Thymol_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Thymol perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Thymol_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.124279
IGFBP3 insulin-like growth factor binding protein 3 0.113405
CD44 CD44 molecule (Indian blood group) 0.0962695
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0831084
CDH13 cadherin 13 0.0776705
NAV1 neuron navigator 1 0.0730957
NRXN3 neurexin 3 0.0722906
CXCL8 chemokine (C-X-C motif) ligand 8 0.0721263
COL6A3 collagen, type VI, alpha 3 0.07018
VEGFC vascular endothelial growth factor C 0.0689735
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.06813
MT2A metallothionein 2A 0.0664937
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0627496
KYNU kynureninase 0.062288
FNDC3B fibronectin type III domain containing 3B 0.0619272
EXT1 exostosin glycosyltransferase 1 0.0584932
IGFBP7 insulin-like growth factor binding protein 7 0.0582471
NAMPT nicotinamide phosphoribosyltransferase 0.0561019
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0556849
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0545478
EGFR epidermal growth factor receptor 0.0543303
DPYD dihydropyrimidine dehydrogenase 0.0539614
VEGFA vascular endothelial growth factor A 0.0535547
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.050518
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0495599
ERRFI1 ERBB receptor feedback inhibitor 1 0.0482515
AUTS2 autism susceptibility candidate 2 0.0468608
TGFBI transforming growth factor, beta-induced, 68kDa 0.0460621
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0452822
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0450244
DST dystonin 0.0450225
WWTR1 WW domain containing transcription regulator 1 0.0444662
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0444431
FLNA filamin A, alpha 0.0440186
EXOC4 exocyst complex component 4 0.0431996
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0430313
NF1 neurofibromin 1 0.0426847
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.0424965
MYLK myosin light chain kinase 0.0419534
MSN moesin 0.041942
WSB1 WD repeat and SOCS box containing 1 0.0396533
ATP13A3 ATPase type 13A3 0.0394726
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0388421
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0388242
GSE1 Gse1 coiled-coil protein 0.0387235
DHRSX dehydrogenase/reductase (SDR family) X-linked 0.0385742
CALD1 caldesmon 1 0.0379213
ZNF638 zinc finger protein 638 0.037844
PDE4D phosphodiesterase 4D, cAMP-specific 0.037669
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0375431
MYO10 myosin X 0.0368215
PSD3 pleckstrin and Sec7 domain containing 3 0.0366696
ANXA5 annexin A5 0.0365603
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0364893
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0356858
KMT2E lysine (K)-specific methyltransferase 2E 0.0356603
ZEB2 zinc finger E-box binding homeobox 2 0.0355214
GRB10 growth factor receptor-bound protein 10 0.0353417
SDK1 sidekick cell adhesion molecule 1 0.0352865
EXOC6B exocyst complex component 6B 0.0352821
EFNA5 ephrin-A5 0.0352465
IL6 interleukin 6 0.0345982
LOXL2 lysyl oxidase-like 2 0.034571
SKAP2 src kinase associated phosphoprotein 2 0.0344169
ENO1 enolase 1, (alpha) 0.0343534
NCOA7 nuclear receptor coactivator 7 0.034279
SOX5 SRY (sex determining region Y)-box 5 0.0338772
WWOX WW domain containing oxidoreductase 0.0337902
MED13L mediator complex subunit 13-like 0.0334391
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0332043
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0329452
TANK TRAF family member-associated NFKB activator 0.0326717
PCDH7 protocadherin 7 0.0323365
GLIS3 GLIS family zinc finger 3 0.031978
IGFBP5 insulin-like growth factor binding protein 5 0.0317646
PRRC2C proline-rich coiled-coil 2C 0.0317274
ETV6 ets variant 6 0.0317226
PRKCA protein kinase C, alpha 0.0314761
RNF216 ring finger protein 216 0.0310208
SHB Src homology 2 domain containing adaptor protein B 0.0309914
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0308512
MAML2 mastermind-like 2 (Drosophila) 0.0304755
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0301749
RAB7A RAB7A, member RAS oncogene family 0.0296183
AKAP12 A kinase (PRKA) anchor protein 12 0.0293897
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0293809
GCC2 GRIP and coiled-coil domain containing 2 0.0291734
CDK6 cyclin-dependent kinase 6 0.0291464
BPTF bromodomain PHD finger transcription factor 0.0290606
MAP1B microtubule-associated protein 1B 0.0290019
ATXN1 ataxin 1 0.0289968
SLC38A2 solute carrier family 38, member 2 0.0286965
RAD51B RAD51 paralog B 0.0286497
SMYD3 SET and MYND domain containing 3 0.0284948
TNRC6B trinucleotide repeat containing 6B 0.028486
BBX bobby sox homolog (Drosophila) 0.0283118
RUNX1 runt-related transcription factor 1 0.0281127
SETBP1 SET binding protein 1 0.0280618
ECE1 endothelin converting enzyme 1 0.0280521
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0279657

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.139475
TMSB10 thymosin beta 10 -0.0856726
