Thymol_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Thymol perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Thymol_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.14196
CD44 CD44 molecule (Indian blood group) 0.112728
VCAN versican 0.104808
TRIO trio Rho guanine nucleotide exchange factor 0.104161
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0827305
ELL2 elongation factor, RNA polymerase II, 2 0.0768539
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0763395
NAMPT nicotinamide phosphoribosyltransferase 0.0737016
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0680405
ANXA2 annexin A2 0.0666171
ZNF292 zinc finger protein 292 0.0660491
PDE10A phosphodiesterase 10A 0.0656079
NAV2 neuron navigator 2 0.0655196
ARRDC3 arrestin domain containing 3 0.0647295
FNDC3B fibronectin type III domain containing 3B 0.064449
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0643636
SOD2 superoxide dismutase 2, mitochondrial 0.0615286
MYOF myoferlin 0.0583948
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0534837
JMJD1C jumonji domain containing 1C 0.0523346
MXI1 MAX interactor 1, dimerization protein 0.0510984
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0498535
STC1 stanniocalcin 1 0.0494379
ZMIZ1 zinc finger, MIZ-type containing 1 0.0437995
FN1 fibronectin 1 0.043377
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0432924
UBA6 ubiquitin-like modifier activating enzyme 6 0.0420127
VEGFA vascular endothelial growth factor A 0.041949
TENT5A terminal nucleotidyltransferase 5A 0.0418467
LDHA lactate dehydrogenase A 0.0412925
ICAM1 intercellular adhesion molecule 1 0.0409036
LAMP2 lysosomal-associated membrane protein 2 0.0401682
SPAG9 sperm associated antigen 9 0.0394083
SMAD3 SMAD family member 3 0.0390583
UGCG UDP-glucose ceramide glucosyltransferase 0.0383537
SYNJ2 synaptojanin 2 0.0380703
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0379135
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0378325
FTH1 ferritin, heavy polypeptide 1 0.0372831
ATP13A3 ATPase type 13A3 0.036858
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0366136
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0365986
MKI67 marker of proliferation Ki-67 0.035611
COL6A3 collagen, type VI, alpha 3 0.0352822
KMT2E lysine (K)-specific methyltransferase 2E 0.0347423
RUNX1 runt-related transcription factor 1 0.0346958
GOLGA4 golgin A4 0.0343063
MBNL1 muscleblind-like splicing regulator 1 0.0339648
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0325554
ESYT2 extended synaptotagmin-like protein 2 0.0325011
RB1CC1 RB1-inducible coiled-coil 1 0.0317898
HELZ helicase with zinc finger 0.0314105
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0312674
FNIP1 folliculin interacting protein 1 0.0311643
CDCP1 CUB domain containing protein 1 0.0308835
ERRFI1 ERBB receptor feedback inhibitor 1 0.0308449
MMP12 matrix metallopeptidase 12 0.0303654
USP9X ubiquitin specific peptidase 9, X-linked 0.0301009
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0299295
ANXA5 annexin A5 0.0297839
ANKRD28 ankyrin repeat domain 28 0.0297475
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.0297198
MSN moesin 0.0295242
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0295171
AHR aryl hydrocarbon receptor 0.0294905
AKAP9 A kinase (PRKA) anchor protein 9 0.0292163
PRELID2 PRELI domain containing 2 0.0291719
OGA O-GlcNAcase 0.0290034
FRMD4A FERM domain containing 4A 0.0289783
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0288353
TXNIP thioredoxin interacting protein 0.0274184
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0271193
SLC35F3 solute carrier family 35, member F3 0.0269111
ALCAM activated leukocyte cell adhesion molecule 0.0266521
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0265585
SMYD3 SET and MYND domain containing 3 0.0263153
ATXN1 ataxin 1 0.0262857
PTBP3 polypyrimidine tract binding protein 3 0.0261831
LPP LIM domain containing preferred translocation partner in lipoma 0.0259236
THBS1 thrombospondin 1 0.0255021
FOXO3 forkhead box O3 0.0254958
IL6ST interleukin 6 signal transducer 0.0254028
PCLO piccolo presynaptic cytomatrix protein 0.0253857
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 0.0253831
PKM pyruvate kinase, muscle 0.0252798
PAWR PRKC, apoptosis, WT1, regulator 0.0252796
PLPP3 phospholipid phosphatase 3 0.0251657
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0250647
TLN1 talin 1 0.0250239
NGLY1 N-glycanase 1 0.024506
KLF6 Kruppel-like factor 6 0.0240254
BCAR3 breast cancer anti-estrogen resistance 3 0.023902
PGK1 phosphoglycerate kinase 1 0.0237638
DST dystonin 0.023651
IL1RAP interleukin 1 receptor accessory protein 0.023573
WTAP Wilms tumor 1 associated protein 0.0233846
SNX9 sorting nexin 9 0.0233235
SFRP1 secreted frizzled-related protein 1 0.0233085
