Thymopentin_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Thymopentin perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Thymopentin_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
N4BP2L2 NEDD4 binding protein 2-like 2 0.0867459
FNDC3B fibronectin type III domain containing 3B 0.0777429
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0528363
LYZ lysozyme 0.0518039
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0482147
TXNIP thioredoxin interacting protein 0.0448285
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.0435259
FNIP1 folliculin interacting protein 1 0.0413038
VMP1 vacuole membrane protein 1 0.0405523
KMT2E lysine (K)-specific methyltransferase 2E 0.0394149
RNF149 ring finger protein 149 0.0391691
ESYT2 extended synaptotagmin-like protein 2 0.0389223
DIAPH1 diaphanous-related formin 1 0.0388843
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.038866
UBR2 ubiquitin protein ligase E3 component n-recognin 2 0.0387254
BCLAF1 BCL2-associated transcription factor 1 0.0385343
VEGFA vascular endothelial growth factor A 0.0376524
ASPH aspartate beta-hydroxylase 0.03731
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0367152
COG6 component of oligomeric golgi complex 6 0.0356374
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0347505
PIAS1 protein inhibitor of activated STAT, 1 0.0339704
PRKCA protein kinase C, alpha 0.0338829
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0336452
PTK2 protein tyrosine kinase 2 0.032254
TSC22D2 TSC22 domain family, member 2 0.0315238
MED13L mediator complex subunit 13-like 0.0313782
KIF16B kinesin family member 16B 0.0307865
HELZ helicase with zinc finger 0.030651
PADI1 peptidyl arginine deiminase, type I 0.0302023
LIMA1 LIM domain and actin binding 1 0.0287859
ZBTB20 zinc finger and BTB domain containing 20 0.0284129
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) 0.0275959
AKAP13 A kinase (PRKA) anchor protein 13 0.0272832
KDM6A lysine (K)-specific demethylase 6A 0.0268392
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.0267662
PDS5B PDS5 cohesin associated factor B 0.026515
PTEN phosphatase and tensin homolog 0.0263705
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0261852
ERRFI1 ERBB receptor feedback inhibitor 1 0.026106
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0260741
UBA6 ubiquitin-like modifier activating enzyme 6 0.0260656
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0259599
SORBS1 sorbin and SH3 domain containing 1 0.0258752
ZCCHC7 zinc finger, CCHC domain containing 7 0.0249405
JMJD1C jumonji domain containing 1C 0.0249366
KDM4C lysine (K)-specific demethylase 4C 0.0247546
SETD5 SET domain containing 5 0.0246426
ARHGAP26 Rho GTPase activating protein 26 0.0244335
ABHD2 abhydrolase domain containing 2 0.0242182
MAML2 mastermind-like 2 (Drosophila) 0.0238062
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0234817
MAP7 microtubule-associated protein 7 0.0232137
PTBP3 polypyrimidine tract binding protein 3 0.022369
GOLGB1 golgin B1 0.0220425
SCARB1 scavenger receptor class B, member 1 0.0220046
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0219372
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.0218733
NPEPPS aminopeptidase puromycin sensitive 0.021838
SEC24D SEC24 family member D 0.0217082
RAB6A RAB6A, member RAS oncogene family 0.0215804
ZNF451 zinc finger protein 451 0.0215348
SCFD1 sec1 family domain containing 1 0.0215152
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0215109
ZNF652 zinc finger protein 652 0.0212502
STS steroid sulfatase (microsomal), isozyme S 0.0211687
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0211601
ERBIN erbb2 interacting protein 0.0211166
RBM26 RNA binding motif protein 26 0.0208853
SRRM2 serine/arginine repetitive matrix 2 0.0208834
ANKRD11 ankyrin repeat domain 11 0.0208679
GSK3B glycogen synthase kinase 3 beta 0.020829
RAD23B RAD23 homolog B (S. cerevisiae) 0.0207723
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa 0.0207462
TJP2 tight junction protein 2 0.0205981
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0204618
TPM3 tropomyosin 3 0.0204476
ANO6 anoctamin 6 0.0199757
TMEM39A transmembrane protein 39A 0.0196849
SH3PXD2A SH3 and PX domains 2A 0.0196814
IGFBP3 insulin-like growth factor binding protein 3 0.0195239
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0195118
TM4SF19 transmembrane 4 L six family member 19 0.0193769
NBAS neuroblastoma amplified sequence 0.0193205
CSTPP1 centriolar satellite-associated tubulin polyglutamylase complex regulator 1 0.0191971
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.0188764
NCOR2 nuclear receptor corepressor 2 0.0188424
NBR1 neighbor of BRCA1 gene 1 0.0184391
BTBD10 BTB (POZ) domain containing 10 0.0184197
CEP152 centrosomal protein 152kDa 0.0183276
PDE8A phosphodiesterase 8A 0.0183099
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0182989
ZFC3H1 zinc finger, C3H1-type containing 0.0182808
RNF145 ring finger protein 145 0.0181856
MYO10 myosin X 0.018091
CNOT4 CCR4-NOT transcription complex, subunit 4 0.0180265