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0817895
CANX calnexin -0.0755584
LOX lysyl oxidase -0.0637738
AHNAK AHNAK nucleoprotein -0.06201
SDC4 syndecan 4 -0.0554538
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0447768
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0426288
HM13 histocompatibility (minor) 13 -0.0336777
PDIA3 protein disulfide isomerase family A, member 3 -0.0327538
ADM adrenomedullin -0.0327288
SOD2 superoxide dismutase 2, mitochondrial -0.0326347
INSIG2 insulin induced gene 2 -0.0292555
SND1 staphylococcal nuclease and tudor domain containing 1 -0.029222
LOC112694756 uncharaterized LOC112694756 -0.0292138
SPDYA speedy/RINGO cell cycle regulator family member A -0.0288842
WASF2 WAS protein family, member 2 -0.0277025
ARF4 ADP-ribosylation factor 4 -0.0275862
TFPI2 tissue factor pathway inhibitor 2 -0.0275294
MT1X metallothionein 1X -0.0274944
PRRC1 proline-rich coiled-coil 1 -0.027462
TMSB4X thymosin beta 4, X-linked -0.0270889
ZMYND8 zinc finger, MYND-type containing 8 -0.026816
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.026528
CLINT1 clathrin interactor 1 -0.0264844
TMEM263 transmembrane protein 263 -0.0264174
TRA2A transformer 2 alpha homolog (Drosophila) -0.0259192
CA12 carbonic anhydrase XII -0.0257404
HDLBP high density lipoprotein binding protein -0.0252692
RPL35A ribosomal protein L35a -0.0251627
FTH1 ferritin, heavy polypeptide 1 -0.0251179
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0249286
GNAS GNAS complex locus -0.0246257
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.0242254
PGK1 phosphoglycerate kinase 1 -0.023435
HBP1 HMG-box transcription factor 1 -0.0233473
LMAN1 lectin, mannose-binding, 1 -0.0233447
RAB8B RAB8B, member RAS oncogene family -0.0233085
FBXO11 F-box protein 11 -0.0230906
HLA-E major histocompatibility complex, class I, E -0.0225762
PDIA5 protein disulfide isomerase family A, member 5 -0.0222298
HLA-C major histocompatibility complex, class I, C -0.0222083
RPL37 ribosomal protein L37 -0.0221976
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0221815
MARCHF6 membrane associated ring-CH-type finger 6 -0.0218586
TUT7 terminal uridylyl transferase 7 -0.0217217
SAR1A secretion associated, Ras related GTPase 1A -0.0214619
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0214458
B2M beta-2-microglobulin -0.0211448
PDIA4 protein disulfide isomerase family A, member 4 -0.0208393
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) -0.0206765
RYBP RING1 and YY1 binding protein -0.0205489
TMED9 transmembrane emp24 protein transport domain containing 9 -0.0204992
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0202582
KDM3A lysine (K)-specific demethylase 3A -0.0202427
EIF1 eukaryotic translation initiation factor 1 -0.0202308
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0201267
MMP14 matrix metallopeptidase 14 (membrane-inserted) -0.0200688
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0199245
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.019872
NUCB2 nucleobindin 2 -0.019859
KDM5B lysine (K)-specific demethylase 5B -0.0198346
RHOA ras homolog family member A -0.0195306
COL6A1 collagen, type VI, alpha 1 -0.0195295
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0194788
IARS1 isoleucyl-tRNA synthetase 1 -0.0194308
RPL31 ribosomal protein L31 -0.0194029
APOLD1 apolipoprotein L domain containing 1 -0.0192661
RPS11 ribosomal protein S11 -0.0192283
CDC50A cell division cycle 50 P4-ATPase accessory subunit A -0.0191777
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0191381
COL3A1 collagen, type III, alpha 1 -0.0191077
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0189843
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha -0.0189232
ATP5F1B ATP synthase F1 subunit beta -0.0189226
WDR45B WD repeat domain 45B -0.0188153
GPR173 G protein-coupled receptor 173 -0.0188033
GNL3 guanine nucleotide binding protein-like 3 (nucleolar) -0.0184233
KCTD9 potassium channel tetramerization domain containing 9 -0.0183157
ABI1 abl-interactor 1 -0.018287
HMGB2 high mobility group box 2 -0.0182728
HOOK2 hook microtubule-tethering protein 2 -0.0182667
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 -0.0182193
TPR translocated promoter region, nuclear basket protein -0.0180516
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme -0.0180342
PDXK pyridoxal (pyridoxine, vitamin B6) kinase -0.0179691
CIRSR corepressor of RBPJ and splicing regulator -0.0179415
PI3 peptidase inhibitor 3, skin-derived -0.0179195
NDUFA4 NDUFA4, mitochondrial complex associated -0.0178135
GPX8 glutathione peroxidase 8 (putative) -0.017786
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5 -0.0176803
TPT1 tumor protein, translationally-controlled 1 -0.0174751
TSC22D2 TSC22 domain family, member 2 -0.0174064
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.0173981
ZMYM1 zinc finger, MYM-type 1 -0.017178
YIPF5 Yip1 domain family, member 5 -0.0169888
CBX3 chromobox homolog 3 -0.016947
PID1 phosphotyrosine interaction domain containing 1 -0.0169078
TPD52 tumor protein D52 -0.0169066