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0232197
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0230284

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.122032
TPT1 tumor protein, translationally-controlled 1 -0.121618
VIM vimentin -0.0944346
HLA-B major histocompatibility complex, class I, B -0.0856871
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0601778
IER3 immediate early response 3 -0.0524334
HLA-A major histocompatibility complex, class I, A -0.0494643
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0489609
RPS24 ribosomal protein S24 -0.0482058
PTMA prothymosin, alpha -0.0444464
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0444009
GLIS3 GLIS family zinc finger 3 -0.0435161
MT2A metallothionein 2A -0.0419115
HMGA2 high mobility group AT-hook 2 -0.0413163
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0404872
RPS23 ribosomal protein S23 -0.0389028
RPL9 ribosomal protein L9 -0.0382389
ENO2 enolase 2 (gamma, neuronal) -0.0371372
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0371283
INTS6 integrator complex subunit 6 -0.0360739
RPL23 ribosomal protein L23 -0.0343141
RPS21 ribosomal protein S21 -0.0338791
RPLP2 ribosomal protein, large, P2 -0.0335678
TMEM132D transmembrane protein 132D -0.033265
RPL26 ribosomal protein L26 -0.0330449
RPL35A ribosomal protein L35a -0.0323683
RPL37A ribosomal protein L37a -0.032313
FTL ferritin, light polypeptide -0.0322288
COL1A1 collagen, type I, alpha 1 -0.0319846
SOX5 SRY (sex determining region Y)-box 5 -0.0312818
EGR1 early growth response 1 -0.0311685
ACTG1 actin gamma 1 -0.0305547
NRN1 neuritin 1 -0.0302458
CTSD cathepsin D -0.0283999
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3 -0.0282136
RPL36A ribosomal protein L36a -0.026664
EIF1 eukaryotic translation initiation factor 1 -0.0265474
RPS3 ribosomal protein S3 -0.0263152
NABP1 nucleic acid binding protein 1 -0.0262047
RPL34 ribosomal protein L34 -0.0257165
STC2 stanniocalcin 2 -0.025261
BICC1 BicC family RNA binding protein 1 -0.0251474
RPS19 ribosomal protein S19 -0.0249722
ZMYND8 zinc finger, MYND-type containing 8 -0.0248402
CDH13 cadherin 13 -0.0243212
RPS14 ribosomal protein S14 -0.0241401
RPS4X ribosomal protein S4, X-linked -0.0238479
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0237245
FAM20C family with sequence similarity 20, member C -0.0236997
RPS10 ribosomal protein S10 -0.0236601
RPL28 ribosomal protein L28 -0.0236228
COL6A1 collagen, type VI, alpha 1 -0.0233334
RPL19 ribosomal protein L19 -0.0231537
RPL36 ribosomal protein L36 -0.0230446
RIGI RNA sensor RIG-I -0.0226285
RPL11 ribosomal protein L11 -0.0224787
RPS27A ribosomal protein S27a -0.0224055
TNS3 tensin 3 -0.0220522
ZCCHC7 zinc finger, CCHC domain containing 7 -0.021915
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0218309
RPL38 ribosomal protein L38 -0.0216418
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0216315
IFI6 interferon, alpha-inducible protein 6 -0.0213521
COL7A1 collagen, type VII, alpha 1 -0.0205764
CANX calnexin -0.0201652
MT1X metallothionein 1X -0.0200999
DIAPH2 diaphanous-related formin 2 -0.0196271
RPL32 ribosomal protein L32 -0.0194565
BTG1 B-cell translocation gene 1, anti-proliferative -0.018746
ASTN2 astrotactin 2 -0.0185415
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0182857
COL6A2 collagen, type VI, alpha 2 -0.0182773
RPL31 ribosomal protein L31 -0.0182246
PDE4D phosphodiesterase 4D, cAMP-specific -0.0180833
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0178134
IGFBP3 insulin-like growth factor binding protein 3 -0.0178034
TCEAL9 transcription elongation factor A like 9 -0.0176828
ADAM12 ADAM metallopeptidase domain 12 -0.0172858
ISG15 ISG15 ubiquitin-like modifier -0.017273
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0172144
EEF2 eukaryotic translation elongation factor 2 -0.0167799
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0165503
S100A9 S100 calcium binding protein A9 -0.0165232
CP ceruloplasmin (ferroxidase) -0.0160582
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0158483
MIDN midnolin -0.0158465
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -0.0157741
ABI3BP ABI family, member 3 (NESH) binding protein -0.0157342
RPS11 ribosomal protein S11 -0.0157091
ATG7 autophagy related 7 -0.0156927
SERINC3 serine incorporator 3 -0.0156364
GNAS GNAS complex locus -0.0155807
ZDHHC14 zinc finger, DHHC-type containing 14 -0.01553
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) -0.015019
UTRN utrophin -0.0150022
PRKG1 protein kinase, cGMP-dependent, type I -0.0149481
LRRC23 leucine rich repeat containing 23 -0.0149428
SPDYA speedy/RINGO cell cycle regulator family member A -0.0148345
EFCAB13 EF-hand calcium binding domain 13 -0.014793
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0147346