -0.0433123
FOXP1 forkhead box P1 -0.0425512
RPS24 ribosomal protein S24 -0.0392916
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0373214
DIAPH3 diaphanous-related formin 3 -0.0373163
RPL34 ribosomal protein L34 -0.0366797
GLI2 GLI family zinc finger 2 -0.0363431
UNC13A unc-13 homolog A (C. elegans) -0.0360451
NFIA nuclear factor I/A -0.0358087
RPL9 ribosomal protein L9 -0.035343
RPS27A ribosomal protein S27a -0.0346071
ZNF438 zinc finger protein 438 -0.0336174
CAMKMT calmodulin-lysine N-methyltransferase -0.0331512
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 -0.0325583
RPS21 ribosomal protein S21 -0.0311047
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0307833
RPL26 ribosomal protein L26 -0.0307329
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0299969
TTC28 tetratricopeptide repeat domain 28 -0.0293874
RPL19 ribosomal protein L19 -0.0293476
FER1L6 fer-1-like family member 6 -0.0283324
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 -0.028083
RPL7A ribosomal protein L7a -0.027929
NAV2 neuron navigator 2 -0.0278607
FUS FUS RNA binding protein -0.0275961
TBCA tubulin folding cofactor A -0.0272175
RRBP1 ribosome binding protein 1 -0.0271433
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0268696
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.026811
MSI2 musashi RNA-binding protein 2 -0.0267818
RPS19 ribosomal protein S19 -0.0267149
AEBP2 AE binding protein 2 -0.0264752
SP100 SP100 nuclear antigen -0.0262991
ENOX1 ecto-NOX disulfide-thiol exchanger 1 -0.0260567
RPL36 ribosomal protein L36 -0.0257158
HEG1 heart development protein with EGF-like domains 1 -0.0254905
EBNA1BP2 EBNA1 binding protein 2 -0.025368
RPS13 ribosomal protein S13 -0.0250911
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0250433
NEBL nebulette -0.0244586
DENND1A DENN/MADD domain containing 1A -0.0243617
RPL37 ribosomal protein L37 -0.0242637
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0242178
RRM2 ribonucleotide reductase M2 -0.023939
SOX6 SRY (sex determining region Y)-box 6 -0.0238828
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0238618
PTPRF protein tyrosine phosphatase, receptor type, F -0.0237699
RAD18 RAD18 E3 ubiquitin protein ligase -0.0236356
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 -0.023558
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -0.0227071
CD44 CD44 molecule (Indian blood group) -0.0226482
ATAD2 ATPase family, AAA domain containing 2 -0.0226115
RPS17 ribosomal protein S17 -0.0223136
RPL23 ribosomal protein L23 -0.022237
ACTN4 actinin, alpha 4 -0.0220632
S100A4 S100 calcium binding protein A4 -0.0220476
RPLP1 ribosomal protein, large, P1 -0.0219965
RPLP0 ribosomal protein, large, P0 -0.0218937
RPL38 ribosomal protein L38 -0.021882
HIBCH 3-hydroxyisobutyryl-CoA hydrolase -0.0215033
FN1 fibronectin 1 -0.0213972
PLXNA2 plexin A2 -0.0211955
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0211568
RPL32 ribosomal protein L32 -0.0207812
PWWP2A PWWP domain containing 2A -0.0207238
ANXA2 annexin A2 -0.0207032
EHBP1 EH domain binding protein 1 -0.0206651
NPAS2 neuronal PAS domain protein 2 -0.0202999
RPS23 ribosomal protein S23 -0.0201399
RPS11 ribosomal protein S11 -0.020091
RPL36A ribosomal protein L36a -0.0200846
SPDYA speedy/RINGO cell cycle regulator family member A -0.0199993
RPS10 ribosomal protein S10 -0.0199833
RPL31 ribosomal protein L31 -0.0198401
PKP4 plakophilin 4 -0.019663
PDE10A phosphodiesterase 10A -0.0194713
CUX1 cut-like homeobox 1 -0.0191826
AKAP12 A kinase (PRKA) anchor protein 12 -0.0191785
BCOR BCL6 corepressor -0.0190004
CRPPA CDP-L-ribitol pyrophosphorylase A -0.0188743
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0187087
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.018706
SMAD3 SMAD family member 3 -0.0183792
RPS4Y1 ribosomal protein S4, Y-linked 1 -0.0183477
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.018321
ANKRD11 ankyrin repeat domain 11 -0.0182205