Thymopentin_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Thymopentin perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Thymopentin_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AREG amphiregulin 0.11823
ERRFI1 ERBB receptor feedback inhibitor 1 0.0873852
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0729189
TMEM41B transmembrane protein 41B 0.0625658
TXNRD1 thioredoxin reductase 1 0.0562842
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0545672
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa 0.0545351
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0543659
KDM3A lysine (K)-specific demethylase 3A 0.0526202
CPOX coproporphyrinogen oxidase 0.0493604
PUM2 pumilio RNA-binding family member 2 0.0490649
NEK7 NIMA-related kinase 7 0.0480132
THOC1 THO complex 1 0.0475772
YBX1 Y box binding protein 1 0.0459325
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0445189
XPO1 exportin 1 0.0442196
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0438733
ZNF292 zinc finger protein 292 0.0428651
KIF5B kinesin family member 5B 0.0412703
STARD4 StAR-related lipid transfer (START) domain containing 4 0.0411533
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0407611
MATR3 matrin 3 0.0400217
BIRC2 baculoviral IAP repeat containing 2 0.0396774
VMP1 vacuole membrane protein 1 0.039108
EEF2 eukaryotic translation elongation factor 2 0.0389454
CCNL1 cyclin L1 0.0382607
CXADR coxsackie virus and adenovirus receptor 0.0379622
CHD1 chromodomain helicase DNA binding protein 1 0.0376713
KLHL24 kelch-like family member 24 0.0368116
MED13L mediator complex subunit 13-like 0.0361702
UBA6 ubiquitin-like modifier activating enzyme 6 0.0361216
TNPO1 transportin 1 0.0356551
ADAM17 ADAM metallopeptidase domain 17 0.0355111
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0339304
PDE4B phosphodiesterase 4B, cAMP-specific 0.0337226
ECT2 epithelial cell transforming 2 0.0335558
TFG TRK-fused gene 0.0334498
PDK4 pyruvate dehydrogenase kinase, isozyme 4 0.0332687
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0329937
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0318045
OXR1 oxidation resistance 1 0.0308674
NAMPT nicotinamide phosphoribosyltransferase 0.0304142
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 0.0303229
CKAP5 cytoskeleton associated protein 5 0.029724
CEP95 centrosomal protein 95kDa 0.0290841
EIF1 eukaryotic translation initiation factor 1 0.0289393
ZBTB20 zinc finger and BTB domain containing 20 0.0286556
VIM vimentin 0.0280743
ARHGAP12 Rho GTPase activating protein 12 0.0276204
CDK19 cyclin-dependent kinase 19 0.0276031
PPP4R1 protein phosphatase 4, regulatory subunit 1 0.0275857
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0273266
GASK1B golgi associated kinase 1B 0.0272842
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0272573
NUP58 nucleoporin 58 0.026884
RNF145 ring finger protein 145 0.026757
TBK1 TANK-binding kinase 1 0.0266308
NCOR1 nuclear receptor corepressor 1 0.0266225
YEATS2 YEATS domain containing 2 0.0264946
MGAT4C MGAT4 family, member C 0.0261654
PNN pinin, desmosome associated protein 0.0258082
COG5 component of oligomeric golgi complex 5 0.0253955
BRWD3 bromodomain and WD repeat domain containing 3 0.0253011
RB1CC1 RB1-inducible coiled-coil 1 0.0251824
PNISR PNN-interacting serine/arginine-rich protein 0.0251099
ETNK1 ethanolamine kinase 1 0.025069
ARRDC3 arrestin domain containing 3 0.0248455
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0244632
FXR1 fragile X mental retardation, autosomal homolog 1 0.0244346
CEP192 centrosomal protein 192kDa 0.0241425
WDR43 WD repeat domain 43 0.0240377
RPL3 ribosomal protein L3 0.023753
CAMTA1 calmodulin binding transcription activator 1 0.0235459
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 0.0234331
OGA O-GlcNAcase 0.0233799
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.023094
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.0229727
NCKAP1 NCK-associated protein 1 0.0229143
CDK17 cyclin-dependent kinase 17 0.0225087
NKTR natural killer cell triggering receptor 0.0223744
CRISPLD1 cysteine-rich secretory protein LCCL domain containing 1 0.022276
RAB6A RAB6A, member RAS oncogene family 0.0220665
YBX3 Y box binding protein 3 0.0219935
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0218441
PALS2 protein associated with LIN7 2, MAGUK p55 family member 0.0218079
TMEM39A transmembrane protein 39A 0.0216962
RPS12 ribosomal protein S12 0.0216793
YTHDC1 YTH domain containing 1 0.021661
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0216436
THOC2 THO complex 2 0.0215126
TRA2A transformer 2 alpha homolog (Drosophila) 0.0214425
AKAP9 A kinase (PRKA) anchor protein 9 0.0213828
HSPA4 heat shock 70kDa protein 4 0.0211645
TNRC6A trinucleotide repeat containing 6A 0.0209991
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0209526
SEC23A Sec23 homolog A (S. cerevisiae) 0.0207985
USP24 ubiquitin specific peptidase 24 0.0205782
CLDND1 claudin domain containing 1 0.0205031
PAWR PRKC, apoptosis, WT1, regulator 0.0204393
KDM6A lysine (K)-specific demethylase 6A 0.0204225

decreased expression

Symbol Name Standardized Value
