Thymopentin_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Thymopentin perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Thymopentin_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.177442
TRIO trio Rho guanine nucleotide exchange factor 0.1671
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.119923
AUTS2 autism susceptibility candidate 2 0.116121
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.109733
DLG1 discs, large homolog 1 (Drosophila) 0.0733627
SOD2 superoxide dismutase 2, mitochondrial 0.0700491
FNDC3B fibronectin type III domain containing 3B 0.0652446
ZEB1 zinc finger E-box binding homeobox 1 0.0645035
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0630371
AHNAK AHNAK nucleoprotein 0.0604901
BHLHE40 basic helix-loop-helix family, member e40 0.0569193
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0530923
ANKRD10 ankyrin repeat domain 10 0.0522316
MSI2 musashi RNA-binding protein 2 0.0500651
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0489959
CYLD cylindromatosis (turban tumor syndrome) 0.0478515
DENND5A DENN/MADD domain containing 5A 0.0469397
NT5C2 5'-nucleotidase, cytosolic II 0.0463768
DST dystonin 0.0461051
CDH13 cadherin 13 0.0458387
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0452936
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0448644
GLS2 glutaminase 2 (liver, mitochondrial) 0.044125
OGA O-GlcNAcase 0.0417312
FMNL2 formin-like 2 0.0413321
ADAM17 ADAM metallopeptidase domain 17 0.040294
ATP13A3 ATPase type 13A3 0.0393831
WAC WW domain containing adaptor with coiled-coil 0.039104
KDM3A lysine (K)-specific demethylase 3A 0.0378454
COPA coatomer protein complex, subunit alpha 0.0375094
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0363858
HELZ helicase with zinc finger 0.0358074
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0358034
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0347622
NAMPT nicotinamide phosphoribosyltransferase 0.0347324
ARL15 ADP-ribosylation factor-like 15 0.0344074
SSBP2 single-stranded DNA binding protein 2 0.0336001
MBNL2 muscleblind-like splicing regulator 2 0.0330983
ZMIZ1 zinc finger, MIZ-type containing 1 0.0317054
RICTOR RPTOR independent companion of MTOR, complex 2 0.0315434
TNIP1 TNFAIP3 interacting protein 1 0.0311373
CD109 CD109 molecule 0.0310699
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0309877
TFG TRK-fused gene 0.030962
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0302946
LCOR ligand dependent nuclear receptor corepressor 0.0301423
ANKRD11 ankyrin repeat domain 11 0.0301356
GPC6 glypican 6 0.0300588
MARCHF6 membrane associated ring-CH-type finger 6 0.0300573
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0300158
KDM6A lysine (K)-specific demethylase 6A 0.0299723
NAV2 neuron navigator 2 0.029782
USP9X ubiquitin specific peptidase 9, X-linked 0.0297101
SBF2 SET binding factor 2 0.0295718
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0293197
JAZF1 JAZF zinc finger 1 0.028772
FNIP1 folliculin interacting protein 1 0.0285003
PCGF5 polycomb group ring finger 5 0.0281212
DENND1A DENN/MADD domain containing 1A 0.0275635
MYOF myoferlin 0.0272251
MXI1 MAX interactor 1, dimerization protein 0.0271767
FBN1 fibrillin 1 0.0270332
SDK1 sidekick cell adhesion molecule 1 0.0267948
TSC22D2 TSC22 domain family, member 2 0.0266537
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0265738
DTNA dystrobrevin, alpha 0.0260939
RREB1 ras responsive element binding protein 1 0.0259611
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0258466
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.0256886
ZFP36L1 ZFP36 ring finger protein-like 1 0.0253416
WTAP Wilms tumor 1 associated protein 0.0253277
NBAS neuroblastoma amplified sequence 0.0252548
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0251989
FCHSD2 FCH and double SH3 domains 2 0.0251568
FAM168A family with sequence similarity 168, member A 0.0246868
ABI1 abl-interactor 1 0.0245151
TTC3 tetratricopeptide repeat domain 3 0.0243799
ZFAND3 zinc finger, AN1-type domain 3 0.0243131
RTN4 reticulon 4 0.0242249
RAB1A RAB1A, member RAS oncogene family 0.0240618
CDC73 cell division cycle 73 0.0240039
AFDN afadin, adherens junction formation factor 0.0239699
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0237916
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.0237036
USP3 ubiquitin specific peptidase 3 0.0236998
PIAS1 protein inhibitor of activated STAT, 1 0.0236045
PDE10A phosphodiesterase 10A 0.0235606
RHOQ ras homolog family member Q 0.0235553
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1 0.0235217
USP12 ubiquitin specific peptidase 12 0.0234726
AP3S1 adaptor-related protein complex 3, sigma 1 subunit 0.0234026
FTH1 ferritin, heavy polypeptide 1 0.0232438
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 0.0231368
MMP12 matrix metallopeptidase 12 0.0230977
DDR2 discoidin domain receptor tyrosine kinase 2 0.0228557
