Thymopentin_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Thymopentin perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Thymopentin_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CXCL8 chemokine (C-X-C motif) ligand 8 0.162463
CADM1 cell adhesion molecule 1 0.106501
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.100229
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0812565
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0740208
CD44 CD44 molecule (Indian blood group) 0.0723457
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0704577
TRIO trio Rho guanine nucleotide exchange factor 0.0696807
ELL2 elongation factor, RNA polymerase II, 2 0.0587846
MYH9 myosin, heavy chain 9, non-muscle 0.0576757
ATP13A3 ATPase type 13A3 0.0543502
ARRDC3 arrestin domain containing 3 0.0532209
FNDC3B fibronectin type III domain containing 3B 0.0510054
TIMP3 TIMP metallopeptidase inhibitor 3 0.0491848
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0485318
NAV2 neuron navigator 2 0.0484808
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0480573
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0461628
HILPDA hypoxia inducible lipid droplet-associated 0.0442999
PRELID2 PRELI domain containing 2 0.0418247
ERRFI1 ERBB receptor feedback inhibitor 1 0.0406344
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0401955
UBA6 ubiquitin-like modifier activating enzyme 6 0.0380396
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0373854
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.037085
ADAM9 ADAM metallopeptidase domain 9 0.0367551
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0360632
CENPF centromere protein F, 350/400kDa 0.0343779
NAMPT nicotinamide phosphoribosyltransferase 0.0342981
MTSS1 metastasis suppressor 1 0.0330359
TNIP1 TNFAIP3 interacting protein 1 0.0327286
PDE10A phosphodiesterase 10A 0.0327252
ZNF292 zinc finger protein 292 0.0322496
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0315552
FAM13A family with sequence similarity 13, member A 0.0314424
VMP1 vacuole membrane protein 1 0.0312705
KTN1 kinectin 1 (kinesin receptor) 0.0303995
PTK2 protein tyrosine kinase 2 0.0298637
EGFR epidermal growth factor receptor 0.0295433
KMT2E lysine (K)-specific methyltransferase 2E 0.0291927
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0291095
ENO1 enolase 1, (alpha) 0.0284897
SPTBN1 spectrin, beta, non-erythrocytic 1 0.028392
UGCG UDP-glucose ceramide glucosyltransferase 0.0282848
RNF145 ring finger protein 145 0.0277509
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0275658
RPL3 ribosomal protein L3 0.0269804
CAMTA1 calmodulin binding transcription activator 1 0.026795
PDIA6 protein disulfide isomerase family A, member 6 0.0264738
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0259749
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0259727
SMAD3 SMAD family member 3 0.0257737
BBX bobby sox homolog (Drosophila) 0.0257166
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0257072
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0253674
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0252248
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0250465
HYOU1 hypoxia up-regulated 1 0.0250079
RB1CC1 RB1-inducible coiled-coil 1 0.024941
ATL1 atlastin GTPase 1 0.0249336
MYO1B myosin IB 0.0249137
NRIP1 nuclear receptor interacting protein 1 0.0245642
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0245424
SOD2 superoxide dismutase 2, mitochondrial 0.0243798
PARP8 poly (ADP-ribose) polymerase family, member 8 0.0242041
SMC4 structural maintenance of chromosomes 4 0.024043
NUCB2 nucleobindin 2 0.0239742
B2M beta-2-microglobulin 0.023871
YEATS2 YEATS domain containing 2 0.023714
JARID2 jumonji, AT rich interactive domain 2 0.0235392
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0234549
RYBP RING1 and YY1 binding protein 0.0233904
ESYT2 extended synaptotagmin-like protein 2 0.0233767
DLG1 discs, large homolog 1 (Drosophila) 0.0230618
FXR1 fragile X mental retardation, autosomal homolog 1 0.0229854
CANX calnexin 0.0227335
MSN moesin 0.0226576
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0225907
VEGFA vascular endothelial growth factor A 0.0222142
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0221426
GOLGA4 golgin A4 0.0221246
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0221044
ALCAM activated leukocyte cell adhesion molecule 0.0219705
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0216814
EEF2 eukaryotic translation elongation factor 2 0.021398
FOSL1 FOS-like antigen 1 0.0212929
AZIN1 antizyme inhibitor 1 0.0211652
CSF1 colony stimulating factor 1 (macrophage) 0.0207823
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0205901
PHF21A PHD finger protein 21A 0.0203675
SNX3 sorting nexin 3 0.0203259
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0203039
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0202902
ADAM17 ADAM metallopeptidase domain 17 0.020226
HIP1 huntingtin interacting protein 1 0.0201872