NLGN1 neuroligin 1 -0.306371
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.214416
HMGA2 high mobility group AT-hook 2 -0.174864
PCDH7 protocadherin 7 -0.129368
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.114189
EHBP1 EH domain binding protein 1 -0.104771
PDE4D phosphodiesterase 4D, cAMP-specific -0.0928783
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0822535
ACTG1 actin gamma 1 -0.0784581
RAB7A RAB7A, member RAS oncogene family -0.0767243
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0745124
INTS6 integrator complex subunit 6 -0.0739442
ZNF804A zinc finger protein 804A -0.0714004
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0702658
ADIPOR2 adiponectin receptor 2 -0.0690841
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0682617
NHSL1 NHS-like 1 -0.0625161
RIMS2 regulating synaptic membrane exocytosis 2 -0.0612428
DPYD dihydropyrimidine dehydrogenase -0.0577852
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 -0.0571609
CMIP c-Maf inducing protein -0.0547292
RASAL2 RAS protein activator like 2 -0.0537029
MSRB3 methionine sulfoxide reductase B3 -0.0536264
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0525163
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0517076
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0513544
DST dystonin -0.0503339
CUX1 cut-like homeobox 1 -0.0500672
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0490468
EGR1 early growth response 1 -0.0476406
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0466367
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0464505
TMSB10 thymosin beta 10 -0.0462247
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B -0.0456956
L3MBTL4 l(3)mbt-like 4 (Drosophila) -0.0456168
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0443539
LRRTM4 leucine rich repeat transmembrane neuronal 4 -0.0440971
AHNAK AHNAK nucleoprotein -0.043423
DLC1 DLC1 Rho GTPase activating protein -0.0428083
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0427454
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0426528
LRRC23 leucine rich repeat containing 23 -0.0407534
LPP LIM domain containing preferred translocation partner in lipoma -0.0397527
TAS2R14 taste receptor, type 2, member 14 -0.0396756
NEBL nebulette -0.0392355
YAP1 Yes-associated protein 1 -0.0388426
CSMD3 CUB and Sushi multiple domains 3 -0.0382119
CDH12 cadherin 12, type 2 (N-cadherin 2) -0.0369463
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0358475
DOCK1 dedicator of cytokinesis 1 -0.0352818
NABP1 nucleic acid binding protein 1 -0.0352385
CUBN cubilin (intrinsic factor-cobalamin receptor) -0.0349299
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0344144
RNF213 ring finger protein 213 -0.0339202
R3HDM2 R3H domain containing 2 -0.0338404
PCDH9 protocadherin 9 -0.0336102
TPT1 tumor protein, translationally-controlled 1 -0.0335488
MACF1 microtubule-actin crosslinking factor 1 -0.0332913
CEP112 centrosomal protein 112kDa -0.0324665
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0322498
MTAP methylthioadenosine phosphorylase -0.0322262
CCSER1 coiled-coil serine-rich protein 1 -0.0319231
COMMD10 COMM domain containing 10 -0.031746
ZNF638 zinc finger protein 638 -0.0314818
ETV6 ets variant 6 -0.0313106
BPTF bromodomain PHD finger transcription factor -0.0312613
MARCHF4 membrane associated ring-CH-type finger 4 -0.0312483
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0311988
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0311782
TBCA tubulin folding cofactor A -0.0308232
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.030707
DENND5A DENN/MADD domain containing 5A -0.0305228
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0303143
RABGAP1L RAB GTPase activating protein 1-like -0.0303031
DTNA dystrobrevin, alpha -0.0301217
BABAM2 BRISC and BRCA1 A complex member 2 -0.0299962
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0297906
ASXL2 additional sex combs like transcriptional regulator 2 -0.0296358
PHACTR4 phosphatase and actin regulator 4 -0.0294948
HDAC9 histone deacetylase 9 -0.0294893
MYPN myopalladin -0.0294226
NSD2 nuclear receptor binding SET domain protein 2 -0.0292921
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0292039
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0291943
ASPH aspartate beta-hydroxylase -0.0290493
RRM2 ribonucleotide reductase M2 -0.0285301
PRIM2 primase, DNA, polypeptide 2 (58kDa) -0.0284278
EXOC4 exocyst complex component 4 -0.0284239
ANKRD17 ankyrin repeat domain 17 -0.0283332
CCND1 cyclin D1 -0.0274833
PRH1 proline-rich protein HaeIII subfamily 1 -0.027475
LARP4B La ribonucleoprotein domain family, member 4B -0.0270105
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0269543
LRMDA leucine rich melanocyte differentiation associated -0.0269329
PPP1R10 protein phosphatase 1, regulatory subunit 10 -0.0269018
ASXL1 additional sex combs like transcriptional regulator 1 -0.0268943
DNAH14 dynein, axonemal, heavy chain 14 -0.0263096
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.026203
TRIO trio Rho guanine nucleotide exchange factor -0.0260354
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.025787