ANKRD18A ankyrin repeat domain 18A 0.0179078
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0178304
SRSF4 serine/arginine-rich splicing factor 4 0.0178082
CNOT1 CCR4-NOT transcription complex, subunit 1 0.017787

decreased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 -0.223388
LMO7 LIM domain 7 -0.163064
STAT1 signal transducer and activator of transcription 1, 91kDa -0.146371
HLA-B major histocompatibility complex, class I, B -0.131024
SQSTM1 sequestosome 1 -0.119406
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.115683
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.114909
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.108116
EXT1 exostosin glycosyltransferase 1 -0.104435
RUNX1 runt-related transcription factor 1 -0.102123
LCN2 lipocalin 2 -0.0857081
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0836801
IRF1 interferon regulatory factor 1 -0.081146
RNF213 ring finger protein 213 -0.0798271
B2M beta-2-microglobulin -0.0793694
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.074229
ANXA2 annexin A2 -0.0719176
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0693801
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0691912
PERP PERP, TP53 apoptosis effector -0.0663655
RRBP1 ribosome binding protein 1 -0.0640628
EPHB2 EPH receptor B2 -0.060792
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0600731
RIGI RNA sensor RIG-I -0.0599766
EZR ezrin -0.0592379
HLA-C major histocompatibility complex, class I, C -0.0588786
H1-0 H1.0 linker histone -0.0586906
NCKAP5 NCK-associated protein 5 -0.0586828
VCL vinculin -0.057326
PLSCR1 phospholipid scramblase 1 -0.0557488
KLF5 Kruppel-like factor 5 (intestinal) -0.0556711
EGLN3 egl-9 family hypoxia-inducible factor 3 -0.0550443
XAF1 XIAP associated factor 1 -0.0549845
MYO1E myosin IE -0.0547076
HLA-E major histocompatibility complex, class I, E -0.0538069
IFI6 interferon, alpha-inducible protein 6 -0.0531678
NCOA7 nuclear receptor coactivator 7 -0.0520785
MX2 MX dynamin-like GTPase 2 -0.0517425
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0504693
ACTN4 actinin, alpha 4 -0.0500772
PTMA prothymosin, alpha -0.048934
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0487316
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0486351
NDRG1 N-myc downstream regulated 1 -0.0474341
PHF3 PHD finger protein 3 -0.047383
MUC13 mucin 13, cell surface associated -0.0469049
TC2N tandem C2 domains, nuclear -0.0465841
FOXP1 forkhead box P1 -0.0465836
EIF1 eukaryotic translation initiation factor 1 -0.045513
PATJ PATJ crumbs cell polarity complex component -0.0452831
JUN jun proto-oncogene -0.0449553
SP100 SP100 nuclear antigen -0.0449491
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0448498
ARF1 ADP-ribosylation factor 1 -0.0447923
ARHGAP5 Rho GTPase activating protein 5 -0.0442602
GCLC glutamate-cysteine ligase, catalytic subunit -0.0441371
RPLP1 ribosomal protein, large, P1 -0.0437769
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0437749
RAD21 RAD21 homolog (S. pombe) -0.04359
KLF6 Kruppel-like factor 6 -0.0430046
MACC1 metastasis associated in colon cancer 1 -0.042745
NKD1 naked cuticle homolog 1 (Drosophila) -0.0421334
MX1 MX dynamin-like GTPase 1 -0.0414874
IRS2 insulin receptor substrate 2 -0.0409758
MUC20 mucin 20, cell surface associated -0.0404076
FUS FUS RNA binding protein -0.0399349
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0398781
SERINC5 serine incorporator 5 -0.039394
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0391861
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0391714
RBM39 RNA binding motif protein 39 -0.0387778
DUSP16 dual specificity phosphatase 16 -0.0386468
IFIH1 interferon induced with helicase C domain 1 -0.0385884
UGDH UDP-glucose 6-dehydrogenase -0.0384337
RPS6 ribosomal protein S6 -0.038391
EPCAM epithelial cell adhesion molecule -0.0375105
SPATA13 spermatogenesis associated 13 -0.0374733
RPL34 ribosomal protein L34 -0.0373386
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0371167
NAMPT nicotinamide phosphoribosyltransferase -0.0368971
PTPRF protein tyrosine phosphatase, receptor type, F -0.0367115
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.0363114
AHNAK AHNAK nucleoprotein -0.0352943
LOC112694756 uncharaterized LOC112694756 -0.0351532
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0346504
RNF43 ring finger protein 43 -0.0346493
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.0344028
ERN1 endoplasmic reticulum to nucleus signaling 1 -0.0339873
C6ORF132 chromosome 6 open reading frame 132 -0.0338905
FMN1 formin 1 -0.0336076
RPL7L1 ribosomal protein L7-like 1 -0.0334137
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa -0.0329436
UBC ubiquitin C -0.0327091
CANX calnexin -0.03259
LAP3 leucine aminopeptidase 3 -0.0324649
S100A10 S100 calcium binding protein A10 -0.0322706
ZNFX1 zinc finger, NFX1-type containing 1 -0.0314659
TNRC6B trinucleotide repeat containing 6B -0.031292
GNAS GNAS complex locus -0.0310563
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0309238