SLC39A14 solute carrier family 39 (zinc transporter), member 14 0.0201618
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 0.0197491
TRAM1 translocation associated membrane protein 1 0.0197215
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.0196611
ANO6 anoctamin 6 0.0196601

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.3339
COL1A1 collagen, type I, alpha 1 -0.226263
IGFBP3 insulin-like growth factor binding protein 3 -0.19094
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.186891
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.121014
TMSB10 thymosin beta 10 -0.0878776
HMGA2 high mobility group AT-hook 2 -0.0769069
VIM vimentin -0.0745928
COL1A2 collagen, type I, alpha 2 -0.0742967
FBN1 fibrillin 1 -0.0695594
GLIS3 GLIS family zinc finger 3 -0.0664298
ACTG1 actin gamma 1 -0.0643768
COL6A3 collagen, type VI, alpha 3 -0.0638902
EXT1 exostosin glycosyltransferase 1 -0.0632722
LOX lysyl oxidase -0.0595386
PSD3 pleckstrin and Sec7 domain containing 3 -0.0579079
NKAIN3 Na+/K+ transporting ATPase interacting 3 -0.0560413
IER3 immediate early response 3 -0.0540834
TGFBI transforming growth factor, beta-induced, 68kDa -0.0537187
TM4SF1 transmembrane 4 L six family member 1 -0.0521746
CAVIN1 caveolae associated protein 1 -0.0505811
WWTR1 WW domain containing transcription regulator 1 -0.0480383
COL3A1 collagen, type III, alpha 1 -0.0477309
PDLIM5 PDZ and LIM domain 5 -0.0473635
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0455687
CDH13 cadherin 13 -0.0447728
EGR1 early growth response 1 -0.0419127
RPL35A ribosomal protein L35a -0.0395962
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0389741
OSMR oncostatin M receptor -0.0387756
TRPS1 trichorhinophalangeal syndrome I -0.0385298
F3 coagulation factor III (thromboplastin, tissue factor) -0.0380129
PALLD palladin, cytoskeletal associated protein -0.0373273
TPM4 tropomyosin 4 -0.0359824
TPT1 tumor protein, translationally-controlled 1 -0.0356994
COL5A1 collagen, type V, alpha 1 -0.0350136
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0349687
CALD1 caldesmon 1 -0.0348588
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.034698
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0341873
VCL vinculin -0.0333039
ZBTB20 zinc finger and BTB domain containing 20 -0.031553
RSU1 Ras suppressor protein 1 -0.0305131
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0302805
MT1X metallothionein 1X -0.0301447
POTEF POTE ankyrin domain family, member F -0.0293707
LOC112694756 uncharaterized LOC112694756 -0.0279325
RPL34 ribosomal protein L34 -0.0274359
MBNL1 muscleblind-like splicing regulator 1 -0.0261381
SEC31A SEC31 homolog A (S. cerevisiae) -0.0257581
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0257016
FTL ferritin, light polypeptide -0.0256646
RPL26 ribosomal protein L26 -0.0248492
PTMA prothymosin, alpha -0.0243222
FKBP10 FK506 binding protein 10, 65 kDa -0.023964
VCAN versican -0.0226997
POSTN periostin, osteoblast specific factor -0.0223755
PXDN peroxidasin -0.0223365
RPL23 ribosomal protein L23 -0.0223307
GNAS GNAS complex locus -0.0215423
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0214363
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0212407
ANKRD28 ankyrin repeat domain 28 -0.0211136
INHBA inhibin, beta A -0.0210348
VDAC1 voltage-dependent anion channel 1 -0.0207442
TMEM263 transmembrane protein 263 -0.0204481
CALU calumenin -0.0200527
RPL28 ribosomal protein L28 -0.0200215
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 -0.0199337
CLMP CXADR-like membrane protein -0.0197823
RPL36 ribosomal protein L36 -0.0194375
NEK10 NIMA-related kinase 10 -0.0193621
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0190873
RPS11 ribosomal protein S11 -0.0190354
RPL30 ribosomal protein L30 -0.018599
DUSP6 dual specificity phosphatase 6 -0.0184133
RPS3 ribosomal protein S3 -0.0181541
HLA-B major histocompatibility complex, class I, B -0.0179262
RPS24 ribosomal protein S24 -0.0178944
SLC38A2 solute carrier family 38, member 2 -0.0178751
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0178702
RPLP1 ribosomal protein, large, P1 -0.0178376
PTPRF protein tyrosine phosphatase, receptor type, F -0.01776
S100A6 S100 calcium binding protein A6 -0.0176431
RPL8 ribosomal protein L8 -0.017577
COL7A1 collagen, type VII, alpha 1 -0.0174799
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0174445
MAML2 mastermind-like 2 (Drosophila) -0.0173931
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -0.0173778
THY1 Thy-1 cell surface antigen -0.0171911
RRBP1 ribosome binding protein 1 -0.0170841
RPL32 ribosomal protein L32 -0.0169865
NABP1 nucleic acid binding protein 1 -0.0168449
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0168159
RHOA ras homolog family member A -0.0167236
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0166604
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0166388
RPL37 ribosomal protein L37 -0.0165457
ZBTB38 zinc finger and BTB domain containing 38 -0.0165388
KPNB1 karyopherin (importin) beta 1 -0.016493