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0226518
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0225912
PDPK1 3-phosphoinositide dependent protein kinase 1 0.0225742
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 0.0225318

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.240261
AKAP12 A kinase (PRKA) anchor protein 12 -0.207294
MT2A metallothionein 2A -0.202882
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.182642
PLAT plasminogen activator, tissue -0.148329
VIM vimentin -0.136373
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.125268
B2M beta-2-microglobulin -0.0964096
TMSB10 thymosin beta 10 -0.0890435
CSTB cystatin B (stefin B) -0.0830175
CD44 CD44 molecule (Indian blood group) -0.0676387
S100A10 S100 calcium binding protein A10 -0.0668976
PODXL podocalyxin-like -0.0666595
NDRG1 N-myc downstream regulated 1 -0.0617347
STC1 stanniocalcin 1 -0.0589962
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0579961
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0543165
POTEF POTE ankyrin domain family, member F -0.0540499
CENPF centromere protein F, 350/400kDa -0.0533141
LMNA lamin A/C -0.0523676
S100A6 S100 calcium binding protein A6 -0.0515007
HLA-B major histocompatibility complex, class I, B -0.05143
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0478473
LOX lysyl oxidase -0.0459798
STAT1 signal transducer and activator of transcription 1, 91kDa -0.045644
PTMA prothymosin, alpha -0.0425914
COL1A2 collagen, type I, alpha 2 -0.0422355
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0396102
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0393837
HLA-C major histocompatibility complex, class I, C -0.038862
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0383097
RPS6 ribosomal protein S6 -0.0376323
MYADM myeloid-associated differentiation marker -0.0374508
LDHA lactate dehydrogenase A -0.0369915
IFITM3 interferon induced transmembrane protein 3 -0.0363677
RPS2 ribosomal protein S2 -0.0343744
RPS8 ribosomal protein S8 -0.0343042
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0335181
TPM4 tropomyosin 4 -0.0329367
LOC112694756 uncharaterized LOC112694756 -0.0327147
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0323305
RPL37A ribosomal protein L37a -0.0316885
TPT1 tumor protein, translationally-controlled 1 -0.0316708
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0313422
MT1X metallothionein 1X -0.0307123
RPS19 ribosomal protein S19 -0.0300685
RPL12 ribosomal protein L12 -0.0293582
CD99 CD99 molecule -0.0283576
S100A11 S100 calcium binding protein A11 -0.0280613
SVIL supervillin -0.0280596
EIF1 eukaryotic translation initiation factor 1 -0.027893
RRBP1 ribosome binding protein 1 -0.0278866
VDAC1 voltage-dependent anion channel 1 -0.0278002
BPTF bromodomain PHD finger transcription factor -0.0272463
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0271757
RPL36 ribosomal protein L36 -0.0270942
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0268259
SEPTIN7 septin 7 -0.0268243
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0267853
IFITM1 interferon induced transmembrane protein 1 -0.026738
TMSB4X thymosin beta 4, X-linked -0.0266681
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0260791
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0260143
RPL26 ribosomal protein L26 -0.0257582
PKM pyruvate kinase, muscle -0.0253189
IFI16 interferon, gamma-inducible protein 16 -0.0251745
TUBB4B tubulin, beta 4B class IVb -0.0250989
ACTG1 actin gamma 1 -0.0250114
COL3A1 collagen, type III, alpha 1 -0.0248173
WWTR1 WW domain containing transcription regulator 1 -0.0245219
S100A9 S100 calcium binding protein A9 -0.0239732
TAGLN2 transgelin 2 -0.0237817
SUCNR1 succinate receptor 1 -0.0231554
LGALS1 lectin, galactoside-binding, soluble, 1 -0.023131
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0230966
CAVIN1 caveolae associated protein 1 -0.0228979
RBM25 RNA binding motif protein 25 -0.0228296
CTSB cathepsin B -0.0227263
RPL28 ribosomal protein L28 -0.0226716
CDH2 cadherin 2, type 1, N-cadherin (neuronal) -0.0226144
MX2 MX dynamin-like GTPase 2 -0.0224537
RPLP2 ribosomal protein, large, P2 -0.0223901
RPS24 ribosomal protein S24 -0.0223036
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0222288
AKAP9 A kinase (PRKA) anchor protein 9 -0.022208
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.022197
CLU clusterin -0.0221067
FSTL1 follistatin-like 1 -0.0218587
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0217473
OSMR oncostatin M receptor -0.0216412
RPS3 ribosomal protein S3 -0.021455
MKI67 marker of proliferation Ki-67 -0.0214216
DPYSL2 dihydropyrimidinase-like 2 -0.0213699
CALR calreticulin -0.0212336
RPL23 ribosomal protein L23 -0.0211769
TBCA tubulin folding cofactor A -0.0210874
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 -0.0210331
RPL9 ribosomal protein L9 -0.0209813
ADAR adenosine deaminase, RNA-specific -0.0206292
GNAS GNAS complex locus -0.0205938